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서버 클라이언트 기반의 실시간 마이크로칩 형광 이미지 분석 시스템 개발
조미경,심재술,Cho, Migyung,Shim, Jaesool 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.5
In the field of clinical medicine and research, the analysis of such as protein and DNA at the molecular level and even at the cell level are necessary for disease diagnosis and treatment. In many cases, a real time image of samples is needed for the accurate analysis and manipulation of samples since experimental samples are degenerated with time. In this research, a three-dimensional fluorescence microscope device was developed for taking images of protein and DNA inside a single cell and the server-client based image analysis system was made for an integrated management of the real-time images taken from the microscope device. The system consists of a fluorescent measurement device, the associated software and a client program on smartphone. The developed system allows doctors or experimental managers to receive and look at the real-time experimental images taken from the samples of patients anywhere in the emergency, to analyze results and to instantly diagnose the disease and to transfer the results to the patients. As a result, the system is able to be utilized in the implementation of ubiquitous health as well. 임상 의료 분야에서 질병 진단 및 치료를 위해서는 분자 수준(프로틴, DNA 등)의 크기 뿐만 아니라, 세포 수준에 대한 분석이 필요하다. 많은 경우 실험 샘플이 시간에 따라 변질되기 때문에 정확한 분석을 위해서는 빠른 분석과 실시간 데이터가 필요하다. 본 연구에서는 나노 마이크로 크기의 세포내 단백질이나 DNA의 변화 과정 등을 촬영할 수 있는 3차원 형광 관측 장치를 제작하고 이로부터 얻은 형광 이미지를 실시간 통합 관리 및 분석하기 위한 서버 클라이언트 기반의 형광 이미지 분석 시스템을 구축하였다. 시스템은 형광 관측 장치와 소프트웨어 그리고 형광 이미지를 실시간으로 분석할 수 있는 모바일 프로그램으로 구성된다. 개발된 시스템은 의료인이 시공간의 제약 없이 응급환자의 샘플에서 획득한 형광이미지를 실시간으로 전송받아 분석 및 진단을 내릴 수 있도록 해 주므로 유비쿼터스 헬스 구현에 활용할 수 있다.
조미경(Mi Gyung Cho),심재술(Jaesool Shim) 대한기계학회 2013 大韓機械學會論文集B Vol.37 No.3
광학 현미경을 통해 일정한 시간 간격으로 얻은 세포 이미지로부터 세포 변화를 자동적으로 추적 및 분석하는 것이 세포 트래킹이라고 한다. 세포 변화 과정에서 이웃에 있는 세포들이 겹쳐져 있는 상태를 클러스터라고 하며 세포트래킹에서 클러스터를 다시 세포로 분리하는 작업은 매우 중요하다. 본 논문에서는 타원 근사법을 기반으로 클러스터를 분리하기 위한 알고리즘을 제안한다. 클러스터의 외곽선을 추출한 후 외곽선의 오목정점을 이용하여 클러스터를 라인 세그먼트들로 분리한 다음 휴리스틱을 이용하여 라인 세그먼트들을 결합해 가며 근사 타원을 생성한다. 실험 결과 두 개의 세포가 겹쳐진 클러스터의 경우 평균적으로 91%, 세 개의 세포가 겹쳐진 경우 평균적으로 84% 그리고 겹쳐진 세포의 개수가 네 개 이상인 경우 약 73%의 정확도로 클러스터를 분리해 주었다. An automated cell tracking system is used to automatically analyze and track the changes in cell behavior in time-lapse cell images acquired using a microscope with a cell culture. Clustering is the partial overlapping of neighboring cells in the process of cell change. Separating clusters into individual cells is very important for cell tracking. In this study, we proposed an algorithm for separating clusters by using ellipse fitting based on a direct least square method. We extracted the contours of clusters, divided them into line segments, and then produced their fitted ellipses using a direct least square method for each line segment. All of the fitted ellipses could be used to separate their corresponding clusters. In experiments, our algorithm separated clusters with average precisions of 91% for two overlapping cells, 84% for three overlapping cells, and about 73% for four overlapping cells.
최소 극단치 분포를 이용한 자동차 도어 래치의 아이링 모델 가속 수명 예측을 위한 회귀 분석 방법 연구
손지훈(Jihoon Son),심재술(Jaesool Shim),배영화(Younghwa Bae),김우엽(Wooyoub Kim),김정재(Jungjae Kim),김청산(Chungsan Kim) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
Door latch of automobile is a necessary component for automobile passengers which performs not only Open/Close but also Lock/Unlock. Also, door latch is strongly controlled by automobile safety regulation and requires high reliability. Door latch is exposed to wide range of temperatures due to climate and repetitive load of motor is applied to gears. Therefore, estimation of cumulative failure rate and lifespan under stress condition is necessary. Therefore, in this study, the theoretical Erying model accelerated life anaylsis, which is the zero failure test method, is proposed using Weibull distribution theory under the log relationship between the Weibull distribution and Minimum extreme value distribution. This research investigated various parts inside of latch which is defined failure mechanisms and factors using step of reliability analysis. Also, HALT was performed for acceleration level decision. Failure mechanism of door latch is gear damage due to high/low temperature and repetitive load and applied temperature (-45℃ ~ 100℃) and load (18V, 24V) conditions to accelerate failure. Common shape parameter and scale parameters were derived as a result of multi-levels, factors ALT. By applying Eyring model, lifespan under specific temperature and load condition is estimated. Also, the theoretical and experimental values predicted by regression analysis using the minimum extreme value distribution under the log relationship with the weibull distribution were compared. As a result, it was confirmed that there was no error in the two values, and it was possible to theoretically predict the multifactor acceleration life.
최소 극단치 분포를 이용한 자동차 도어 래치의 아이링 모델 가속 수명 예측을 위한 회귀 분석 방법 연구
손지훈(Jihoon Son),심재술(Jaesool Shim),배영화(Younghwa Bae),김우엽(Wooyoub Kim),김정재(Jungjae Kim),김청산(Chungsan Kim) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
Door latch of automobile is a necessary component for automobile passengers which performs not only Open/Close but also Lock/Unlock. Also, door latch is strongly controlled by automobile safety regulation and requires high reliability. Door latch is exposed to wide range of temperatures due to climate and repetitive load of motor is applied to gears. Therefore, estimation of cumulative failure rate and lifespan under stress condition is necessary. Therefore, in this study, the theoretical Erying model accelerated life anaylsis, which is the zero failure test method, is proposed using Weibull distribution theory under the log relationship between the Weibull distribution and Minimum extreme value distribution. This research investigated various parts inside of latch which is defined failure mechanisms and factors using step of reliability analysis. Also, HALT was performed for acceleration level decision. Failure mechanism of door latch is gear damage due to high/low temperature and repetitive load and applied temperature (-45℃ ~ 100℃) and load (18V, 24V) conditions to accelerate failure. Common shape parameter and scale parameters were derived as a result of multi-levels, factors ALT. By applying Eyring model, lifespan under specific temperature and load condition is estimated. Also, the theoretical and experimental values predicted by regression analysis using the minimum extreme value distribution under the log relationship with the weibull distribution were compared. As a result, it was confirmed that there was no error in the two values, and it was possible to theoretically predict the multifactor acceleration life.
Opto-electrokinetic 효과에 의한 Toroidal Microvortex 형성에 관한 수치해석적 연구
김동(Dong Kim),심재술(Jaesool Shim),김경천(Kyung Chun Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
In this study, the formation of a toroidal microvortex by optoelectrokinetic effect was numerically simulated using COMSOL v4.2a multiphysics software. AC voltage was applied to the two parallel electrodes in a microchannel to generate temperature gradient in the fluids. In addition to the AC electrothermal (ACET) effect, local heating by a laser illumination was also considered. Numerical simulations were conducted for dielectric fluids. The toroidal microvortex induced by the optoelectrokinetic effect shows that two counter-rotating vortices are produced above the bottom electrodes. Fluid motions in the middle of bottom boundary are cancelled out by flows in opposite directions and consequently producing stagnation. It is expected that micro/nano particles are deposited in bottom electrode. Local heating enhanced the intensity of microvortex substantially due to the additional temperature gradient, it was confirmed that the ACET effect with laser illumination can be used for rapid concentration of micro/nano particles in the spot area.
조미경(Migyung Cho),심재술(Jaesool Shim),김진석(Jinseok kim),문상준(Sangjun Moon) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1C
셀 트래킹의 목적은 셀의 이동(translocation), 분할(mitosis), 통합(fusion), 아포토시스(apoptosis), 셀의 모양 변형, 셀들 간의 상호 작용 등을 포함하는 모든 셀의 행동들을 분석하기 위한 것이다. 셀은 시간이 경과함에 따라 새롭게 나타나기도, 죽기도 하며 한 개 이상의 셀이 부분적으로 겹쳐 클러스터를 형성하기도 하고 클러스터는 다시 여러 개의 셀로 분리되기도 한다. 본 연구에서는 현미경으로부터 얻은 이미지에서 셀 트래킹을 위한 이미지 처리 방법과 오목 정점을 이용하여 셀과 클러스터를 구분하여 계수하는 방법을 제시한다. 또한 타원 근사법(ellipse fitting)을 통해 클러스터를 몇 개의 셀로 분리하기 위한 방법을 제시하고 결과를 분석한다.