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Oh, Jaemin,Hur, Jungmu,Kim, Yourim,Kwon, Young-Mi,Kim, Kyungsuk,Chung, Yeuntai,Choi, Minkyu Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.20 No.4
Background: Crohn's disease is characterized by a chronic relapsing inflammation of the bowel. Gliotoxin has been known to play strong immunosuppressive properties, while mechanisms for its anti-inflammatory actions are not completely understood. Here, we investigated the effects of gliotoxin in trinitrobenzene sulfonic acid (TNBS) induced mouse colitis, an animal model of Crohn's disease. Results: Gliotoxin dramatically improved clinical and histopathological symptoms in accompanied with reduced expression of TNF-$\alpha$, IL-1$\beta$, and ICAM-1 protein levels in TNBS induced colitis. Interestingly Gliotoxin induced Heme oxygenase-1 (HO-1) and the HO-1 inducer cobalt protoporphyrin IX (CoPPIX) completely mimicked the protective effects of gliotoxin in TNBS induced colitis mice. In contrast, the HO-1 inhibitor zinc protoporphyrin IX (ZnPPIX) could reverse the anti-inflammatory effects of gliotoxin and CoPPIX. Conclusions: Gliotoxin is a potential therapeutic agent targeting for the treatment of Crohn's disease by inducing HO-1.
Jaemin Oh,Jungmu Hur,Yourim Kim,Young-Mi Kwon,Kyungsuk Kim,Yeuntai Chung,Minkyu Choi 한국독성학회 2004 Toxicological Research Vol.20 No.4
Crohn’s disease is characterized by a chronic relapsing inflammation of the bowel. Gliotoxin has been known to play strong immunosuppressive properties, while mechanisms for its anti-inflammatory actions are not completely understood. Here, we investigated the effects of gliotoxin in trinitrobenzene sulfonic acid (TNBS) induced mouse colitis, an animal model of Crohn’s disease. Results: Gliotoxin dramatically improved clinical and histopathological symptoms in accompanied with reduced expression of TNF-α, IL-1β, and ICAM-1 protein levels in TNBS induced colitis. Interestingly Gliotoxin induced Heme oxygenase-1 (HO-1) and the HO-1 inducer cobalt protoporphyrin IX (CoPPIX) completely mimicked the protective effects of gliotoxin in TNBS induced colitis mice. In contrast, the HO-1 inhibitor zinc protoporphyrin IX (ZnPPIX) could reverse the antiinflammatory effects of gliotoxin and CoPPIX. Conclusions: Gliotoxin is a potential therapeutic agent targeting for the treatment of Crohn’s disease by inducing HO-1.
CoPPIX Protects against TNBS Induced Colitis Through HO-1 Induction
오재민(JaeMin Oh),김진오(JinOh Kim),권영미(Young-Mi Kwon),유민욱(MinWook Rheu),김유림(YuRim Kim),김경숙(KyoungSuk Kim),박승택(SeungTaeck Park),김정중(JeongJoong Kim),최민규(MinKyu Choi),정연태(YeunTai Chung) 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.5
크론병은 만성 염증성 대장 질환으로 면역반응을 억제함으로써 치료를 시도하고 있으나 치료가 쉽지 않고 치료하는 과정에서 많은 부작용이 생기는 질환이다. 따라서 부작용이 적은 새로운 약제의 개발이 절실한 실정이다. HO-1는 염증 반응을 억제하는 효과가 있다고 알려져 있으나 크론병에서의 그 작용기전은 거의 알려져 있지 않다. 따라서 우리는 크론병 동물모델인 TNBS에 의해 유도된 만성 대장염 모델에서 HO-1의 항 염증 기전을 조사하였다. HO-1의 유도제인 CoPPIX 는 생쥐에서 TNBS에 의한 체중감소, MPO 활성, NF-κB 활성 및 병리, 조직학적 증상 등을 현 저히 개선하였다. 또한 염증의 유지에 중요한 역할을 하는 TNF-α와 IL-1β 등의 발현 역시 억제하였다. 이러한 CoPPIX의 효과들은 HO-1 활성 억제제인 ZnPPIX에 의해 차단되었다. 이상의 결과로 CoPPIX는 HO-1의 유도를 통해서 TNBS에 의해 유도된 만성 대장염의 증상들을 개선시킬 수 있다고 생각되었다. 결론적으로 CoPPIX는 크론병의 치료에 있어 중요한 치료제가 될 수 있다고 생각하며 HO-1은 크론병의 치료에 중요한 target 물질이 될 수 있다고 생각한다. Crohn’s disease is a severe chronic inflammation that is treated mainly by immunosuppression, which often has serious side effects. There is a need to develop new drugs for treating this disease that have few side effects. Heme oxygenase-1 (HO-1) has immunosuppressive properties, but the mechanism of its anti-inflammatory actions is unclear. We investigated the protective effects of HO-1 on trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. An HO-1 inducer, cobalt protoporphyrin IX (CoPPIX), dramatically improved the clinical and histopathological symptoms in TNBS-induced colitis. CoPPIX suppressed tumor necrosis factor-α and interleukin-1β expression and down-regulated the nuclear transcription factor κB activity caused by TNBS. The vehicle copper protoporphyrin IX (CuPPIX) failed to duplicate the protective effects seen with CoPPIX. Moreover, an inhibitor of HO-1 activity-zinc protoporphyrin IX-reversed the protective effects of CoPPIX on TNBS-induced colitis. In conclusion CoPPIX protects against TNBS-induced colonic damage by inducing HO-1, which might be an important target in the treatment of Crohn’s disease.
Asymmetric diversity modulation scheme in wireless fading relay channels
Jaemin Han,Eunsung Oh,Hyungsik Ju,Daesik Hong IEEE 2009 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.8 No.7
<P>In this paper, we propose an asymmetric diversity modulation (ADM) scheme for a single-source relay system that utilizes the relay's higher transmission ability as a form of diversity. To achieve this, the proposed method transmits multiple source bits over a high-order modulating relay as a way to provide additional time diversity. The spatial and time diversity then undergo 'bit'-based combining at the destination. Using the proposed 'bit'-based channel combining method, we derive the theoretical bit error rate (BER) for such a system. Moreover, we investigate the fact that the proposed scheme shows a performance trade-off between bit power and time diversity resulting from the reduced bit power caused by a high-order modulating relay.</P>
Oh, Yunjung,Yang, Wooseok,Tan, Jeiwan,Lee, Hyungsoo,Park, Jaemin,Moon, Jooho The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.8
<P>Although a unique light-harvesting property was recently demonstrated in a photocathode based on 2-dimensional (2D) opals of CuFeO2-shelled SiO2 microspheres, the performance of a monolayer of ultra-thin CuFeO2-shelled microspheres is limited by ineffective charge separation. Herein, we propose an innovative design rule, in which an inner CuFeO2/outer CuAlO2 double-shelled heterojunction is formed on each partially etched microsphere to obtain a hexagonally assembled 2D opal photoelectrode. Our Cu-delafossite double-shelled photocathode shows a dramatically improved charge separation capability, with a 9-fold increase in the photocurrent compared to that of the single-shelled counterpart. Electrochemical impedance spectroscopy clearly confirms the reduced charge transport/transfer resistance associated with the Cu-delafossite double-shelled photocathode, while surface photovoltage spectra reveal enhanced polarization of the photogenerated carrier, indicating improved charge separation capability with the aid of the heterojunction. Our finding sheds light on the importance of heterojunction interfaces in achieving optimal charge separation in opal architectures as well as the inner-shell/electrolyte interface to expedite charge separation/transport.</P>