Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.

In_xGa_1-xN/GaN 다중양자우물 구조의 광학적 성질 연구

김기홍,김인수,박헌보,배인호,유재인,장윤석,Kim, Ki-Hong,Kim, In-Su,Park, Hun-Bo,Bae, In-Ho,Yu, jae-In,Jang, Yoon-Seok 한국진공학회 2009 Applied Science and Convergence Technology Vol.18 No.1

$In_xGa_{1-x}N$/GaN 다중양자우물 구조의 EL 특성을 온도와 주입전류 변화에 따른 특성을 조사하였다 저전류와 고전류 주입시 EL 효율의 온도 의존 변화는 매우 다르게 나타나는데, 이러한 온도와 전류의 변화에 의한 독특한 EL 효율의 변화는 내부전기장의 존재 하에 순방향 바이어스에 기인한 외부전기장의 영향인 것으로 볼 수 있다. 그리고 $In_xGa_{1-x}N$/GaN 다중양자우물 구조에서 In 성비의 증가는 발광파장위치의 적색이동을 보였다. 15K에서 주입 전류의 증가에 따라 녹색 양자우물 구조는 80 meV와 청색 양자우물 구조는 22 meV의 청색 편이를 하였다. 이는 전류의 증가에 의해 단위 시간당 생성되는 캐리어 수가증가하게 되고 그에 따라 subband가 급격히 채워지는 band filling 현상이 일어나게 되어 짧은 파장에서 재결합이 증가하기 때문이다. 그리고 청색과 녹색 다중 양자우물구조의 짧은 파장 쪽으로의 편이 차이는 In 농도에 기인한 것으로 In 농도가 높으면 양자우물 깊이가 증가되어 더 강한 양자속박효과가 작용하여 캐리어 구속력이 증가하기 때문 것으로 볼 수 있다. Temperature and injection current dependence of electroluminescence(EL) spectral intensity of the $In_xGa_{1-x}N$/GaN multi-quantum wells(MQW) have been studied over a wide temperature range and as a function of injection current level. It is found that a temperature-dependent variation pattern of the EL efficiency under very low and high injection currents shows a drastic difference. This unique EL efficiency variation pattern with temperature and current can be explained field effects due to the driving forward bias in presence of internal(piezo and spontaneous polarization) fields. Increase of the indium content in $In_xGa_{1-x}N$/GaN multiple quantum wells gives rise to a redshift of 80 meV and 22 meV for green and blue MQW, respectively. It can be explained by carrier localization by potential fluctuation of multiple quantum well and MQW structures also shows a keen difference owing to the different indium content in InGaN/GaN MQW.

한의약 컨텐츠를 가미한 강원도 리조트형 웰니스 프로그램 제안

유준상, 권보인, 이재형 상지대학교 한의학연구소 2023 尙志韓醫論文集 Vol.11 No.1

Objectives: As interest in wellness tourism is increasing in Korea, we sought to propose a program with Korean Medicine Contents for eight resorts in Gangwon-do, which has forests and marine resources. Methods: The authors visited eight designated resorts in Gangwon-do, observed the facilities, and interviewed the people in charge. Questions and answers were asked and answered in the form of a questionnaire regarding any deficiencies in the interviews. Afterwards, the contents were analyzed and a Korean Medicine program suitable for each resort was proposed. Results: A total of 17 Korean Medicine Programs were proposed, of which the meditation/yoga program and diet/drink program tailored to each constitution were proposed to be applicable to all 8 resorts. The rest were proposed considering each resort's facilities, environmental characteristics, and main product programs. Conclusions: It appears that the ‘meditation/yoga program’ and ‘constitutional diet and beverage development’ sectors are programs that can be commonly carried out by all facility companies, and for this purpose, the Sasang constitution test and Korean medicine measurement within the resort in Gangwon-do are used to create a program linked to this. In addition, we believe that efforts to improve the program through verification of efficacy will be necessary in the future

상사 성격이 부하 직원의 상사신뢰와 성과에 미치는 영향분석

이인재(In-Jae Lee),유희경(Hee-Kyung Yu) 한국산업경영학회 2011 경영연구 Vol.26 No.2

본 연구에서는 서울에 소재한 특급호텔 직원을 대상으로 상사의 성격과 부하 직원의 상사에 대한 신뢰 및 성과에 대한 분석을 실시하였다. 상사 성격은 성격을 5가지 요인으로 구분하는 5요인모델을 이용하였으며, 직원성과는 업무성과와 업무외성과로 구분하여 분석을 실시하였다. 연구결과를 요약하면 다음과 같다. 첫째. 상사 성격 중 외향성/개방성과 안정성이 상사신뢰에 유의적인 정의 영향을 미치고 있으며, 친화성과 성실성은 상사신뢰에 유의적인 영향을 미치지 아니하였다. 다만 유의적이지 아니한 친화성과 성실성도 상사신뢰에 정의 영향을 미치고 있음을 보여주었다. 둘째, 상사 성격의 요인으로 구분된 외향성/개방성, 안정성, 친화성, 성실성은 모두 직원의 업무성과에 유의적인 정의 영향을 미치고 있음을 보여주었다. 또한 상사의 성격 중 유일하게 친화성만이 직원의 업무외성과에 유의적인 정의 영향을 보여주었다. 다만 외향성/개방성, 안정성, 성실성도 통계적으로 유의적이지는 않았으나 정의 영향을 미치고 있었다. 셋째, 직원의 상사신뢰는 자신의 업무성과와 업무외성과에 유의적인 정의 영향을 미치고 있었다. 다만 그 결정계수값은 높지 않았다. 마지막으로, 상사신뢰는 상사 성격과 직원의 업무성과의 관계에서 부분적인 매개효과를 보였으나, 그 의미는 없었으며, 상사 성격과 직원의 업무외성과의 관계에서는 매개효과를 보이지 않았다. This study, based on a sample of 223 employees from upscale hotels located in Seoul, shows the relationships among supervisor personality, employee trust in supervisor, and employee performance. Personality five factor model was used and employee performance was divided into in-role performance and extra-role performance. Findings of the study are summarized as follows. First, interpersonal trust was found to be the most strongly related to extraversion/agreeableness and emotional stability. Second, all five personality traits of supervisor exerted significant influences on employee in-role performance. However, extraversion/agreeableness was the only trait which exerted a significant influence on employee extra-role performance. Third, employee trust in supervisor was positively related to in-role and extra-role performance of employees. Fourth, employee trust in supervisor had no mediating effect on the relationship between supervisor personality and employee in-role performance, and also between supervisor personality and employee extra-role performance.

Analysis of Patients with Hemoptysis in a Tertiary Referral Hospital

( Bo Ram Lee ),( Jin Yeong Yu ),( Hee Jung Ban ),( In Jae Oh ),( Kyu Sik Kim ),( Yong Soo Kwon ),( Yu Il Kim ),( Young Chul Kim ),( Sung Chul Lim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.2

Background: This study attempted to investigate the main causes of hemoptysis, the type of examinations used for diagnosis, the treatment modalities and outcomes. Methods: A retrospective study was conducted on the medical records of 221 patients admitted to the Chonnam National University Hospital, between January 2005 and February 2010, with hemoptysis. Results: Bronchiectasis (32.6%), active pulmonary tuberculosis (18.5%), fungus ball (10.8%), and lung cancer (5.9%) accounted for most causes of hemoptysis. Computed tomography scan was the most sensitive diagnostic test when employed alone, with positive yield of 93.2%. There were 161 cases of conservative treatment (72.9%), 42 cases of bronchial artery embolization (BAE) (19.0%), and 18 cases of surgery (8.1%). Regarding the amount of hemoptysis, 70 cases, out of 221 cases, were mild (31.5%), 36 cases moderate (16.2%), and 115 cases massive hemoptysis (52.0%). Most of the patients were treated conservatively, but if there was more bleeding present, BAE or surgery was more commonly performed than the conservative treatment (p≤0.0001). In the multivariate model, severe hemoptysis and lung cancer were independently associated with short-term recurrence. BAE was independently associated with long-term recurrence, and lung cancer was associated with in-hospital mortality. The overall in-hospital mortality rate was 11.3%. Conclusion: Hemoptysis is a common symptom with a good prognosis in most cases. However, patients exhibiting massive bleeding or those with malignancy had a poorer prognosis. In-hospital mortality was strongly related to the cause, especially in lung cancer.

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

Early Percutaneous Catheter Drainage Reduces Hospital Stay but Not Mortality in Patients with Pyogenic Liver Abscess

( Chang Hun Lee ),( Yun Chae Lee ),( Jaehee Park ),( Song Yi Yu ),( Hun Gil Jo ),( Jae Sun Song ),( Gum Mo Jung ),( Yong Keun Cho ),( Eun Young Cho ),( In Hee Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: To investigate the factors associated with prolonged hospital stay and mortality among patients with pyogenic liver abscess (PLA) who underwent percutaneous drainage (PCD). Methods: We retrospectively reviewed data from PLA patients admitted from 2005 to 2018 at three tertiary hospitals in Jeonbuk province. We selected patients who underwent PCD during the admission period and early PCD was defined whether the procedure was done within 3 days of admission. Results: Among 655 patients diagnosed with PLA, 366 patients who underwent PCD were enrolled for the study. The patients had a mean age of 65.5 ± 14.7 years, and mean maximal diameter of the hepatic abscess was 6.1 ± 2.6 cm and 71.9% of the lesion was single. Next, two groups were divided depending on the time period of PCD and 269 patients (73.5%) underwent PCD within 3 days of hospitalization. In baseline characteristics, early PCD group was significantly higher in the number of abscess as well as the maximal abscess diameter. However, hospitalization period was significantly lower in the early PCD group though in-hospital mortality was not different. We checked laboratory results at 1 week after the admission and CRP levels were significantly lower in the early PCD group. We further analyzed the factors related to the long-term hospitalization more than 14 days. In multivariate analysis, underlying diabetes, lower albumin levels, and PCD inserted after 3 days of admission were independent factors associated with prolonged hospital stay. Conclusions: Early PCD facilitated improvement of inflammatory laboratory markers and shortened the hospital stay. Early PCD may be beneficial in patients with PLA.

Comparison of clinical characteristics and prognosis of pneumocystis jirovecii pneumonia in patients with immunocompromised and non-immunocompromised conditions

( Hong-joon Shin ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young- Chul Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Pneumocystis jirovecii pneumonia (PCP) is a fatal respiratory infection frequently associated with immunocompromised (IC) conditions. Although PCP has been reported in non-immunocompromised (non-IC) patients, however, few studies have been conducted. This study was aimed to compare the clinical characteristics and prognosis of PCP in IC and non-IC patients. Methods: We retrospectively analyzed patients who were suspected of having PCP with polymerase chain reaction (PCR) test positive for Pneumocystis jirovecii from January 2013 to May 2019. IC group was classified into human immunodeficiency virus (HIV), hematologic, solid organ tumor, rheumatologic and immunosuppressive agent group. Results: A total 192 PCP cases including 176 IC cases and 16 non-IC cases were analyzed. Patients were older in the non-IC group compared with the IC group (72.5 vs. 62.0, P=0.002). Hematologic malignancy was the most common (47.2%), followed by HIV (14.8%) in the IC group. The interval between test for PCP-PCR and PCP treatment was shorter in the IC group compared with non-IC group (0 [0-3] vs. 4.0 [2.2-7.7] days, P=0.001). In-hospital mortality was not significantly different between IC and non-IC groups (43.2% vs. 62.5%, P=0.189). Age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02-1.09; P=0.002) and PaO₂/FiO₂ (OR 0.99; 95% CI 0.98-1.00; P=0.039) were the prognostic factors for in-hospital mortality in the multivariate logistic regression analysis. There was no significant difference between IC and non-IC group in 6-month survival. However, HIV group had better 6-month survival compared with non- IC group in the subgroup analysis (Hazard ratio 0.16; 95% CI 0.05-0.53; P=0.003]. Conclusion: Patients with PCP in non-IC group were older than IC group, and had similar prognosis as other IC group except HIV group.

Helicobacter pylori cagE 유전자 다형성이 위상피세포주에서 Interleukin-8 유도능에 미치는 영향

이수민,이학성,이인석,조유경,한혜원,오정환,박재명,최명규,정인식,Lee Su-Min,Lee Hak-Sung,Lee In-Suk,Co Yu-Kyung,Han Hae-Won,Oh Jung-Hwan,Park Jae-Myung,Choi Myung-Gyu,Chung In-Sik 한국생명과학회 2004 생명과학회지 Vol.14 No.6

Helicobacter pylori infection is highly prevalent, as high as 2/3 of whole population infected, in Korea. H. pylori infection initiates inflammation by induction of interleukin-8 through type IV secretion of CagA. It was recently suggested that induction failure of IL-8 is not associated with defect in cag PAI but associated with cagE locus diversity. This study was designed to investigate ability of 11-8 in-duction according to sequence variation within the cagE gene, cagA TP motifs and vacA m-types in vitro study using AGS cell-line, and to evaluate its association with different clinical outcome. Seventy-four H. pylori stains were isolated from 23 patients with gastric cancer (Ca), 24 subjects with gastritis (G) and 27 patients with duodenal ulcer (Du) in Kangnam St. Mary's Hospital, Seoul, Korea. cagE gene diversity was confirmed by the PCR-RFLP methods with MboI/NlaIII and tyrosine phosphate motifs (TPMs) of cagA was determined TPM-A and C by using DdeI/Tsp5091 restriction enzyme and TPM-B was determend by Real time PCR the method of Owen et al. and IL-8 was measured by ELISA assay. IL-8 activity was positively detected in 59 among 74 strains $(79.7\%)$. IL-8 secretion was significantly increased in MboI A and MboI B type compared to MboI C type and in MboI/NlaIII A-C and B-C type than C-C type. 1L-8 activity was not associated with either the number or composition of cagA tyrosine phosphorylation motifs and vacA m-type. There was no significant difference in IL-8 activity among patient groups. cagE gene diversity is thought to be mainly associated with the induction of IL-8 in H. pylori infection. 한국에서 분리한 Helicobacter pylori 균주가 위암 세포주에서 IL-8를 유도하는 유도능을 관찰하고자 하였으며, 특히 4형 분비구조의 주요 구성체인 cagE 유전자의 다형성에 따라 IL-8 유도능의 차이 및 각 질환에서 분리한 균주에서의 차이가 있는지 검토하고자 하였다. 강남성모병원 내시경검사를 받은 환자들 중 H. pylori 감염 양성으로 확인된 위암 23명 $(31.0\%)$, 위염 24명$(32.6\%)$, 십이지장궤양27명$(36.4\%)$ 총 74명을 대상으로 하여 H. pylori를 분리한 후 PCR-RFLP방법을 이용하여 cagE 다형성을 확인하였으며, PCR 및 Real-time PCR을 이용하여 ragA TPMs를 결정하였다, 또한 분리된 균주를 위암세포주에 감염시켜 상등액을 취하여 ELISA방법으로 IL-8을 정량화 하였다. 전체 74개의 분리 균주 중 59개의 균주$(79.7\%)$에서 IL-8 유도능이 있는 것으로 확인되었으며, cagE 다형성 중에서 가장 높은 빈도로 관찰되는 형태는 MboI/NlaIII B-C, A-C 및 C-C 타입 이었으며, 이중 A-C와 B-C 형태가 C-C 형태에 비해 유의적으로 높은 IL-8 유도능을 나타냈다. 그러나 cagA TPMs의 분류 및 vacA m-아형 분류와 IL-8 유도능과는 연관성이 없었다. 비록 본 연구에서 cagE 다형성과 IL-8 유도능과 아주 밀접한 연관성이 나타나지는 않았지만 vacA m-아형이나 cagA TPMs 보다는 cagE 다형성이 IL-8 유도능과 연관성이 클 것으로 생각된다.

Al_(0.24)Ga_(0.76)As/GaAs HEMT 구조에서의 표면 광전압에 관한 연구

유재인,김종수,배인호,신영남,박성배 대구대학교 기초과학연구소 2000 基礎科學硏究 Vol.16 No.2

We report a surface photovoltage(SPV) study of Al_(0.24)Ga_(0.76)As/GaAs HEMT structure grown by molecular beam epitaxy. The energies of Eo transition for GaAs and Al_(0.24)Ga_(0.76)As were 1.41 and 1.71 eV, respectively. These values were in good agreement with photo reflectance(PR) measurement. As the frequency is increased from 25 to 55 Hz, the intensity of SPV signal is gradually reduced. Meanwhille, the intensity of SPV signal gradually increased as the temperature increased from 100 K to room temperature. From the former, the surface photovoltage of Al_(0.24)Ga_(0.76)As layer is 8.61 mV, which is about 1.4 times smaller than that of GaAs. This is due to influence of carrier mobility.