수면장애호흡환자의 두부방사선학적 특징

이금숙,김재형,김병국,정성수 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

Objective : The objectives was to compare the measurement on skull lateral projection, skull posteroanterior projection, and lateral cephalogram in normal control group and Sleep-disordered breathing(SDB) group. Material and methods : A prospective study of 20 adult group with SDB and 24 normal control group was done. The skull lateral projection, skull posteroanterior projection, and lateral cephalometric indexes were measured to assess skeletal structures, dental structures, and velopharyngeal anatomic features. Results : The compromised radiographic parameters that may be found in patients with SDB include dental convexity, SPAS, minimum PAS, PNS-P, and minimum transverse diameter of posterior airway space. Conclusion : SDB is associated with structural changes in a number of radiologic mesurements. The analysis of the skull lateral projection and skull posteroanterior projection may provide some informations regarding the prediction of the SDB.

Prednisolone과 Prednisone의 임상약동학적 평가

신재국,윤영란,차인준,이경훈,장인진,신상구,박찬웅 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

알루미늄과 헤테로폴리산으로 개질된 메조포러스 실리카 상에서의 AKD 합성

김현국,우창수,최재석,박민태,이병민,이호인 한국공업화학회 2003 응용화학 Vol.7 No.1

AKD(alkyl ketene dimer) used widely as a neutral sizing agent is produced industrially by halogenization of stearic acid followed by dimerization of alkyl ketene. In the present work, to suppress the byproduct of hydrochloric acid and to improve reaction pathway. AKD was prepared through of ketene intermediate by dehydration of stearic acid in gas phase using reaction with silanol on silica as active sites of the catalyst SBA-15 showed the highest activity due to the large and open tubular pores. It was found that main products were dimer and trimer. Our goal of the present work was to increase of the selectivity for the dimer.

약물을 이용한 의식진정시 발생한 부작용에 대한 치험례

한국재,이창섭,이상호,김현식 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.4

The patients visiting pediatric dental office have been being younger than the previous, and they were often combined with systemic disease. But, we aren't able to perform the verbal communication, because of their impediment and youthfullness. And, we can't carry out the behavior control via physical restraint, as the developed social structure and the attitude of children and their parents. So, the importance and concerning of conscious sedation using sedative medicine are increased by time and time. Among the various conscious sedation, Chloral Hydrate and Nitrous Oxide inhalation are most popularly used, and barbiturates, benzodiazepine, opioids and hydroxyzine are used often. But, these medications have some side-effects and adverse reactions, may be failed to sedate the children. And limited use of medically compromised patients, especially for ASA class Ⅲ, Ⅳ or more dangerous patients. We, the Department of Pediatric Dentistry, Chosun University have met some dangerous situation due to unfavorable pharmacogenic reactions, but we can control the situation and get well healed results. The below results are common situations and their solutions during conscious sedation. 1. By the intravenous administration, thrombophlebitis is the most common side-effects, but it may be healed with time without any special treatment. 2. Under the definitive guidelines about conscious-sedation, we can perform a safe conscious sedation for ASA class Ⅲ patients. 3. When adversed reaction of Benzodiazepine is occured, it could be cared effectively with benzodiazepine antagonist, named Flumazenil.

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

能動 振動制御 半徑方向 磁氣베어링의 强性에 관한 硏究

김재실,안승국,이재환,안대균,최헌오 창원대학교 산업기술연구소 2001 産技硏論文集 Vol.15 No.-

This article describes (1) 2 and 3 dimensional electromagnetic finite element models for an active heteropolar radial magnetic bearing, (2) the procedure for obtaining the bearing stiffnesses by simulating the models and (3) the reviews of the models by comparing an experimental test to the ideal closed loop analysis with the stiffnesses calculated from(2). The 3 dimensional model for the magnetic bearing may be very effectively applied to several types of magnetic bearings.

십이지장 제2부에 전이된 자궁경부암 1예

이화영,손희정,이규택,김재준,백승운,이종균,이준혁,고광철,이풍렬,이종철,손정일,서연림,전성국 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.1

In Korea, careinoma of the cervix is the most common malignancy in women annually affecting 25 per every 100,000 female. The widespread use of the Papanicolaou smear has resulted in earlier detection of the tumor and a reduction in the number of patients with advanced disease, but the incidence of cervix. carcinoma is still the fifth most common malignancy in the world. Cervical carcinoma spreads to the small bowel primarily by direct extension from involved lymph nodes, most commonly from peraaortic or mesenteric nodes to the serosa of the bowel. But, the involvement of small bowel by cervical carcinoma is so rare, and shows a maximum incidence of small bowel involvement of less than 1.5%. We report a patient with squamous cell carcinoma of the cervix metastases to the second portion of the duodenum in whom the diagnosis was made by endoscopic biopsy of the lesion.

Identification and functional assessment of BCRP polymorphisms in a Korean population.

Lee, Sang Seop,Jeong, Hye-Eun,Yi, Joo-Mi,Jung, Hyun-Ju,Jang, Jae-Eun,Kim, Eun-Young,Lee, Su-Jun,Shin, Jae-Gook American Society for Pharmacology and Experimental 2007 Drug metabolism and disposition: the biological fa Vol.35 No.4

<P>The breast cancer resistance protein (BCRP) is a member of the ATP-binding cassette transporters. The aim of the present study was to identify genetic variants of BCRP in Koreans and to assess the functional consequences of BCRP polymorphisms. Twenty single nucleotide polymorphisms (SNP), including four nonsynonymous SNP, were identified by DNA sequencing of the BCRP gene in 92 Korean subjects. BCRP V12M, Q141K, P269S, and Q126Stop were detected at frequencies of 23, 28, 0.2, and 1.9%, respectively. These four coding variants were also screened in Chinese and Vietnamese subjects; the allelic frequencies among the three populations were compared; and predictions were made as to the potential frequency of each variant. In vitro functional analyses of the P269S protein and the promoter SNP -19031C>T (mutated in the hypoxia-inducible factor-1alpha binding site) were performed and compared with those of the wild type. P269S exhibited a 35 to 40% decrease in vesicular uptake of [(3)H]estrone-3-sulfate and [(3)H]methotrexate compared with the wild type. The promoter SNP -19031C>T did not affect BCRP promoter activity in either the presence or absence of chemical-induced hypoxic stress. Our results suggest that the P269S variant could be a functionally altered variant. Genotyping of this variant in clinical studies is needed to address its phenotypic role. Genetic polymorphisms of BCRP were found to be very common in Koreans, as well as in other ethnic groups. Comparative analyses among three Asian populations revealed different frequencies for the four functional BCRP variants.</P>

Small-Signal Modeling of Gate-All-Around (GAA) Junctionless (JL) MOSFETs for Sub-millimeter Wave Applications

Lee, Jae-Sung,Cho, Seong-Jae,Park, Byung-Gook,Harris, James S. Jr.,Kang, In-Man The Institute of Electronics and Information Engin 2012 Journal of semiconductor technology and science Vol.12 No.2

In this paper, we present the radio-frequency (RF) modeling for gate-all-around (GAA) junctionless (JL) MOSFETs with 30-nm channel length. The presented non-quasi-static (NQS) model has included the gate-bias-dependent components of the source and drain (S/D) resistances. RF characteristics of GAA junctionless MOSFETs have been obtained by 3-dimensional (3D) device simulation up to 1 THz. The modeling results were verified under bias conditions of linear region (VGS = 1 V, VDS = 0.5 V) and saturation region (VGS = VDS = 1 V). Under these conditions, the root-mean-square (RMS) modeling error of $Y_{22}$-parameters was calculated to be below 2.4%, which was reduced from a previous NQS modeling error of 10.2%.

MODULES OF QUOTIENTS OVER COMMUTATIVE RINGS

Lee, Jae-Gook,Rij, Seog-Hoon Korean Mathematical Society 1999 대한수학회논문집 Vol.14 No.2

In this paper, we give an affirmative answer to the question raised in [5]; whether L((P)) is principal or not. Using this fact, we try to give concrete form of module of quotient with respect to a torsion theory determined by L((P)).