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Jacqueline M. E. Harrison,Leah M. Quanstrom,Alex R. Robinson,Bruce Wobeser,Stacy L. Anderson,Baljit Singh 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.1
Sepsis causes significant mortality in neonatal foals; however, there is little data describing the cellular and molecular pathways of lung inflammation in septic foals. This study was conducted to characterize lung inflammation in septic foals. Lung tissue sections from control (n = 6) and septic (n = 17) foals were compared using histology and immunohistology. Blinded pathologic scoring of hematoxylin and eosin stained samples revealed increased features of lung inflammation such as thickened alveolar septa and sequestered inflammatory cells in septic foals. Septic foal lungs showed increased expression of von Willebrand factor in blood vessels, demonstrating vascular inflammation. Use of MAC387 antibody to detect calprotectin as a reflection of mononuclear cell infiltration revealed a significant increase in their numbers in alveolar septa of lungs from septic foals compared to those from control foals. The mononuclear cells appeared to be mature macrophages and were located in the septal capillaries, suggesting they were pulmonary intravascular macrophages (PIMs). Finally, lungs from septic foals showed increased expression of Toll-like receptor 4 and 9 in mononuclear cells relative to the control. Taken together, this study is the first to show the expression of inflammatory molecules and an increase in PIMs in lungs from foals that died from sepsis.
Young-Eun C Lee,David R Williams,Jacqueline F I Anderson 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
Introduction: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson’s syndrome (PSP-RS) and two atypical ‘brainstem predominant’ PSP phenotypes (PSP-Parkinsonism; PSP-P and PSP- Pure Akinesia with Gait Freezing; PSP-PAGF) using a comprehensive neuropsychological battery. Methods: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests. Results: The classic PSP-RS subgroup demonstrated greater impairments in processing speed, t (19) = -4.10, p = 0.001 (d = 1.66), and executive function, t (19) = -2.63, p = 0.02 (d = 1.20) compared to the ‘brainstem predominant’ PSP phenotypes. Conclusion: This is the first prospective study to demonstrate that PSP-RS and ‘brainstem predominant’ PSP phenotypes can be differentiated on cognitive grounds. These differences correspond with variations in pathological profile reported in the literature.