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Jo, Suyeon,Yang, Jayoon,Park, Jun-Young Electrochemical Society 2017 ECS Transactions Vol.78 No.1
<P>The La<SUB>0.4</SUB>Sr<SUB>0.6</SUB>TiO<SUB>3</SUB> (LST) is considered as a candidate material for anodes to solve the drawbacks of Ni-based cermets in solid oxide fuel cells (SOFCs). In this work, LST materials are fabricated with highly conductive Nd<SUB>0.1</SUB>Ce<SUB>0.9</SUB>O<SUB>2</SUB> (NDC) electrolytes and characterized to investigate the feasibility of SOFCs at the intermediate temperature (IT). In addition, LST is composited with the NDC to improve the ionic conductivity and decrease the thermal expansion mismatch of anode materials to the electrolyte. The electrochemical impedance spectra analysis shows that the area specific resistance of the LST-NDC composite anode decreases with increasing NDC concentrations and a ratio of 7:3 (LST:NDC) in weight fraction exhibits the lowest polarization resistance value at 650. The maximum power density of the LST-NDC composite anode-cell is 143 mW cm<SUP>-2</SUP> at 650. We thus confirm that LST could be used as an anode material for the application of IT-SOFCs.</P>
Comparison of Preferred Real-Ear Insertion Gain between Open- and Closed-Canal Fitting Hearing Aids
Hyeryeong Jo,Hyekyung Kong,Suyeon Shin,Mikyung Lee,Kwangjae Kim,Hyungoo Lee,Soohyun Ahn,Kyoungwon Lee 한국청각언어재활학회 2021 Audiology and Speech Research Vol.17 No.2
Purpose: To calculate the real-ear insertion gain (REIG) according to the types of hearing aids, we evaluated the preferred REIGs of Korean hearing-impaired listeners and psychoacoustic differences between open-canal fitting (OF) and closed-canal fitting (CF). Methods: The subjects with sensorineural hearing loss were divided into OF group (4 monaural fittings, 15 binaural fittings with 34 ears), and CF group (8 monaural fittings, 13 binaural fittings with 34 ears). There were no statistical differences in hearing threshold level (HTL) at each octave frequencies, word recognition score (WRS) and Korean Adaptation of the International Outcome Inventory for Hearing Aids (K-IOI-HA) between the two groups. When there was no need for further electroacoustic adjustment of the hearing aid, sharpness and occlusion of amplified sound, clarity of sentence, and loudness of noise were evaluated based on the everyday experience. And REIGs with international speech test signal and WRS in sound-treated room were measured. Results: Preferred REIG for HTL was low for OF compared to CF in 0.5 kHz and 0.75 kHz at input SPL of 55 dB, 0.5 kHz at 60 dB SPL, 0.25 kHz and 0.5 kHz at 80 dB SPL. However, there were no differences in aided WRS and psychoacoustics between the two groups. Conclusion: In this study, the preferred REIG of OF and CF groups showed a difference under 0.75 kHz although there were no psychoacoustic differences between the two groups. Therefore, the results of this study should be considered when formulating Korean-type hearing aid fitting formula.
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma
Kim, Suyeon,Kim, Jaewon,Jung, Yeonjoo,Jun, Yukyung,Jung, Yeonhwa,Lee, Hee-Young,Keum, Juhee,Park, Byung Jo,Lee, Jinseon,Kim, Jhingook,Lee, Sanghyuk,Kim, Jaesang Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.7
In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of TNNC1 was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, TNNC1 expression was enhanced by suppression of KRAS, and ectopic expression of TNNC1 in turn inhibited KRAS<SUP>G12D</SUP>-mediated anchorage independent growth of NIH3T3 cells. Consistently, activation of KRAS pathway in LUAD patients was shown to be strongly correlated with down-regulation of TNNC1. In addition, ectopic expression of TNNC1 inhibited colony formation of multiple LUAD cell lines and induced DNA damage, cell cycle arrest and ultimately apoptosis. We further examined potential correlations between expression levels of TNNC1 and various clinical parameters and found that low-level expression is significantly associated with invasiveness of the tumor. Indeed, RNA interference-mediated down-regulation of TNNC1 led to significant enhancement of invasiveness in vitro. Collectively, our data indicate that TNNC1 has a novel function as a tumor suppressor and is targeted for down-regulation by KRAS pathway during the carcinogenesis of LUAD.
Quon, Suyeon,Jo, Deok Yeon,Han, Geun-Ho,Han, Sang Soo,Seo, Myung-gi,Lee, Kwan-Young Elsevier 2018 Journal of catalysis Vol.368 No.-
<P><B>Abstract</B></P> <P>Pd-Pt bimetallic catalysts have been studied for improvement of H<SUB>2</SUB>O<SUB>2</SUB> selectivity in direct synthesis of H<SUB>2</SUB>O<SUB>2</SUB>; however, the role of Pt on the Pd surface has not been clearly identified. Herein, we investigated the role of Pt atoms on Pd(1 1 1) facets by realizing the surface in two different ways: nano-synthesis and density functional theory (DFT) calculation model. Pd(1 1 1) were modified into 3 kinds of Pd-Pt-alloyed surfaces, a minor Pt-substituted Pd, a major Pt-substituted Pd and a Pt-shell, covering bulk Pd. We successfully embedded Pt atoms in the octahedral Pd surface. Reaction tests showed that the minor Pt-substituted octahedral Pd catalyst had the highest H<SUB>2</SUB>O<SUB>2</SUB> selectivity, production rate and the lowest H<SUB>2</SUB>O<SUB>2</SUB> decomposition rate. The experimental results were consistent with our DFT calculations which predicted the lowest activation barrier for the O<SUB>2</SUB> hydrogenation step and the highest one for the H<SUB>2</SUB>O<SUB>2</SUB> dissociation step on the minor Pt-substituted Pd surface.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pd(1 1 1) were modified into Pd-Pt-alloyed surfaces with various ratios of Pt and Pd. </LI> <LI> A minor Pt-substituted Pd octahedral catalyst showed enhanced H<SUB>2</SUB>O<SUB>2</SUB> selectivity. </LI> <LI> O<SUB>2</SUB> hydrogenation was favored on the PdPt1 surface in terms of activation barriers. </LI> <LI> H<SUB>2</SUB>O<SUB>2</SUB> dissociation and H<SUB>2</SUB>O formation were not favored on the PdPt1 surface. </LI> <LI> The experimental results were consistent with our calculations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Kwanghee Won ),( Suyeon Jo ),( Yejin Lee ),( Sungeun Chang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Tyrosine kinase inhibitors are associated with various adverse cutaneous reactions including pigmentary change. Radotinib is a novel and selective BCR-ABL1 tyrosine kinase inhibitor which has shown activity and safety in the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia. A 69-year-old Korean man presented with lentiginosis after taking radotinib for 6 months. On histopathologic examination, the numbers of melanocytes and melanin pigment were increased due to c-KIT activation, consequently up-regulating MITF. It is discordant with mechanisms of previously reported tyrosine kinase inhibitors inhibiting c-KIT.
웹소설 키워드를 통한 이용 독자 내적 욕구 및 특성 파악
조수연,오하영,Jo, Suyeon,Oh, Hayoung 한국정보통신학회 2020 한국정보통신학회논문지 Vol.24 No.2
모바일 상에서 연재되고 소비되는 웹소설은 다른 문화콘텐츠와 마찬가지로 우리 사회의 한 단면을 포착해낼 수 있는 특징이 있다. 본 논문은 웹소설 키워드 정보를 수집해 웹소설의 주요 모티프 및 트렌드를 파악하고, 나아가 기존 논문들과 연관 지어 이용 독자의 내적 욕구 및 특성을 분석하는 것을 목적으로 한다. 분석 결과 접근성이 높고 가독성이 편리한 모바일 환경과 관련해 현대물과 성인 작품이 인기가 높았다. 남자주인공은 웹소설 상에서 이상적으로 그려지는 경향이 있었으나, 현재 남자주인공의 주요 키워드는 2000년대 초와 비교했을 때 변화를 확인할 수 있었다. 이는 곧 현대인들의 젠더 관념의 변화를 시사한다. 이와 상반되게 여자주인공은 내면에 상처를 지닌 캐릭터가 인기가 많았고, 이에 대한 원인 중 하나로 사회구조적인 환경 속에서 좌절을 겪어야 했던 현대 여성의 현실을 설명했다. 본 논문은 웹 크롤링의 한계로 성인 작품에 대해 심층적인 분석을 진행하지는 못했지만, 정량적 분석이 미흡했던 기존 웹소설 연구들에 키워드라는 파라텍스트를 활용하여 현대인들의 내적 욕구 및 특성을 분석했다는 의의를 지닌다. Web novels that are consumed on mobile devices are characterized by capturing one aspect of our society. The purpose of this study was to collect the keywords from web novels, to identify trends of web novels, and further to analyze the covert needs and characteristics of readers in connection with the existing researches. As a result of the analysis, novels with modern backgrounds and adult novels were popular in relation to easily readable and accessible mobile environment. Male characters tend to be ideally depicted in web novels. In contrast, characters with inner scars were popular among female characters. Although this study did not conduct an in-depth analysis of adult novels due to the limitation of web crawling, it is meaningful that this study analyzed modern people's inner needs and characteristics using the para-text like keywords in existing web novel studies that previously lacked quantitative analysis.