급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

혼합치열기의 miniscrew를 이용한 교정치료

임수민,양연미,김재곤,백병주,이용훈,신정근 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

Anchorage plays an important role in orthodontic treatment, Skeletal anchorage like the miniscrew is considered a more effective method in anchorage control than conventional anchorage which needs much patient s cooperation. The miniscrew offers many advantages. 1) It is easy to insert and to remove. 2) It can endure the force needed for moving teeth. 3) It can be immediately loaded and 4) Patient cooperation is not needed. 5) It is economic compared to other skeletal anchorage systems, In comparison to adult's bones, children s bones have comparatively poor bone quality and quantity. Therefore, it is hard to obtain primary stability in younger patients. However, if the miniscrew can be retained successfully, it will be effective in many orthodontic treatments. In these cases we used the miniscrew in correcting of diastema, in aligning dental midline, and in rendering a forced eruption of impacted tooth in mixed dentition patient. We obtained satisfactory results. 교정치료 시 고정원은 항상 염두에 두면서 치료를 진행해야 하는 중요한 요소이다. 전통적인 고정원을 이용한 치료는 환자의 적극적인 협조를 필요로 하고 원하는 치아이동에 대한 반작용이 나타날 수 있는 등의 부작용을 가지고 있다. 그러므로 보다 견고한 구강 내 고정원이 요구되어져 왔으며 이를 위해 miniscrew가 임상에서 흔히 이용되고 있다. Miniscrew를 통한 고정원의 확보는 구외력 의존도 감소,치료기간의 단축,식립 후 즉시 교정력 적용,환자의 협조도 불필요,식립의 간편성,저렴한 비용 등의 장점을 가지고 있다. 그러나 성장기 환자는 성인에 비해 골질이 좋지 않아 miniscrew의 성공률이 성인에 비해 낮다. 그러나 일단 고정에 성공하면 많은 교정치료 시 매우 유용하게 이용할 수 있다. 본 증례는 흔합치열기 환자를 miniscrew를 이용하여 정중이개 및 정중선 불일치,매복치에 대한 양호한 교정치료를 하였기에 보고하는 바이다.

Lipopolysaccharide와 dexamethasone의 처치가 마우스 신장내 프리라디칼 계에 미치는 영향

임재용 외 중앙대학교 의과대학 의학연구소 2005 中央醫大誌 Vol.30 No.3·4

Lipopolysaccharide (LPS) develops sepsis through various immune and inflammatory reactions to induce the generation of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) in several different organs. In this study, the effects of dexamethasone (DM) on the generation of ROI and RNI as well as the activities of enzymes removing ROI were examined in the kidney of mouse model of sepsis with LPS. LPS (2.5 mg/kg body weight) significantly (p < 0.01) enhanced nitric oxide generation (NO) in serum. The increased NO generation, however, was effectively (p < 0.01) blocked by pretreatment with DM (10 mg/kg). The activity of xanthine oxidase, a marker for generation of superoxide radical, was increased by LPS (p < 0.01), and the enhancement was attenuated by pretreatment with DM. The activities of Mn-superoxide dismutase and glutathione peroxidase, ROI removing enzymes, were not changed in mouse kidney by LPS and/or DM. However, the activities of Cu,Zn-superoxide dismutase and catalase were effectively reduced by LPS and/or DM (p < 0.01 or p < 0.05). These results demonstrated that the effects of dexamethasone (DM) and LPS on the generation of ROI and RNI as well as the activities of enzymes removing ROI may play a pathophysiologic role in the kidney injury of mouse model of sepsis.

지반의 고유진동주기를 고려한 사장교의 지진해석

임병용,한재익 群山大學校 1997 論文集 Vol.25 No.-

The dynamic responses of cable-stayed bridge subjected to seismic load are presented here, and they are considered as seperating the horizontal load and vertical load, but other simple bridges are considered horizontal load. The numerical analysis model is somplified, which is consist of thirty-one mass-point on the girder and the tower of cable-stayed bridge, and the seismic load is sine-wave function which is varied by the time, and the amplitude and period of which are equal to the maximum acceleration and the period of the vibration mode of the ground. Estimating the result of numerical analysis, as the maximum acceleration is increased, the deflections and the sectional forces of bridge are increased linearly, and as the period of vibration mode of the ground is varied, the deflections and the sectional forces of bridge are differ greatly from each other. And the maximum dynamic responses are on the period of the ground which is equal to period of vibration mode of the structure. Thus, these factors must be considered in designation of cable-stayed bridge.

1,2,4-트리메틸벤젠에 피폭된 노동자의 뇨 중 3,4-디메틸히푸르 산과 크레아티닌의 정량

임정미,장재연,이용문,강종성 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

Creatinine and 3.4-Dimethylhippuric acid (3.4-DMHA), a glycine conjugate of 1.2.4-trimethylbenzene (1.2.4-TMB) were determined in the urine of workers exposed to 1.2.4-TMB vapor. The best condition for the simultaneous determination of 3.4-DMHA and creatinine by high performance liquid chromatography was obtained by reverse phase C-18 column (4.6×150㎜, 5㎛) as stationary phase and 20% acetonitrile in 20mM phosphate buffer (pH 3.0) containing 4mM sodium octylsulfate (SOS) 96%. The concentration of urinary 3.4-DMHA of workers had a positive correlation with the environmental level of 1.2.4-TMB(r=0.866). The data suggest that urinary 3.4-DMHA concentration is a useful biological index for 1.2.4-TMB exposure.

토륨 핵연료주기를 이용한 열중성자로심의 핵전환 특성 연구

임재용,김명현 경희대학교 산학협력기술연구원 1998 산학협력기술연구논문집 Vol.4 No.-

An optimization of conceptual nuclear design was done for a high converting pressure-tube type light water cooled reactor(HCPLWR) applied with an once-through thorium cycle. Fuel rod bundles are configured in hexagonal lattice array in a similar size of those of CANDU, fuel pin size is the same with conventional PWR rods. Driver fuel bundles and blanket fuel bundles are loaded in separate channels which have different reloading cycle duration and different thermal-hydraulic conditions. Two optimized designs was found to be better than conventional reactors in both conversion ratio and fuel cycle economics. In the aspect of safety, fuel temperature coefficient and moderator coefficient were negative, and light water injection into calandria tank worked as an additional shutdown device.

Sr·페라이트의 자기특성에 관한 연구

임재근,서강수,문현욱,신용진 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

This thesis is the study on the magnetic properties of strontium (Sr) ferrite. Specimens of SrO·nFe₂O₃,basic composition, with n=5.9 which is nonstoichiomatric composition region were prepared by sintering at 1275°C for 1hr, whthin air surroundings. In order to increase coercivity, additives of 0.4wt%SiO₂ and 0.7wt%CaCO₃ were added into basic composition, and 0.5wt%∼2.0wt%Cr₂O₃ was added as second additives. In case of second additives 1.5wt%Cr₂O₃, it was obtained uniformed grain size and magnetic properties was increased. The sintering temperature was 1150°C, 1180°C, 1210°C, 1240°C and 1270°C respectivily and cooling was performed in furnance. From the research and experiments on the magnetic properties of strontium (Sr) ferrite based on the complex additive technique, it was obtained good magnetic properties of (BH)mas=0.72MGOe, at the sintering temperature of 1210°C, in the case of (basic composition)+(basic additive)+(1.5wt%Cr₂O₃)

간세포암의 크기와 알파 피토프로틴의 연관성

임효순,정용연,김재규,윤웅,강형근,박진균 全南大醫大 2001 전남의대학술지 Vol.37 No.4

관상동맥질환의 중증도와 혈중지질치 및 아포지단백과의 상관관계

임현주,황종현,류재근,정병천,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 관상동맥질환의 위험인자로서 혈청지질 및 혈장 지단백에 대한 관심이 높아지고 있고 또 아포지단백이 관상동맥 질환을 일으키는데 다른 지질보다 더 중요하다는 연구가 많이 발표되고 있으나 우리나라에서는 아포지단백에 대한 연구가 그리 많지 않은 편이다. 이에 저자등은 혈중지질치와 새로운 위험인자로 알려지고 있는 아포지단백치를 측정하고 이들과 관상동맥질환 중증도와의 상관 관계를 알아보았다. 대상 및 방법 : 관상동맥질환이 의심되어 관상동맥조영술을 실시한 69명의 환자를 대상으로 하였으며 12시간 이상 공복후 혈청을 채취하여 총콜레스테롤, 중성지방, HDL-콜레스테롤, 아포지단백 AI (ape AI), 아포지단백 B (ape B)를 측정하였다. 관상동맥조영상 50%이상의 협착이 있는 혈관의 수 (lesion number), 최대협착을 합한 값 (lesion score), 각 분절의 최대협착을 합한 값 (total score), 가장 심한 협착 값 (peak stenosis) 등으로 관상동맥 중증도를 알아본 다음 이들과 혈청지질치, 아포지단백과의 상관 관계를 비교해 보았다. 상관 관계는 Spearman's correlation coefficient를 구하였다. 결과 : 관상동맥질환의 중증도와 각 지질치 간의 상관 관계를 비교해 보았을때 lesion number와 관계있는 것은 연령 (r=0.2789), 중성지방치 (r=0.2829)이며 lesion score와 관계있는 것은 연령(r=0.2911), 중성지방치0 (r=0.3316), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2361), apo B 치(r=0.2759), apo AI과 apo B의 비 (-0.3154)로 나타났다. Total score는 연령 (r=0.3100), 총콜레스테롤치 (r=0.2452), 중성지방치 (r=0.3022), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2770), apo B치 (r=0.2927), apo AI과 apo B의 비 (r=-0.3408)와 연관이 있었고 peak stenosis는 중성지방 치(r=0.3305), ape B 치 (r=0.2968), apo AI과 apo B의 비 (r=-0.3977)와 관계가 있었다. 연령으로 조정하여 partial correlation을 좌면, 관상동맥조영술상 중증도는 중성지방치 (r=0.3408), apo B 치(r=0.2877), apo AI과 apo B의 비 (r=-0.3460)와 유의한 상관 관계가 있었다. 이중 ape AI과 ape B의 비는 lesion score (r=-0.2640), total score (r=-0.3057), peak stenosis (r=-0.3460)와 유의한 상관관계를 보였다. 결론 : 이상의 결과로 보아 apo B치 그리고 apo AI과 apo B의 비가 관상동맥 중증도의 예견인자로 다른 혈중 지질 치보다 더 유용하다는 것을 알 수 있었다. Objectives : Recently, it was reported that the measurements of apolipoprotein levels may be valuable in the clinical assessment of coronary artery disease severity. However there are a few reports regarding to the relationship between coronary artery disease severity and apolipoprotein levels in Korea. Thus, we measured serum lipid and apolipoprotein levels and studied the relationship between coronary artery disease severity and serum lipids and apolipoproteins levels. Subjects and Methods : The 69 patients who underwent coronary angiography to evaluate chest pain were subjected to this study. We measured the levels of serum cholesterol, triglycerides, HDL cholesterol, apolipoprotein AI(apo AI) and apolipoprotein B(Apo B) and measured the severity of coronary artery disease by lesion number, lesion score, total score and peak stenosis. Then, we studied the relationship between coronary artery disease severity and apolipoproteins and calculated the correlation coefficient. Results : The results were as follows. There are significant correlation(r=0.3) between age, triglycerides, apo B levels, apo AI/B ratio and coronary artery disease severity. In controlling for age, tyiglycerides, apo B levels and apo AI/B ratio shows significant correlation(r=0.3) with coronary artery disease severity. Especially, apo AI/B ratio shows significant correlation(r=0.3) with lesion number, total score and peak stenosis. Conclusion : These results suggest that the apo B levels and the ratio of apo AI/B can be used as significant independent predictor for coronary artery disease severity rather than other serum lipid levels.

아몰퍼스 리본에 의한 변위센서

임재근,강재덕,신용진 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

In this thesis, we fabricate a zero-magnetostrictive amorphous ribbon, measure the impedance effect, and then investigate possibility to be used as a sensor material. Co72.5Fe5.5MoB15Si5 is used as composition of specimen alloy. We first melt the specimen in high frequency induction furnace and then rapidly quench it by using single roll technique. As the result, we obtain a ribbon where length=93㎜, thickness=12㎛ and width=1㎜. Consequently, it is proved through this study that zero-magnetostrictive amorphous ribbon can be used as an excellent magnetic sensor material.