http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Attenuated reovirus displays oncolysis with reduced host toxicity
Kim, M,Garant, K A,zur Nieden, N I,Alain, T,Loken, S D,Urbanski, S J,Forsyth, P A,Rancourt, D E,Lee, P W K,Johnston, R N Nature Publishing Group 2011 The British journal of cancer Vol.104 No.2
<P><B>Background:</B></P><P>Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart, liver, pancreas and neural structures.</P><P><B>Methods:</B></P><P>We characterized an attenuated form of reovirus (AV) derived from a persistently infected cell line through sequence analysis, as well as western blot and <I>in vitro</I> transcription and translation techniques. To examine its pathogenesis and oncolytic potential, AV reovirus was tested on healthy embryonic stem cells, various non-transformed and transformed cell lines, and in severe combined immunodeficiency (SCID) mice with tumour xenografts.</P><P><B>Results:</B></P><P>Sequence analysis of AV reovirus revealed a premature STOP codon in its sigma 1 attachment protein. Western blot and <I>in vitro</I> translation confirmed the presence of a truncated <I>σ</I>1. In comparison to wild-type reovirus, AV reovirus did not kill healthy stem cells or induce black tail formation in SCID mice. However, it did retain its ability to target cancer cells and reduce tumour size.</P><P><B>Conclusion:</B></P><P>Despite containing a truncated attachment protein, AV reovirus still preferentially targets cancer cells, and compared with wild-type reovirus it shows reduced toxicity when administered to immunodeficient hosts, suggesting the potential use of AV reovirus in combination cancer therapy.</P>