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Brogan, C. L.,Goss, W. M.,Hunter, T. R.,Richards, A. M. S.,Chandler, C. J.,Lazendic, J. S.,Koo, B.-C.,Hoffman, I. M.,Claussen, M. J. IOP Publishing 2013 The Astrophysical journal Vol.771 No.2
<P>We present a comprehensive view of the W51B H II region complex and the W51C supernova remnant (SNR) using new radio observations from the VLA, VLBA, MERLIN, JCMT, and CSO along with archival data from Spitzer, ROSAT, ASCA, and Chandra. Our VLA data include the first lambda = 400 cm (74 MHz) continuum image of W51 at high resolution (88 ''). The 400 cm image shows non-thermal emission surrounding the G49.2-0.3 H II region, and a compact source of non-thermal emission (W51B_NT) coincident with the previously-identified OH (1720 MHz) maser spots, non-thermal 21 and 90 cm emission, and a hard X-ray source. W51B_NT falls within the region of high likelihood for the position of TeV gamma-ray emission. Using the VLBA, three OH (1720 MHz) maser spots are detected in the vicinity of W51B_NT with sizes of 60-300 AU and Zeeman effect magnetic field strengths of 1.5-2.2 mG. The multiwavelength data demonstrate that the northern end of the W51B HII region complex has been partly enveloped by the advancing W51C SNR and this interaction explains the presence of W51B_NT and the OH masers. This interaction also appears in the thermal molecular gas which partially encircles W51B_NT and exhibits narrow pre-shock (Delta v similar to 5 km s(-1)) and broad post-shock (Delta v similar to 20 km s(-1)) velocity components. RADEX radiative transfer modeling of these two components yield physical conditions consistent with the passage of a non-dissociative C-type shock. Confirmation of the W51B/W51C interaction provides additional evidence in favor of this region being one of the best candidates for hadronic particle acceleration known thus far.</P>
miRTarVis+: Web-based interactive visual analytics tool for microRNA target predictions
L'Yi, S.,Jung, D.,Oh, M.,Kim, B.,Freishtat, R.J.,Giri, M.,Hoffman, E.,Seo, J. Academic Press 2017 Methods Vol.124 No.-
<P>In this paper, we present miRTarVis+, a Web-based interactive visual analytics tool for miRNA target predictions and integrative analyses of multiple prediction results. Various microRNA (miRNA) target prediction algorithms have been developed to improve sequence-based miRNA target prediction by exploiting miRNA-mRNA expression profile data. There are also a few analytics tools to help researchers predict targets of miRNAs. However, there still is a need for improving the performance for miRNA prediction algorithms and more importantly for interactive visualization tools for an integrative analysis of multiple prediction results. miRTarVis+ has an intuitive interface to support the analysis pipeline of load, filter, predict, and visualize. It can predict targets of miRNA by adopting Bayesian inference and maximal information-based nonparametric exploration (MINE) analyses as well as conventional correlation and mutual information analyses. miRTarVis+ supports an integrative analysis of multiple prediction results by providing an overview of multiple prediction results and then allowing users to examine a selected miRNA-mRNA network in an interactive treemap and node-link diagram. To evaluate the effectiveness of miRTarVis+, we conducted two case studies using miRNA-mRNA expression profile data of asthma and breast cancer patients and demonstrated that miRTarVis+ helps users more comprehensively analyze targets of miRNA from miRNA-mRNA expression profile data. miRTarVis+ is available at http://hcil.snu.ac.kr/research/mirtarvisplus. (C) 2017 Elsevier Inc. All rights reserved.</P>
( Brian L. Hollenbeck ),( Megan Hoffman ),( Christopher J. Fang ),( Kevin Counterman ),( Susan Cohen ),( Christine A. Bell ) 대한고관절학회 2021 Hip and Pelvis Vol.33 No.4
Purpose: Routine preoperative urinalysis has been the standard of care for the orthopedic population for decades, regardless of symptoms. Studies have demonstrated antibiotic overuse and low concordance between bacteria cultured from the surgical wound and the urine. Testing and treatment of asymptomatic urinary tract colonization before total joint arthroplasty (TJA) is unnecessary and increases patient risk. We investigated reducing antibiotic use by (1) modifying testing algorithms to target patients at risk, (2) modifying reflex to culture criteria, and (3) providing treatment guidelines. Materials and Methods: A pre-post study was conducted to determine identify the impact of eliminating universal urinalysis prior to TJA on surgical site infection (SSI) and catheter-associated urinary tract infection (CAUTI) rates and number of antibiotic prescriptions. Patients who underwent primary hip or knee TJA or spinal fusions from February 2016 to March 2018 were included. Patient data was collected for pre- and post-practice change period (February 2016-October 2016 and August 2017-March 2018). Patient demographics, urinalysis results, cultures, and prescriptions were analyzed retrospectively from every tenth chart in the pre-period and prospectively on all patients in the post-period. Results: A total of 4,663 patients were studied. There was a 96% decrease in urinalyses performed (P<0.0001), and a 93% reduction rate in antibiotic utilization (P< 0.001). No significant difference in SSI and CAUTI rates was observed (P >0.05). Conclusion: The elimination of routine urinalysis before orthopedic surgery resulted in a reduction in antibiotic utilization with no significant change in the SSI or CAUTI rates. Cost savings resulted from reduced antibiotic usage.
Kim, S.,Hoffman, Gregory R.,Poulogiannis, G.,Buel, Gwen R.,Jang, Y.,Lee, K.,Kim, B.Y.,Erikson, Raymond L.,Cantley, Lewis C.,Choo, Andrew Y.,Blenis, J. Cell Press 2013 Molecular cell Vol.49 No.1
The metabolism of glucose and glutamine, primary carbon sources utilized by mitochondria to generate energy and macromolecules for cell growth, is directly regulated by mTORC1. We show that glucose and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 through an AMPK-, TSC½-, and Rag-independent mechanism by regulating mTORC1 assembly and its lysosomal localization. We discovered that the ATP-dependent TTT-RUVBL½ complex was disassembled and repressed by energy depletion, resulting in its decreased interaction with mTOR. The TTT-RUVBL complex was necessary for the interaction between mTORC1 and Rag and formation of mTORC1 obligate dimers. In cancer tissues, TTT-RUVBL complex mRNAs were elevated and positively correlated with transcripts encoding proteins of anabolic metabolism and mitochondrial function-all mTORC1-regulated processes. Thus, the TTT-RUVBL½ complex responds to the cell's metabolic state, directly regulating the functional assembly of mTORC1 and indirectly controlling the nutrient signal from Rags to mTORC1.
Effect of Substrate Temperature on Residual Stress of ZnO Thin Films Prepared by Ion Beam Deposition
Ju-Won Jeon,Myoung Kim,장이운,J. L. Hoffman,Peter Kim,In-Hwan Lee 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.1
We have investigated the effect of substrate temperature on micro-structural properties of ZnO thin films prepared by ion beam deposition technique. ZnO thin films were deposited on AlN-buffered Si (111) and sapphire (001) substrates at various substrate temperatures. The structural properties and surface morphologies were examined by high resolution X-ray diffraction (XRD) and field emission scanning electron microscopy,respectively. The RMS roughness was measured by atomic force microscopy. XRD measurements confirmed that the ZnO thin films were grown well on the AlN-buffered Si (111) and sapphire (001) substrates along the c-axis. Minimization of residual stress was carried out by tuning the substrate temperature. The structural properties were notably improved with increasing substrate temperature.