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The emergence and implications of Technologized Marketing
Jürgen Kai-Uwe Brock 한국마케팅과학회 2021 마케팅과학연구 Vol.31 No.3
Technology is as old as human activity and marketing is as old as human economic activity. Accordingly, marketing technology has evolved. Drawing on evolutionary technology systems theory, this paper discusses the emergence and implications of Technologized Marketing, which will be the next evolutionary phase. The implications of Technologized Marketing focus on the question how excellence in marketing will look like. For each implication testable research hypotheses are developed.
Brock, G.,Heiselman, D.,Maggi, M.,Kim, S.W.,Rodriguez Vallejo, J.M.,Behre, H.M.,McGettigan, J.,Dowsett, S.A.,Hayes, R.P.,Knorr, J.,Ni, X.,Kinchen, K. Williams and Wilkins Co 2016 The Journal of urology Vol.195 No.3
<P>Purpose: We determined the effect of testosterone solution 2% on total testosterone level and the 2 symptoms of hypogonadism, sex drive and energy level. Materials and Methods: This was a randomized, multicenter, double-blind, placebo controlled, 16-week study to compare the effect of testosterone and placebo on the proportion of men with a testosterone level within the normal range (300 to 1,050 ng/dl) upon treatment completion. We also assessed the impact of testosterone on sex drive and energy level measured using SAID (Sexual Arousal, Interest and Drive scale) and HED (Hypogonadism Energy Diary), respectively. A total of 715 males 18 years old or older with total testosterone less than 300 ng/dl and at least 1 symptom of testosterone deficiency (decreased energy and/or decreased sexual drive) were randomized to 60 mg topical testosterone solution 2% or placebo once daily. Results: Of study completers 73% in the testosterone vs 15% in the placebo group had a testosterone level within the normal range at study end point (p < 0.001). Participants assigned to testosterone showed greater baseline to end point improvement in SAID scores (low sex drive subset p < 0.001 vs placebo) and HED scores (low energy subset p = 0.02 vs placebo, not significant at prespecified p < 0.01). No major adverse cardiovascular or venous thrombotic events were reported in the testosterone group. The incidence of increased hematocrit was higher with testosterone vs placebo (p = 0.04). Conclusions: Once daily testosterone solution 2% for 12 weeks was efficacious in restoring normal testosterone levels and improving sexual drive in hypogonadal men. Improvement was also seen in energy levels on HED though not at the prespecified p < 0.01. No new safety signals were identified.</P>
Liu, J.,Chan, S.H.J.,Brock-Nannestad, T.,Chen, J.,Lee, S.Y.,Solem, C.,Jensen, P.R. Academic Press 2016 Metabolic engineering Vol.36 No.-
Biocompatible chemistry is gaining increasing attention because of its potential within biotechnology for expanding the repertoire of biological transformations carried out by enzymes. Here we demonstrate how biocompatible chemistry can be used for synthesizing valuable compounds as well as for linking metabolic pathways to achieve redox balance and rescued growth. By comprehensive rerouting of metabolism, activation of respiration, and finally metal ion catalysis, we successfully managed to convert the homolactic bacterium Lactococcus lactis into a homo-diacetyl producer with high titer (95mM or 8.2g/L) and high yield (87% of the theoretical maximum). Subsequently, the pathway was extended to (S,S)-2,3-butanediol (S-BDO) through efficiently linking two metabolic pathways via chemical catalysis. This resulted in efficient homo-S-BDO production with a titer of 74mM (6.7g/L) S-BDO and a yield of 82%. The diacetyl and S-BDO production rates and yields obtained are the highest ever reported, demonstrating the promising combination of metabolic engineering and biocompatible chemistry as well as the great potential of L. lactis as a new production platform.
Modelling the Thermo-Mechanical Behavior of Magnesium Alloys during Indirect Extrusion
D. Steglich,S. Erturk,J. Bohlen,D. Letzig,W. Brocks 한국소성가공학회 2010 기타자료 Vol.2010 No.6
One of the basic metal forming process for semi-finished products is extrusion. Since extrusion involves complex thermo-mechanical and multiaxial loading conditions resulting in large strains, high strain rates and an increase in temperature due to deformation, a proper yield criterion and hardening law should be used in the numerical modelling of the process. A phenomenological model based on a plastic potential has been proposed that takes strain, strain rate and temperature dependency on flow behaviour into consideration. A hybrid methodology of experiment and finite element simulation has been adopted in order to obtain necessary model parameters. The anisotropy/asymmetry in yielding was quantified by tensile and compression tests of specimens prepared from different directions. The identification of the corresponding model parameters was performed by a genetic algorithm. A fully coupled thermo-mechanical analysis has been used in extrusion simulations for calculation of the temperature field by considering heat fluxes and heat generated due to plastic deformation. The results of the approach adopted in this study appeared to be successful showing promising predictions of the experiments and thus may be extended to be applicable to other magnesium alloys or even other hcp metals.
Zimmerman Darin T.,Johnson Earnie J.,Ma JunKun,Miskovsky Nicholas M.,Weisel Gary J.,Weiss Brock L. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
We present a systematic study of the heating and pre-sintering behavior of porous copper powder metal compacts. We employ a TE102 single mode microwave system to position the samples in the separated electric field (E) or magnetic field (H) anti-node of the cavity. We observe significant differences in the heating, pre-sintering, and microstructure evolution of the samples due to the individual fields. We note that sample history (whether heated first in the E-field or H-field) greatly effects a difference in heating trends and subsequent heating behavior and does not appear to be solely a thermal process.
Kim,Sun-Geon,Han,Young-Soo,Jang,Hee-Dong,Lee,Kun-Moo,Brock,J.R. 중앙대학교 생산공학연구소 1998 생산공학연구소 논문집 Vol.7 No.1
The 'general dynamic' equation (GDE) has been numerically solved to simulate the growth of ultrafine particles (UFPs) in a tubular aerosol reactor, approximating the particle size distribution by a lognormal function. The GDE includes all the terms describing diffusion, thermophoresis, nucleation, condensation and coagulation. We have also considered the efficiency of coagulation to primary particles. The data calculated from our model was compared with those from the previous model and also with some experimental results from a TiO₂ UFP generator. The condensation term, which we split from single coagulation term in the previous model, well described the monomer behavior that was important in the particle growth. Introduction of one adjustable parameter, the efficiency of coagulation was successful to limit the growth of primary particles and fit the experimental data.
Loredana Amoroso,Giovanni Erminio,Guy Makin,Andrew D. J. Pearson,Penelope Brock,Dominique Valteau-Couanet,Victoria Castel,Marlène Pasquet,Genevieve Laureys,Caroline Thomas,Roberto Luksch,Ruth Ladenste 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1
Purpose Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR) or partial response (PR) with " three abnormal skeletal areas on iodine 123-metaiodobenzylguanidine ([123I]mIBG) scintigraphy and no bone marrow disease proceed to high dose therapy (HDT). In this study, topotecan-vincristine-doxorubicin (TVD) was evaluated in patients failing to achieve these criteria, with the aim of improving the metastatic response rate. Materials and Methods Patients with metastatic high-risk neuroblastoma who had not achieved the SIOPEN criteria for HDT after induction received two courses of topotecan 1.5 mg/m2/day for 5 days, followed by a 48-hour infusion of vincristine, 2 mg/m2, and doxorubicin, 45 mg/m2. Results Sixty-three patients were eligible and evaluable. Following two courses of TVD, four (6.4%) patients had an overall CR, while 28 (44.4%) had a PR with a combined response rate of 50.8% (95% confidence interval [CI], 37.9 to 63.6). Of these, 23 patients achieved a metastatic CR or a PR with " 3 mIBG skeletal areas and no bone marrow disease (36.5%; 95% CI, 24.7 to 49.6) and were eligible to receive HDT. Toxicity was mostly haematological, affecting 106 of the 126 courses (84.1%; 95% CI, 76.5 to 90.0), and dose reduction was necessary in six patients. Stomatitis was the second most common nonhematological toxicity, occurring in 20 patients (31.7%). Conclusion TVD was effective in improving the response rate of high-risk neuroblastoma patients after induction with COJEC enabling them to proceed to HDT. However, the long-term benefits of TVD needs to be determined in randomized clinical trials.