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Harada, Nobuya,Ishitani, Eiichi,Gotoh, Masafumi,Shiba, Naoto Korean Shoulder and Elbow Society 2022 대한견주관절의학회지 Vol.25 No.3
Background: This study aimed to examine the preliminary clinical results of the infraspinatus rotational transfer procedure for irreparable posterosuperior rotator cuff tears. Methods: This study included 34 patients (mean age, 68.4 years). Their mean tear width and length measurements were 50.9 mm and 50.6 mm, respectively. The functional outcomes, including physician-determined and patient-reported scores, were evaluated before and at 1 year after surgery. The structural outcomes determined using the magnetic resonance imaging examination results were also assessed. Results: The clinical scores significantly improved after surgery compared with the scores before surgery: the Constant-Murley score (53.3±21.1 to 76.8±10.5), University of California at Los Angeles Shoulder score (15.6±3.6 to 27.8±6.7), American Shoulder and Elbow Surgeons Shoulder score (51.8±18.3 to 89.1±13.5), and WORC score (925.0±436.8 to 480.3±373.2) (all p<0.001). Postoperative re-tears were noted in two patients (5.9%). Conclusions: One year postoperatively, the patient's clinical scores significantly improved, with a re-tear rate of 5.9%.
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis
Kim, Wantae,Khan, Sanjoy Kumar,Gvozdenovic-Jeremic, Jelena,Kim, Youngeun,Dahlman, Jason,Kim, Hanjun,Park, Ogyi,Ishitani, Tohru,Jho, Eek-hoon,Gao, Bin,Yang, Yingzi American Society for Clinical Investigation 2017 The Journal of clinical investigation Vol.127 No.1
<P>Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting pathways restrains proliferation in normal cells and prevents tumor initiation is still poorly understood. Here, we have reported that the Hippo, Wnt/beta-catenin, and Notch pathways form an interacting network to maintain liver size and suppress hepatocellular carcinoma (HCC). Ablation of the mammalian Hippo kinases Mst1 and Mst2 in liver led to rapid HCC formation and activated Yes-associated protein/WW domain containing transcription regulator 1 (YAP/TAZ), STAT3, Wnt/beta-catenin, and Notch signaling. Previous work has shown that abnormal activation of these downstream pathways can lead to HCC. Rigorous genetic experiments revealed that Notch signaling forms a positive feedback loop with the Hippo signaling effector YAP/TAZ to promote severe hepatomegaly and rapid HCC initiation and progression. Surprisingly, we found that Wnt/beta-catenin signaling activation suppressed HCC formation by inhibiting the positive feedback loop between YAP/TAZ and Notch signaling. Furthermore, we found that STAT3 in hepatocytes is dispensable for HCC formation when mammalian sterile 20-like kinase 1 and 2 (Mst1 and Mst2) were removed. The molecular network we have identified provides insights into HCC molecular classifications and therapeutic developments for the treatment of liver tumors caused by distinct genetic mutations.</P>
Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development
Cho, S.J.,Cha, B.S.,Kwon, O.S.,Lim, J.,Shin, D.M.,Han, D.W.,Ishitani, T.,Jho, E.h.,Fornace, A.J.,Cha, H.J. Elsevier Science Publishers B.V 2017 Biochimica et biophysica acta. Molecular basis of Vol.1863 No.4
Mice null for wild-type p53-induced phosphatase 1 (WIP1) display defects in testis development and spermatogenesis, resulting in reduced fertility. However, the molecular mechanism underlying these abnormalities in the testis remains uncharacterized. We report that the phosphatase activity of WIP1 increases Wnt activity through Nemo-like kinase (NLK). WIP1 directly interacted with NLK, which is highly homologous to p38 MAPK, a WIP1 substrate, and dephosphorylated its activation site. The WIP1-mediated inhibition of NLK activity markedly decreased the phosphorylation of lymphoid enhancer-binding factor 1 (LEF1), enhancing its interaction with β-catenin. Additionally, WIP1 depletion impaired germ cell development, as evidenced by the expression of Oct4 and the germ cell-specific markers Ddx4, Nanos3 and Dnd1 during the development of germ cells from Oct4-GFP transgenic (OG2) mouse embryonic stem cells (mESCs). The expression of WIP1, whose level was significantly lower after the differentiation of germ cells from mESCs, occurred in parallel with the expression of germ cell development markers and SRY-box 17 (Sox17), a downstream target of Wnt. These results indicate that WIP1 is essential for germ cell development, which is known to require Wnt activity.
Eun Sook Hwang,Hyung Jae Lee,A. Yoshikawa,C.-H. Hong,E. M. Park,E.-K. Suh,S.B. Che,X. Wang,Y. Ishitani 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.4
Unintentionally doped n-type InN epilayers were grown on sapphire by using plasma-assisted molecular beam epitaxy and were characterized by using Hall effect and X-ray diffraction. The electron density was in a narrow range of 3.6 . 4.5 × 1018 cm.3. Hall effects showed that two scattering mechanisms due to ionized impurities and space charges dominate at temperatures lower than room temperature. The lattice-limited mobility was calculated at 5800 cm2/V·s at 300 K. Despite the high density of edge dislocations, scattering due to those dislocations turned out to be negligible. Instead, space-charge scattering was significant and likely originated from randomly clustered dislocations, typically in InN layers. Two donor states were observed, one above and the other below the conduction band minimum. The thermal activation energy of the lower state donor was high due to the Fermi energy level being located deep in the conduction band, and the state seemed to be related to the dislocations.docum