Natural products used as a chemical library for protein–protein interaction targeted drug discovery

Jin, Xuemei,Lee, Kyungro,Kim, Nam Hee,Kim, Hyun Sil,Yook, Jong In,Choi, Jiwon,No, Kyoung Tai Elsevier 2018 Journal of molecular graphics & modelling Vol.79 No.-

<P><B>Abstract</B></P> <P>Protein–protein interactions (PPIs), which are essential for cellular processes, have been recognized as attractive therapeutic targets. Therefore, the construction of a PPI-focused chemical library is an inevitable necessity for future drug discovery. Natural products have been used as traditional medicines to treat human diseases for millennia; in addition, their molecular scaffolds have been used in diverse approved drugs and drug candidates. The recent discovery of the ability of natural products to inhibit PPIs led us to use natural products as a chemical library for PPI-targeted drug discovery. In this study, we collected natural products (NPDB) from non-commercial and in-house databases to analyze their similarities to small-molecule PPI inhibitors (iPPIs) and FDA-approved drugs by using eight molecular descriptors. Then, we evaluated the distribution of NPDB and iPPIs in the chemical space, represented by the molecular fingerprint and molecular scaffolds, to identify the promising scaffolds, which could interfere with PPIs. To investigate the ability of natural products to inhibit PPI targets, molecular docking was used. Then, we predicted a set of high-potency natural products by using the iPPI-likeness score based on a docking score-weighted model. These selected natural products showed high binding affinities to the PPI target, namely XIAP, which were validated in an <I>in vitro</I> experiment. In addition, the natural products with novel scaffolds might provide a promising starting point for further medicinal chemistry developments. Overall, our study shows the potency of natural products in targeting PPIs, which might help in the design of a PPI-focused chemical library for future drug discovery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper provides <I>in silico</I> drug discovery strategy to identify natural products capable to inhibit the protein–protein interactions. </LI> <LI> The predicted PPI inhibitor-like natural products were validated in an in vitro experiment. </LI> <LI> The XIAP inhibitor LENP0044 could be used as a potent template for further chemical optimization. </LI> <LI> Natural products can be used as potent candidates in the design of a PPI-focused chemical library for drug discovery. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

漢文科 評價를 위한 成就基準 개發 方向에 대하여 : 高等學校를 中心으로 On the Direction of the Development of Completion Criteria for the Valuation in the Education of Sino-Korean Letters and Lit with the education in high school

秦仁燮 한국한문교육학회 2002 한문교육논집 Vol.19 No.-

敎育評價의 본질적 기능은 학생이 도달하여야 할 목표를 어느 정도 성취하였는지 점검하고, 그 결과를 학생이나 교사, 부모에게 제공해 주어 학생이 나아갈 좌표를 일러주고 도와주는 역할을 담당하는 것이다. 즉 교육의 장에서 評價는 학생이 지속적으로 성장하고 발달할 수 있도록 돕는 역할을 수행한다고 할 수 있다. 학교 연장 評價의 관행상 문제점으로 인하여 보다 적극적인 기준 개발의 필요성이 절실하다. 즉 評價 결과를 바탕으로 학생들의 학습 결손 상태를 파악하여 이를 개선하기 위해 敎授·學習 과정에 송환시키기보다는 학습자의 우·열을 가리기 위한 수단으로만 사용하는 등 교육과정의 기본 방향에 위배되는 상황들을 학교 교육이 주도했기 때문이다. 成就基準이란 해당 학년에서 배워야 할 敎授·學習 활동의 실질적인 기준으로, 교육과정의 목표 및 학습·내용을 실제 수업과 연관 시켜 이해할 수 있도록 명료하게 구체적으로 해석, 나열한 것이며, 또한 현장에서의 敎授·學習활동을 계획하고 구안할 수 있도록 기초 자료로 제시되는 것이며, 교육의 총체인 評價를 위한 준거로서 교육과정의 질 관리와 기초학력 보장을 위하여 개발되어야 하는 것이다. 따라서 敎育目標와 敎授·學習 활동, 評價 활동의 일치를 評價의 방향으로 두고 이를 위한 일관성 있고 체계적인 면모를 보이기 위해서는 교사와 학생이 무엇을 어떻게 가르치고 배워야 하며, 그것을 어떻게 評價해야 할 것인가에 대한 합리적인 준거인 成就基準을 마련하는 것이 시급한 실정이다. 한문과 성취기준 개발 방향에 대해 몇 가지 살펴보면 다음과 같다. ① 現場 適用性 및 自律性이 떨어지고 모호하다. ② 成就基準 영역 설정에 있어서 漢文과 교육과정의 논리와 특성에 따라 구별하고, 학급의 효율성을 극대화시켜야 한다. ③ 評價를 위한 成就基準에 대한 道具選擇과 活動課題가 斷片的이다. ④ 實業界 高等學校 學生들의 基礎學力 정도를 감안하지 않았다. ⑤ 동아시아권에서의 漢字의 활용을 위한 속자·약자·간자의 학습에 대한 기준이 없다. ⑥ 高等學校 敎育用 基礎漢字 900字에 대한 成就基準이 級別로 정해져 있지 않다. ⑦ 成就 水準을 정함에 있어 難易度나 重要度 등을 따져 학년별로 구분지어져 있어야 한다. ⑧ 敎授·學習 활동 시간 및 학생 수준의 조정이 필요하다. ⑨ 成就基準 영역을 설정함에 있어 실용적인 사안을 고려해야 한다. ⑩ 暗記 위주에서 探究 위주로 탈바꿈해야 한다. ⑪ 현재 시행되고 있는 대학 수학 능력 시험도 고려되어야 한다. 이상과 같이 成就基準의 개발의 방향성을 제시하였는바 이는 적정한 評價 기준을 세우는데 그 목적이 있다. 물론 이와 같이 成就基準을 만들어 놓고 評價基準을 마련하는 것이 너무 세부적으로 나누어지게 되어 혼란을 가중시킬 수도 있겠으나, 오히려 학생들이 반드시 성취해야 하고 이에 따라 정당한 評價를 받기를 원한다면 쌍방의 만족을 이끌어 낼 수 있으리라 본다. 그리고 절대 불변의 확고한 지침을 제공할 수 있는 성격은 아니므로 앞으로 교육 과정의 확대 적용에 따른 현장 교사들의 경험, 학습자, 교육 전문가, 행정 기관 그리고 학부모의 반응과 의견을 조사하고 우리의 교육 현실을 반영하여 成就基準의 기본적인 의미를 확대 또는 수정하여 보완하는 가능성은 열어두고자 한다. The essential function of educational valuation is the inspection of educational completion of students and advising them to acquire future angular by informing the result to teachers and parents. But the valuation in educational field had been performed usually, so if we couldn't this problem we wouldn't achieve the improvement of educational quality. To be frank, the conception of completion criteria can be explained by three as belows. 1) Elementary criteria of education to be taught in every grades, in other words, that comments on the goal and contents in curriculum distinctly and concretely relating to real educational processes. 2) That was issued as the basic datum to plan the education-learning schedules. 3) That have to be developed for the management of educational quality in curriculum and the guarantee of elementary scholarship as the standard of valuation. As mentioned above, I will present several directions to correct problems of current completion criteria and to establish new criteria suited to present educational systems. ① Field applicability and autonomy are depreciated and vague. ② In the fixing the area of completion criteria, we must distinguish according to the logic and the characteristics of educational curriculum, and must deal all students differently. ③ The choice of instrument and performing subjects in the completion criteria for test are fragmentary. ④ That didn't take into account the degree of elementary scholarship in industrial high school. ⑤ There is no clear criterium for using the simplified Chinese characters of Japan and China. ⑥ There is no graded completion criterium for 900 elementary letters in high school education. ⑦ We must take into account the degree of difficulty and importance in deciding the level of completion. ⑧ We must settle the time of teaching-learning and the level of student. ⑨ In the fixing the area of compleyion criteria, we must take into account pragmatic aspects. ⑩ We must transform memory centered curriculums into investigating centered one. ⑪ We must take into account the test for entrance of university(college) current operated.

한국인의 종교성과 종교적 배타성

윤인진(Yoon, In Jin),양대영(Yang, Dae Young) 고려대학교 아세아문제연구소 2013 亞細亞硏究 Vol.56 No.2

In recent decades, Korean religious groups have increased their political influence and conflicts between different religions have become visible and intensified. In this context, we examined the levels and patterns of religious exclusiveness in both private and public domains and the reasons for their expression in South Korean society. We used both statistical analyses that used the 2008 KGSS dataset and in-depth interviews with 15 interviewees. After pointing out limitations of the religious index developed in the United States in the multi-religious South Korean religious context, we introduced a multidimensional index that consists of religious faith, religious act, and religious function and employed both conventional variables commonly used in religious studies and new variables that seem to capture multi-religious aspects of South Korea. Results of statistical analyses show that religious faith and act have significant effects on the tolerance toward a spouse of different religion. But religious function has no significant effect on this matter. Especially the level of faith in Buddhist doctrines and the frequency of attendance in religious meetings have significant effects. In the case of support for political candidates of different religion, only religious act has an significant effect while both religious faith and religious function have no effects. Especially, the frequency of prayers is the most significant variable. Also, in general, both Buddhists and Catholics are less exclusive than Protestants in matters of marital selection and political support. Results of in-depth interviews show that religious exclusiveness is the lowest in friendship, and in support for political candidates and interpersonal relationship at workplace in decreasing order. It is the highest in marital selection. As seen in statistical analyses, differences among religious groups are also observed in in-depth interviews. Protestants are the most religious exclusive toward people of different religious in both private and public domains, and both Buddhists and Catholics are not exclusive toward other religions. Protestants exhibit strong propensity to apply their Christian teachings, rituals and practices, and values to other people, workplace and political arenas, and this causes ill feeling and repulsion among Buddhists and Catholics toward Protestants.

고형배지의 종류가 수경재배 멜론의 품종별 과실의 생육과 품질에 미치는 영향

전하준,황진규,김인규,손미자 대구대학교 생명과학연구소 2004 생명과학연구 Vol.3 No.1

In order to examine how growth substances influence to fruit growth and its quality, we cultivated 3 different kinds of melons which grown in hydroponic system into 3 different types of growth substances, such as perlite, perlite/rock wool and rock wool/perlite. In this experiment, “Siroi Kagayaki”, showed no significant difference in fruit weight and its diameter in any of growth substances, but higher in plant height in perlite/rock wool than Perlite. In case of “TS-1806”, there were no significant differences in soluble solids, fruit weight and diameter in all the substances. However, it showed longer in fruit length in rock wool / perlite than that in perlite/ rock wool. In addition, the soluble solids in placenta and flesh were higher in perlite than those in rock wool/perlite.

晋州地方의 諸 氣象要素에 關한 分析的 硏究 : 第5報 雲量의 變化에 關하여 (1931~'60) 5. On the Changes of Cloud amount(1931~'60)

宋珍燮,崔文錫,金仁湖 慶尙大學校 1974 論文集 Vol.13 No.-

1931年 1月부터 1960年 12月까지 晉州地方의 雲量에 관하여 調査 分析되어진 바를 要約하면; (1) 年中 雲量의 平年値(Normals)는 4.7로 나타나고 있으며, (2) 年別 年中의 變化는 1958年의 4.0으로 最低이고 1946年과 1952年의 5.1이 最高를 보이고 있다. (3) 觀測全年의 季節別 雲量의 最低値는 冬季의 3.6이고 夏季의 6.2가 最高値를 나타내고 있다. (4) 年中의 月別 雲量가운데 12月과 1月의 3.5가 最低이고 7月의 6.8이 最高値를 보여 주고 있다. (5) 全年의 흐림, 개임 및 맑음의 日數의 百分率은 各各 42.5%, 20.3% 및 37.2%를 나타내고 있다. In the district of Jinju, the statistical reserch on the cloud amount has been carried out from the matterials which is observed at The Office of Rural Development, Gyeongnam Province from Jan. 1931 to Dec. 1960. To analyze the data numerically, the mean value has been calcuted daily, dekad and monthly during the years. The normal values are listed on the Table (1), (2), (3) and (4). The changes of dekad, monthly and yearly are plotted on Fig (1) and (2). From the tables and figures, the results are summarized as follows: 1) The annual value of the cloud amount is 4.7. 2) In the yearly changes, the lowest mean value is 4.0 in 1958 and the highest is 5.1 in 1952. 3) In the seasonal changes, the lowest mean value is 3.6 in winter and the highest is 6.2 in summer. 4) In the monthly changes, the lowest mean value is 3.5 in Dec. and the highest is 6.8 in July. 5) In the dekad changes, the lowest mean value is 3.1 inthe 3rd ekad in Fed. and the highestis 7.7 in the lst in July. 6) In the daily changes, the lowest mean value is 8.1 i Jan. 27the and the highest is 8.3 in June 29th and July 10th. 7) The percentage of annual Cloudy, Fair and Clear days are 42.5%, 20.3% adn 37.2%.

전산화 신경인지기능 검사를 이용한 외상성 두뇌손상환자의 신경인지기능평가

정인원,최인석,김재진 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

뇌영상검사상 국소적인 병변을 보이지 않는 경도 외상성 두뇌손상환자를 대상으로 한 신경인지기능검시에서 인지기능결함이 보고되고 있으며 이에 대하여 객관적인 인지기능장애 평가도구가 요구돼 왔다. 본 연구에서는 외상성 두뇌손상환자들을 대상으로 뇌 영상검사를 시행하여 국소적인 병변의 유무에 따라 병변군과 비병변군으로 분류하였으며, 이와 동시에 신경인지기능검사를 시행하여 병변의 유무에 따른 Bender-Gestalt Test, 표준도형검사, 인식력검사. 신호탐지검사 결과를 비교해 보았다. 또한 KWIS 지능지수와 표준도형검사 지능지수간의 상관관계를 조사하여 지능검사도구로 표준도형검사의 유용성을 알아보고자 하였다. 외상성 두뇌손상환자집단의 신경인지기능검사 결과는 다음과 같았다. 1) 신경정신과적 주요 증상 비교에서 병변군은 인지장애 호소가 맡았으며. 비병변군은 신체장애 호소가 많았다. 2) BGT 전체수행오류는 병변군이 비병변군보다 많았다. 3) KWIS 지능검사상 병변군과 비병변군간의 차이는 없었다. 4) 표준도형검사 소항목 검사결과 병변군은 정상대조군이나 비병변군에 비하여 난이도가 높을수록 수행이 낮았다. 5) 인식력검사 결과 병변군은 정상대조군보다 수행이 낮았다. 6) 외상성 두뇌손상환자집단에서 표준도형검사 지능지수는 KWIS 지능지수와 r=0.67의 높은 상관관계를 보였다. . 이와 같은 결과로 외상성 두뇌손상환자 중 병변군은 공간구성능력, 미세운동협응능력. 형태기억능력, 반응속도에서 장애를 보임을 알 수 있었다. 통계적인 의미는 없었으나 인식력검사결과에서 비병변군은 정상대조군과는 다른 반응 경향을 나타내고 있었다. 인식력검사상 비병변군의 이러한 차이는 비병변군이 신체장애를 주로 호소하였고. 경도 외상성 두뇌손상에서 보상과 같은 심리적 요인들이 증상의 유지에 기여할 수 있다는 보고를 고려할 때. 신경인지기능검사의 임상적,인 해석에 주의를 요하고 있다. 그리고 외상성 두뇌손상환자에서 표준도형검사 지능지수와 KWIS 지능지수는 정상대조군보다 높은 상관관계를 보여 표준도형검사는 두뇌손상환자와 같이 지적능력이 저하된 진단에서 KWIS 지능검사를 보완할 수 있는 유용한 지능검사로 임상상황에서 경제적이고 객관적인 지능검사 도구가 될 수 있음을 알 수 있었다. Irrespective of focal lesion in brain imaging study, the deficits in cognitive function have been reported in mild traumatic brain injury patients. Therefore, they have been asked sensitive and objective assessment tools measuring cognitive deficits. In this study, traumatic brain injury patients were classified into lesion group and non-lesion group by presence of focal lesion in brain imaging study At the same time, Results of Bender-Gestalt test, Standard Progressive Matrices, Cognitrone, and Signal Detection were analyzed among the groups. We assessed usefulness of Standard Progressive Matrices as assessment tool of intelligence in traumatic brain injury patients by correlation coefficients between KWIS and Standard Professive Matrices intelligence quotients. 1) Most lesion group showed severe deficits in cognitive function, and most non-lesion group showed severe somatic symptoms. 2) The lesion group showed higher Bender-Gestalt test total error score than non-lesion group. 3) There was no difference in KWIS intelligence quotients between lesion and non-lesion group. 4) The lesion group showed lower performance than normal control and non-lesion group as increasing complexity of Standard Progressive Matrices subset. 5) The lesion group showed poor performance than normal control group in Cognitrone. 6) There were higher correlation coefficients than normal control group between Standard Progressive Matrices intelligence quotients and KWIS intelligence quotients in traumatic brain injury patients. According to the above results, lesion group showed deficits in space-construction ability, fine-motor coordination ability, form-memory ability, and delayed response-time. Although there are no statistical significance, comparing with normal control group, non-lesion group showed different response-trend in Cognitrone. Considering somatic symptoms in most nonlesion group and contribution of psychological factors in maintenance of symptoms in mild traumatic brain injury patients, the differences in Cognitrone must be interpreted carefully. These result suggest than Standard Professive Matrices can be a useful tool for assessment of intelligence in traumatic brain injury patients who showed deficits in cognitive function.

병원중심 가정간호중재 분석 : NIC 체계 적용

용진선,유인자,유지연 성인간호학회 2000 성인간호학회지 Vol.12 No.4

The purpose of the study was to investigate the characteristics of the clients registered in the department of home health care nursing in a hospital and to analyze nursing intervention activities recorded in charts by application of Nursing Intervention Classification (NIC) system For the descriptive survey study, data were collected by reviewing charts of 572 home health care clients between May. 1997 and July, 2000 at K hospital in Seoul. The average alee of the clients was 66 years and the number of clients in their 70s ranted first with 28.2 percent(158 people). The mean length of home care servile was 47 days with the highest frequency of less than four weeks(56 %). With regard to medical diagnosis, cancer showed the highest frequency (48%. 271 people) fellowed by cerebrovascular disease (19%). anti pulmonary disease (6.9%). According to analysis of nursing interventions by the NIC system, the most frequently used nursing interventions in level 1 were interventions in the Physiological: Complex domain which were used 3.663 times (33%) among 11.107 total interventions. The Safety domain was the second most frequently used intervention, followed by the Physiological Basic, and the Behavioral domains. In level 2. the Risk Management class was the most frequently used interventions with 3,108 interventions (27.9%). followed by Drug Management, and Tissue Perfusion Management classes. In level 3 interventions. Vital Sign Monitoring was the most frequently used intervention. 569 times (5.1%) followed by Health Screening, and Neurological Monitoring interventions. In sum, half of the clients in the study had cancer and were in their 70s. The most frequent reason for ending home care was death(40%). followed by readmission (28%). These findings represent clients with severe conditions referred to the home care nursing decal-foment as it was a University leaching hospital. Further research on analyzing nursing interventions performed in earth institution needs to be conducted to develop a standardized list of nursing interventions to use in home health care settings.

백서 중대뇌 동맥의 폐쇄에 따른 경색의 시간적 변화

정진명,정영섭,박인성,이상형,김현집,최길수,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

For the assessment of clinical management, for the confirmation of clinical findings, and also for the evaluation of new diagnostic techniques to determine the location as well as the extent of area of infarction on evolution in cerebral tissue is essential. Sequential evolution of infarction in 2% 2, 3, 5-triphenyltetrazolium hydrochloride(TTC) staining and its concomitant neurological changes were investigated in the rat following left middle cerebral artery occlusion(MCAO). In addition, the pathological evaluation was performed in the same coronal cut slice of each TTC staining. The results were : 1) In the TTC staining method, the cerebral infarction was not found in the 2 hour group rats, and appeared as white or pink color after 4 hours. 2) The size of infarction was significantly correlated with time of occlusion before sacrifice(p<0.05). The size increment was most obvious between 8 hour and 24 hour groups. 3) The time evolution of cerebral infarction was most prominent in the cerebral cortex, and was minimal in the basal ganglia which are supplied by the 'end artery'. 4) The cerebral infarction appeared first in the coronal cuts at the 4, 6, and 8㎜ from the frontal pole, which is the main territory of MCA. 5) The cerebral infarction, mainly presented in the 4, 6, and 8㎜ coronal cuts from the frontal pole, extended from the pyriform cortex to the fronto-parietal cortex. It also appeared at 2, 10㎜ coronal cuts from the frontal pole in 24 hour group. 6) The neurologic sign was not correlated to the time of MCAO and the size of infarction on evolution. Therefore, the prediction of location and size of area of infarction on evolution was impossible by the neurological status. 7) The histopathological change was detected as early as in 2 hours. However, hematoxylin and eosin(H & E) stained sections showed only subtle changes, such as small irregular areas of cortical spongiosis and neuronal shrinkage up to 8 hours. There was no significant difference between lesion areas of 2 hour and 8 hour groups. The pathological findings of 24 hour group rats was definite and appeared as a central area of coagulation necrosis and rare faction surrounded by a zone of peripheral spongiosis.

순천대학교 농과대학 개편 방안

임행진,배인휴,임준택,배영환 순천대학교 1996 大學發展硏究論文集 Vol.2 No.-

1. 대학 명칭 변경 농과대학을 생명자원 과학대학으로 개편 2. 학부제 운영 방안 1) 제1차안에 따른 6개 학부로 개편하되 추가적인 여론 수렴이 반드시 요망됨. 2) 학부 운영시 정원 감축 요망 현행 395명 → 300명 (24% 감축) 3) 학부 구성시 전공의 세분화는 지양하되 통합을 위한 새로운 분야는 인정한다. 3. 교과과정의 운영 1) 교양과목―외국어 및 전산 교육 강화 2) 전공과목 ① 강의 책임시수를 하향 조정하여 강의 내실화 도모 ② 유사과목 중복 개설 지양 ③ 복수전공제 도입 ④ Team teacing, 동일 과목 분반제 등의 도입으로 전문성 제고 3) 교과과정의 개편 절차 (1) 농대에 교과과정 개편위원회를 설치하여 자체 의견을 수렴 (2) 교과과정 개편위원회에서 ① 교양과목 이수 학점 조정 ② 학부(전공)간 중복 및 유사 교과목 조정 ③ 공통 과목 담당 교수진과 강의분담 방법 결정 ④ 복수전공 허용 범위 및 시행 방안 조정 4. 대학 발전 방안 1) 농과대학 특성화 시설원예 분야로의 특성화유도 2) 대 농민 기술지원 센타 설립을통한 현장애오 해결 연구부, 교육부, 지도부, 농업정보부, 식물병원 등 설치 3) 대학의 자립 능력 배양 ① 농대 발전기금 조성, 농대 부석기관의 자체 수익사업 운영 ② 부속기관의 수익을 재투자할 수 있도록 제도 개선 4) 연구 여건 개선 ① 연구 전담 교수제 확대 시행 ② 공동기기동 설치 및 전공별 공동기기실 운영 The problems that College of Agriculture in Korea are confronted with consist of a few number of faculty members in very department, and hence too many lecture hours per prefessor, departments with similar speciality, duplicated subjects, and hence duplicated lectures in similar subjects, poor experimental equipments, poor extension system, and a small amount of budget. It would be necessary to reorganize the system of College of Agriculture to solve these problems. The objective of the study is to construct the direction of reorganization of College of Agriculture in Sunchon National University. For the objective, survey composed of all professors in the Agricultural College and discussions among committee members were adopted. Survey data was collected and analysed. Through the study, reorganization strategies were built as the point of change of college name, administration of school system by unifying departments with similar major area, basic directions in reconstructing the curriculum for the school system, and strategies for the growth of the College. 1) Name of College of Agriculture will be changed to College of Life and Resource Science. 2) College of Agriculture can be reorganized into six schools based on survey, and for more concrete reorganization, additional opinions must be gathered. Number of incoming student can be reduced for school system from 395 at present to 300 (24% reduction). Finely specialized major should be prohibited, but addition of departments or speciality of new research area can be allowed for the establishment of administration of school system. 3) In management of curriculum, foreign language and computer science should be reinforced as general course in the school system. Obligated lecture hours of professor should be reduced, which would enhance the quality of lecture, and offerring lectures with similar subjects should be restricted. Dual major system is going to be allowed. Team teaching and class separation for the same subject should be allowed for the enhancement of lecture quality. In curriculum revision process, committee of curriculum revision in College of Agriculture must be set up and gather opinios for better revision. The committee regulate the credits for the general course, control overlapping or similar subjects among the schools(majors), select lectures for team teaching and the way of class separation in the same subject. They also provide permitted limits of and the way of conducting dual major system. 4) For further growth of the college, the following items should be satisfied. With the limited number of faculties, concentrating facilities and research capability of the college into specialized area is needed to enhance the competitive power of the college. In this study, the committee agreed to select horticultural area in greenhouse as the specialized area. This will be achieved gradually by employing new faculty members with major in this area and conducting cooperative research among faculty members. An extension system to train farmers for the newly developed technologies in agriculture should be established. In this facility, farmers can exchange their experiences among them, and farmers and the university faculty members can conduct experiments to solve problems occurred in farming practices. The extension system consists of division of reasearch, education, advise, information in agricultural area, and diagnosis of pest and diseases. Annual budget of the college largely depends upon the budget from the Ministry of Education. With the limited budget, it is almost impossible for the college to invest into the area where college faculty members intend to for the farmers. Collection of a fund for the growth of the college is needed. This fund can be gathered either from the alumni, faculty members and students or by reinvesting the profit from experimental farm of the college. The system for the reinvestment of the profit from appendges of the college should be established. The condition of research should be improved. This can be achieved by employing full-time researchers as faculty members and reducing lecture load of professors. Building for the center of cooperative research and systematic installation of experimental facility and equipments might also be needed for the improvement.

95학년도 2학년 학생의 인성 특성의 분석

장국진,이인경 용인대학교 학생생활연구소 1996 학생생활연구 Vol.3 No.-

The purpose of this study was to analyze and understand sophomores personaliy traits and to help their adjustments to university life and soceity in harmony, using Personality Trait Test. The results were as followings. First, for overall distribution of response, scores of seven traits in descriptive scale were distributed between percentile and 60 percentile of normal range. Three traits in clinical scale were distributed between 30 percentile and 92 percentile. Second, comparing between responses in 1994 and those in 1995, there were similar patterns in descriptive pattern between them. The tendency in psychosis and anti-social behavior increased whereas the tendency in psychoneurosis decreased. Third, each college revealed its unique profile. Forth, percentage of the expected adjusting Problem (below 25 percentile in descriptive scale and above 75 percentile in clinical scale) showed as following; for descriptive scale, 24.7% in activity, 25.7% in stability, 18.9% in dominance, 28.2% in reflectiveness, 12.5% in sociality, 23.6% in autonomy, 25.8% in achievement, for clinical scale, 0.4% in psychoneurosis, 43.8% in psychosis, 70.2% in anti-social personality. Fifth, there were no significant differences among colleges in descriptive scale, while there were significant differences in clinical scale. In addition, implication and suggestions for further study were discussed based on the results.