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LB30057 Inhibits Platelet Aggregation and Vascular Relaxation Induced by Thrombin
Byoung-InJung,Kyu-TaeKang,배옥남,Moo-YeolLee,Seung-MinChung,Sang-KooLee,In-ChulKim,Jin-HoChung 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.6
Previous study showed that an amidrazonophenylalanine derivative, LB30057, which has high water solubility, inhibited the catalytic activity of thrombin potently by interaction with the active site of thrombin. In the current investigation, we examined whether LB30057 inhibited platelet aggregation and vascular relaxation induced by thrombin. Treatment with LB30057 to plateletrich plasma (PRP) isolated from human blood resulted in a concentration-dependent inhibition of thrombin-induced aggregation. Values for IC50 and IC100 were 54 ± 4 nM and 96 ± 3 nM, respectively. This inhibition was agonist (thrombin) specific, since IC50 values for collagen and ADP were much greater than those for thrombin. In addition, concentration-dependent inhibitory effects were observed on the serotonin secretion induced by thrombin in PRP. Consistent with these findings, thrombin-induced increase in cytosolic calcium levels was inhibited in a concentration-dependent manner. When LB30057 was treated with aortic rings isolated from rats, LB30057 resulted in a concentration-dependent inhibition of thrombin-induced vascular relaxation. All these results suggest that LB30057 is a potent inhibitor of platelet aggregation and blood vessel relaxation induced by thrombin.
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( Chul Kim ),( In Gu Kim ) 국제지역학회 2005 국제지역연구 Vol.9 No.2
본 연구는 IT기업군의 합병 전·후의 재무비율 변화추이를 측정하여 IT기업의 M & A를 통한 시너지효과가 유의적으로 존재하는지를 분석하는 것이다. 기업의 안정성·수익성·성장성·활동성 측면에서 M & A를 통한 합병의 시너지 효과가 미미한 수준이거나 부정적인 영향을 미치는 것으로 나타났는데 그 원인은 한국에서의 M & A가 많은 부분에서 정부 및 금융기관의 기업구조조정 및 시장점유율 확대와 외형성장 수단으로 활용되고 있기 때문이라 생각된다. 이는 2000년 후반부터 전세계적인 IT산업의 불황 및 투자위축으로 인한 국내 IT산업의 수요감소와 코스닥시장의 침체로서 설명될 수 있다. IT기업의 경영성과측면에서 M & A가 유의한 시너지효과를 창출하기 위해서는 지금까지의 기업구조조정목적이 아닌 기업의 전반적 생산성 제고와 R & D 개발 등의 경쟁력 강화방안으로서 활용되어야 한다. 예를 들어 선진국 자본시장에서 M & A가 활성화되고 있는 것도 M & A 중개기관을 통해 합병기업과 피합병기업 쌍방의 기업가치를 높여 M & A 관련기업들간에 경영성과 측면에서 시너지효과가 발생할 수 있도록 시장자체 뿐만 아니라 제도적 장치가 마련되어 있기 때문이다. 또한 M & A를 통한 시너지효과 추구에만 전념할 경우에 예상 이외의 막대한 기회 비용을 초래하게 되는 경우가 발생하더라도 M & A 이후에 이러한 기회비용을 충분히 상쇄할 수 있으리라는 기대가 오히려 시너지 효과를 악화시키는 결과를 낳을 수 있다. 따라서 단계적으로 시너지효과를 창출할 수 있도록 IT산업의 활성화와 생산성 제고와 경영성과 개선측면에서의 M & A의 유용성과 성패요인에 중점을 두어야 할 것이다. The purpose of this study is to analyze the influence of Information technology companies in stability, profits, growth and activity before and after the M & A (Merger & Acquisition). Accordingly with this analysis, this study vertified the effective influence of M & A in creation of values. Information technology companies stability was achieved by comparing stockholders` equity to total assets, current ratio and debt ratio. Profits were achieved by comparing ordinary income to total assets, net income to total assets, ordinary income to sales and net income to sales. Growth was achieved by comparing gross rate of total asset, growth rate of sale. Activity was achieved by comparing total assets turnover, stockholders` equity turnover. To measure the performance of M & A, sample company list and financial data was obtained from Nov. 1999 to Nov. 2001 by KOREA STOCK EXCHANGE and KOSDAQ. Responding to analysis above, 11 hypothesis were formulated and vertificated. 1. In relation to stability, there were no significant changes in stockholders` equity to total assets, current ratio and debt ratio after M & A. Generally, stability ratio increase after M & A, but in this study there were no significant changes. 2. In relation to profits, there were decrease in ordinary income to total assets, net income to total assets, ordinary income to sales and net income to sales. In the maximum profit aspect, one of the most useful methods to increase profit is M&A. But in the matter of Information technology companies, there is negative influence about creation of value. 3. In relation to growth, although expected asset increase, there was decrease in Gross rate of total asset but there was no significant changes in growth rate of sale. 4. In relation to activity, there were no significant changes in total assets turn-over, stockholders` equity turnover.
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