Personality Characteristics and Prevalence of Personality Disorders in Subjects with Bulimia Nervosa: Korean College Women in the United States of America

Lyoo, in Kyoon Seoul National University 1995 The seoul journal of medicine Vol.36 No.3

Family Environment in Depressed Patients with Borderline Personality Disorder : Differences in Perception between patients and Parents

Lyoo,In Kyoon 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5

연구목적 : 본 연구는 성인 境界線 人格障碍환자와, 환자와 心理的, 經濟的으로 밀접한 관계를 가지고 있는 부모와의 家族環境에 대한 認識의 차이를 알기 위함이다. 연구방법 : Structural Clinical Interview for DSM-Ⅲ-R과 Revised Diagnostic Interview for Personality Disorders를 사용하여 연구대상 집단으로 경계전 인격장애를 가진 주요 우울증 환자(N=24)와 이 집단의 정신과적 비교집단으로 경계선 인격장애를 가지지 않는 주요우울증 환자(N=21)를 선택하였다. 각 집단의 환자와 그 부모에게 Family Environment Scale을 시행한 후, 같은 집단 내에서 환자와 부모사이의 차이 그리고 부모간의 차이를 분석하였고, 두 집단의 구성원 사이의 가족환경에 대한 평가의 차이를 분석하였다. 연구결과 : 경계선 인격장애 환자집단은 결합력(Cohesion), 갈등(Conflict), 독립성(Independence)의 소척도에서 그들의 부모보다 부정적으로 가족환경을 인식했다. 환자의 父 와 母는 가족환경 인식에서 통계적으로 유의한 차이를 보이지 않았다. 경계선 인격장애를 가지지 않는 대조군에서는 환자와 그 부모사이 혹은 부모 서로 간에 Family Environment Scale의 어느 소척도에서도 통계적으로 유의한 차이가 없었다. 결 론 : 본 연구는 경계선 인격장애 환자와 그 부모사이의 가족환경에 대한 인식의 차이점을 구체적으로 파악하였다. 臨床的 측면에서는 이 차이점에 대한 치료적 접근의 필요성을 제기하였으며, 硏究적 측면에서는 지금까지 경계선 인격장애 환자의 시각과 회상에 주로 의존하여 환자의 가족환경, 가족관계 및 부모의 성격특성을 기술하고 정의하여 온 것에 대해서 재고가 필요함을 제시하였다.

Lithium-Induced Gray Matter Volume Increase As a Neural Correlate of Treatment Response in Bipolar Disorder: A Longitudinal Brain Imaging Study

Lyoo, In Kyoon,Dager, Stephen R,Kim, Jieun E,Yoon, Sujung J,Friedman, Seth D,Dunner, David L,Renshaw, Perry F American College of Neuropsychopharmacology 2010 Neuropsychopharmacology Vol.35 No.8

Preclinical studies suggest that lithium may exert neurotrophic effects that counteract pathological processes in the brain of patients with bipolar disorder (BD). To describe and compare the course and magnitude of gray matter volume changes in patients with BD who are treated with lithium or valproic acid (VPA) compared to healthy comparison subjects, and to assess clinical relationships to gray matter volume changes induced by lithium in patients with BD, we conducted longitudinal brain imaging and clinical evaluations of treatment response in 22 mood-stabilizing and antipsychotic medications-naive patients with BD who were randomly assigned to either lithium or VPA treatment after baseline assessment. Fourteen healthy comparison subjects did not take any psychotropic medications during follow-up. Longitudinal data analyses of 93 serial magnetic resonance images revealed lithium-induced increases in gray matter volume, which peaked at week 10–12 and were maintained through 16 weeks of treatment. This increase was associated with positive clinical response. In contrast, VPA-treated patients with BD or healthy comparison subjects did not show gray matter volume changes over time. Results suggest that lithium induces sustained increases in cerebral gray matter volume in patients with BD and that these changes are related to the therapeutic efficacy of lithium.

Family Environment in Borderline Personality Perception between Depressed Patients with Disorder: Differences in Patients and Parents

In Kyoon Lyoo 대한신경정신의학회 1995 신경정신의학 Vol.34 No.5

정신자극제 사용자에서의 최신 뇌영상 연구

류인균(In-Kyoon Lyoo),심민영(Min-Young Sim),이지영(Jee-Young Rhee) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.2

Methamphetamine (MA) and cocaine are representative psychostimulants which have a common characteristic of direct amplification of dopamine concentration at the mesolimbic dopaminergic receptor. Since mesolimbic pathway, including the amygdale and the nucleus a ccumbens, is known to be related to reward and craving, deficits of the mesolimbic pathway have been implicated in drug addiction. Recently, functional brain imaging studies using PET, SPECT, and MRS and structural brain imaging studies including VBM/optimized VBM and DTI has been conducted in MA and cocaine abusers. It has been consistently suggested that there were functional and structural deficits of the mesocortical pathway including orbitofrontal cortex and anterior cingulate cortex in MA and cocaine abusers. These deficits may be partially recovered through long term abstinence. Consequently, functional and structural abnormalities in the mesocortical pathway as well as the mesolimbic pathway may be the underlying mechanism of psychostimulant addiction. Since the mesocortical pathway is implicated in craving, compulsive drug administration, and inhibition dyscontrol, we should be aware that these behavioral and neuropsychological characteristics could be based on organic brain deficits. We could also make full use of this understanding for treatment and rehabilitation to prevent frequent relapse of drug administration.

만성적 허무함과 불안정한 대인관계를 보이는 21세 여자

柳仁鈞 대한의사협회 1999 대한의사협회지 Vol.42 No.9

韓國古典小說 '沈淸傳'의 精神力動的 硏究

趙斗英,柳仁均 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.2

We have examined the classic novel, Sim Chong Chon whose main theme is filial piety, upon the assumption that the collective unconscious finds its way into the folktale and thus we can gain some insight into the collective unconscious of Korean people through studies of folktales such as Sim Chong Chon. While much research hitherto has explained the extremity of her filial piety as a product of her natural goodness, this study focused on the family dynamic to determine what make her filial piety so extreme. Sim Chong's father has implicitly demonstrated hostility toward Sim Chong since his wife's death soon after Sim Chong's birth. Some part of her motive for filial piety stems from her guilty feelings towards her father because of her reactive hostility to his treatment of her. The fact that Sim Hak-Gyu, the object of filial piety, is described as selfish and exploitative may reflect the unconscious repulsion of Koreans against the Korean culture in which filial piety receives too much emphasis. Also, Sim Chong's Oedipus Complex is one of the two motives of her filial piety. By making Sim Chong recognize her dead. but potent mother as a model to follow and the rival to compete with, her Oedipus Complex becomes an important motive for masochistic filial piety with her counter aggression against her father's anger and hostility toward her.

한국 성인 기억력 평가를 위한 전산화 도구의 개발과 표준화

권준수,류인균,홍경수,연병길,하규섭 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.2

연구목적 : 본 연구는 전산화 평가도구를 개발하고, 신뢰도와 타당도를 검증하며, 표준화 자료를 얻기 위하여 수행되었다. 방 법 : 숫자 따라하기검사, 시각 단기기억력검사, 한글언어청각학습검사, 시각도형학습검사를 전산화하였으며, 27명의 정상인을 대상으로 하여 검사-재검사 신뢰도를 검증하였다. 타당도를 검증하기 위하여 48명의 정상인을 대상으로 검사 성적을 기존의 인지기능 검사 성적과 비교하였으며, 또한 본 연구에서 개발된 검사들의 내적 일치도를 평가하였다. 20세부터 50세까지 고졸이상의 학력을 가진 한국 남녀 성인 150명을 대상으로 표준화 자료를 얻었다. 결 과 : 전산화 기억력 검사들의 검사-재검사 성적은 paired t-test 결과 차이가 없었으며, Pearson 상관계수 0.405∼0.873의 높은 상관관계를 보였다. 숫자 따라하기검사, 시각 단기기억력검사, 언어청각학습검사는 기존의 지필 혹은 전산화 검사 결과와 높은 상관관계를 보였다. 시각도형학습검사는 유용한 검사이나, 향후 방법론적 개선이 필요한 것으로 생각된다. 전산화 기억력 검사 성적은 학력이 높을수록 우수하였으며, 성별과 연령도 결과에 영향을 미쳤다. 전산화 기억력 검사의 표준화 자료와 해석기준을 제시하였다. 결 론 : 20세부터 50세까지 고졸 이상의 학력을 가진 한국 성인 남녀에서 신뢰성 있고 타당성 있게 사용할 수 있는 전산화 언어 및 시각 기억력 검사도구가 개발되었으며, 표준화 자료와 해석기준이 마련되었다. Objectives : This study was conducted to develop the computerized memory tests for Korea adults. It also aimed at evaluating the reliability and validity of these tests and providing their normative data. Methods : Computerized versions of digit span, visual span, auditory applications and correction. The test-retest reliabilities of each test was evaluated by the paired t-test and Pearson's correlation coefficient using the data from 27 normal persons. The validity of each test was evaluated by the Pearsons's correlation coefficient between the computerized test scores and the pre-existing cognitive function tests using the data from 48 normal persons. The normative data were obtained from the 150 Korean adults, age 20 to 50, whose educational levels were higher than high school graduate Results : There were no statistical difference between the means of the test and retest scores. High correlations were also observed between the tests and the retest scores(r ranged from 0.405 to 0.873). The computerized digit span, visual span, and auditory verval learning tests scores were highly correlated with the pre-existing memory measures. The computerized memory test scores were greatly influenced by the educational level. The visual learning test seems useful, however, it requires methodological refinement. The normative data and guidelines for interpretation were provided. Conclusions : Clinically applicable computerized memory assessment tools with high reliability and validity were developed. The normative data for the Korean adults aged 20 to 50 were obtained and the guidelines for the interpretation were provided.

Decreased frontal white-matter integrity in abstinent methamphetamine abusers

Chung, Ain,Lyoo, In Kyoon,Kim, Seog Ju,Hwang, Jaeuk,Bae, Soojeong C.,Sung, Young Hoon,Sim, Minyoung E.,Song, In Chan,Kim, Jihyun,Chang, Kee Hyun,Renshaw, Perry F. CAMBRIDGE UNIVERSITY PRESS 2007 INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol.10 No.6

Effects of the Family Environment and the Biogenetic Temperament/Character on the Emotional and Behavioral Aspects of the Filial Piety

Cho, Doo-Young,Lyoo, In Kyoon,Hong, Kang-E 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 본 연구의 목적은 成長期의 家族環境과 先天的인 氣質 및 性格特性이 行動的 孝認識과 情緖的 孝認識의 形成에 미치는 特定한 選擇的 影響을 分析하는 것이다. 연구방법 : 多段階 群集分析方法으로 선정된 서울지역 男女大學生 132명을 대상으로 Structured Clinical Interview for DSM-Ⅲ-R과 Personality Disorder Questionnaire-Revised를 사용하여 共存 Axis I 및 Axis Ⅱ 精神科 障碍 有無를 검사하였다. 共存 精神科 障碍 및 기타 배재요건을 가진 34명을 제외한 서울 지역 대학생(男子 49명, 女子 49명)과 그 父母가 硏究對家群이 되었다. 이들을 대상으로 孝尺度를 사용하여 孝認識의 다양한 側面을 측정하였고, 家族環境尺度를 사용하여 成長期의 家族環境을 측정하였으며, 氣質 및 性格檢査道具를 사용하여 先天的인 氣質 및 性格的 傾向을 측정하였다 연구결과 : 1)孝尺度上의 평가에서 大學生 硏究對家群은 父母群과 비교하여, 家族調和, 義務/責任感, 犧牲, 補償, 이웃간의 調和 및 家門繼承의 孝側面을 덜 중요하게 認識하고 있었다. 家族環境의 多樣한 側面에서는 硏究家群과 父母群 사이에 有意한 統計的 차이가 있었다. 2)成長期 家族環境이 孝認識에 미치는 影響에 관한 연구결과를 요약하면, 成就指向的이고 道德性-倫理性을 강조하는 小兒-靑少年期 家族環境은 行動的 측면의 孝 認識과 有意한 相關關係가 있었으며, 家族간의 凝集性 및 表現性이 높은 家族環境은 情緖的 측면의 孝의 認識과 有意한 相關關係가 있었다. 3) 先天的 性格을 代辯하는 生物遺傳的 氣質 및 性格이 孝認識에 미치는 影響에 관한 연구결과를 요약하면, 낮은 自己中心性은 行動的 孝認識과 유의한 相關關係가 있었으며, 높은 協助性은 情緖的 측면의 孝認識과 有意한 相關關係가 있었다. 결 론 : 本 硏究는 成長期 家族環境과 生物遺傳的 氣質 및 性格이 孝認識 樣相, 즉 行動的 및 情緖的 孝認識의 形成에 미치는 特定한 影響을 報告한다. Objective : This study aimed to tap the influence of the childhood and adolescent family environment and biogenetic temperament/character on the filial piety profile, i,e., its behavioral and emotional aspects in Korean college students. Methods : Ninety-eight college students(male=49, female=49, the main study group) in the Seoul Metropolitan area were selected using multi-stage(randomized) cluster procedures. Their parents(N=174) became the 'generation' comparison group, The Filial piety Scale was used to evaluate the perception of filial piety, both in 13 individual items and in two factor-analytically-produced behavioral and emotional aspects of filial piety. The Family Environment Scale was used to evaluate the childhood and adolescent family environment. The Temperament and Character Inventory was used to assess biogenetic temperament and character of the study subjects. Results : Parents of college students scored significantly higher on filial piety items of familial harmony, responsibility/obligation, sacrifice, compensation, neighborhood. harmony, and family continuity than their offspring did. There were no significant differences between study subjects and their parents in perceiving their family environment. Childhood environment with high moralethical emphasis and high achievement orientation was significantly correlated with the behavioral aspect of filial piety whereas cohesive and expressive family environment was shown to be linked to the emotional aspect of filial piety. Regarding the biogenetic temperament/character-filial piety relationship, low self-directedness was positively correlated with behavioral aspect of filial piety while high cooperativeness was positively correlated with emotional aspect of filial piety. Conclusions : This study reports distinct patterns of relationship between childhood family environment and the filial piety profile and between biogenetic temperament/character and the filial piety profile in Korean college students.