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KIM, Jae Kyeom,BAE, Heyri,KIM, Mi-Jeong,CHOI, Soo Jung,CHO, Hong Yon,HWANG, Han-Joon,KIM, Young Jun,LIM, Seung Taik,KIM, Eun Ki,KIM, Hye Kyung,KIM, Bok Yong,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2009 Bioscience, biotechnology, and biochemistry Vol.73 No.5
<P>Various native Korean plants were screened to find an effective acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer’s disease (AD). Among these plants, the ethanol extract of <I>Poncirus trifoliate</I> was selected for isolating the AChE inhibitor because it exhibited the highest inhibitory activity (47.31%). To separate the active compound from <I>Poncirus trifoliate</I>, solvent partition, open column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were utilized. The putative chemical structure of the AChE inhibitor was identified as <I>methoxsalen</I> by successive analysis with electron ionization mass spectrometry (EI-MS) and <SUP>13</SUP>C/<SUP>1</SUP>H-nuclear magnetic resonance (NMR). To confirm the attenuating effect of the <I>Poncirus trifoliate</I> extract against trimethyltin (TMT)-induced neurotoxicity, <I>in vivo</I> behavior tests were carried out. Our findings suggest that the <I>Poncirus trifoliate</I> extract significantly reversed TMT-induced learning and memory impairment. These results demonstrate that the <I>Poncirus trifoliate</I> extract could possess a wide range of beneficial activities for neurodegenerative disorders, notably AD.</P>
KIM, Jae Kyeom,CHOI, Soo Jung,BAE, Hyeri,KIM, Cho Rong,CHO, Hong-Yon,KIM, Young Jun,LIM, Seung Taik,KIM, Chang-Ju,KIM, Hye Kyung,PETERSON, Sabrina,SHIN, Dong Hoon Japan Society for Bioscience, Biotechnology, and A 2011 Bioscience, Biotechnology, and Biochemistry Vol.75 No.10
<P>Previously, we identified methoxsalen (8-methoxy-2′,3′,6,7-furocoumarin) as the bioactive compound probably responsible for acetylcholinesterase (AchE) inhibition achieved by feeding crude extract of <I>Poncirus trifoliate.</I> To confirm the activity of methoxsalen, Institute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing effects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. Methoxsalen effectively reversed TMT-induced memory impairment on both Y-maze and passive avoidance tests. Brain AchE activity was inhibited by the oral consumption of all concentrations of methoxsalen. Moreover, the level of oxidative stress was significantly ameliorated in the groups on methodsalen containing diets. This is the first <I>in vivo</I> study conducted with methoxsalen in the field of AD research, and it indicates that further investigation of methoxsalen is warranted.</P>
Kim, Yee Hyung,Yoo, Kwang Ha,Yoo, Jee-Hong,Kim, Tae-Eun,Kim, Deog Kyeom,Park, Yong Bum,Rhee, Chin Kook,Kim, Tae-Hyung,Kim, Young Sam,Yoon, Hyoung Kyu,Um, Soo-Jung,Park, I-Nae,Ryu, Yon Ju,Jung, Jae-Woo The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.2
Background: The purpose of this study was to assess the effect of our new video-assisted asthma education program on patients' knowledge regarding asthma and asthma control. Methods: Adult asthmatics who were diagnosed by primary care physicians and followed for at least 1 year were educated via smart devices and pamphlets. The education sessions were carried out three times at 2-week intervals. Each education period lasted at most 5 minutes. The effectiveness was then evaluated using questionnaires and an asthma control test (ACT). Results: The study enrolled 144 patients (mean age, $56.7{\pm}16.7years$). Half of the patients had not been taught how to use their inhalers. After participating in the education program, the participants' understanding of asthma improved significantly across all six items of a questionnaire assessing their general knowledge of asthma. The proportion of patients who made errors while manipulating their inhalers was reduced to less than 10%. The ACT score increased from $16.6{\pm}4.6$ to $20.0{\pm}3.9$ (p<0.001). The number of asthmatics whose ACT score was at least 20 increased from 45 (33.3%) to 93 (65.3%) (p<0.001). The magnitude of improvement in the ACT score did not differ between patients who received an education session at least three times within 1 year and those who had not. The majority of patients agreed to the need for an education program (95.8%) and showed a willingness to pay an additional cost for the education (81.9%). Conclusion: This study indicated that our newly developed education program would become an effective component of asthma management in primary care clinics.
KIM, Jae Kyeom,CHOI, Soo Jung,CHO, Hong Yon,HWANG, Han-Joon,KIM, Young Jun,LIM, Seung Taik,KIM, Chang-Ju,KIM, Hye Kyung,PETERSON, Sabrina,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2010 Bioscience, biotechnology, and biochemistry Vol.74 No.2
<P>To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using <I>in vitro</I> assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)-induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer’s disease.</P>
Kim, Jae Kyeom,Shin, Eui-Cheol,Lim, Ho-Jeong,Choi, Soo Jung,Kim, Cho Rong,Suh, Soo Hwan,Kim, Chang-Ju,Park, Gwi Gun,Park, Cheung-Seog,Kim, Hye Kyung,Choi, Jong Hun,Song, Sang-Wook,Shin, Dong-Hoon Hindawi Publishing Corporation 2015 Journal of analytical methods in chemistry Vol.2015 No.-
<P>Few studies have investigated <I>Seomae</I> mugwort (a Korean native mugwort variety of <I>Artemisia argyi</I> H. Lév. & Vaniot), exclusively cultivated in the southern Korean peninsula, and the possibility of its use as a food resource. In the present study, we compared the nutritional and chemical properties as well as sensory attributes of <I>Seomae</I> mugwort and the commonly consumed species <I>Artemisia princeps</I> Pamp. In comparison with <I>A. princeps, Seomae</I> mugwort had higher contents of polyunsaturated fatty acids, total phenolic compounds, vitamin C, and essential amino acids. In addition, <I>Seomae</I> mugwort had better radical scavenging activity and more diverse volatile compounds than <I>A. princeps</I> as well as favorable sensory attributes when consumed as tea. Given that scant information is available regarding the <I>Seomae</I> mugwort and its biological, chemical, and sensory characteristics, the results herein may provide important characterization data for further industrial and research applications of this mugwort variety.</P>
Nonvolatile Memory Characteristics of Double-Stacked Si Nanocluster Floating Gate Transistor
Kim, Eun-Kyeom,Kim, Kyong-Min,Son, Dae-Ho,Kim, Jeong-Ho,Lee, Kyung-Su,Won, Sung-Hwan,Sok, Jung-Hyun,Hong, Wan-Shick,Park, Kyoung-Wan The Institute of Electronics and Information Engin 2008 Journal of semiconductor technology and science Vol.8 No.1
We have studied nonvolatile memory properties of MOSFETs with double-stacked Si nanoclusters in the oxide-gate stacks. We formed Si nanoclusters of a uniform size distribution on a 5 nm-thick tunneling oxide layer, followed by a 10 nm-thick intermediate oxide and a second layer of Si nanoclusters by using LPCVD system. We then investigated the memory characteristics of the MOSFET and observed that the charge retention time of a double-stacked Si nanocluster MOSFET was longer than that of a single-layer device. We also found that the double-stacked Si nanocluster MOSFET is suitable for use as a dual-bit memory.
Kim, Cho Rong,Kim, Jae Kyeom,Shin, Eui-Cheol,Choi, Soo Jung,Kwon, Yoon Kyung,Kim, Youn-Jung,Kim, Chang-Ju,Park, Gwi Gun,Park, Cheung-Seog,Shin, Dong-Hoon 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6
Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.