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Baek, In-Jeoung,Jung, Ki Youn,Yon, Jung-Min,Lee, Se-Ra,Lee, Beom Jun,Yun, Young Won,Nam, Sang-Yoon Springer 2011 In vitro cellular & developmental biology. Animal Vol.47 No.8
<P>Although it has been suggested that the transcription of phospholipid hydroperoxide glutathione peroxidase (PHGPx), an essential antioxidant selenoenzyme, may be affected by the estrogen state in mammals, the direct mechanism underlying the regulation of the PHGPx gene by estrogens in mammalian tissues remains to be clearly elucidated. In this study, we evaluated the expression of the PHGPx mRNA in cultured mouse fetuses (embryonic days 8.5-10.5) exposed to 17관-estradiol (E(2); 0.1, 1, 10, 100, and 1,000 ng/ml); estrogen receptor (ER) agonists [propyl pyrazole triol (PPT, an ER관-selective ligand, 1 관l/ml) and diarylpropionitrile (DPN, an ER관-selective ligand, 1 관l/ml)]; and/or ER antagonist [ICI 182,780 (ICI, 1 관l/ml)] using a whole embryo culture system. E(2)-alone treatment significantly stimulated the expressions of both ER관 and ER관 mRNAs in all the cultured fetuses (p < 0.05), although the ER관 mRNA levels were higher than ER관 mRNA. PHGPx mRNA expression was significantly increased in all the fetuses treated with E(2) (1-1,000 ng/ml), PPT, and DPN (p < 0.05). Furthermore, pretreatment with ICI completely blocked the E(2)-induced PHGPx mRNA expression in the fetuses. In addition, the mRNA levels of cytosolic GPx, the other intracellular antioxidant selenoenzyme, did not differ significantly from the controls by an exposure to those agents. These results suggest that the PHGPx gene is regulated via an estrogen and ER signal pathway in the cultured mouse fetus.</P>
움직임 학습 연구 동향에 대한 고찰 -동작의 과제 학습과 수행력 향상을 중심으로
백정희(Jeoung Hee Baek) 한국무용과학회 2010 한국무용과학회지 Vol.20 No.-
본 논문은 움직임 학습 연구 동향을 동작의 과제 학습과 수행력 향상의 측면에서 분석하고 향후 연구방향을 제시하는 데에 그 목적이 있다. 관련 학술논문을 선정하여 내용분석을 실시한 결과, 연구 내용에 있어 움직임 제어 연구(145편, 61.2 %)가 움직임 학습 연구 (92편, 38.8%)에 비해 주를 이루었다. 세부적인 내용은 움직임 협응(40편, 16.9%), 움직임 학습의 지도와 보강 피드백에 관한 연구가 주를 이루었다. 연구 방법에 있어서는 준 실험 연구(140편, 59.1%)가 가장 많았으며, 연구에 사용된 실험도구로는 반응시간 측정(41편, 18.4 %), 동작 분석기(21편, 9.4%)가 널리 이용되었다. 움직임 학습 연구 동향에 대한 고찰을 통해서 향후 움직임 및 무용 학습 연구의 질적 향상을 위해 연구방법, 연구 주제 및 내용의 다양성이 필요할 것이다. 연구 방법에 있어 인간-움직임 학습 연구를 위한 뇌 활동 연구 방법 등이 고려되어야 하겠으며, 연구 주제에 있어서도 인간 움직임의 근원을 밝혀내는 보다 심도 깊은 접근이 응용 심리학, 의학, 로봇 공학과 같은 인간 움직임 연구 인접 학문과의 학제 간 연구를 통해 마련되어야 할 것이다. This paper studies trends in the movement of the action learning project in terms of learning and improving performs analyze and present the future direction of research on it has its purpose. Selected scientific papers related to the analysis conducted for the results, research in motion control study (145 flights, 61.2%), the study moves research (92 ed, 38.8%) was achieved compared to the Lord. Details of the movement coordination (40 ed, 16.9%), the movement of the Study of feedback and reinforcement on the study notes has been made. Given experimental studies it comes to research studies (140 flights, 59.1%) were the best. Research tools are used in the experiment, the reaction time measurements (41 flights, 18.4%), behavior analyzer (21 flights, 9.4%) have been widely used. Reflections on research on learning trends move through movement and dance training future research to improve the quality of research methods, research topics and the diversity of information is required. How to study in humans-the movement to study brain activity for learning and research will be considered, Also research on the subject are even able to find the source of human movement is an approach more in-depth psychology, medicine, robotics engineering research, such as the adjacent study human movement through interdisciplinary research.
In-Jeoung Baek,Jung-Min Yon,Se-Ra Lee,Wook-Jun Yoo,Sang-Soep Nahm,Yun-Bae Kim,Jai Seup Ro,Bang Yeon Hwang,Soon Sun Kim,Dae Hyun Cho,Beom-Jun Lee,Young Won Yun,Sang-Yoon Nam 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
Banha (Pinellia ternata) is a herbal medicine which is composed of alkaloid substances, homegentisic acid, 3,4-dihydroxybenzaldehyde and 3,4-diglycosilic benzaldehyde and is mainly prescribed in cough with dyspnea, gastric retention, distention and pain of the thorax and abdomen, lymph node tuberculosis, carbuncle, and furuncle. The use of raw Banha has been prohibited in pregnant woman because of it's strong toxicity. In this study, to investigate whether Banha affects the antioxidant system of male reproductive organs, we analyzed the mRNA expression patterns of glutathione peroxidase (GPx) family (type 1-4) in the reproductive organs of rats exposed to Banha. Banha extracts (0.05, 0.1, 0.2, 0.5, 1, and 2 g/㎏ body weight) were treated to 6 week-old rats for 4 weeks per oral. Total RNAs were extracted from testis, epididymis, prostate, and seminal vesicle and then RT-PCR was perfomed with the specific primers of each GPx enzyme. In epididymis and prostate, GPx1 mRNA were decreased by Banha treatment except for 2 g/㎏ treatment in prostate. However, GPx1 mRNA in seminal vesicle was increased by Banha treatment. GPx2 mRNA was increased in testis and seminal vesicle. GPx4 (PHGPx) mRNA was decreased in seminal vesicles by 0.1 and 1 g/㎏ treatment of Banha. These findings indicate that Banha may affect the antioxidant system of male reproductive organs, although further study is necessary.