http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A Human Infection with Thelazia sp. in Korea
Im,Kyung-Il,Kim,Sang-June,Min,Duk-Young,Kim,Seong-Deuk,Lew,Ho-Min INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1974 YONSEI REPORTS ON TROPICAL MEDICINE Vol.5 No.1
Human thelaziasis have been reported from various country involving with two different species; Thelazia callipaeda and T. californiensis. Iensis. The first case of human infection of oriental eye worm, Thelasia callipaeda in Korea was described by Nakata(1934), and followed by Suzuki(1935), Silman(1953), and Chu and Cho (1973). The present report deals with the 5th case of thelaziasis in Korea as far as the literature is concerned.
Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients
Im, Jung Ho,Yoon, Hong In,Kim, Sunghoon,Nam, Eun Ji,Kim, Sang Wun,Yim, Ga Won,Keum, Ki Chang,Kim, Young Tae,Kim, Gwi Eon,Kim, Yong Bae BioMed Central 2015 Radiation oncology Vol.10 No.-
<P><B>Background</B></P><P>To investigate the role of radiotherapy (RT) in and to suggest radiotherapeutic strategies for patients presenting with disseminated cervical cancer.</P><P><B>Methods</B></P><P>We retrospectively analyzed 50 patients diagnosed as the disseminated cervical cancer with distant lymph nodal or visceral organ metastasis between September 1980 and August 2012. Patients were divided into two subgroups according to visceral organ metastasis: 35 patients diagnosed with distant lymph node metastasis only (group A) and 15 patients with visceral organ metastasis (group B). All patients received external beam RT to the pelvis (median dose 45 Gy) and high-dose rate intracavitary RT (median dose 30 Gy). Thirty-nine patients (78%) received chemotherapy.</P><P><B>Results</B></P><P>Median follow-up time was 74 months. The 5-year pelvic control rate (PCR) was 85.8%, and the progression-free survival (PFS), and overall survival (OS) rates were 28.7%, and 36.2%, respectively. The major treatment failure was systemic progression (32 patients, 64%). The 5-year PCRs in groups A and B were 87.4% and 74.7%, respectively (<I>p</I> > 0.05). Meanwhile, PFS and OS rates for group A were significantly better than those for group B (35.3% vs. 13.3%, <I>p</I> = 0.010; and 46.3% vs. 13.3%, <I>p</I> = 0.009, respectively).</P><P><B>Conclusion</B></P><P>Our data revealed considerable prognostic heterogeneity in disseminated cervical cancer. Even though a high PCR was achieved in patients treated with definitive RT, survival outcomes were dependent on progression of visceral organ metastasis. Therefore, personalized RT and chemotherapy treatment strategies according to the presence of visceral organ metastasis in disseminated cervical cancer patients may help improve clinical outcomes.</P>
Im, Ilkyun,Jang, Mi-jin,Park, Seung Ju,Lee, Sang-Hee,Choi, Jin-Ho,Yoo, Han-Wook,Kim, Seyun,Han, Yong-Mahn American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.49
<P>A defective mitochondrial respiratory chain complex (DMRC) causes various metabolic disorders in humans. However, the pathophysiology of DMRC in the liver remains unclear. To understand DMRC pathophysiology <I>in vitro</I>, DMRC-induced pluripotent stem cells were generated from dermal fibroblasts of a DMRC patient who had a homoplasmic mutation (m.3398T→C) in the mitochondrion-encoded NADH dehydrogenase 1 (<I>MTND1</I>) gene and that differentiated into hepatocytes (DMRC hepatocytes) <I>in vitro</I>. DMRC hepatocytes showed abnormalities in mitochondrial characteristics, the NAD<SUP>+</SUP>/NADH ratio, the glycogen storage level, the lactate turnover rate, and AMPK activity. Intriguingly, low glycogen storage and transcription of lactate turnover-related genes in DMRC hepatocytes were recovered by inhibition of AMPK activity. Thus, AMPK activation led to metabolic changes in terms of glycogen storage and lactate turnover in DMRC hepatocytes. These data demonstrate for the first time that energy depletion may lead to lactic acidosis in the DMRC patient by reduction of lactate uptake via AMPK in liver.</P>
Sung Kwon Kim,윤홍인,Wan-Soo Yoon,Jin Mo Cho,Jangsup Moon,Kyung Hwan Kim,김세훈,김영일,김영준,Ho Sung Kim,도윤식,박재성,Ji Eun Park,서영범,Kyoung-Su Sung,송진호,Chan Woo Wee,Se-Hoon Lee,임도훈,Jung Ho Im,장종희,한명훈,홍제범,Kihwan Hwan 대한뇌종양학회 2020 Brain Tumor Research and Treatment Vol.8 No.1
Background The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part II of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with diffuse midline glioma and meningioma. Methods A web-based survey was sent to all members of the KSNO by email. The survey included 4 questions of diffuse midline glioma and 6 questions of meningioma (including 2 case scenarios). All questions were developed by consensus of the Guideline Working Group. Results In the survey about diffuse midline glioma, 76% respondents performed histologic confirmation to identify H3K27M mutation on immunohistochemical staining or sequencing methods. For treatment of diffuse midline glioma, respondents preferred concurrent chemoradiotherapy with temozolomide (TMZ) and adjuvant TMZ (63.8%) than radiotherapy alone (34.0%). In the survey about meningioma, respondents prefer wait-and-see policy for the asymptomatic small meningioma without peritumoral edema. However, a greater number of respondents had chosen surgical resection as the first choice for all large size meningiomas without exception, and small size meningiomas with either peritumoral edema or eloquent location. There was no single opinion with major consensus on long-term follow-up plans for asymptomatic meningioma with observation policy. As many as 68.1% of respondents answered that they would not add any adjuvant therapies for World Health Organization grade II meningiomas if the tumor was totally resected including dura. Conclusion The survey demonstrates the prevailing clinical practice patterns for patients with diffuse midline glioma and meningioma among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of diffuse midline glioma and meningioma.
Im, Se Pyeong,Kim, Jaesung,Lee, Jung Seok,Kim, Si Won,Jung, Jae Wook,Lazarte, Jassy Mary S.,Kim, Jong Yong,Kim, Young Rim,Lee, Jeong Ho,Chong, Roger S. M.,Jung, Tae Sung American Association of Immunologists 2018 Journal of Immunology Vol. No.
<P>The variable lymphocyte receptor (VLR) B of jawless vertebrates functions as a secreted Ab of jawed vertebrates and has emerged as an alternative Ab with a single polypeptide chain. After observing an upregulated VLRB response in hagfish immunized with avian influenza virus (AIV) subtype H9N2, we screened AIV H9N2–specific VLRB using a mammalian expression system. To improve the binding avidity of the Ag-specific VLRB to the Ag, we enabled multimerization of the VLRB by conjugating it with C-terminal domain of human C4b-binding protein. To dramatically enhance the expression and secretion of the Ag-specific VLRB, we introduced a glycine–serine linker and the murine Ig κ leader sequence. The practical use of the Ag-specific VLRB was also demonstrated through various immunoassays, detected by anti-VLRB Ab (11G5). Finally, we found that the Ag-specific VLRB decreased the infectivity of AIV H9N2. Together, our findings suggest that the generated Ag-specific VLRB could be used for various immunoapplications.</P>