Glutamate 억제제가 Pilocarpine에 의한 경련 및 기억장애에 미치는 영향

천임순,한형수,박정숙,정헌주,이만기,김중영 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : Pilocarpine에 의한 경련 및 기억력 저하에 glutamate 수용체가 관련이 있는지 검토하였다. 대상 및 방법 : 생쥐에 pilocarpine을 투여하여 야기되는 경련 및 기억력저하가 glutamate 수용체 길항 약물인 MK-801 및 NBQX를 전처치하였을 때의 반응을 Morris Water Maze의 방법으로 관찰하였다. 결과 : MK-801과 NBQX를 전처치하고 pilocarpine을 투여하였는 바 pilocarpine에 의한 경련유발은 억제되지 않았으나, pilocarpine에 의한 reference memory와 working memory의 저하는 MK-801이나 NBQX를 처치로서 억제되었다. 결론 : Pilocarpine에 의한 경련작용에 비하여 기억력저허가 glutamte 수용체와 관련이 있는 것으로 보인다. The role of glutamate receptors in the genesis of pilocarpine-induced seizure and seizure-related memory deficit was studied using MK-801 and NBQX. After pretreatment with MK-801 or NBQX, pilocarpine was administered intraperitoneally. Both drugs had no effect on the behavioral seizure activity and onset of seizure activity. Memory was tested with reference and working memory version of Morris water maze at 20th day after pilocarpine treatment. Reference and working memory deficit was produced by pilocarpine. These deficit were prevented by MK-801 or NBQX, which were given in once a day for 4 day at 7th to 10th days after pilocarpine treatment. These results show that although MK-801 and NBQX do not have anticonvulsant property they can prevent pilocarpine-induced memory deficit.

마이크로 컴퓨터를 이용한 과학교육 실험 학습방안에 관한 연구(1) : 정량적 연속변화법을 이용한 화학 양론의 학습

이대형,신순임 春川敎育大學 1990 論文集 Vol.30 No.-

갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

자연 교과 지도에 대한 초등 교사의 인식

김광명,신순임,강태완,이대형,장병기 춘천교육대학교 과학교육연구소 1995 과학교육연구 Vol.18 No.-

폐경기 여성에서 1년간 호르몬 대치 요법이 혈청 지질에 미치는 영향

이해혁,남계현,김승형,이임순,이권해,최승도 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Cardiovascular disease is one of the most common cause of death in postmenopausal women. After the onset of menopause, the risk of cardiovascular disease is increased. Several risk factors of cardiovascular disease are well known to us. Among the risk factors, the changes of lipid profiles are roles for cardiovascular disease. Estrogen appears to protect the development of cardiovascular disease, by several mechanism. Especially the protective effect is believed to be mediated by the changes of lipid profiles. Decreased high-density lipoprotein (HDL)-cholesterol and increased low density lipoprotein (LDL)-cholesterol are important factors for development of cardiovascular disease. The purpose of this study was to evaluate the effect of hormone replacement therapy on the lipid profiles to include total cholesterol (TC), high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol, and triglycerides. We measured lipid profiles in 31 postmenopausal women and gave each conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12) for 12months. The levels of serum TC, LDL-cholesterol, and triglycerides were decreased significantly (p<0.05) and HDL-cholesterol was increased significantly (p<0.05) after 12months of hormone replacement therapy. These data suggest that hormone replacement therapy appears to protect agianst the development of cardiovascular disease by the changes of lipid profiles.

제6차 교육과정에 따라 편찬된 초등학교 자연 교과서의 분석(Ⅱ)

김광명,장병기,이대형,신순임,강태완 춘천교육대학교 과학교육연구소 1997 과학교육연구 Vol.20 No.-

Zn₃P₂–Zn₃As₂ Solid Solution Nanowires

Im, Hyung Soon,Park, Kidong,Jang, Dong Myung,Jung, Chan Su,Park, Jeunghee,Yoo, Seung Jo,Kim, Jin-Gyu American Chemical Society 2015 NANO LETTERS Vol.15 No.2

<P>Semiconductor alloy nanowires (NWs) have recently attracted considerable attention for applications in optoelectronic nanodevices because of many notable properties, including band gap tunability. Zinc phosphide (Zn3P2) and zinc arsenide (Zn3As2) belong to a unique pseudocubic tetragonal system, but their solid solution has rarely been studied. Here In this study, we synthesized composition-tuned Zn-3(P1-xAsx)(2) NWs with different crystal structures by controlling the growth conditions during chemical vapor deposition. A first type of synthesized NWs were single-crystalline and grew uniformly along the [110] direction (in a cubic unit cell) over the entire compositional range (0 <= x <= 1) explored. The use of an indium source enabled the growth of a second type of NWs, with remarkable cubic-hexagonal polytypic twinned superlattice and bicrystalline structures. The growth direction of the Zn3P2 and Zn3As2 NWs was also switched to [111] and [112], respectively. These structural changes are attributable to the Zn-depleted indium catalytic nanoparticles which favor the growth of hexagonal phases. The formation of a solid solution at all compositions allowed the continuous tuning of the band gap (1.0-1.5 eV). Photocurrent measurements were performed on individual NWs by fabricating photodetector devices; the single-crystalline NWs with [110] growth direction exhibit a higher photoconversion efficiency compared to the twinned crystalline NWs with [111] or [112] growth direction.</P>

Band Gap Tuning of Twinned GaAsP Ternary Nanowires

Im, Hyung Soon,Jung, Chan Su,Park, Kidong,Jang, Dong Myung,Lim, Young Rok,Park, Jeunghee American Chemical Society 2014 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.118 No.8

<P>GaAs<SUB>1–<I>x</I></SUB>P<SUB><I>x</I></SUB> ternary alloy nanowires have drawn much interest because their tunable band gaps, which range from the near-infrared to visible region, are promising for advanced and integrated nanoscale optoelectronic devices. In this study, we synthesized compositionally tuned GaAs<SUB>1<I>–x</I></SUB>P<SUB><I>x</I></SUB> (0 ≤ <I>x</I> ≤ 1) alloy nanowires with two average diameters of 60 and 120 nm by vapor transport method. The nanowires exhibit exclusively twinned superlattice structures, consisting of zinc blende phase twinned octahedral slice segments between wurtzite phase planes. Smaller diameter and higher P content (<I>x</I>) result in shorter periodic superlattice structures. The band gap of the smaller diameter nanowires is larger than that of the larger diameter nanowires by about 90 meV, suggesting that the twinned superlattice structure increases the band gap. The increase in band gap is ascribed to the higher band gap of the wurtzite phase than that of the zinc blende phase.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-8/jp500458j/production/images/medium/jp-2014-00458j_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp500458j'>ACS Electronic Supporting Info</A></P>

Phase Evolution of Tin Nanocrystals in Lithium Ion Batteries

Im, Hyung Soon,Cho, Yong Jae,Lim, Young Rok,Jung, Chan Su,Jang, Dong Myung,Park, Jeunghee,Shojaei, Fazel,Kang, Hong Seok American Chemical Society 2013 ACS NANO Vol.7 No.12

<P>Sn-based nanostructures have emerged as promising alternative materials for commercial lithium–graphite anodes in lithium ion batteries (LIBs). However, there is limited information on their phase evolution during the discharge/charge cycles. In the present work, we comparatively investigated how the phases of Sn, tin sulfide (SnS), and tin oxide (SnO<SUB>2</SUB>) nanocrystals (NCs) changed during repeated lithiation/delithiation processes. All NCs were synthesized by a convenient gas-phase photolysis of tetramethyl tin. They showed excellent cycling performance with reversible capacities of 700 mAh/g for Sn, 880 mAh/g for SnS, and 540 mAh/g for SnO<SUB>2</SUB> after 70 cycles. Tetragonal-phase Sn (β-Sn) was produced upon lithiation of SnS and SnO<SUB>2</SUB> NCs. Remarkably, a cubic phase of diamond-type Sn (α-Sn) coexisting with β-Sn was produced by lithiation for all NCs. As the cycle number increased, α-Sn became the dominant phase. First-principles calculations of the Li intercalation energy of α-Sn (Sn<SUB>8</SUB>) and β-Sn (Sn<SUB>4</SUB>) indicate that Sn<SUB>4</SUB>Li<SUB><I>x</I></SUB> (<I>x</I> ≤ 3) is thermodynamically more stable than Sn<SUB>8</SUB>Li<SUB><I>x</I></SUB> (<I>x</I> ≤ 6) when both have the same composition. α-Sn maintains its crystalline form, while β-Sn becomes amorphous upon lithiation. Based on these results, we suggest that once α-Sn is produced, it can retain its crystallinity over the repeated cycles, contributing to the excellent cycling performance.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-12/nn404837d/production/images/medium/nn-2013-04837d_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn404837d'>ACS Electronic Supporting Info</A></P>

Germanium and Tin Selenide Nanocrystals for High-Capacity Lithium Ion Batteries: Comparative Phase Conversion of Germanium and Tin

Im, Hyung Soon,Lim, Young Rok,Cho, Yong Jae,Park, Jeunghee,Cha, Eun Hee,Kang, Hong Seok American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.38

<P>Germanium and tin sulfide nanostructures are considered the most promising candidates for useful alternative materials in commercial Li–graphite anodes of lithium ion batteries. Selenides have received less attention, but the electrochemical reaction mechanism is still being debated. We report the novel synthesis of GeSe<SUB><I>x</I></SUB> and SnSe<SUB><I>x</I></SUB> (<I>x</I> = 1 and 2) nanocrystals by a gas-phase laser photolysis reaction and their excellent reversible capacity for lithium ion batteries. The capacity was 400–800 (mA h)/g after 70 cycles, which is close to the theoretical capacity (Li<SUB>4.4</SUB>Ge or Li<SUB>4.4</SUB>Sn). Remarkably, SnSe<SUB><I>x</I></SUB> exhibited higher rate capabilities than GeSe<SUB><I>x</I></SUB>. Ex situ X-ray diffraction and Raman spectroscopy revealed the <I>cubic</I>–<I>tetragonal</I> phase conversion of Ge and Sn upon lithiation/delithiation to support their distinctive lithium ion battery capacities. First-principles calculations of the Li intercalation volume change indicate that the smallest volume expansion in the cubic Sn phase can guarantee the enhanced cycling capability of the Sn compounds.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-38/jp507337c/production/images/medium/jp-2014-07337c_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp507337c'>ACS Electronic Supporting Info</A></P>