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강익호,김정욱,신휘범,이정훈,고상호 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-
In this paper, the dynamics of actuators for generating the input of plants is considered in a design of the variable structure systems. While the input for plants is usually implemented by means of a certain actuator, the actuator dynamics is not incorporated in most of the VSS researches until now. The control algorithm of a VSS incorporating actuator dynamics is presented. and the simulation is given the usefulness of the algorithms.
( Ik Soo Kim ),( Hyeong Min Kim ),( Jie Un Ro ),( Kang Hee Jo ),( San Deep Karki ),( Prakash Khadka ),( Gyi Ae Yun ),( Jae Hwi Lee ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.3
β-Lapachone has drawn increasing attention as an anti-inflammatory and anti-cancer drug. However, its oral bioavailability has not been yet assessed, which might be useful to develop efficient dosage forms possibly required for non-clinical and clinical studies and future market. The aim of the present study was thus to investigate pharmacokinetic properties of β-lapachone as well as its first-pass metabolism in the liver, and small and large intestines after oral administration to measure the absolute bioavailability in rats. A sensitive HPLC method was developed to evaluate levels of β-lapachone in plasma and organ homogenates. The drug degradation profiles were examined in plasma to assess the stability of the drug and in liver and intestinal homogenates to evaluate first-pass metabolism. Pharmacokinetic profiles were obtained after oral and intravenous administration of β-lapachone at doses of 40 mg/kg and 1.5 mg/kg, respectively. The measured oral bioavailability of β-lapachone was 15.5%. The considerable degradation of β-lapachone was seen in the organ homogenates but the drug was quite stable in plasma. In conclusion, we suggest that the fairly low oral bioavailability of β-lapachone may be resulted from the first-pass metabolic degradation of β-lapachone in the liver, small and large intestinal tracts and its low aqueous solubility.
Growth Characters and Sugar Content During Grain Filling in New Hybrid, Chalok 1/Cooktail 51 Corn
Kim Ik Hwi,Soon Kwon Kim,Sang Chul Lee 韓國作物學會 2001 Korean journal of crop science Vol.46 No.2
Chalok 1/Cooktail 51' corns, supersweet corn gene controlled by either brittle-l (bt l) or shrunken-2(sh2) gene introduced into waxy corn, showed agronomic characteristics between supersweet corn and waxy corn. The ears were harvested at different development stages from 15 to 35 days after silking (DAS). Ear diameter of Cocktail 51 and 'Cocktail 51'/Chalok 1 increased from 15 DAS to 30 DAS and little increased thereafter, but that of Chalok 1/Cocktail 51 and 'Chalok l' increased until 35 DAS. Diameter of ear extension increased more in Cocktail 51 and Chalok 1/Cocktail 51 corn than Chalok 1. Ear fresh weight of Cocktail 51 decreased later 30 DAS but those of the other hybrids were vice versa. Rate of super-sweet kernels per ear of Chalok 1/Cocktail 51 corns was about 38 %. Development, and elongation of kernel were much more prominent in supersweet kernel than in waxy kernel, but fresh weight increased higher in waxy kernel than supersweet kernel. Moisture content in kernel decreased from 15 DAS to 35 DAS. Total sugar content of the kernel increased until 25 DAS, and that of Cocktail 51 kernel showed the highest among of them. After cooked by steam, flavor and mastication feeling rate cooked by steam of Cocktail 51 and Chalok 1/Cocktail 51 were increased from 15 DAS to 25 DAS and markedly decreased thereafter. But those of Chalok l/Cocktail 51 and, Chalok 1 were decreased after 30 DAS. These results suggested that the optimum harvest date for fresh supersweet corn (Cocktail 51), Cocktail 51/Chalok 1 seems to be about 20 DAS and Chalok 1/Cocktail 51 and waxy com (Chalok 1) was about 25 DAS.
( Dong Hwi Kim ),( Hyo Jeong Yong ),( Sunam Mander ),( Huong Thi Nguyen ),( Lan Phuong Nguyen ),( Hee-kyung Park ),( Hyo Kyeong Cha ),( Won-ki Kim ),( Jong-ik Hwang ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3
Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer arises in the context of hepatic inflammation, such as hepatitis B virus and hepatitis C virus infection. Despite significant improvements in the therapeutic modalities for liver cancer, patient prognosis is not satisfactory due to the limited efficacy of current drug therapies in anti-metastatic activity. Therefore, developing new effective anti-cancer agents with anti-metastatic activity is important for the treatment of liver cancer. In this study, SP-8356, a verbenone derivative with anti-inflammatory activity, was investigated for its effect on the growth and migration of liver cancer cells. Our findings demonstrated that SP-8356 inhibits the proliferation of liver cancer cells by inducing apoptosis and suppressing the mobility and invasion ability of liver cancer cells. Functional studies revealed that SP-8356 inhibits the mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways, which are related to cell proliferation and metastasis, resulting in the downregulation of metastasis-related genes. Moreover, using an orthotopic liver cancer model, tumor growth was significantly decreased following treatment with SP-8356. Thus, this study suggests that SP-8356 may be a potential agent for the treatment of liver cancer with multimodal regulation.
김재익(Jae-Ik Kim)ㆍ권진휘(Jin-Hwi Kwon) 한국주택학회 2009 주택연구 Vol.17 No.2
도심공동화는 인구의 교외화로 인하여 도심지의 상주인구가 감소하는 현상이다. 도심공동화 현상은 도심지역의 세수감소, 공공서비스의 질적ㆍ양적 수준의 저하, 주거환경악화 등의 연쇄반응을 거쳐 궁극적으로 도심지역을 슬럼화시키는 근본원인으로 받아 들여져 왔다. 이러한 이유로 도심공동화는 곧 심각한 도시의 병리현상으로 간주되어 도심재개발(도심재창조) 등을 통하여 극복해야 한다는 주장이 설득력을 얻었다. 그러나 도심공동화 현상을 시장의 자율적 조정기능의 결과라고 보면 그 사회적 효과는 달라질 수 있다. 즉 도심공동화는 인구 및 일자리의 교외화의 산물로써 가계와 기업의 여건변화에 적응한 적정입지 모색의 결과라고 본다면 건전한 조정과정으로 이해할 수 도 있다. 이 경우 도심재개발을 위한 투자는 건전한 시장조절기능을 역행하기 때문에 그 효과를 거두기 쉽지 않게 된다. 본 연구는 이러한 상반된 견해를 염두에 두고 도심공동화의 사회적 효과를 주거 및 토지이용의 측면에서 분석함으로써 도심재생 투자에 선행하여 도심기능의 변화와 이에 따른 투자의 타당성을 심도있게 검토해야 할 필요성을 강조하고자 한다. 분석결과 도심공동화는 인구 및 가구의 감소와 더불어 주택수를 감소시키지만 이에 대한 시장의 긍정적인 조정도 동반하는 것으로 나타난다. 즉 주택규모, 일인당 주거면적등의 측면에서 주거조건이 개선되었으며, 토지이용도 인구이탈에 적응하여 도심 기능에 적합토록 전환되고 있다. 이같은 도심공동화의 득과 실의 공존이라는 분석결과는 도심공동화 현상을 어떠한 관점을 갖고 판단하느냐에 따라 도심재개발 혹은 도심재창조를 위한 공공투자의 타당성이 달라질 수 있다. The inner city decline is known as one of the significant urban illness because it causes the vicious cycle to the central city. However, the decline of population in the core region can also be considered as the adjustment process of market mechanism. In this respect, this study analyzes the social effects of inner city decline in terms of living conditions and land use in the case of Daegu Metropolitan City. The main findings are follows. First, the decline of housing stock in core region is led by the decrease in single family housing stock. Second, the phenomenon improves living conditions of residents by increasing living area per house and per capita. Third, the urban emptiness phenomenon shifts land use from low density residential use to high density commercial and public use.Based on these findings this study concludes that the emptiness phenomenon observed in the urban core region may represent sound functions of market mechanism, rather than a serious social illness which calls vast amount of public investment.
( Dae Won Jun ),( Byung Ik Kim ),( Yong Kyun Cho ),( Hong Ju Kim ),( Young Oh Kwon ),( Soo Young Park ),( Sang Young Han ),( Yang Hyun Baek ),( Yong Jin Jung ),( Hwi Young Kim ),( Won Kim ),( Jeong He 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.2
Background/Aims: Carnitine and vitamin complex (Godex®) is widely used in patients with chronic liver disease who show elevated liver enzyme in South Korea. The purpose of this study is to identify the efficacy and safety of carnitine from entecavir combination therapy in Alanine aminotransferase (ALT) elevated Chronic Hepatitis B (CHB) patients. Methods: 130 treatment-na?ve patients with CHB were enrolled from 13 sites. The patients were randomly selected to the entecavir and the complex of entecavir and carnitine. The primary endpoint of the study is ALT normalization level after 12 months. Results: Among the 130 patients, 119 patients completed the study treatment. The ALT normalization at 3 months was 58.9% for the monotherapy and 95.2% for the combination therapy (P<0.0001). ALT normalization rate at 12 months was 85.7% for the monotherapy and 100% for the combination group (P=0.0019). The rate of less than HBV DNA 300 copies/mL at 12 months was not statistically significant (P=0.5318) 75.9% for the monotherapy, 70.7% for the combination and it was. Quantification of HBsAg level was not different from the monotherapy to combination at 12 months. Changes of ELISPOT value to evaluate the INF-Y secretion by HBsAg showed the increasing trend of combination therapy compare to mono-treatment. Conclusions: ALT normalization rate was higher in carnitine complex combination group than entecavir group in CHB. Combination group was faster than entecavir mone-treatment group on ALT normalization rate. HBV DNA normalization rate and the serum HBV-DNA level were not changed by camitine complex treatment.
김성국,이영두,이승엽,최용환,박언휘,탁원영,조창민,배한익,염현규,권영오,정준모 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4
Focal nodular hyperplasia (FNH) is a rare benign hepatic tumor occurring predominantly in women of childbearing age. Generally oral contraceptive is not associated with FNH but might accentuate the vascular abnormalities which may cause the lesion to enlarge and, very rarely, to rupture. FNH is typically asymptomatic and seldom bleeds. Often it is incidentally observed during imaging procedures performed for some other reasons. The histologic feature of FNH is characterized by areas of localized growth of mature hepatocytes and septal fibrosis. Surgical resection is seldom required because of the benign nature of the lesion and its lack of significant complication. We experienced a case of focal nodular hyperplasia without liver cirrhosis confirmed by surgical resection and histologic examination. in a 47-year-old man..(Korea J Hepatol 2000;6:524-529).