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가미삼령백출산(加味蔘?白朮散)의 B16 흑색종 암모델에 대한 항종양효과(抗腫瘍效果)와 면역증강효과(免疫增强效果)에 관한 연구(硏究)
임철홍,금종철,이상재,김광호,Iem Cheol-Hong,Keum Jong-Chul,Lee Sang-Jae,Kim Kwang-Ho 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.1
Background : Gamisamryungbaekchul-san(加味蔘?白朮散) is a herbal medicine which has been used for the traditional therapeutic agent of augmentation of the spleen and reinforcement of the Qi. Objective : This Study was performed to investigate the effect of Gamisamryungbaekchul-san on the tumor and immune response in the moose B16 melanoma tumor model. Materials and Methods : The tumor was induced by subcutaneous inoculation of B16BL6 melanoma cells in the shaved dorsal region of mice. Mice were orally administered with Gamisamryungbaekchul-san extract(26.3mg/mouse) for 14days after inoculation. For making examination of antitumor effect, the Increase of life span, Tumor growth inhibition rate, change of body weight were measured and evaluated. For the immune response increasing effect, the percentage of T lymphocyte and B Lymphocyte in the peripheral blood, the percentage of CD4+ T-cell, CD8+ T-cell and CD4+/CD8+ ratio in the peripheral blood and spleen, interleukin-2 productivity were measured and evaluated. Results : Gamisamryungbaekchul-san showed 16.59% increase of life span, 31.64% tumor growth inhibition rate and increase of body weight. Gamisamryungbaekchul-san increased the percentage of T lymphocyte in the peripheral blood, CD4+ T cell percentage of peripheral blood and spleen, and Interleukin-2 productivity as compared with the Control group. Whereas Gamisamryungbaekchul-san had no effect on the percentage of B lymphocyte in the peripheral blood, the percentage of CD8+ T cell, CD4+/CD8+ T-cell ratio in both of peripheral blood and spleen as compared with the Control group. Conclusion : This study shows that Gamisamryungbaekchul-san has anti-tumor effects and immunoregulatory effects on the B16 melanoma tumor model. It is suggested that Gamisarmyungbaekchul-san could be a useful immunomodulator and anti-tumor agent.
Keum, Jong-Chul,Iem, Cheol-Hong,Lee, Sang-Jae,Kim, Kwang-Ho INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2001 JOURNAL OF ORIENTAL MEDICINE Vol.6 No.1
Backgroud : Gagamtongsun-san(加減通順算) is a herbal medicine which has been used for the traditional therapeutic agent of removal of Phlegm and tumor by Phlegm in the oriental medicine. Objective : This study was performed to investigate the effect of Gagamtongsun-san on the tumor and immune response in the mouse B16 melanoma tumor model. Materials and Methods : The tumor was induced by subcutaneous inoculation of B16BL6 melanoma cells in the shaved dorsal region of mice. Mice were orally administered with Gagamtongsun-san extract (28mg/mouse) for 14days after inoculation. For making examination of antitumor effect, the Increase of life span, Tumor growth inhibition rate, change of body weight were measured and evaluated. For the immune response increasing effect, the percentage of T lymphocyte and B Lymphocyte in the peripheral blood, the percentage of CD4+ T-cell, CD8+ T-cell CD4+/CD8+ ratio in the peripheral blood and spleen, interleukin-2 productivity were measured and evaluated. Result : Gagamtongsun-san showed 18.55% increase of life span, 35.23% tumor growth inhibition rate and increase of body weight. Gagamtongsun-san increased the percentage of T lymphocyte in the peripheral blood, CD4+ T cell percentage of peripheral blood and spleen, and Interleukin-2 productivity as compared with the control group. Whereas Gagamtongsun-san had no effect on the percentage of B lymphocyte in the peripheral blood, the percentage of CD8+ T cell. CD4+/CD8+ T-cell ratio in both of peripheral blood and spleen as compared with the control group. Conclusion : This study shows that Gagamtongsun-san has anti-tumor effects and immunoregulatory effects on the B16 melanoma tumor model. It is suggested that Gagamtongsun-san could be a useful immunomodulator and anti-tumor agent.