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Taeko Ishii,Masaru Ishii,Yutaka Shimazu,Junichi Kikuta 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.5
Sphingosine-1-phosphate (S1P), a biologically active lysophospholipid that is enriched in blood, controls the trafficking of osteoclast precursors between the circula-tion and bone marrow cavities via G protein-coupled receptors, S1PRs. While S1PR1 mediates chemoattraction toward S1P in bone marrow, where S1P concentration is low, S1PR2 mediates chemorepulsion in blood, where the S1P concentration is high. The regulation of precursor recruitment may represent a novel therapeutic strategy for controlling osteoclast-dependent bone remodeling. Through intravital multiphoton imaging of bone tissues, we reveal that the bidirectional function of S1P temporospatially regulates the migration of osteoclast precursors within intact bone tissues. Imaging technologies have enabled in situ visualization of the behaviors of several players in intact tissues. In addition, intravital microscopy has the potential to be more widely applied to functional analysis and intervention.
( Takamasa Ishii ),( Masaki Miyazawa ),( Phil S. Hartman ),( Naoaki Ishii ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5
Most intracellular reactive oxygen species (ROS), especially superoxide anion (O2·-) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial O2·- production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in O2·- overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial O2·- and aging phenomena in mev-1 animal models. [BMB reports 2011; 44(5): 298-305]
Changes in species diversity of ground beetle assemblages in riverbanks of the Yamato River, Japan
Cheol-min Lee,Ishii Minoru 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
We investigated ground beetles in riverbank of the Yamato River in Nara and Osaka Prefectures,to elucidate changes in the species diversity and assemblage structure.Ground beetles were collected with unbaited pitfall traps once a week from April to December 2006 at five sites; sandy and grassy riverbanks in Ikaruga (Site 1) and Sangoh Towns, Nara Prefecture (Site 2),a gravelly riverbed in a valley in Kashiwara City (Site 3),and sandy and grassy riverbanks with willow trees in Fujiidera (Site 4) and Matsubara Cities,Osaka Prefecture (Site 5). A total of 4,319 individuals belonging to 53 species from two families were captured at the 5 sites. Species richness was the highest at Site 4 (40 spp.), higher at Sites 2, 5 and 1 (31, 30 and 29 spp. respectively), and the lowest at Site 3 (19 spp.). Compared with results in 1988 (Ishii etal., 1996), species richness of both small-and middle-sized specie sand both temperate and northern species increased, and 2 southern species and 2 species endemic to Japan were newly recorded. It should be noted that large numbers of Bembidion lissonotum and Nobria lewisi, "gravel riverspecialists", were caught at Site3. Our results demonstrate that ground-beetle fauna was well maintained in riverbank of the Yamato River in last 18 years.
Ishii, Naohiro,Oji, Tomito,Kishi, Kazuo Korean Society of Plastic and Reconstructive Surge 2017 Archives of Plastic Surgery Vol.44 No.4
We present the case of a patient with severe postoperative scarring from surgical treatment for gastroschisis, with the intestine located immediately under the dermal scar. Although many patients are unsatisfied with the results of scar repair treatment, few reports exist regarding severe or difficult cases involving the surgical repair of postoperative scar contracture. We achieved an excellent result via simulation involving graph paper drawings that were generated using computed tomography images as a reference, followed by dermal scar deepithelialization. The strategy described here may be useful for other cases of severe postoperative scar contracture after primary surgery for gastroschisis.
DEVELOPMENT OF INTERFACIAL AREA TRANSPORT EQUATION
ISHII MAMORU,KIM SEUNGJIN,KELLY JOSEPH Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.6
The interfacial area transport equation dynamically models the changes in interfacial structures along the flow field by mechanistically modeling the creation and destruction of dispersed phase. Hence, when employed in the numerical thermal-hydraulic system analysis codes, it eliminates artificial bifurcations stemming from the use of the static flow regime transition criteria. Accounting for the substantial differences in the transport mechanism for various sizes of bubbles, the transport equation is formulated for two characteristic groups of bubbles. The group 1 equation describes the transport of small-dispersed bubbles, whereas the group 2 equation describes the transport of large cap, slug or chum-turbulent bubbles. To evaluate the feasibility and reliability of interfacial area transport equation available at present, it is benchmarked by an extensive database established in various two-phase flow configurations spanning from bubbly to chum-turbulent flow regimes. The geometrical effect in interfacial area transport is examined by the data acquired in vertical fir-water two-phase flow through round pipes of various sizes and a confined flow duct, and by those acquired In vertical co-current downward air-water two-phase flow through round pipes of two different sizes.