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Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption
Kim, C.,Yang, H.,Fukushima, Y.,Saw, P.,Lee, J.,Park, J.S.,Park, I.,Jung, J.,Kataoka, H.,Lee, D.,Do Heo, W.,Kim, I.,Jon, S.,Adams, R.H.,Nishikawa, S.I.,Uemura, A.,Koh, G. Cell Press 2014 CANCER CELL Vol.25 No.1
Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho GTPase, during tumor progression. RhoJ blockade provides a double assault on tumor vessels by both inhibiting tumor angiogenesis and disrupting the preformed tumor vessels through the activation of the RhoA-ROCK (Rho kinase) signaling pathway in tumor endothelial cells, consequently resulting in a functional failure of tumor vasculatures. Moreover, enhanced anticancer effects were observed when RhoJ blockade was employed in concert with a cytotoxic chemotherapeutic agent, angiogenesis-inhibiting agent, or vascular-disrupting agent. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.
Modelling and experiments of phase distribution and turbulence in bubbly two-phase flow
Serizawa, A.,Kataoka, I. 대한기계학회 1995 International Forum on Advances in Mechanical Engi Vol.1 No.1
Gas-liquid bubbly two-phase flow is characterized as the flow where gas phase is dispersed in a form of discrete bubbles in continuous liquid phase. Although this type of flow is popularly encountered in various industrial equipments, our present knowledge of physical structures of such flows is still quite limited because of very complex hydrodynamical mechanisms involved such as time- and spatially-varying and deforming characters of gas-liquid interfaces with relative random motions of bubbles. Typical features of bubbly two-phase flow reflect on multi-dimensional effects which are closely related to a triangular linkage among turbulence and interfacial structures and phase distribution. This triangular linkage is, in turn, very sensitive to bubble size and configurations. In this report the state-of-the-art in multidimensional effects in bubbly two-phase flow is reviewed with particular attention directed towards experimental results and modelling in phase distribution and turbulence. Prediction models incoporate the equation of turbulence kinetic energy conservation derived based on two-flvuid model formulation. It will be shown that this turbulence energy conservation equation leads to an interesting conclusion that the turbulence energy of the liquid phase can be converted to surface energy and vice versa. Turbulence reduction in bubbly flow will be also discussed based on experimental results and predictions.
Compressed-exponential relaxations in supercooled liquid trehalose
Seo, J.A.,Kwon, H.J.,Kataoka, K.,Ohshima, K.i.,Shin, D.M.,Kim, H.K.,Hwang, Y.H. Elsevier 2012 Current Applied Physics Vol.12 No.6
We investigated the α-relaxations in supercooled liquid trehalose by using photon correlation spectroscopy (PCS) and found an interesting compressed-exponential relaxation at temperatures above 140 <SUP>o</SUP>C. The q<SUP>-1</SUP> dependence of its relaxation time corresponds to an ultraslow ballistic motion due to the local structure rearrangements. In the same temperature range, we found the glycosidic bond structure changes in trehalose molecule from the Raman scattering and the X-ray direction measurements. We concluded that the compressed-exponential relaxation in supercooled liquid trehalose might originate from the intra-molecular (glycosidic bond) structure change.