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Generalized Inverse Aided PAPR-Aware Linear Precoder Design for MIMO-OFDM System
Hyunsu Cha,Hyukjin Chae,Kiyeon Kim,Jinyoung Jang,Janghoon Yang,Dong Ku Kim IEEE 2014 IEEE communications letters Vol.18 No.8
<P>We propose a linear precoding scheme for a single user multiple-input-multiple-output orthogonal frequency division multiplexing (OFDM) system to minimize peak to average power ratio (PAPR) by using redundant spatial resources at the transmitter through a singular-value-decomposition-based generalized inverse. The proposed precoder based on the generalized inverse is composed of two parts. One is for minimizing PAPR, and the other is for obtaining the multiplexing gain. Moreover, the proposed precoder contains a scalar parameter α that quantifies the received signal-to-noise power ratio (SNR) loss at the cost of PAPR reduction. Even in cases of small SNR loss, the proposed scheme dramatically reduces PAPR. Furthermore, simulation results show that we can obtain a PAPR close to 1 by using dozens of transmission antennas with small SNR loss.</P>
Industrial Production of 2,3-Butanediol from the Engineered Corynebacterium glutamicum
Yang, Jeongmo,Kim, Borim,Kim, Hyunsu,Kweon, Yuhyeon,Lee, Soojin,Lee, Jinwon Springer-Verlag 2015 Applied biochemistry and biotechnology Vol.176 No.8
<P>The platform chemical 2,3-butanediol (2,3-BDO) is a valuable product that can be converted into several petroleum-based chemicals via simple chemical reactions. Here, we produced 2,3-BDO with the non-pathogenic and rapidly growing Corynebacterium glutamicum. To enhance the 2,3-BDO production capacity of C. glutamicum, we introduced budA encoding acetolactate decarboxylase from Klebsiella pneumoniae, a powerful 2,3-BDO producer. Additionally, budB (encoding α-acetolactate synthase) and budC (encoding acetoin reductase) were introduced from K. pneumoniae to reinforce the carbon flux in the 2,3-BDO production. Because budC had a negative effect on 2,3-BDO production in C. glutamicum, the budB and budA introduced strain, SGSC102, was selected for 2,3-BDO production, and batch culture was performed at 30?C, 250?rpm and pH 6.86 with pure glucose, molasses, and cassava powder as carbon substrates. After batch culture, significant amount of 2,3-BDO (18.9 and 12.0?g/L, respectively) was produced from 80?g/L of pure glucose and cassava powder.</P>
Yang Juwon,Bae Hyunsu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in suppressing anticancer immune responses; therefore, various strategies targeting Tregs are becoming important for tumor therapy. To prevent the side effects of nonspecific Treg depletion, such as immunotherapy-related adverse events (irAEs), therapeutic strategies that specifically target Tregs in the TME are being investigated. Tumor-targeting drug conjugates are efficient drugs in which a cytotoxic payload is assembled into a carrier that binds Tregs via a linker. By allowing the drug to act selectively on target cells, this approach has the advantage of increasing the therapeutic effect and minimizing the side effects of immunotherapy. Antibody–drug conjugates, immunotoxins, peptide–drug conjugates, and small interfering RNA conjugates are being developed as Treg-targeting drug conjugates. In this review, we discuss key themes and recent advances in drug conjugates targeting Tregs in the TME, as well as future design strategies for successful use of drug conjugates for Treg targeting in immunotherapy.
Park, Hyunsu,Kim, Jieun,Choi, Kyoung-Hwa,Hwang, Sungmin,Yang, Sung-Jae,Baek, Nam-In,Cha, Jaeho American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.33
<P>Piceid is widely used in food, cosmetics, and pharmaceuticals because of its therapeutic benefits. However, the use of piceid as a drug is limited because of its low solubility. To increase solubility, we synthesized piceid glucosides using maltosyltransferase from Caldicellulosiruptor bescii. The MTase gene was cloned and expressed in Escherichia coli. The enzyme had a unique transfer specificity to the transfer of maltosyl units. Four piceid transglycosylation products were present and identified by thin-layer chromatography and recycling preparative high-performance liquid chromatography. The major product was purified by C<SUB>18</SUB> and gel filtration chromatography, and its molecular structure was determined using nuclear magnetic resonance spectroscopy to be α-<SMALL>d</SMALL>-maltosyl-(1→4)-piceid. The solubility of maltosyl piceid was 8.54 × 10<SUP>3</SUP> and 1.86 × 10<SUP>3</SUP> times those of natural resveratrol and piceid, respectively, suggesting that the transglycosylation greatly increased the water solubility. This suggests that dietary intake of this compound can enhance the bioavailability of resveratrol in the human body.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2012/jafcau.2012.60.issue-33/jf302127a/production/images/medium/jf-2012-02127a_0008.gif'></P>