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Kim, Jamin,Kim, Haemin,Moon, Hyungwon,Lee, Hohyeon,Chang, Jin Ho,Kim, Jungwook,Kim, Hyuncheol American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.11
<P>The use of small interfering RNA (siRNA) with chemotherapeutic drugs has a synergistic effect of inhibiting target genes. Furthermore, theranostics, which enables therapeutic drug delivery and provides immediate diagnosis, is also emerging as a promising technique. In line with this novel concept, we have developed an albumin-based nanomedicine capable of combination therapy (chemo-and gene therapy) and photoacoustic imaging. The multifunctional (combination therapy and photoacoustic imaging) theranostic nanomedicine contains paclitaxel (PTX), siRNA, and indocyanine green (ICG). Sulfhydryl-modified siRNA and sulfhydryl-modified human serum albumin form more stable nanoparticles mainly through the disulfide bond, unlike prevalent nanomedicines (e. g., lipid-based nanomedicine or siRNA bioconjugates). The albumin-based multifunctional nanomedicine shows double gene inhibition ability and a synergistic effect of chemoand gene therapy. Inhibition of the expression of target genes (Bcl-2, VEGF, etc.) and simultaneous treatment with PTX exhibit a synergistic effect compared to single treatment in vitro and in vivo. Furthermore, using ICG, photoacoustic imaging was very efficient. Our study demonstrates that this multifunctional theranostic nanomedicine could perform co-delivery of PTX and siRNA and yield a synergistic effect for target cells. By virtue of combination gene therapy, this the ranostic nanomedicine has great potential to cure various diseases, including cancer, and aid the prognosis of target tumor cells or tissues by photoacoustic imaging. To the best of our knowledge, this is the first report of the development of a multifunctional theranostic nanomedicine for combination therapy and non-invasive photoacoustic imaging.</P>
Touch Position Recovery Algorithm for Differential Sensing Touch Screen
Kim, Ji-Ho,Won, Dong-Min,Kim, HyungWon The Korea Institute of Information and Commucation 2016 Journal of information and communication convergen Vol.14 No.2
Differential sensing methods are more effective in alleviating panel noise than single-line sensing, and thus have been increasingly used in the touch screen industry. However, they have a drawback: they tend to cancel out multiple touches and need touch position recovery algorithms. This paper introduces a novel algorithm of touch position recovery for differential sensing, which is a low-complexity but high-accuracy approach for determining multiple touch positions. We have implemented the proposed method in a touch screen controller system on a chip. In the simulation experiments using realistic touch screen models and a differential sensing circuit, the algorithm exhibited a high detection performance of a signal-to-noise ratio gain of up to 52.21 dB. Therefore, we can conclude that the proposed method is substantially more accurate than the previous method. Further, the proposed method incurs little or no overhead in terms of the detection speed and the chip size.
Moon, Hyungwon,Kumar, Dinesh,Kim, Haemin,Sim, Changbeom,Chang, Jin-Ho,Kim, Jung-Mu,Kim, Hyuncheol,Lim, Dong-Kwon American Chemical Society 2015 ACS NANO Vol.9 No.3
<P>We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both <I>in vitro</I> and <I>in vivo</I> systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4–11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-3/nn506516p/production/images/medium/nn-2014-06516p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn506516p'>ACS Electronic Supporting Info</A></P>