톡소포자충 감염마우스의 Cytokine 및 Heat shock protein 생산 분석

노형준,최인욱,신대환,이영하 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

T. gondii frequently causes severe congenital defects and life-threatening disease in immunocompromised individuals. Cytokines. nitric oxide (NO) and heat shock proteins (HSP) are important to control the parasite multiplication and host resistance. However. there were only fen reports about HSP70 in toxoplasmosis. Moreover. we do not know the cytokines and HSP70 production in case of NO inhibition. Therefore. this study was performed to analyze the production of NO. HSP70 and cytokines after adminstration of aminoguanidine (AMG. suppressor of NO production) in mice infected with T. gondii. BALB/c and C57BL/6 mice were injected with either 5 brain cysts of Me49 strain of T. gondii or 50㎍ of AMG for 2 weeks every day. and then mice were sacrificed at day 4. 7. 14 and 28. HSP70 production in the brain and spleen of both mice strains mere decreased after treatment with AMG. however Toxoplasma-infected ones were significantly increased. HSP70 production of Infection/AMG-treated group of C57BL/7mice was significantly decreased in comparison to Infection group. Whereas Infection/AMG-treated group of BALB/c mice showed similar HSP70 production compared to Infection group. After T. gondii infection. the IFN-γ and TNF-α mRNA expression in the brain and spleen was significantly increased in BALB/c or C57BL/6 mice. IFN-γ mRNA expression in the brain and spleen of Infection/AMG-treated BALB/c mice were not significant differences compared to those of infected ones. however there were significant differences in the spleen of C57BL/6 mice. TNF-α mRNA expression in the spleen of Infection/AMG-treated BALB/c or C57BL/6 mice were significantly decreased in comparison to those of infected ones. Taken together. HSP70. IFN-γ and TNF-α production were significantly increased in Toxoplasma-infected BALB/c and C57L/6 mice. After treatment with NO inhibitor in infected C57BL/6 mice, the production of HSP70 and IFN-γ were significantly decreased. whereas BALB/c mice were not significant differences of HSP70 and IFN-γ production between Infection and Infection/AMG-treated group.

접착용 시멘트의 균일한 도포를 위한 교정용 밴드 장착방법의 모색

김형준,정태성,김신 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

마이크로 마우스의 주행기법에 대한 연구

지준근,류신형 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

This paper proposes the new maze running strategy that micro-mouse can run on theshortest path and time in the maze. Also it is explained that the conceptual structure of micro mouse to implement the strategy. And to solve the complex motion control problem, motion tabling method in introduced and implemented. Through computer simulation about the pose control of micro-mouse during running the maze, it is proved that proposed strategy is excellent.

수영운동이 흰쥐의 MDA와 근육 LDH 활성도 및 Pyruvate 함량에 미치는 영향

고기준,신군수,박형하 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of the present investigation was to evaluate the effects of swimming on response of lipid peroxidation and muscle enzymes activity of hyperlipidemia rats. Twenty-five male SD rats(6 weeks old) were randomly divided into control group and 4 swimming groups after hyperlipidemia induction for 4 weeks 1% cholesterol diet, and then swimming groups swam for 6 weeks(7days/week) divided into 35 min, unloaded swimming group, 30 min, loaded swimming group, 60 min, unloaded swimming group and 50 min. loaded swimming group by swimming duration and intensity. The loaded swimming group rats among swimming groups swam a lead weight equivalent to 5% of Lady weight attached to the base of the tail, Analytical items were MCA, muscle LDH enzymes activity and pyruvate content. All data were expressed as mean and standard deviation by using SPSS/PC+ program and to evaluate the differences between and inter groups, data were analyzed by one-way analysis of variance and Duncan multiple range test(α=.05) was performed to test the significant levels of differences between groups, The conclusions obtained from this study were as follows: 1. There was not significant between groups in malondialdehyde(MDA). 2. In muscle lactate dehydrogenase activity, 30 min, unloaded swimming group and 30 min, Loaded swimming group were significantly lower than control group and 60 min, unloaded swimming group(P<.001). 3. In muscle pyruvate content, all swimming groups were significantly higher than control group(P<.001).

애엽, 지각, 아교주 및 목향의 투여가 임신중 생쥐의 생식능력에 미치는 효과

정형민,차수경,임정묵,신태은,박찬,장준복,이경섭,송병기 경희대학교 2000 慶熙醫學 Vol.16 No.2

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

초등학교용 웹 기반 교수-학습 자료 개발 전략

김홍래,정인기,신준식,이대형 춘천교육대학교 과학교육연구소 2001 과학교육연구 Vol.25 No.-

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

Effects of Advertising Model Type depending upon Each Form of Advertising upon Advertising Effect

Hyung-Jun Shin,Young-Chun Cho,Hoe-Chang Yang 한국유통과학회 2012 한국유통과학회 학술대회 논문집 Vol.2012 No.-

The purpose of this study is to find if there are differences in the effects of advertising depending on the types of forms of advertising divided into PSA and commercial ads and the types of advertising model. Because we have an assumption about the purpose of PSA and commercial advertising is fundamentally different. As this study is to investigate if there would be any difference in the advertising effects towards the types of advertising and forms of advertising model will expect to be able to get the effect of the optimized ads. In this study, students in Jangan University were asked to answer a questionnaire. Excluding non-appropriate 12 respondents, a total of 102 questionnaires were analyzed. Firstly, non-parametric test was used to see if there are differences among the types of advertising model. Secondly, paired-sample t-test was used to see if there are differences between PSA and commercial advertising. Finally, in order to verify the causal effect between the types of ad models and ads, simple regression and multiple regression analysis was conducted. There were different among celebrities, professionals and CEO’s except typical model at PSA, and there were different among celebrities, professionals and the typical model except CEO at commercial advertising. Simple regression results showed that both professionals and CEO model was positive impact on effect of advertising in the case of PSA, respectively. But in the case of commercial advertising, celebrities, professionals and the typical model was positive impact on effect of advertising in the case of PSA, respectively. Especially, it was identified as the most affecting type is celebrities for commercial advertising. These results suggested that appropriate selection of types of model for production of advertising is very important factor. For example, if we create PSA contents, it is more effective to choose professionals or CEO models because they have referent power and trust than cele

Refractory pseudomembranous colitis that was treated successfully with colonoscopic fecal microbial transplantation

( Jun Young Shin ),( Eun Jung Ko ),( Seung Ho Lee ),( Jong Bum Shin ),( Shin Il Kim ),( Kye Sook Kwon ),( Hyung Gil Kim ),( Yong Woon Shin ),( Byoung Wook Bang ) 대한장연구학회 2016 Intestinal Research Vol.14 No.1

Pseudomembranous colitis (PMC) is a nosocomial and opportunistic infection caused by Clostridium difficile. PMC is related to the use of antibiotics leading to intestinal dysbiosis and an overgrowth of C. difficile. Metronidazole or vancomycin is considered to be the standard therapy for the management of PMC. However, PMC has a 15%.30% recurrence rate and can be refractory to standard treatments, resulting in morbidity and mortality. Here we describe a patient who experienced refractory PMC who was treated with fecal microbiota transplantation. A 69-year-old woman was admitted to the hospital with consistent abdominal pain and diarrhea, which had been present for 5 months. She was diagnosed with PMC by colonoscopy and tested positive for C. difficile toxin. Even though she took metronidazole for 10 days, followed by vancomycin for 4 weeks, her symptoms did not improve. Because of her recurrent and refractory symptoms, we decided to perform fecal microbiota transplantation. Fifty grams of fresh feces from a donor were obtained on the day of the procedure, mixed with 500 mL of normal saline, and then filtered. The filtered solution was administered to the patient’s colon using a colonoscope. After the procedure, her symptoms rapidly improved and a follow-up colonoscopy showed that the PMC had resolved without recurrence. (Intest Res 2016;14:83-88)