결절성 근막염양 간질을 가진 갑상선의 유두상 암종 : 1예 보고 A Case Report

한원철,윤기중,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Papillary carcinoma of thyroid has variable morphologic variants preserving the characteristic nuclear features; encapsulated, follicular, encapsulated-follicular, diffuse sclerosing, oxyphilic, tall and columnar cell, cribriform and nodular fasciitis-like types. We report a case of papillary thyroid carcinoma with nodular fasciitis-like stroma in a 40-year old woman who had a thyroid mass. The cut surface of the lesion is white myxoid, and the microscopical findings show papillary carcinoma admixed with nodular fasciitis-like stromal cells.

(AgCu)_0.43-Au_0.54Pd_0.03 합금의 시효경화 특성

배동화,설효정,이희경,김형일,김교한 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.3

팔라디움이 함유된, 시효경화성 치과주조용 고금합금의 연구를 위한 기초자료를 얻기 위하여, 4원계 □ 합금의 등온시효경화 거동과 상변태를 경도 시험, X선회절 실험으로 조사하여, 다음과 같은 결과를 얻었다. 본 합금을 250~350℃에서 등온시효처리하면, 면심정방구조를 갖는 준안정상 AuCu Ⅰ'형 규칙상이 면심정방구조를 갖는 AuCu Ⅰ형 규칙상과 면심입방구조를 갖는 Ag-rich a₁상이 생성되기 전에 생성되었다. 본 합금은 시효처리 온도에 따라 다른 시효경화 거동을 보여주었다. 350℃에서 시효처리를 하면, 경도는 시효 초기에 상승하지 않았고, 최고 경도에 도달하여 유지되고나서 시효시간을 연장함에 따라 경도가 급격히 저하하였다. 250℃에서 시효처리를 하면, 경도는 시효 초기부터 뚜렷히 상승하기 시작하였다. 그 후, 약간의 경도 하강을 보이고나서 경도는 다시 서서히 상승을 지속하였다. 350℃에서 경화는 준안정상 AuCu Ⅰ'형 규칙상의 균일핵생성에 기인하였다. 낮은 시효온도에서의 초기 경화는 다른 상변태에 의해 초래되었고, 이어서 일어나는 경화는 준안정상 AuCu Ⅰ'형 규칙상의 생성에 기인하였다. 시효시간을 연장함에 따라 생기는 과시효 연화는 평형상 AuCu Ⅰ형 규칙상의 생성에 기인하는 것으로 생각된다.

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

반측안면소체증의 측두골 전산화 단층촬영소견

한종규,한경렬,백병준,김형환,배원경,김일영 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Hemifacial microsomia(HFM) is a craniofacial disorder and complex malformation syndrome with a variable and asymmetric malformation involving first and second pharyngeal arch derivatives. Multiple etiological mechanisms for HFM have been considered. Mechanisms proposed include genetic factors, early embryogenesis insults involving abnormal neural crest development and migration, and stapedial artery hematoma. HFM is the second most common craniofacial malformation but has been rarely reported in korea, and we report five cases of HFM in temporal bone CT findings. The temporal bone CT findings of five patients aged 6 days and 19 years(mean, 9 years) with hemifacial microsomia were reviewed and evaluated. Particular attention was focused on auricular malformation, external auditory canal, volume of middle ear cavity, ossicular anomaly, facial nerve anomaly and inner ear anomaly. In all patients, temporal bone CT scans revealed the stenosis or atresia of external auditory canals, decreased middle ear cavities, matoid underdevelopment and ossicular anomalies including ossicular ankylosis, but only one patient showed facial nerve or inner ear anomaly. In conclusion, temporal bone CT scan is a useful diagnosis modality of hemifacial microsomia, which is especially more useful in preoperative evaulation and estimation of postoperative prognosis that demonstate middle and inner ear anomalies.

칼슘 통로 봉쇄제가 Pilocarpine에 의한 경련 및 기억장애에 미치는 영향

한형수,배현혜,박정숙,김중영 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 칼슘 통로 봉쇄제인 nifedipine과 flunarizine이 pilocarpine으로 유발된 경련의 발생과 뇌 조직 손상으로 인한 기억력 저하에 어떤 영향을 미치는지 연구하고자 하였다. 대상 및 방법 : ICR계의 생쥐 수컷을 사용하여 pilocarpone 투여후 6단계로 나누어 경련발작을 관찰하였으며, nifedipine과 flunarizine 전처치후 pilocarpine 투여에 따른 항경련작용을 측정하였다. Working memory를 통하여 기억력검사를 실시하였다. 결과 : nifedipine과 flunarigine 두 약물은 모두 경련 강도를 감소시켰고 flunarizine은 경련 시작 시간도 지연시켜 항경련 작용이 있음을 보였다. 칼슘 통로 봉쇄제는 주로 3일에서 10일 사이에 투여한 경우에 pilocarpine에 의해 기억력이 저하되는 것을 억제하는 것으로 나타났다. 결론 : 이상의 실험 결과에서 칼슘 통로 봉쇄제는 pilocarpine에 의한 경련 억제 작용과 기억력 저하를 억제할 수 있는 작용을 가지고 있음을 확인하였다. The effect of calcium channel blockers, nifedipine and flunarizine, on the pilocarpine-induced seizure and neuronal damage-induced memory deficit in mice was studied. After pretreatment of nifedipine or flunarizine, pilocarpine was administered intraperitoneally. Both drugs attenuated behavioral seizure activity and delayed onset of seizure activity. Memory was tested with working memory version of Morris water mazein 20 days following pilocarpine treatment and showed memory deficit. This deficit in memory was prevented when nifedipine or flunarizine were given during 3 to 6 day or 7 to 10 days after pilocarpine treatment. These results show that calcium channel blockers have anticonvulsant property and depress on pilocarpine-induced memory deficit.

볏짚의 가성소다 處理水準이 재래산양의 볏짚섭취량 飮水量 및 腸內 通過速度에 미치는 影響

辛炯泰,裵熙東,孫鎭漢 成均館大學校 科學技術硏究所 1988 論文集 Vol.39 No.1

These experiments(I, II) were conducted to determine the nutritive value of NaOH-treated rice straw by voluntary intake, water consumption, rate of passage and retention time in goat's gastrointestinal tracts. The results which were obtained with these experiments (I, II) as follows; 1. Volutary intake of 0%, 3% and 6% NaOH-treated rice straw by goats was 1,012ml, 1,427ml and 1,612 ml, respectively. 2. Water consumption of 0%, 3% and 6% NaOH-treated rice straw by goats was 1,012ml, 1,421ml and 1,612ml, respectively. 3. The first excretion time of stained rice straw particles in goat's feces was 0% NaOH, 20 hours: 3% NaOH, 18 hours and 6% NaOH, 16 hours, respectively. 4. Total mean retention time (R value) of 0%, 3% and 6% NaOH-treated rice straw by goats was 72.0 hours, 61.2 hour, and 56.8 hours, respectively. 5. The optimal level of NaOH for increasing the nutritive value of rice straw was 3% in goat's rations.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구

문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.

蛋白質 水準 및 供給源이 泌乳初期搾乳牛의 産乳量에 미치는 影響

辛炯泰,韓泳根,金秉泰,裵熙東,孫重天 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2

Eighteen Holstein cows capable of producing at least 23㎏ of milk per day were assigned randomly in equal numbers and fed one of three isocaloric total rations of 15.8 (soybean meal), 15.8 (urea), or 14.1% (urea) crude protein in dry basis. All cows were fed their assigned ration continuously for 63 days beginning on the 20 day postpartum. This experiment was designed to determine the influence of concentration and source of dietary protein on milk production(kg) and milk fat(%) during early lactation. The results which were obtained in this experiment as follows: 1. Milk yields (4.0% fat corrected milk, FCM) of cows for 42 day trial in early lactation were 23.80, 20.32, 18.44kg for the respective treatment. In this experiment the higher protein concentration (15.8% vs 14.1%) increased milk production, and source of protein influenced milk production. 2. Milk fat of 3.63, 3.52, and 3.39% showed that dietary protein concentration and source influenced milk fat in early lactating cows. 3. Income above feed cost for 42 day trial was greatest for the group fed the 15.8% crude protein from soybean meal (5,406 won/cow/day) and lowest for the group fed the 14.1% crude protein from urea (3,919.5 won/cow/day). income above feed cost for 15.8% crude protein from urea was 4,154.4 won /cow/day.

fcc(face-centered cubic) structure의 에너지 밴드 측정

한성원,홍진수,배형철 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

Photonic band gaps(PBGs) are investigated for face-centered cubic structure composed of dielectric spheres and air spheres. It was found that PBGs exist for both cases. PBGs lie between the 6th-7th and 13th-14th for dielectric spheres and the 8th-9th for air spheres.