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Alteration of disorder emotional behavioral following chronic kidney disease
Hyuna Im,Yeon Hee Yu,Yejin Song,Yu Ran Lee,Gun Woo Kim,Dae Young Yoo,Dae-Kyoon Park,Duk-Soo Kim 대한체질인류학회 2021 대한체질인류학회 학술대회 연제 초록 Vol.64 No.-
Chronic kidney disease (CKD) is affected the structure and function of the kidney and lead to albuminuria and reduction in glomerular filtration rate (GFR). In addition to, chronic kidney disease (CKD) has been observed neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system. Especially, psychological distress and depression are serious concerns in patients with CKD. However, the relevance between CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Thus, In this study we are investigated that psychomotor functional disorders by CKD. We identified higher level of serum creatinine, blood urea nitrogen (BUN) and worsening fibrosis in CKD rats than wild-type rats. To determine whether CKD affects anxiety disorders, we performed -open-field, elevated plus-maze, and light-dark transition -three anxiety-related behavioral assays in CKD rat models. Level of anxiety and depression-like behaviors was increased in the 10 weeks CKD rat models compared with wild-type rat. In the recording of local field potentials (LFP) for cross-check results of behavior test, the power of theta (4-7 Hz), and alpha rhythm (7-12 Hz) was obviously increased in the CKD rat. These results demonstrate that CKD is responsible for anxiogenic behaviors and hypolocomotion in rats. Thus, this study we suggested that anxiogenic behaviors and depression can be induced by uremia of CKD.
Yeon Hee Yu,Hyuna im,Dae Young Yoo,Dae-Kyoon Park,Seo Jeong Kim,Yejin Song,Duk-Soo Kim 대한체질인류학회 2021 대한체질인류학회 학술대회 연제 초록 Vol.64 No.-
Febrile seizure (FS) is the most common seizure type in the infant and young child, because prolonged FS may induce functional changes in the hippocampal circuitries and then contributed toward the development of temporal lobe epilepsy (TLE). Early developmental insults by FS may associated with disorders in emotional recognition and the growth of cognitive functions in children is sensitive with the adverse influence of epilepsy. But, it is not well-defined the psychophysiology following FS. Therefore, in this study we are investigated the interrelation that cognitive/emotional sequelae following prolonged FS rats. In the results of this study, to characterize of behavioral disturbance by emotional and cognitive dysfunction in FS rats, we were experimented behavior test. In consequence, we were confirming that defected of recognition and emotional behavior after FS rats. In addition, we were investigated field excitatory postsynaptic potential (fEPSP) in the CA1 region of hippocampus for identifying impairs synaptic transmission, observed that resultant slope of fEPSP were markedly reduced more than control rats. Additionally, we observed decreasing of interneurons in the hippocampus through cresyl violet staining following FS rats. Immunoreactivity of GABAA receptor was enhancing in CA1 and DG regions of hippocampus compared with control rats. Therefore, our findings may provide that regional specific neuronal damage and hyperthermic degenerations induced by FS may play an important role in the pathogenesis of epilepsy and occurring diverse behavioral sequelae
Verification for sildenafil as a potential therapeutic effector following mild ischemic stroke
Yejin Song,Yeon Hee Yu,Hyuna im,Geon Guk Kim,Dae Young Yoo,Dae-Kyoon Park,Duk-Soo Kim 대한체질인류학회 2021 대한체질인류학회 학술대회 연제 초록 Vol.64 No.-
Ischemic stroke is one of the major diseases and leading cause of death in the worldwide. In particular, ischemic stroke is induced by the occlusion of the cerebral blood vessel due to either embolism or thrombus, thus this serious occurrence leads to the major cause of long-term disability in surviving patients. Sildenafil, as known as Viagra is a phosphodiesterase-5 inhibitor and effect the nitric oxide-cyclic guanosine monophosphate pathways, which are deeply involved in the pathogenesis of the neurological diseases by causing intracellular accumulation of cGMP. Therefore, sildenafil may have a favorable therapeutic effect on the treatment of stroke, neurodegenerative disorders and vascular dementia by enhancing angiogenesis and neurogenesis. In our current study, we found a therapeutic effect of sildenafil on mild stroke model. After establishing the mild MCAo, we injected Sildenafil in mild stroke model and conducted a behavioral test to identify the cognitive function. In addition, mild stroke animal models were tested field excitatory postsynaptic potential (fEPSP) in the hippocampus following MCAo. Moreover, to confirm the infarct volume of brain, histological staining was performed. As a result, we obtained significant results compared with the mild stroke animal model treated with and/or without Sildenafil, which means that improving the cognitive behavioral phenotypes and the potential role for reducing the symptomatic outcomes after mild MCAo. According to these results in this study, therefore, our findings indicate that it may involve to the novel therapeutic effects for progressing the diverse phenotypes of mild ischemic stroke following MCAo
Yeon Hee Yu,Seong-Wook Kim,Juhyeon Kang,Yejin Song,Hyuna Im,Seo Jeong Kim,Dae Young Yoo,Man-Ryul Lee,Dae-Kyoon Park,Jae Sang Oh,Duk-Soo Kim 대한신경외과학회 2022 Journal of Korean neurosurgical society Vol.65 No.5
Objective : Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with mild ischemic stroke by acute stroke. Sildenafil (SIL), a phosphodiesterase-5 inhibitor (PDE5i), is a known remedy for neurodegenerative disorders and vascular dementia through its angiogenesis and neurogenesis effects. In this study, we investigated the efficacy of PDE5i in the emotional and behavioral abnormalities in rats with mild ischemic stroke. Methods : We divided the rats into four groups as follows (n=20, respectively) : group 1, naïve; group 2, middle cerebral artery occlusion (MCAo30); group 3, MCAo30+SIL-pre; and group 4, MCAo30+SIL-post. In the case of drug administration groups, single dose of PDE5i (sildenafil citrate, 20 mg/kg) was given at 30-minute before and after reperfusion of MCAo in rats. After surgery, we investigated and confirmed the therapeutic effect of sildenafil on histology, immunofluorescence, behavioral assays and neural oscillations. Results : Sildenafil alleviated a neuronal loss and reduced the infarction volume. And results of behavior task and immunofluorescence shown possibility that anti-inflammation process and improve motor deficits sildenafil treatment after mild ischemic stroke. Furthermore, sildenafil treatment attenuated the alteration of theta-frequency rhythm in the CA1 region of the hippocampus, a known neural oscillatory marker for anxiety disorder in rodents, induced by mild ischemic stroke. Conclusion : PDE5i as effective therapeutic agents for anxiety and movement disorders and provide robust preclinical evidence to support the development and use of PDE5i for the treatment of mild ischemic stroke residual disorders.