羅里洞. 白鹿澤 火口內의 植物 分布 調査硏究

都象學,朴壽現 同德女子大學校 1975 同大論叢 Vol.5 No.1

Research of the Plants Distribution in the Na-Ree Dong of Dagelet Island and Baik-Rok Dam of Cheiu Islard. I found out 143 genera, 187 species of plants in the Na-Ree Dong of Dagelet island by four tinges of exploration during the years of 1961 to 1971. From 1957 to 1974 I found out 113 genera, 174 species of plants in Baik-Rok Dam of Cheju Island by five times of exploration and also I had a comparative study of Crater-Plants in Baik-Rok Dam and Na-Ree Dong.

Ligand-based QSAR Studies on the Indolinones Derivatives as Inhibitors of the Protein Tyrosine Kinase of Fibroblast Growth Factor Receptor by CoMFA and CoMSIA

Hyun, Kwan-Hoon,Kwack, In-Young,Lee, Do-Young,Park, Hyung-Yeon,Lee, Bon-Su,Kim, Chan-Kyung Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.12

Ligand-based quantitative structure-activity relationship (QSAR) studies were performed on indolinones derivatives as a potential inhibitor of the protein tyrosine kinase of fibroblast growth factor receptor (FGFR) by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) implemented in the SYBYL packages. The initial X-ray structure of docked ligand (Su5402) to FGFR was used to minimize the 27 training set molecules using TRIPOS force field. Seven models were generated using CoMFA and CoMSIA with grid spacing 2 ${\AA}$. After the PLS analysis the best predicted CoMSIA model with hydrophobicity, hydrogen bond donor and acceptor property showed that a leave-one out(LOO) cross validated value $({r^2}_{cv})^$ and non-cross validated conventional value $({r^2}_{ncv})^$ are 0.543 and 0.938, respectively.

편두통 환자의 임상 양상 및 생체전기 자율반응과의 상관성 고찰

이현종,정인태,김수영,이두익,김건식,이재동,이윤호,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : We had a clinical report in headache but didn't in migraine. We have planned this study in order to get the basic data of migraine in oriental medicine. Methods : The patient of 36 in migraine checked sec, age, onset, family history, severity of pain, influences of life, induced cause, clinical pain characteristics, associated symptom, treatment style, and paescription, frequency, using period of analgesics by a questionnaire and differentiated syndromes in migraine and evaluated autonomic bioelectric response recorder(ABR-2000). Results : There are 23.4% in prevalence rate of migraine. The ratio of sex is M: F=1:17. The age of an attack is the highest in thirties. The patient are the most in forties. The mean duration of illness is 12.0±9.9 years. 83.4% had a family history. 61.1% had a moderate grade in severity of pain. 77.8% selected fatigue in induced cause of migraine. 69.4% had tingling sense, nausea and vomiting in the associated symptoms. 91.7% used analgesics for treatment and 51.5% of them used analgesics voluntarily. 61.9% of them take analgesics less than once in a week. 33.6% had the phlegm syncope headache in differentiation of syndrome. In ABR-2000 results, item of graph showed low tendency mostly. Conclusions : We expected that this re port of clinical progress, differentiation of syndromes and ABR-2000 results in migraine would be used basic data by oriental medicine to treat migraine.

인공 석회화 기질의 개발 및 파골세포에 의한 기질흡수에 관한 연구

김현만,박주철,임도선,박수진,김윤지,고재승 대한구강해부학회 1997 대한구강해부학회지 Vol.21 No.1

To develop artificial matrix resorbable by osteoclasts can be used as a model system that biological function of osteoclasts would be assayed in vitro in a standardized condition instead of using heterogenous bone or dentin slices. The present study developed artificial substrates consisted of apatite crystals. collagen gen. agar, apatite crystals under collagen film, mixture of apatite crystals and collagen, and mixture of agar and apatite crystals. And osteoclastic attachement and resorption activity on the each substrate was assayed in vitro. Osteoclasts attached to apatite crystals, collagen, mixture of apatite crystals and collagen, and mixture of apatite crystals and agar, however, not to agar. This suggested that apatite crystals and collagen should be exposed on the surface of artificial substrate where osteoclasts can attach. Osteoclasts attached to the substrate resorbed the substrate consisted of apatite crystals, mixture of apatite crysals and collagen, and apatite crystals under thin film of collagen, however, not of collagen, mixture of apatite crystals and agar. This suggested that the first phase of osteoclasts in resorbing matrix is to secrete acid and the end result of this phase, whatever it may be, may activate secretion of hydrolytic enzymes specific to organic components.

유리섬유 폐재가 첨가된 플라이 애쉬계 인공경량골재의 소성특성

김도수,박종현,박병배,노재성 공주대학교 자원재활용신소재지역협력센터 2000 2차년도 센터 사업 성과집 Vol.2000 No.1

The lightweight aggregate was artificially pelletized, with use of fly ash, obtained from coal power plant, and waste glass wool as a flux, by sintering process in electrical muffle furnace. Those were fired at 1,000℃ and 1,100℃ for 3 and 6 minutes respectively. IDT(Initial Deformation Temperature) of fly ash, was appeared 1,360℃, but fly ash, when mixed with 50wt% of waste glass wool and 5wt% borax as fluxes, came into 1,156℃. Absorption ratios of sintered pellets for 24hrs had the lower values in the range of 4.3 to 6.3% than 16.8% of ILA(imported lightweight aggregate). Increasing of sintering temperature and time, absolute dry specific gravity of sintered pellet tended upward. Absolute dry specific gravity of pellet sintered at 1,000℃ for 3 minutes was 1.36 and this value was similar to that of ILA. SEM showed that the fractured surface of pellet, sintered at 1,000℃, had more fused phases in outer region rather than inner. It was shown, however, that the pellet, sintered at total pore surface was increased because large pores transfer into small pores by increasing sintering temperature.

거대첨규 콘딜로마로부터 속발된 음경암 1치험예 : A Case Report

김수현,정충식,노준,박도영,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The giant condyloma or carcinoma-like condylima is relatively rare. Although the disease is considered clinically mailgant. the possiblity of maligant changes from them are controversial even among the investigators but cannot be entirely overlooked. Most authorists consider that they get the possibility of malignant change. A case of malignancy of the penis which have apparently been transformed from giant condyloma acuminatum of the penis is herein presented with review of literature.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

급성신부전, 막성 신병증과 간염이 합병된 제2기 매독1례

김현수,박영정,엄흥식,이활연,최상봉,김상현,박원도 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Syphilis is a systemic infectious disease infected by the spirochete Treponema pallidum. It shows variable clinical manifestations. Nephrotic syndrome from secondary syphilis is a rare complication in Korea. One letter was reported before in Korea. This report describes 64-year-old male patient with syphilis presented with feature of hepatitis, acute renal failure and nephrotic syndrome. A diagnosis of secondary syphilis was done by the serologic test for syphilis. After diagnosis of syphilis, we supposed that nephrotic syndrome and hepatitis were the complication of secondary syphilis and performed a kidney biopsy. A kidney biopsy revealed membranous nephropathy characterized by subepithelial deposits involving the glomerular basement membrane and effacement of epithelial foot-process on electron microscopy. The patient was treated with intramuscular benzathine penicillin 2.4 million units. Proteinuria, renal failure, hepatitis were resolved in 3 weeks after penicillin therapy.

Lipomyces starkeyi KSM 22 Glucanhydrolase 함유 용액의 치은 섬유아세표에 대한 영향

윤현정,정현주,김옥수,김도만 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.3

A novel glucanhydrolase from a mutant of Lipomyces starkeyi KSM 22 has additional amylase activity besides mutanolytic activity and has been suggested as promising anti-plaque agent. It has been shown effective in hydrolysis of mutan, reduction of mutan formation by Streptococcus mutans and removal pre-formed sucrose-dependent adherent microbial film and has been strongly bound to hydroxyapatitie. These in vitro properties of Lipomyces starkeyi KSM 22 glucanllydrolase are desirable for its application as a dental plaque control agent. In human experimental gingivitis model and 6month clinical trial. mouthrinsing with Lipomyces starkeyi KSM 22 dextranase was comparable to 0.12% chlorhexidine mouthwash in inhibition of plaque accumulation and gingival inflammation and local side effect was negligible. This study was aimed to evaluate the cytotoxic effect of Lipomyces starkeyi KSM 22 glucanhydrolase on human gingival fibroblasts. Primary culture of human gingival fibroblasts at the 4th to 6th passages were used. Glucanhydrolase solution was made from lyophilized glucanhydrolase powder from a mutant of Lipomyces starkeyi KSM 22 solved in PBS and added to DMEM to the final concentration of 0.5, 1, and 2unit. Cells were exposed to glucanhydrolase solution or 0.1% chlorhexidine and the cells cultured in DMEM with 10% FBS and 1% antibiotics as control. After exposure, the morphological change, cell attachmcnt. and cell activity by MTT assay were evaluated in 0.5, 1.5, 3, 6, 24 hours after treatment. The cell proliferation and cell activity was also evaluated at 2 and 7days after Iminute exposure, twice a day. The cell morphology was similar between the Lipomyces starkeyi KSM 22 glucanllydrolase groups and control group during the incubation periods. while most fibroblasts remained as round cell regardless of incubation time in the chlorhexidine group. The numbers of the attached cells in the glucanhydrolase groups were comparable to that of control and significantly higher than the chlorhexidine group. The numbers of the proliferated cells in the glucanhydrolase groups at 7 days of incubation were comparable to the control group and higher than the chlorhexidine group. The cell activity in glucanhydrolase groups paralleled with the increased cell number by attachment and proliferation. According to these results, Lipomyces starkeyi KSM 22 glucanhydrolase has little harmful effect on attachment and proliferation of human gingival fibroblasts, in contrast to 0.1% chlorhexidine which was cytotoxic to human gingival fibroblasts. Therefore this glucanhydrolase preparation is considered as a safe and promising agent for new mouthwash formula in the near future.

인간 재조합 인터루긴-32 면역조절작용에 대한 유세포 분석

이광수,김영관,채정일,심정현,김은미,강형식,김수현,윤도영,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

Xenotransplantation of porcine organs has the potential to overcome the severe shortage of human tissues and organ available for human transplantation. however, it remains various hurdles for clinical xenotransplantation. In pig and mouse xenotransplantation, porcine xenograft evoke a strong cellular rejection response in immunocompetent host and grafts are destroyed within a week. This cellular immune response could involved both T cells and NK cells. A number of groups have shown that human NK cells can recognize and damage porcine endothelial cells. In addition, human T cells can respond to porcine endothelial cells through both direct and indirect mechanisms. Cellular rejection of porcine tissues requires T cells, particularly CD4^(+) cells. A new cytokine recombinant human interleukin-32α,β(IL-32α,β) has a role innate and acquired immune system. In order to investigate the role of recombinant mouse IL-18 and recombinant human IL-32α,β in xenograft rejection, we transplanted the PK(15) cells to C57BL/6 mice with or without intraperitoneal injection of recombinant mouse IL-18 or recombinant human IL-32 α,β. It was analyzed the population of NK cell, T cell and B cell in the C57BL/6 mice transplanted with PK(15) cells and recombinant mouse IL-18 or recombinant human IL-32α,β by flow cytometry analysis. As a result, lymph node and thymus of PK15/IL18, PK15/IL32α and PK15/IL32β injected group were increased to T cell activation population than normal injected groups. CD8^(+) T cells were decreased in lymph node of PK15/IL18, PK15/IL32α and PK15/IL32β injected groups. CD4^(+) T cells were increased in lymph node cell of PK15/IL32α and PK15/IL32β injected group and also, B cell population were increased in lymph node cell and spleen of PK15/IL18, PK15/IL32α and PK15/IL32β injected group. Therefore, we suggest that recombinant mouse IL-18 and recombinant human IL-32α,β suppress xenograft rejection in cellular xenotransplantation.