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Subchronic Safety Test for IonCluster<SUP>®</SUP> in Mice
Yoon Ju Cho,Young Ah Lee,Hyun Jhung Jhun,Jong Sung Kim,Robert Pyagai,Chul Ahn,Jong Woo Hong,Ki Won Jung,Jin Soo Han 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
In recent years there have been renewed interests in the use of air ionization to control the spread of airborne infection and malodor. An ion cluster is a group of 10-60 oxygen molecules. Clustered ions tend to bundle up microbes, germs and fungi. Deodorization and sterilization are achieved through those characteristics. The ion cluster turns back into a simple oxygen molecule status due to the ion equilibrium in 120 seconds. However, it remains unclear whether clustered ions are safe or not for physical and biological mechanisms. A study was, therefore, undertaken to determine the safety associated with common use of the IonCluster<SUP>®</SUP> (SUDO Premium Engineering Co., Ltd.). We installed the IonCluster<SUP>®</SUP> in supply duct of one individual ventilated cages (IVC) rack for test groups. And the animals were analyzed for body weighing, water intakes, food intakes, blood pressure, heart rate, organ weight, histopathology (cornea, trachea and lung), hematology and blood chemistry in 11 and 22 weeks, control versus treatment groups. Food intake in 9 weeks old IonCluster<SUP>®</SUP>-treated females was significantly lower than controls. Water intakes were significantly increased in 11, 18 and 19 weeks old IonCluster<SUP>®</SUP>-treated males, compared to those of controls. The levels of alkaline phosphatase in male mice and phosphorus in female mice were significantly lower than controls. There were no considerable treatment-related changes in the body weights and absolute organ weights except for the decrease in the weight of left adrenal gland of IonCluster<SUP>®</SUP>-treated males. In addition, no meaningful changes in the histopathological findings of target organs were observed in treatment groups compared to controls. This study demonstrates that IonCluster<SUP>®</SUP> does not cause any toxicological signs, and has safety by newly developed deodorizer of the air in the laboratory animal facility.
( So Yoon Ryoo ),( Suk Ha Lee ),( Seung Hyun Jo ),( Si Young Lee ),( Areum Kwak ),( Eun Som Kim ),( Jong Ho Lee ),( Jae Woo Hong ),( Hyun Jhung Jhun ),( Young Min Lee ),( Anshul Shyam Sobti ),( Soo Hy 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.3
Avascular necrosis of the femoral head (ANFH) is commonly observed in patients treated with excessive glucocorticoid (GC). Single administration of lipopolysaccharide (LPS) has shown to induce immune stimulatory factors. However, the effect of repeated administration of LPS on GC-induced ANFH has not been studied. Thus, the purpose of this study was (i) to examine the cytokine profile induced by repeated LPS administrations and (ii) to test the effect of repeated LPS treatments on GC-induced ANFH. A mouse necrosis model of ANFH was designed by chronic GC administration with co-treatment of LPS. Mice body weights in the LPS/prednisolone (PDN) co-treated group were lower than that of the untreated control group, but spleen weights were greater than the control group. The levels of IL-6, TNFα, and IL-33 in the liver and spleen of the LPS/PDN group were lower than the untreated control group, whereas TNFα level in the femoral head of the LPS/PDN group increased. Collectively, the effect of repeated LPS on the pathogenesis of GC-induced ANFH was associated with the TNFα level in the femoral head, but the pathogenesis did not correspond to cytokine levels in immune tissues.
New Establishment of International Animal Biosafety Level 3 Facility
Yoon Ju Cho,Young Ah Lee,Hyun Jhung Jhun,Ho Suk Ham,Young Duk Ju,Jin Soo Han 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
As the use of laboratory animals has increased in Korea, the need for new facilities has also grown. Today, the increased risk of handling infectious microorganisms of animals could lead to an increase in contamination of the laboratory environment and personnel. The World Health Organization (WHO) has recognized that biosafety is an important international issue; in response, the organization published the third edition of the Laboratory Biosafety Manual, 2004. More recently, the Public Health Agency of Canada published its own biosafety document, the third edition of Laboratory Biosafety Guidelines, in 2004. Additionally, the U.S. Department of Health and Human Services published the fifth edition of its Biosafety in Microbiological and Biomedical Laboratories in 2007. The National Institutes of Health, the Korea Centers for Disease Control and Prevention (KCDC) updated its Guideline for Laboratory Biosafety, concerning biosafety facilities, in May 2007. We analyzed the A-BL facilities in Canada, Australia, Japan, and the U.S.A. to compare them with our circumstances here in Korea. The Laboratory Animal Research Center of Konkuk University (KULARC) has recently established the Animal Biosafety Level-3 facility (ABL3). To ensure whether the KULARC’s A-BL3 facility was properly designed and built, we inspected it using a biosafety checklist to aid us in the process of uncovering latent defects in existing facilities, and we now believe that we have met the related guidelines. We are sure that this facility provides an excellent example to other institutions and organizations planning to build an A-BL3 facility.
Min Il-guk,Lee Kang-pa,Lee Hyeon-jae,Chang Hae-ryong,Park Won-hwan,Jhun Hyun-jhung J-INSTITUTE 2016 Kinesiology Vol.1 No.2
Cancer is one of the leading causes of death worldwide. Cancer motility plays a central role in malignant tumorigenesis. Hence, several studies have been focused on investigating effective treatments for this disease. Natural compounds are among the potential therapeutic agents against cancer. Allium tuberosum has been used in Korean traditional medicine to improve stamina, and has been recently reported to possess anti-cancer properties. In the present study, we aimed to investigate the effect of A. tuberosum juice extracts(ATS) on mi-gration and proliferation of glioma cells. The composition of ATS was determined using gas chromatography-mass spectrometry(GC/MS). Cell viability and proliferation were determined using MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), and cell migration was assessed using scratch wound-healing assay. The expression levels of proteins were determined using western blot with specific antibodies such as the extra cellular signal-regulated kinase 1/2(ERK1/2) and MMP2. Our data showed that ATS did not affect cell viability at a concentration of 300 μg/mL in C6 glioma cell lines. However, ATS significantly reduced the migration of C6 glioma cells. Moreover, ATS significantly suppressed ERK1/2 phosphorylation and MMP2 expression at dosages of 100 and 300 μg/mL. A total of 34 constituents of ATS were detected using GG/MS. Therefore, we suggest that ATS is a potential agent against glioma.