위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Ultrasoft X선을 이용한 탄수화물분해효소를 고생산하는 Lipomyces Starkeyi 돌연변이 개발 및 특성 연구

전선미,정종,노은민,김현주,김도만 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

We have isolated a carbohydrase(dextranase and amylase; DXAMase) hyper-producing constitutive mutant from Lipomyces starkeyi JLC26 using ultrasoft X-ray irradiation obtained from Pohang accelerator laboratory(PAL). After partial purification of dextranase and amylase by membrane filtration, PEG, and DEAE-Sepharose column chromatography, the specific activities of amylase and dextranase were 3193 and 2822 unit/mg, respectively. The pH effects for activity and stability of both enzymes were similar to each other: Optimum pH and temperature for activity were at 5.5 and 50℃ and optimum ranges for stability were at pH 2.5-6.0 and 4-37℃, respectively. When the enzyme and maltotriose were reacted, glucose, maltose, isomaltose, maltotriose, panose and α (1→6) glucosylmaltotriose were produced by disproportionation reaction. When the enzyme and nigerose were reacted, glucose, nigerose, new product were produced.

웹 카메라를 이용한 시설 내 국화생산 광 환경 원격 모니터링

정선옥(Sun-Ok Chung),김용주(Yong-Joo Kim),이규호(Kyu-Ho Lee),성남석(Nam-Seok Sung),이철휘(Cheol-Hwi Lee),노현권(Hyun-Kwon Noh) 충남대학교 농업과학연구소 2015 농업과학연구 Vol.42 No.4

Increase of national family income improved demand of high-quality and year-round horticultural products including chrysanthemum. To meet these demand, farmers have introduced protected facilities, such as greenhouses, of which environmental conditions could be monitored and controlled. Environment management up to three weeks after transplanting is critical for chrysanthemum quality. Artificial lighting and light-blocking screen are especially important for long-day (day period > 13 hours) and short-day (night period > 13 hours) treatments. In this study, a web-camera was installed, and the image was obtained and transmitted to mobile phones to monitor the status of 3-wavelength(RGB) lighting environments. RGB pixel values were used to determine malfunctioning of the lighting lamps, and leaking out and incoming illumination status during short-day and long-day treatment periods. Normal lighting lamps provided RGB pixel values of 240~255. During long-day treatment period, G pixel values were useful to detect abnormal lighting conditions (e.g., leaking). During short-day treatment period, R pixel values were useful to determine incoming light (e.g., sun-light). Results of this study would provide useful information for remote monitoring of light conditions for protected chrysanthemum production under artificial lights.

수학과 교육과정 실제 및 분석

김민경,노선숙,유현주,조성민,차인숙 이화여자대학교 사범대학 교과교육연구소 2001 교과교육학연구 Vol.5 No.1

21세기 지식기반사회는 자기 주도적으로 정보를 처리하고 해석하며 판단하는 능력과 지적 가치를 창조할 수 있는 능력을 길러주는 학교수학 교육을 요구하고 있다. 이에 수학교육과정에 담겨져야 할 수학적 지식의 구조․내용․범위, 지식기반 사회에 적합한 수학과 교수-학습, 평가, 교사역할 등 역시 새로운 관점에서 재조명될 필요가 있으며, 이러한 연구는 학교 현장에 대한 이해에서 출발하고 개인의 필요성과 사회의 요구를 반영한 것이어야 한다. 이에 본 연구에서는 지식기반사회에 대비하기 위한 수학과 교육과정 개발 연구의 기초 단계로 교사, 학생, 학부모를 대상으로 현장 설문 조사를 전국 규모로 실시하였다. 설문 조사는 Goodlad의 학교 교육과정 탐구의 개념적 구도를 바탕으로 한국 교육의 실정을 반영하여 설계되었다. 수학 교육과정 실체의 다양한 국면을 조사하기 위한 설문 내용은 목적 및 목표, 교과내용, 교수-학습방법, 평가, 수학적 지식의 성격, 교육정보화, 교사교육, 사교육, 교육과정일반으로 구성되었다. 본 고에서는 Goodlad의 교육과정 탐구모형과 그 모형에 기초하여 작성된 본 연구의 수학교육과정 탐구모형, 실시된 설문조사의 방법 및 절차를 소개하였고, 설문조사의 주된 결과를 토대로 수학교육과정 개발연구에의 시사점을 찾고자 하였다. This study is to provide suggestions for the development of better mathematics curriculum model of Korea based on a national survey of teachers (527), students (1314), and parents (638). It is our belief that understanding the perceptions and experiences of those involved in the process of teaching and learning of mathematics education needs to be the first priority in any effort to explore better mathematics curriculum model. For the study, Goodlad's conceptual system for curriculum inquiry has been used, but modified to take into account Korean context and the nature of mathematics curriculum. In this paper we introduce the Goodlad's curriculum inquiry model and mathematics curriculum inquiry model based on the Goodlad's conceptual system as well as the survey process. We made few recommendations from the main results of the survey for the research and development of mathematics curriculum model in Korea.

청소년기 문제행동과 부모 양육행동에 관한 연구

손석한,노경선,허묘연,정현옥,이소희,김세주 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 일반 청소년의 문제행동(내재화 문제, 외현화 문제)을 평가하고, 그들을 정상 집단과 문제행동 집단으로 나누어 집단간에 부모 각각의 양육행동이 어떠한 차이를 보이는지 알아보고자 한다. 방 법 : 서울 소재의 일반 고등학교 학생 792명을 대상으로 부모 양육행동 척도와 K-YSR을 실시하여 청소년이 지각하는 부모의 양육행동과 청소년의 문제행동을 평가하였다. 부모의 양육행동과 청소년의 문제행동과의 상관관계를 분석하였다. 학생들이 보고한 각 문제행동을 상/하위 25% tile을 기준으로 정상 집단과 문제행동 집단으로 나누어 부모의 양육행도의 차이를 분석하였다. 결 과 : 다음과 같다. 1) 부모의 애정, 합리적 설명, 감독의 긍정적인 양육행동은 대부분의 청소년 문제행동들과 유의한 부적 상관을 보였다. 반면에 학대, 과잉간섭, 과잉기대, 방임, 비일관성이 부정적인 양육행동은 문제행동들과 유의한 정적 상관이 있었다. 2)내재화 문제를 보이는 청소년들은 정상 집단에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 애정을 유의하게 더 적게 받았다고 지각하고 있었다. 외현화문제를 보이는 청소년들은 정상집단의 청소년들에 비해 부모로부터 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동을 유의하게 더 많이 받았고, 반면에 감독을 유의하게 더 적게 받았다고 지각하고 있었다. 3) 내재화 및 외현화 문제를 모두 보이는 집단이 내재화 문제만 보이는 집단과 외현화 문제만 보이는 집단에 비해서 양쪽 부모로부터 유의하게 더 많은 과잉간섭을 받을 것으로 지각하고 있었다. 또한, 내재화-외현화 집단과 내재화 집단은 외현화 집단에 비해서 어머니로부터 유의하게 더 적은 애정과 더 많은 방임을 받고 있고, 아버지로부터 유의하게 더 많은 학대를 받은 것으로 지각하고 있었다. 결 론 : 이상의 결과로 미루어 볼 때, 청소녕이 지각한 부모의 학대, 과잉간섭, 과잉기대, 방임, 비일관성의 양육행동은 청소년의 내재화 및 외현화 문제 모두와 유의한 연관이 있고, 반면에 부모의 애정, 감독, 합리적 설명의 양육행동은 다양한 청소년기 문제행동을 줄일 수 있음을 시사하고 있다. Objectives : The purpose of this study is to evaluate the problem behaviors of adolescents and to discriminate between parenting behaviors of problem behavior groups and those of non-problem behavior group. Methods : The subjects of this study were 792 high school students in Seoul. We administered 'parenting behavior Inventory' and Korean version of Youth Self-Report(K-YSR) to the subjects in order to evaluate the parenting behaviors perceived by adolescents and the problem behaviors of adolescents. We analzed the relationship between parenting behaviors and problem behaviors. We classified the subjects into problem behavior groups(internalizing group, externalizing group, internalizing-externalizing group) and a non-problem behavior(normal) group. We studied the differences of parenting behaviors among the groups. Results : The results are as follows. 1) There were significant negative correlations between the positive parenting behaviors such as affection, reasoning, and monitoring and the problem behaviors of adolescents. By contrast, there were significant positive correlations between the negative parenting behaviors such as physical abuse, intrusiveness, over-expectation, neglect, and inconsistency and the problem behaviors of adolescents. 2) Adolescents of the internalizing group perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Meanwhile, they perceived significantly less affection than normal adolescents. Adolescents of the externalizing group also perceived significantly more parental abuse, intrusiveness, over-expectation, neglect, and inconsistency than those of normal group. Also, they perceived significantly less monitoring than normal adolescents. 3) Adolescents of the internalizing-externalizing group perceived significantly more intrusiveness from both parents than those of either the internalizing or the externalizing groups. Adolescents of the internalizing-externalizing group perceived significantly less affection and more neglect from their mothers than those of the internalizing of the externalizing groups. In addition, adolescents of the internalizing-externalizing group perceived significantly more physical abuse from their fathers than those of the internalizing or the externalizing groups. Conclusion : Parenting behaviors such as abuse, intrusiveness, over-expectation, neglect, and inconsistency are associated with both internalizing and externalizing problems. In contrast, our results suggest that parenting behaviors such as affection, monitoring, and reasoning might decrease the various problem behaviors of adolescents.

LED를 이용한 복합레진의 광조사시, 중합수축의 속도와 양, 미세경도에 관한 연구

박성호,김수선,조용식,이순영,김도현,장용주,문현승,서정원,노병덕 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

This study evaluated the effectiveness of the light emitting diode(LED) units for composite curing. To compare its effectiveness with conventional quartz tungsten halogen (QTH) light curing unit, the microhardness of 2mm composite, Z250, which had been light cured by the LEDs (Ultralume LED2, FreeLight, Developing product D1) or QTH (XL 3000) were compared on the upper and lower surface. One way ANOVA with Tukey and Paired t-test was used at 95% levels of confidence. In addition, the amount of linear polymerization shrinkage was compared between composites which were light cured by QTH or LEDs using a custom-made linimeter in 10s and 60s of light curing, and the amount of linear polymerization shrinkage was compared by one way ANOVA with Tukey. The amount of polymerization shrinkage at 10s was XL3000 > Ultralume 2, 40, 60 > FreeLight, D1 (P<0.05) The amount of polymerization shrinkage at 60s was XL3000 > Ultralume 2, 60 > Ultralume 2, 40 > FreeLight, D1 (P<0.05) The microhardness on the upper and lower surface was as follows; <본문 참조> It was concluded that the LEDs produced lower polymerization shrinkage in 10s and 60s compared with QTH unit. In addition, the microhardness of samples which had been cured with LEDs was lower on the lower surfaces than the upper surfaces whereas there was no difference in QTH cured samples.