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이영진,손주한,조현철,이권순 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1
In this paper, cell-mediated immune algorithm(CMIA) controller was proposed and applied for the autonomous guided vehicle(AGV) driving. It was based on specific immune response of the biological immune system which is the cell-mediated immunity. To verify the performance of the designed CMIA controller, some experiments were performed for the control of steering and speed of AGV. And then the displacement and speed tracking error of the AGV was mainly investigated. As a result, the capability of realization and reliableness were proved by comparing the response characteristics of the classical controller with the proposed CMIA controller
우리나라 폐동맥고혈압환자에 대한 Bosentan과 Iloprost의 비용-효용 분석
손현순(Hyun Soon Sohn),이태진(Tae-Jin Lee) 대한약학회 2010 약학회지 Vol.54 No.2
This study was conducted to analyze cost-utility of bosentan versus iloprost indicated for pulmonary arterial hypertension (PAH) in a Korean healthcare setting from a payer’s perspective. We constructed a Markov model to estimate total costs and outcomes for 1-year time horizon in a hypothetical cohort of 50-year-old patients with PAH. Base analysis showed that bosentan resulted in KW 5.5 billions saving and 18 quality-adjusted life year (QALY) gains per 100 patients compared to iloprost. Bosentan as a dominant strategy was found to be robust through various sensitivity analyses.
손현순(Hyun Soon Sohn),구정선(Jung seon Koo),백드보라(Deborah Baik),김현진(Hyun Jin Kim),강혜영(Hye-Young Kang) 대한약학회 2021 약학회지 Vol.65 No.3
Medical humanities are important disciplines in the education of healthcare professionals to achieve the goal of training healthcare professionals with a deep understanding of human beings and society. In this study, we investigated the scope of humanities and social science education proposed by the accreditation criteria of healthcare professional colleges, including medical, dentistry, oriental medicine, and nursing schools in Korea. Specific curricula related to humanities education were investigated from 19 medical schools, nine dentistry schools, 12 oriental medical schools, and 18 nursing schools. The most frequently offered liberal arts courses were English and writing, while major courses included ethics, regulations, communication, psychology, history, and management. Humanities courses tend to be placed in lower grades and social sciences in higher grades, but overall, education in humanities and social studies is spread throughout the entire school grades. This result would be an important reference in designing humanities and social medicine curricula integrated with six-year pharmacy school educational programs. Subjects such as pharmacy ethics, professionalism, pharmacy communication, history of pharmacy, healthcare policies and health insurance, regional public health and health promotion, management, and evidence-based pharmacy are suggested. Further discussions on the best selection of subjects and teaching methods should be continued.
세균성결막염에 대한 안과용 플루오로퀴놀론계 항균제의 효과 : 체계적문헌고찰
손현순(Hyun Soon Sohn) 대한약학회 2011 약학회지 Vol.55 No.1
This systematic review was conducted to assess the clinical effect of ocular fluoroquinolones used for the treatment of bacterial conjunctivitis. A literature search for randomized controlled clinical trials registered up to January 2010 based on PubMed database, using the following search terms: conjunctivitis and fluoroquinolones (besifloxacin, moxifloxacin, gatifloxacin, levofloxacin, lomefloxacin, ciprofloxacin and ofloxacin) were performed. Pooled data on the clinical resolution and bacterial eradication rates derived from selected 16 studies were reported as the relative risk (RR) and 95% confidence interval (95% CI) compared with placebo. Early clinical resolution and microbiological eradication rates in placebo were 28% and 62% respectively. Fluoroquinolones were significantly effective comparing to placebo: early RR 1.94 (95% CI 1.60~2.34) and late RR 1.30 (1.19~1.43) in clinical resolution rates, and early RR 1.75 (1.58~1.94) and late RR 1.28 (1.18~1.39) in microbiological eradication rates. Besifloxacin, ciprofloaxain and moxifloxacin in clinical resolution, and besifloxacin and levofloxacin in microbiological eradication showed higher RRs than pooled overall fluoroquinolones' RRs. New quinolones had higher antibacterial potencies for all pathogens isolated from bacterial conjunctivitis and resistant isolates than old generation quinolones. In conclusion, ocular 7 fluoroquinolones were all effective than placebo for bacterial conjunctivitis and there were differences between quinolones in early and late clinical resolutions and microbiological eradications, and no differences in safety comparing to placebo.
정신신경용계 의약품의 치료군 중복처방 평가기준(안) 개발
손현순(Hyun Soon Sohn),최윤영(Yoon Young Choi),이영숙(Young Sook Lee),최경업(Kyung Eob Choi),신현택(Hyun Taek Shin) 대한약학회 2011 약학회지 Vol.55 No.3
Therapeutic duplication (TD) is frequently reported inappropriate drug use in healthcare settings in Korea. This study was aimed to develop TD criteria for psycho-nervous system drugs (KFDA classification 117 and 119). ATC classification was used to determine therapeutic and/or chemical similarities among the 93 ingredients reviewed. Clinical practice guidelines, textbooks and product labels were referenced for principles and evidences of possible drug combination usage. 16 groups that listed ingredients to be considered as TD were established and the criteria would be helpful to prevent TDs.
Efficient in vitro amplification with teflon beads of PrPCWD in CWD affected cervid
Hoo Chang Park(Hoo Chang Park),Kyung-Je Park(Kyung-Je Park),In-Soon Roh(In-Soon Roh),Hyo-Jin Kim(Hyo-Jin Kim),Tae-Young Suh(Tae-Young Suh),Hae-Eun Kang(Hae-Eun Kang),Hyun-Joo Sohn(Hyun-Joo Sohn) 한국예방수의학회 2018 한국예방수의학회 학술대회자료집 Vol.2018 No.-
Effect of genetically modified rice producing resveratrol on the soil microbial communities
Sohn, Soo-In,Oh, Young-Ju,Kim, Byung-Yong,Kweon, Soon-Jong,Cho, Hyun-Suk,Ryu, Tae-Hoon The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.6
Cultivation of genetically modified (GM) crops has rapidly increased in the global agricultural area. However, cultivation of GM crops in the field evoked the concern of the possibility of unintentional consequences from transgenic plant into environment. In our present study, we have assessed the effects of RS526, GM rice producing resveratrol on the surrounding soil microbial community. The effects of RS526 on the soil microbial community in its field of growth were assessed using a conventional culture technique and culture-independent molecular methods. Three replicate field plots were planted with single GM rice and a non-GM counterpart, Dongjin. The soil microbial communities around these plants were compared using colony counting, denaturing gradient gel electrophoresis (DGGE), pyrosequencing analysis, and community-level physiological profiling during the growing periods. The bacterial, fungal, and actinomycetes population densities of the RS526 soils were found to be within the range of those of the non-GM rice cultivar. The DGGE banding patterns of the GM and non-GM soils were also similar, suggesting that the bacterial community structures were stable within a given month and were unaffected by the presence of a GM plant. The data obtained from pyrosequencing analysis showed that the bacterial community distribution at the phylum level were highly similar to DGGE patterns between two tested groups. The substrate utilization pattern of RS526 and Dongjin rice soil was quite similar between each sampling time. These results indicate that soil microbial communities are not significantly affected by the cultivation of RS526 within the experimental time frame.