연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

반복성 혈뇨(IgA 신병증 및 non-IgA 신병증)와 알레르기성 자반증 신염의 면역지표의 변동에 관하여

현명철,고철우,구자훈 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

A prospective study was conducted to see the changes of immune system in recurrent gross hematuria(IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-Scho¨nlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices(total T, T4, T8 cells and T4/T8 ratio) and humoral immune indices (IgG, A, M and E) were measured during the hematuric and non-hematuric period. Following results were obtained. The proportion of T4 cells of peripheral blood during the hematuric period of patients with IgA nephropathy rose to 35.4±14.9% from the non-hematuric value of 20.0±9.1%. The T4/T8 ratio during hematuric period of patients with IgA nephropathy rose to 1.51±0.77 from non-hematuric value of 0.73±0.33. The values of serum IgA and IgE during hematuric period of patients with IgA nephropathy rose to 237±106 ㎎/dl, 231±226 IU/dl from non-hematuric values of 140±10, 28±23, respectively. These changes of cellular and humoral immune indices showed statistically significant differences(p<0.05). However, these changes were not found in patients with non-IgA nephropathy nor HSP nephritis. In conclusion, it can be said that the immune mechanism involved in IgA nephropathy is different from that of HSP nephritis.

긴 말뚝기초의 축하중 전이 거동에 관한 연구

김명학,이호근,이성철,김상현 인제대학교 1999 仁濟論叢 Vol.14 No.3

현행 우리 나라 말뚝 기초는 대부분 선단 지지 말뚝으로만 설계되어 말뚝 주변에서 크게 발휘되는 주변 마찰력을 무시하므로 매우 비경제적인 설계가 이루어지고 있고, 뿐만 아니라 말뚝 축하중 전이 거동은 전혀 반영하지 못한 추정 설계 (또는 예비 설계) 만이 이루어지고 있는 실정이다. 본 연구에서는 국내 외의 말뚝 설계 사례들을 각 지반 종류별로 선정하여, 이들을 APILEPLUS로 해석하여 예측된 계산치와 측정된 결과치 들을 분석하여 축하중 전이 특성을 고찰하였다. 하중 전이 실험이 수반된 말뚝 정재하 시험 결과, 주변마찰력의 전지지력에 대한 비율은 점성토의 경우 80%를 상회하였으며, 사질토의 경우 70% 정도였다. 그리고, APILEPLUS에 의한 예측 결과에 대한 마찰력 분담률은 점성토의 경우 95% 이상이었으며, 사질토의 경우 60-70% 정도였다. 말뚝 선단이 단단한 지층에 관입되어 있더라도 사질토층 이외의 지층에서는 마찰력에 의해 지지되고 있으며, 사질토층에서도 상대관입 깊이가 10 이하로 극히 작은 단말쪽이 아닌 경우에는 마찰력이 전체 극한 지지력의 20%이상을 차지하고 있었다. 따라서, 현행 설계 개념에서 무시하고 있는 마찰력을 고려한 설계를 수행할 때에 비로소 말뚝 기초의 최적화 설계가 이루어질 수 있을 것이다. Current design method on pile foundation in Korea depend highly on the estimated design method without performing the pile load test, which means most pile foundation have been designed as end-bearing capacity pile only. Due to the neglect of side shear friction capacity of pile that should be large enough to support the superstructure, the highly uneconomical and estimated design has been conducted. Thus the behavior study of axial load transfer for long piles has not been considered. In this study, several research examples with different types of soil in domestic and out of country were selected to analyze the axial load transfer, with comparison between measured results in field and estimated results by the calculated from the program APILEPLUS. The friction ratio from pile load test showed more than 80% in cohesive soils and about 70% in cohesionless soils, while from the program APILEPLUS more than 95% in cohesive soils. Even though the tip of pile penetrated into a relative hard layer, except being installed in a cohesionless soil, mostly a side friction resistance supported the pile. In case of being installed in a cohesionless soil, the friction ration was more than 20%. Therefore, the proper and economical design procedure that shall utilize both end hearing and side friction resistance should be conducted.

흉통의 양상에 따라 분류한 불안정형 협심증 환자의 임상적 소견의 비교

김명수,김성구,정호석,온영근,신원용,김철현,최태명,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background and aims : The clinical syndrome unstable angina pectoris that encompasses a variety of symptoms and clincal presentations of transient episode of myocardial ischemia, was devided to several subgroups. Also, it has variable pathophysiologic factors to cause myocardial ischemia. According to clincal presentation, coronary angiographic finding and prognostic factor, the result of unstable angina pectoris is variable. In fact, there were a few data reported on the prognosis of wide spectrum of patients with unstable angina. However, the precise risk of subgroups according to classitication has not been established because it was difficult to compare between studies. We classified unstable angina pectoris by clinical nature of chest pain, and performed to establish and compare the clinical presentations, coronary angiographic findings, treatement and prognosis of patients with unstable angina within subgroups of classification. Methods : Retrospenctive data for 164 unstable angina pectoris patients admitted to the Internal Cardiology Division of Soon Chun Hyang University Hospital from May 1996 to July 1999 was analyzed. The patients were classified into one of the following categories: Class I, new onset of severe angina; Class II, acceleration of previous chronic stable angina; Class III, angina at rest. Clinical presentations, echocardiographic findings, coronary angiographic findings, treatment and prognosis were compared. Results : From the total 164 patients, the subjects of classes were as follows : Class I, 46 cases (28.1%); Class II, 74 cases (45.1%); Class III, 44 cases (26.8%). In view of age distribution, the 7th decade had the highest incidence, and then, 6th, 8th decades were followed. There was no baseline differences among the 3 classes with respect to gender, number of risk factors. Significantly, class II showed more severe findings in abnormal Q wave 15 cases (20.8%), total occclusive lesion 10 cases (20.8%) and three vessel coronary disease 11 cases (22.9%) than other classes. The change of ST segment was significantly apparent (p<0.02) among class I 28 cases (60.8%), class III 26 cases (59.0%), comparing with class II 30 cases (40.5%). Class III had the higher incidence of one vessel coronary artery disease than class I and III. The heparin treatment was performed in 99 cases (60.1%). The incidence of nonfatal myocardial infarction was much more in class I and III, each 4 cases (8.7%, 9.8%) than in class II 1 cases (1.4%). In-Hospital death was occurred in class I and II, each 1 case. Conclusion : The patients with the acclerated angina from chronic stable angina had more severe coronary artery disease than other classes, but they had better in-hospital prognosis.

음향방출 센서를 이용한 세라믹 가공 상태 감시

한명철,김정관,허승현,김성렬,김찬봉 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

The acoustic emission (AE) sensor has been widely used for monitoring the machining states or tool abrasion, etc. This paper presents the relation between machining time and states such as tool abrasion for ceramic machining processes, which can be applicable to develop the dentistry machining center. A commercial PZT-type of AE sensor was used for experiments, and the aquisition data was analyzed in the AE signal strength versus machining time. The results show that it is possible to estimate the tool life and the ceramic machining state. In the future, additional experiments for various machining conditions such as depth of cut and feed rate are strongly necessary so as to design an effective monitoring system for the ceramic machining processes through detecting the AE signal.

김해지역 토질특성에 관한 연구

이성철,김상현,장원일,김명학 인제대학교 1999 仁濟論叢 Vol.15 No.1

김해와 그 인근지역의 공학적 토질특성을 파악하고자 하는데 목적을 두었다. 그러나 전 지역에 걸쳐 조사하기는 불가능하기에 강서경기장부근 지역을 중심으로 해서 직접 조사해 보았고 그 외 몇몇 자료를 참고했다. 김해지역은 옆으로는 낙동강과 아래로는 바다를 끼고 있어서 하성 및 해성 충적층이 발달되어 있기 때문에 자연함수비가 상당히 높고 지반이 매우 연약하며 세립질 흙이 아주 많은 것을 알수 있다. 보링된 시료에서 직접 조사해보면 자갈의 함유는 극히 미비하고 대신 조개껍질이 많이 발견된다. 또한 흙의 특성이 다른 지역의 그것과 많은 차이를 보이고 있기 때문에 독특한 이름을 가진 흙들이 많다. 그것은 이미 1969년에 농업을 목적으로한 토양도 제작을 위해 조사를 실시한 결과 붙여진 이름들이다. 액성한계는 보통 27∼34%인데 자연함수비는 보통 28∼50%로 대개 액성한계를 훨씬 넘어선 범위에 있다. 비중은 2.60∼2.71정도였다. Soil properties of Kimhae area were investigated, especially focused at the area of Kangseo athletic complex. Natural water content of soil in Kimhae area was very high and the shear strength was very weak due to the soil composition of silty and clayey minerals deposited in river and marine alluvium. Boring samples showed that most of soil Bayer was silt and silty clay partly mixed with shell debris. The test results showed that the range of natural water content was 28 to 50 per cent, which was over the range of liquid limit (27 to 34 per cent). Also the specific gravity of soil was 2.60 to 2.71.

배소 어류의 N-nitrosamine 함량

김수현,오명철 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

The contents of N-nitrosamines and its precursors such as TMAO-N, TMA-N, DMA-N, nitrite-N and nitrate-N after broiling of sea-bream, Filefish, and Squid upon gas range were investigated. The contents of TMAO-N decreased remarkably in all tested fishes after broiling. TMA-N increased approximately 5 and 4 times in squid and sea-bream, respectively. DMA-N increased in all tested fishes after broiling, and especially showed the highest in squid. Nitrate-N descreased in all tested fishes after broiling, while nitrite-N increased. N-nitrosamines detected in broiled fishes were NDMA and NDEA. The contents of NDMA were in the range of 9.5~14.1μg/kg and NDEA were 1.2~2.5 ㎍/kg.

육류의 배소 방법에 따른 N-nitrosamine 함량에 관한 연구

김수현,오명철,오창경 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

The contents of N-nitrosamines and its precursors such as TMAO-N, TMA-N, DMA-N, nitrite-N and nitrate-N after broiling of beef-ribs, pork-ribs and chicken upon gas range and charcoal fire were investigated. The contents of TMAO-N, TMA-N and DMA-N no changed in all tested meats before and after broiling, and were in the range of N.D-0.77mg/kg, N.D- 2.57mg/kg and 0.02 - 0.06mg/kg, respectively. Nitrate-N discreased and Nitrite-N increased after broiling, and the contents were in the range of 4.0-6.7mg/kg and 0.7-3.2mg/kg, respectively. N-nitrosamines detected NDMA and NDEA in the broiled meats, and the contents were in the range of 5.9 ~ 20.9 ㎍/kg and 0 ~ 3.0 ㎍/kg respectively.

만성 폐쇄성 폐질환 환자에서 장기간의 스테로이드 복용 중 발생한 중증 분선충 감염 1예

하원철,이영현,하경임,안명희 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Strongyloides stercoralis is a soil-transmitted intestinal nematode that may cause long-lived auto-infection in the host. It is distributed worldwide, especially in the tropical and subtropical regions, but has been rarely reported in Korea. Chronic infections by S. stercoralis are mostly inapparent infections that carry nonspecific gastrointestinal and pulmonary symptoms. However, In immunocompromised patients such as those receiving long-term steroid therapy and patients with AIDS or malignant tumors, S. stercoralis can induce hyperinfection by autoinfection. This may lead to increased rate of complications such as resistance to chemotherapy and sepsis, In such cases mortality rate of up to 87% has been reported. We report a case of severe strongyloidiasis in a patient with chronic obstructive pulmonary disease who was receiving long-term steroid therapy. The chief complaint was repeated dyspnea and hematochezia, and strongyloidiasis was diagnosed by the presence of rhabditiform larvae of S. stercoralis in the fecal smear and isolation of filari-form larvae from the stool culture. The patient developed septic shock during treatment with albendazole and showed clinical signs of hyperinfection of S. stercoralis. He eventually died despite aggressive treatment.