연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

반복성 혈뇨(IgA 신병증 및 non-IgA 신병증)와 알레르기성 자반증 신염의 면역지표의 변동에 관하여

현명철,고철우,구자훈 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

A prospective study was conducted to see the changes of immune system in recurrent gross hematuria(IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-Scho¨nlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices(total T, T4, T8 cells and T4/T8 ratio) and humoral immune indices (IgG, A, M and E) were measured during the hematuric and non-hematuric period. Following results were obtained. The proportion of T4 cells of peripheral blood during the hematuric period of patients with IgA nephropathy rose to 35.4±14.9% from the non-hematuric value of 20.0±9.1%. The T4/T8 ratio during hematuric period of patients with IgA nephropathy rose to 1.51±0.77 from non-hematuric value of 0.73±0.33. The values of serum IgA and IgE during hematuric period of patients with IgA nephropathy rose to 237±106 ㎎/dl, 231±226 IU/dl from non-hematuric values of 140±10, 28±23, respectively. These changes of cellular and humoral immune indices showed statistically significant differences(p<0.05). However, these changes were not found in patients with non-IgA nephropathy nor HSP nephritis. In conclusion, it can be said that the immune mechanism involved in IgA nephropathy is different from that of HSP nephritis.

육류의 배소 방법에 따른 N-nitrosamine 함량에 관한 연구

김수현,오명철,오창경 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

The contents of N-nitrosamines and its precursors such as TMAO-N, TMA-N, DMA-N, nitrite-N and nitrate-N after broiling of beef-ribs, pork-ribs and chicken upon gas range and charcoal fire were investigated. The contents of TMAO-N, TMA-N and DMA-N no changed in all tested meats before and after broiling, and were in the range of N.D-0.77mg/kg, N.D- 2.57mg/kg and 0.02 - 0.06mg/kg, respectively. Nitrate-N discreased and Nitrite-N increased after broiling, and the contents were in the range of 4.0-6.7mg/kg and 0.7-3.2mg/kg, respectively. N-nitrosamines detected NDMA and NDEA in the broiled meats, and the contents were in the range of 5.9 ~ 20.9 ㎍/kg and 0 ~ 3.0 ㎍/kg respectively.

입원한 기분장애 소아청소년의 임상특성 : 주요 우울증과 양극성장애의 우울삽화 비교를 중심으로

임명호,조수철,백기청,이경규,김현우,홍강의 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.2

본 연구는 소아청소년에서의 우울증 및 조울증의 우울삽화에 대한 임상특성을 알아보고자 하였다. 1993년 3월 1일부터 1999년 10월 31일까지 ○○대학교 어린이 병원 소아청소년 정신과에 입원하였던 34명의 우울증 환아와 17명의 조울증 우울삽화 환아를 대상으로 병록지 기록을 통해서 이들의 사회인구학적 특성, 진단적 분류, 입원시 주 증상 및 문제점, 증상의 빈도, 주산기 모 병력과 아동기 발달력, 공존정신 질환 및 신경 심리학적 검사 가족의 임상적 특성, 가족 정신병리 및 가족 병력, 치료반응등에 대하여 조사하였다. 1) 우울증에서 남자의 비율이 여성의 경우보다 높았으며, 조울증 우울삽화에서는 남녀의 비율이 비슷하였다. 2) 평균 발병 연령은 조울증 우울삽화에서 14.1세, 우울중에서 12.8세로 우울증에서 일찍 발병하는 양상을 나타냈으며, 입원 횟수에 있어서는 조울증 우울삽화에서 우울증에 비해서 많았다. 3) 조울증 우울삽화와 우울증 모두에서 식물증상의 호소가 신체증상보다 많았으며, 자살사고 증상은 우울증에서, 공격적인 증상은 조울증 우울삽화에서 많았고, 정신병적 증상에서는 망상은 우울증에서 환각은 조울증 우울삽화에서 많이 나타났다. 4) 두 집단 모두에서 불안장애가 가장 많이 동반되었으며, 신체형 장애, 정신지체, 인격장애 등이 동반되었다. 5) 조울증 우울삽화와 우울증 모두 높은 가족력을 보였고, 특히 우울증은 아동 학대력과 가족의 부적절한 양육과 관련성을 보였다. 성인에서 조울증과 우울증이 분명한 임상적 차이를 갖고있는 것처럼 소아에서도 조울증 우울삽화와 우울증은 발병연령, 신체증상 및 식물증상을 비롯한 임상증상의 차이, 공존질환 등에서 서로 다른 임상 양상을 나타내었다. 중심 단어 : 주요 우울증ㆍ우울 삽화ㆍ임상 특성. The purpose of this study is to find out the characteristics of depressive episode about major depression and bipolar disorder in child and adolescent. The subjects of this study were 34 major depression patients and 17 bipolar disorder patients hospitalized at child and adolescent psychiatry in ○○ university children's hospital from 1st March 1993 to 31st October 1999. The method of this study is to review socio-demographic characteristics, diagnostic classification, chief problems and symptoms at admission, frequency of symptoms, maternal pregnancy problem history, childhood developmental history, coexisting psychiatric disorders, family psychopathology and family history and therapeutic response through their chart. 1) The ratio of male was higher than that of female in major depressive disorder while they are similar in manic episode, bipolar disorder. 2) Average onset age of bipolar disorder was 14 years 1 month and it was 12 years 8 months in the case of major depression As a result, average onset age of major depression is lower than that of bipolar disorder. 3) The patients complained of vegetative symptoms than somatic symptoms in both bipolar disorder and depressive disorder. Also, the cases of major depression developed more suicide idea symptom while the case of bipolar disorder developed more aggressive symptoms. In the respect of psychotic symptoms, delusion was more frequently shown in major depression, but halucination was more often shown in bipolar disorder. 4) Anxiety disorder coexisted most frequently in two groups. And there coexisted symptoms such as somartoform disorder, mental retardation and personality disorder in both cases. 5) The influence of family loading was remarkable in both cases. Above all, the development of major depression had to do with child abuse history and inappropriate care of family. It is apparent that there are distinctive differences between major depression and bipolar disorder in child and adolescent through the study, just as in adult cases. Therefore the differences of clinical characteristics between two disorders is founded in coexisting disorders and clinical symptoms including onset age, somatic symptoms and vegetative symptoms. KEY WORDS : Major depressive disorderㆍDepressive episodeㆍClinical characteristics.

齒科技工士의 健康障碍 呼訴와 關聯要因 分析

朴明子,南喆鉉 대한보건협회 2000 대한보건연구 Vol.26 No.1

The objective of this study was to obtain fundamental data for the development of health educational program about prevention of occupation- related disease and promotion of health among dental technicians. The subjects were 339 dental technicians who were working in 159 dental laboratories, Teagu area. A survey with a questionnaire was conducted from June, 15, 1998 to August, 15. 1998. 30 examiners were trained for the questionnaires surveys. The questionnaires composed of general characteristics, occupational characteristics, health life, working condition(such as stress, wearing protector, working posture), health knowledge. Subjects were also asked about experience on health complaints during last 1 year. The obtained results were as follows: (1) The distribution of subjects were male(88.5%), married(53.7%). The most characteristics were twenties(46.9%), below than 4 years of work duration(34.5%), other technicians(53.3%), all works of working part(17.4%), above 10 hours in a day of working time(68.2%). The 4 health life, 7 hours of sleep on the average were 35.7%, who regularly exercise were 25.3%, who drink 1-2 times per week were 42.8%, 3-4 times were 28.9%. (2) Health complaints by general characteristics, occupational characteristics, health life were significantly different as follows: Eye symptoms by gender(p<0.01), duration of work(p<0.05), position(p<0.05), working part(p<0.05), working time(p<0.05), hours of sleep(p<0.05); Ear symptoms by hours of sleep(p<0.05), exercise(p<0.05);General symptoms by gender(p<0.05), position(p<0.05), smoking(p<0.05);Dermal symptoms by age(p<0.05), marital status (p<0.05), position(p<0.01);Musculoskeletal symptoms by gender(p<0.05), age(p<0.01), duration of work(p<0.05), position(p<0.05), workingtime(p<0.05), exercise(p<0.05), smoking(p<0.05);Digestive symptoms by gender(p<0.01), age(p<0.05), duration of work(p<0.05), position(p<0.01), alcohol consumption(p<0.05);Respiratory symptoms by working part(p<0.01), exercise(p<0.05), smoking(p<0.05). (3) In the correlation of health complaints and stress, working posture, wearing protector, the stress was factor which had positive correlation to all symptoms (p<0.01), the working posture was factor which had positive correlation to general psymptoms(p<0.05), dermal symptoms(p<0.05), musculoskeletal symptoms(p<0.01). (4) In the correlation of health complaints and health knowledge were as follows: The knowledge level of occupation-related disease was factor which had positive correlation to eye symptoms(p<0.05), ear symptoms(p<0.01), general symptoms(p<0.05), musculoskeletal symptoms(p<0.015), digestive symptoms(p<0.05), respiratory symptoms(p<0.05). The knowledge level of work hazard was factor which had positive correlation to all symptoms(p<0.001). (5) In the regression analysis, The factors which affected health complaints were as follows: Eye symptoms were gender(β=0.4542), position(β=0.3409), hours of sleep(β=0.1733), alcohol consumption(β=0.2824), stress(β=0.2871), knowledge level of work hazard(β=0.2262), explained them by 13.4%. Ear symptoms were stress(β=0.4447), knowledge level of occupation related disease(β=0.1492), explained them by 11.3%. General symptoms were gender(β=0.2685), position(β=0.3196), stress(β=0.3570), explained them by 19.6%. Dermal symptoms were position(β=0.1437), stress(β=0.2734), explained them by 15.6%. Musculoskeletal symptoms were position(β=0.2411), stress(β=0.1335) explained them by 23.3%. Digestive symptoms were gender(β=0.3402), marital status(β=0.2073), position(β=0.2461), stress(β=0.2850), explained them by 17.7%. Respiratory symptoms were smoking(β=0.1851), stress(β=0.4542), knowledge level of work hazard(β=0.1780), explained them by 15.0%.

성토사면에 적용된 Soil Nailing의 주면마찰특성 연구

이성철,김명학,김상현,윤성학 인제대학교 2001 仁濟論叢 Vol.16 No.1

Soil Nailing 공법은 사면안정을 목적으로 보강재를 사용하여 지반을 보강하는 현장 지반보강 공법의 일종이다. 지금까지는 일반적으로 Soil nailing이 주로 절토사면을 보강하는 기술로 사용되고 연구되어 왔으나 본 논문에서는 붕괴된 사면에 재성토를 시행한 현장에 대한 보강공법으로서의 적용성을 연구하였다. 이를 위하여 네일에 스트레인 게이지를 부착하고 현장인발실험을 수행하여 최대인발하중을 조사하고 각 지층에서 발휘되는 단위 주면마찰력을 산정하였다. 그리고 본 연구에서 얻어진 겉보기 평균 주면마찰력을 일반적인 절토사면에서 현장인발실험을 수행한 다른 사례의 겉보기 평균주면마찰력과 비교분석해 보았다. Soil nailing is in-situ ground improvement technique of reinforcing soils using passive inclusions for the purpose of slope stability. Also soil nailing, in general, was used and studied as a reinforcement technique at cut slope, but this paper presents the results of study for soil nailing application as a reinforcement technique at the banking over slided slope. In-situ pull-out tests of nails, instrumented with strain gauges, were performed to investigate the maximum pull-out load and to calculate the unit side resistance in each different layer, And the apparent average unit side resistance of this study was compared with that of other sites installed at cut slop.

방사선치료 후 영구치 치배 발육장애 증례보고 : REPORT OF CASE

강명봉,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

두경부 악성 종양에 대한 방사선치료는 유용한 방법이다. 하지만 방사선치료의 부작용으로 다양한 구강내 합병증을 동반한다. 이 글에서 치열 발육 단계에 방사선치료를 받은 두 증례를 보고하는 바이다. 첫 번째 증례는 생후 19개월에 급성 골수성 백혈병으로 진단 받아 방사선치료를 받은 7세 여자 환아로 영구치 치배의 선천적 결손과 왜소치 소견을 보였다. 두 번째 증례에서는 생후 13개월에 양측성 망막아세포종으로 진단 받아 방사선치료를 받았고 영구치 치배의 선천적 결손, 왜소치, 치근의 저형성 그리고 법랑질 저형성증 소견을 보였다. Radiotherapy for head and neck tumors is a viable treatment modality. However, a wide range of potentially debilitating dental complications may be accompanied by this treatment. We report two cases of developmental disturbance of permanent tooth germs after radiotherapy. The one was that of a seven-year-old girl, who had congenitally missing teeth, and microdontia of permanent tooth germs. she had received radiotherapy for acute myelocytic leukemia at the age of 19 months. The other was that of a nine-year-old boy, in which congenitally missing teeth, microdontia, root hypoplasia, and enamel hypoplasia of permanent teeth were observed. He had undergone a course of radiotherapy for bilateral retinoblastoma at the age of 13 months.

긴 말뚝기초의 축하중 전이 거동에 관한 연구

김명학,이호근,이성철,김상현 인제대학교 1999 仁濟論叢 Vol.14 No.3

현행 우리 나라 말뚝 기초는 대부분 선단 지지 말뚝으로만 설계되어 말뚝 주변에서 크게 발휘되는 주변 마찰력을 무시하므로 매우 비경제적인 설계가 이루어지고 있고, 뿐만 아니라 말뚝 축하중 전이 거동은 전혀 반영하지 못한 추정 설계 (또는 예비 설계) 만이 이루어지고 있는 실정이다. 본 연구에서는 국내 외의 말뚝 설계 사례들을 각 지반 종류별로 선정하여, 이들을 APILEPLUS로 해석하여 예측된 계산치와 측정된 결과치 들을 분석하여 축하중 전이 특성을 고찰하였다. 하중 전이 실험이 수반된 말뚝 정재하 시험 결과, 주변마찰력의 전지지력에 대한 비율은 점성토의 경우 80%를 상회하였으며, 사질토의 경우 70% 정도였다. 그리고, APILEPLUS에 의한 예측 결과에 대한 마찰력 분담률은 점성토의 경우 95% 이상이었으며, 사질토의 경우 60-70% 정도였다. 말뚝 선단이 단단한 지층에 관입되어 있더라도 사질토층 이외의 지층에서는 마찰력에 의해 지지되고 있으며, 사질토층에서도 상대관입 깊이가 10 이하로 극히 작은 단말쪽이 아닌 경우에는 마찰력이 전체 극한 지지력의 20%이상을 차지하고 있었다. 따라서, 현행 설계 개념에서 무시하고 있는 마찰력을 고려한 설계를 수행할 때에 비로소 말뚝 기초의 최적화 설계가 이루어질 수 있을 것이다. Current design method on pile foundation in Korea depend highly on the estimated design method without performing the pile load test, which means most pile foundation have been designed as end-bearing capacity pile only. Due to the neglect of side shear friction capacity of pile that should be large enough to support the superstructure, the highly uneconomical and estimated design has been conducted. Thus the behavior study of axial load transfer for long piles has not been considered. In this study, several research examples with different types of soil in domestic and out of country were selected to analyze the axial load transfer, with comparison between measured results in field and estimated results by the calculated from the program APILEPLUS. The friction ratio from pile load test showed more than 80% in cohesive soils and about 70% in cohesionless soils, while from the program APILEPLUS more than 95% in cohesive soils. Even though the tip of pile penetrated into a relative hard layer, except being installed in a cohesionless soil, mostly a side friction resistance supported the pile. In case of being installed in a cohesionless soil, the friction ration was more than 20%. Therefore, the proper and economical design procedure that shall utilize both end hearing and side friction resistance should be conducted.

배소 어류의 N-nitrosamine 함량

김수현,오명철 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

The contents of N-nitrosamines and its precursors such as TMAO-N, TMA-N, DMA-N, nitrite-N and nitrate-N after broiling of sea-bream, Filefish, and Squid upon gas range were investigated. The contents of TMAO-N decreased remarkably in all tested fishes after broiling. TMA-N increased approximately 5 and 4 times in squid and sea-bream, respectively. DMA-N increased in all tested fishes after broiling, and especially showed the highest in squid. Nitrate-N descreased in all tested fishes after broiling, while nitrite-N increased. N-nitrosamines detected in broiled fishes were NDMA and NDEA. The contents of NDMA were in the range of 9.5~14.1μg/kg and NDEA were 1.2~2.5 ㎍/kg.