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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
김원,임경수,오병연,홍은석,김영식,김선만,이부수,현석천,김영득 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4
Background: The initial history, physical examination, and ECG assessment should focus on identification of potentially serious noncardiac or cardiac disorders, including coronary artery disease, congestive heart failure, and electrical instability at the emergency room. additionally, it is essential to define disease severity, stability and need for emergency therapy. echocardiography is a useful tool for this purpose. especially Doppler echocardiography may be more sensitive and time-saving diagnostic tool for the evaluation of patients presenting with cardiogenic symptoms. So we evaluate the feasibility of the echocardiographic measurement by emergency physicain after short-term course. Method and Results: Twenty volunteers(10 male, 38.8±9.3 years) were included in the study for measurement of myocardial performance index and established parameters of ventricular function using conventional echo-Doppler methods. Myocardial performance index: (ICT+IRT)/ET, was obtained by subtracting ejection time(ET) from the interval between cessation and onset of the mitral inflow velocity to give the sum of isovolumic contraction time(ICT) and isovolumic relaxation time(IRT). The most of mean values of echocardiogrphic parameters were not significantly different between those of cardiologist and those of emergency physicians(p<0.01). The duration for measuring myocardial performance index was shortest among echocardiographic parameters. the validity of echocardiographic parameters measured by emergency physicians was proved relatively good. Conclusion: It is proved to be feasible for emergency physician to perform echocardiographic evaluation of ventricular function after short-term course
일렬 자가조혈모세포이식을 받은 다발성 골수종 환자에서 발생한 뇌 톡소포자충증 1례
김계형,송경호,전재현,박완범,박상원,김홍빈,김남중,김인호,오명돈 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant recipients, usually associated with allogeneic hematopoietic stem cell transplantation (HSCT). We report a case of cerebral toxoplasmosis in a patient with multiple myeloma, following tandem autologous stem cell transplantation. A 55-year-old Korean male presented with weakness in both legs that had progressed to both arms. A magnetic resonance imaging scan of the brain revealed multiple, variablesized ring-enhancing lesions with surrounding edema in the cerebral hemispheres and brain stem. Stereotactic biopsy revealed bradyzoites of Toxoplasma gondii in the brain tissue. The patient received trimethoprim-sulfamethoxazole, followed by pyrimethamine and sulfadiazine, accompanying treatment for progressive multiple myeloma. Cerebral toxoplasmosis should be considered as one of the differential diagnoses in patients with neurologic signs following autologous HSCT.
김현경(Kim Hyun Kyoung),권정심(Kwon Jung Sim) 한국유아교육·보육복지학회 2008 유아교육·보육복지연구 Vol.12 No.3
본 연구는 유아교사의 자아분화와 정서신념에 관한 상관성을 알아보고자 유아 교사 186명을 대상으로 하여 Bowen(1986)이 개발하고 제석봉(1989)과 김원금(2004)이 사용한 자아분화 검사도구와 Hyson과 Lee(1996)가 개발한 정서신념 평가 척도(Caregiver"s Beliefs About Feelings, CBAF)를 검사도구로 하여 연구하였다. 연구결과 유아교사의 자아분화와 정서신념 수준은 3.73과 3.23으로 각각 중간보다 다소 높은 수준을 보였으며, 자아분화 수준은 유아교사의 경력에 따라서 차이가 없었으나, 정서신념에 있어서는 유의한 차이가 있었으며, 유아교사의 자아분화수준과 정서신념 간에는 높은 상관관계가 있는 것으로 나타났다. 특히 유아교사의 자아분화 하위 요소 중 인지적 기능 대 정서적 기능, 정서적 단절 가족 퇴행, 사회적 퇴행은 정서신념과 매우 유의한 상관성이 있는 것으로 나타났다. 이러한 연구결과는 가족 체계적 관점에서 볼 때 유아교사의 성장과정에서 얻게 되는 원가족 경험이 유아교사의 개인적 경험에 국한되기보다는 유아교사의 전문적 지식 구성에 영향을 미치는 것으로 유아교사의 자아 분화 촉진을 위한 교사 지원 프로그램의 기초자료로 활용할 시사점을 제공해 준다고 볼 수 있다. The objective of this research is to scrutinize the relativity between the level of kindergarten teachers" differentiation of self based on base family and belief about emotion. The sample group of this research is 186 public and private kindergarten teachers in Seoul or Gyeonggi area. Self-differentiation measurement tool which Bowen developed and Jae-seckbong(1989), Kim-wangum(2004) used and assessment scale of belief about emotion which Hyson and Lee developed is revised, complemented and then used. The results showed that they had higher levels of self-differentiation than average (M=3.73), and their belief about emotion (M=3.23). According to the result, the level of self-differentiation based on kindergarten teachers" career back ground is not different but the level of belief about emotion, based on kindergarten teachers" career is significantly different. Relation between kindergarten teachers" self-differentiation and belief about emotion is closely related. It was found that especially cognitive functions vs. emotional functions, emotional rupture, family regression and social regression among kindergarten teachers" self-differentiation factors are significantly related to sub factors of belief about emotion, This finding shows that from the perspective of family system, kindergarten teachers" experience of base family affects professional knowledge of kindergarten teachers beyond the limitation of kindergarten teachers" personal experience and can be used as preliminary data of teachers supporting program for kindergarten teachers" self-differentiation.
RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
복합섬유의 고속방사에 있어서 섬유구조형성(Ⅱ) : LLDPE/PET 복합의 효과 Effects of LLDPE/PET Bicomponent System
김경효,조현혹,장정대 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-
sheath-core형 복합섬유를 고속용융방사하여 방사속도에 따른 섬유구조의 변화를 검토하였다. 복합섬유는 폴리에틸렌테레프탈레이트(PET) 및 2종류의 선상 저밀도폴리에틸렌(LLDPE), 즉 융체유동속도(MFR)가 45, 50인 것을 사용하여 LLDPE를 sheath에 PET를 core에 배치하였다 고속방사된 복합섬유중의 각 성분의 구조형성을 복굴절, 광각X선회절 및 열분석 등으로 검토한 결과, PET성분을 단독으로 고속방사한 경우에 비해 LLDPE의 MFR에 상관없이 LLDPE/PET 복합섬유중의 PET성분은 약 1km/min 낮은 방사속도에서 배향결정화가 일어나 PET성분의 섬유구조형성은 촉진되었으며, LLDPE성분의 섬유구조형성은 LLDPE 단독으로 방사한 경우에 비해 억제됨을 확인하였다. High-speed melt spinning of sheath-core type bicomponent fibers was performed and the change of fiber structure with increasing take-up velocity was investigated. Three kinds of polymers, poly(ethylene terephthalate) (PET), linear low-density polyethylene(MFR=45) (LLDPE(45)) and linear low-density polyethylene(MFR=50) (LLDPE(50)), were selected and two sets sheath/core combinations, LLDPE(45)/PET and LLDPE(50)/PET(i.e. sheath/core), were studied. The structure of each component in high-speed spun bicomponent fibers was analyzed through the birefringence, wide-angle X-ray diffraction measurements and DSC thermogram measurements. The development of molecular orientation and the initiating of the orientation-induced crystallization of PET in LLDPE/PET bicomponent fibers occurred at lower take-up velocities regardless of the type of LLDPE as compared to those in the single component spinning. The fiber structure formation of LLDPE component in LLDPE/PET bicomponent fibers was suppressed as compared to that in the single component spinning.