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지주막낭종이 동반된 신경섬유종증 환자에서 발생한 유도성 동적 안구돌출
조영준,이성복,권현조,남기엽,이연희,Young Joon Jo,Sung-Bok Lee,Hyon Jo Kwon,Ki Yup Nam,Yeon-Hee Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.1
Purpose: To report a case of proptosis occurring during a Valsalva maneuver in a neurofibromatosis patient with an arachnoid cyst. Case summary: A 42-year-old man diagnosed with type I neurofibromatosis visited our hospital with a 20-year history of enophthalmos in the left eye. The patient also complained of exophthalmos during the abdominal straining. On exophthalmometry, a 4 mm enophthalmos was found. The patient also presented with a limited motion to the superior and lateral direction. There was an ocular pulsation corresponding to the heart rate. During the Valsalva maneuver, a marked exophthalmos of the left eye occurred. The patient had light brown spots on the skin of the face and body trunk. Following an orbital computed tomography (CT), defects of the left sphenoid bone were present. Posteriorly, an arachnoid cyst was found; however, there was a lack of varix. The archnoid cyst was also observed to expand into the orbit during the Valsalva maneuver and forward the globe. Conclusions: To date, cases of proptosis occurring during a Valsalva maneuver by causes other than orbital varix are rare. Herein, the authors report a case with a review of literature. J Korean Ophthalmol Soc 2011;52(1):93-96
CoCl₂ 처리로 유도된 hypoxia상태에서 세포자살과 ER stress에 관련된 인자의 발현
Seon-Hwan Kim(김선환),Hyon-Jo Kwon(권현조),Hyeon Song Koh(고현송),Shi-Hun Song(송시헌),Kisang Kwon(권기상),O-Yu Kwon(권오유),Seung Won Choi(최승원) 한국생명과학회 2010 생명과학회지 Vol.20 No.12
PC12 세포에서 CoCl₂에 의한 hypoxia 유도는 HIF1 alpha의 상승 발현으로 확인하였다. 이때 apoptosis의 유도는 genomic DNA의 fragmentation과 apoptotic body는 Hoechst 염색으로 확인되었고, ER luminal chaperone의 발현 및 ER stress signal에 관여하는 ER membrane kinase인 IRE1, PERK, ATF6의 발현도 확인되었다. 이들이 apoptosis로 연결되는 고리 역할을 하는 IRE1-XBP1 mRNA splicing, PERK-eIF2 alpha, ATF6 protein cleavage도 반응하는 것으로 확인되었다. 위의 결과는 신경세포의 hypoxia상태는 ER stress signal pathway를 거쳐서 apoptosis가 된다는 것을 증명한 것으로 신경세포의 hypoxia치료를 위한 기초 자료가 될 것으로 생각한다. Cobalt(Ⅱ) chloride, a chemical compound with the formula CoCl₂, has been widely used in the treatment of anemia, as a chemical agent for the induction of hypoxia in cell cultures, and is known to activate hypoxic signaling. However, excessive exposure to cobalt is associated with several clinical conditions, including asthma, pneumonia, and hematological abnormalities, and can lead to tissue and cellular toxicity. It is also known to induce apoptosis. One of the questions was that of whether CoCl₂ might induce apoptosis via endoplasmic reticulum (ER) stress in neurons. To address this question, first, the level of DNA fragmentation was measured for assay of apoptotic rates using CoCl₂ with neuron PC12 cells. After confirmation of apoptosis inductions, under the same conditions, the expression levels of ER stress associated factors [ER chaperones Bip, calnexin, ERp72, ERp29, PDI, and ER membrane kinases (IRE1, ATF6, PERK)] were examined by RT-PCR and Western blotting. These results indicated that apoptosis is induced through activation of ER membrane kinases via ER stress. In conclusion, during induction of apoptosis through CoCl₂-induced hypoxia in neuron PC12 cells, ER membrane kinase of IRE1 was dominantly up-expressed, and, consecutively, TRAF2, which has been suggested to be one of the links connecting apoptosis and ER stress, was strongly up-expressed.
후두개와 수술 후 경막 하 콜라겐 매트릭스 이식술의 뇌척수액 유출 방지에 대한 효용성
정은오(Eun-Oh Jeong),김선환(Seon-Hwan Kim),임정욱(Jeong-Wook Lim) 권현조(Hyon-Jo Kwon),최승원(Seung-Won Choi),고현송(Hyeon-Song Koh),염진영(Jin-Young Youm),송시헌(Shi-Hun Song) 대한두개저학회 2016 대한두개저학회지 Vol.11 No.2
Objective : Complete protection from CSF(cerebrospinal fluid) leakage after posterior fossa surgerywas difficult, although many variable methods has been performed. Collagen matrix is product toprotect dura defect and prevent CSF leakage. The authors performed collagen matrix underlay graftand identified effectiveness of this technique for CSF sealing.Methods : The authors evaluated 92 posterior fossa surgery used fibrin glue, polyethylene glycol(PEG) sealant, fibrinogen based collagen fleece, collagen matrix between January 2006 andDecember 2015. CSF leakage incidence according to use of variable dura sealing materials wasassessed.Results : CSF leakage occurred 8 cases(8.7%) in 92 posterior fossa surgery. CSF leakage didn’toccur in 42 cases underwent collagen matrix underlay graft. Cases of fibrin glue, polyethyleneglycol(PEG) sealant, fibrinogen based collagen fleece had effect of CSF leakage block, howeverdidn’t have significant difference according to use of this materials.Conclusion : Collagen matrix underlay graft after posterior fossa surgery didn’t have complicationsuch as chemical injury and infection and had effect of CSF sealing.