http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
송인선,이정림,나효석,신지나,하광수,Song, In-Sun,Lee, Jeong-Lim,Na, Hyo-Seok,Shin, Ji-Na,Ha, Kwang-Su 대한한방소아과학회 2004 대한한방소아과학회지 Vol.18 No.2
Objectives : Alopecia is a physical problem. also it makes psychological damage in childhood. Alopecia may be an obstruction in the social life. We tried Oriental medical cure on this disease. Method : We used herbal medicine, acupuncture, scalp acupuncture therapy to increase the root of hair and hair. Result : After treatments, patient's scalp has the root of hair and hair in some parts. But not all parts. Conclusion : we think that Oriental medical cure is effective on Alopecia. The more study is needed.
증례보고 : 예상 못한 측두하악관절의 해부학적 변이로 인해 마취 유도 중에 발생한 개구 장애
배진호 ( Jin Ho Bae ),나효석 ( Hyo Seok Na ),김건 ( Geon Kim ),김경원 ( Kyoung Won Kim ),임승운 ( Seung Woon Lim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.6
A 36-year-old woman with an unremarkable medical history presented for laparoscopic cholecystectomy. Routine preoperative assessment of the patient`s airway revealed normal jaw opening. Upon induction of anesthesia, her jaw locked in a nearly closed position. X-ray and MRI of the temporomandibular joints that were taken postoperatively showed normal findings except for the steeper posterior angles of the articular eminences. During the next induction of anesthesia, intubation was readily accomplished by opening the mandible with a forward pulling of the chin. (Korean J Anesthesiol 2006; 51: 738~41)
증례보고 : 우측 개흉술 중에 긴장성 기흉으로 인해 발생한 심정지
유승문 ( Seung Moon Ryu ),나효석 ( Hyo Seok Na ),배진호 ( Jin Ho Bae ),홍종면 ( Jong Myeon Hong ),임승운 ( Seung Woon Lim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.6
Tension pneumothorax during one-lung ventilation is an insidious, life threatening emergency. Even though early diagnosis and rapid intervention are necessary to prevent mortality, treatment may be difficult because of the clinical diagnosis-mediastinal shift, hypoxemia, hypotension and increased airway pressure may be confusing in the operative setting. We present here the case of a patient who underwent right thoracotomy with one-lung ventilation and the patient developed left tension pneumothorax with resulting cardiac arrest. (Korean J Anesthesiol 2006; 51: 756~9)
Effects of Tianeptine on The Activity of Glutamate Transporter EAAT3 Expressed in Xenopus Oocytes
Bon-Wook Koo(구본욱),Hyo-Seok Na(나효석),Jung-Hee Ryu(유정희),Jung-Seok Choi(최정석),Sang-Hwan Do(도상환),Zhiyi Zuo(주오지이) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.3
배경:티아넵틴(tianeptine)은 최근 주목받고 있는 항우울제로 기존의 모노아민 항우울제(monoaminergic antidepressants)와 달리 케타민(ketamine)과 같이 글루타메이트(glutamate)의 신경전달에 영향을 미치는 것으로 알려져 있다. 글루탐산염 전달체, 특히 흥분성 아미노산 전달체 3형(Excitatory Amino Acid Transporter 3, EAAT3)에 대한 연구가 계속되어 왔지만 티아넵틴이 EAAT3에 미치는 영향에 대한 연구는 부족하다. 방법:개구리(Xenopus laevies) 난모세포에 EAAT3의 mRNA를 세포질내 주입하여 발현시킨 후, 2개의 전극을 이용한 전압클램프를 사용하여 L-glutamate 투여 전, 중, 후로 막전위를 측정하였다. 반응값은 막전위의 변화를 적분하여 구하였으며, microcoulomb 단위로 제시하였다. 데이터는 평균 ± 표준오차로 표기하였다. 결과:티아넵틴은 EAAT3의 활성도를 농도의존적으로(0.1~100μM) 감소시켰으며 1mM 티아넵틴을 72시간 동안 노출 시켰을 때 Km(27.0±7.6 vs. 23.3±4.9mM, n=84, p=0.72)의 변화없이 Vmax(6.9±0.6 vs. 4.8±0.3mC, n=84, p<0.05)를 유의미하게 줄였다. 결론:개구리 난모세포에 티아넵틴을 72시간 동안 노출시켰을 때 농도의존적으로(1~100mM) EAAT3의 활성도를 감소시켰다. 이번 연구의 결과는 티아넵틴이 EAAT3의 이용 가능한 수나 회전률을 감소시킴으로써 활성도를 감소시키는 것을 시사한다. Objectives : Tianeptine is an antidepressant that has drawn attention recently. Unlike traditional monoaminergic antidepressants, tianeptine is known to affect glutamate neurotransmission like ketamine. However, there has been paucity of studies investigating the role of tianeptine on glutamate transporters, especially excitatory amino acid transporter type 3 (EAAT3). Methods : After expression of EAAT3 by intracellular injection of EAAT3 mRNA, we investigated the effect of tianeptine on the activity of EAAT3, by measuring membrane current in response to L-glutamate administration using Xenopus oocyte expression system and two-electrode voltage clamps. Results : Tianeptine (1mM for 72h) significantly reduced Vmax (6.9±0.6 vs. 4.8±0.3mC, n=14-22, p<0.05) without changing Km (27.0±7.6 vs. 23.3±4.9mM, n=14-22, p=0.72). Conclusion : When tianeptine was exposed for 72h, it decreased the activity of EAAT3 in a concentration-dependent manner (1-100mM). Our results suggest that tianeptine decreases EAAT3 activity by reducing the available number or turnover rate of EAAT3.
자가조절 진정을 이용한 기관지 내시경술에서 Midazolam 전투여가 환자 만족도에 미치는 영향
권원경 ( Won Kyoung Kwon ),최은수 ( Eun Su Choi ),김지영 ( Ji Young Kim ),박상리 ( Sang Ri Park ),나효석 ( Hyo Seok Na ),박상헌 ( Sang Hyun Park ),박희평 ( Hee Pyoung Park ),전영태 ( Young Tae Jeon ),황정원 ( Jung Won Hwang ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.1
Background: Patient-controlled sedation (PCS) with propofol is a safe and effective method of attenuating discomfort during fiberoptic bronchoscopy. The purpose was to evaluate the usefulness of midazolam in addition to PCS for fiberoptic bronchoscopy. Methods: We randomly assigned 155 patients undergoing diagnostic bronchoscopy to two groups. Group M (n=79) received 0.03 mg/kg of midazolam for premedication while group P (n=76) received a loading dose (0.05 ml/kg) of PCS solution composed of 200 mg (20 ml) of propofol and 1 mg (2 ml) of alfentanil. Both groups received the PCS solution 0.2 ml/kg/hr with a bolus of 1 ml and a lockout time of 1 min. Vital signs, pulmonologist satisfaction, patient satisfaction and amnesia were evaluated. Results: After the insertion of the bronchoscope, there was a slight decrease of SpO2 and an increase of blood pressure and heart rate in both groups with no significant differences between the two groups. The group P required more bolus injections (1.6±1.7 in the group M vs 2.5±2.2 in group P; P<0.05). There was no difference in the satisfaction of pulmonologists, but the satisfaction of patients was higher in the group M (P<0.05). More patients in the group P (93%) remembered the procedure than in the group M (70%) (P<0.05). Conclusions: PCS is an effective method for sedating patients undergoing fiberoptic bronchoscopy and midazolam provides more patient satisfaction and amnesia. (Korean J Anesthesiol 2009;56:1~5)
Midazolam 전투약이 목표농도 조절방식으로 투여되는 Propofol과 Rocuronium 작용 발현에 미치는 영향
구의경 ( Eui Kyoung Goo ),정철희 ( Cheol Hee Jung ),김환희 ( Hwan Hee Kim ),소윤미 ( Yun Mi So ),나효석 ( Hyo Seok Na ),박희평 ( Hee Pyoung Park ),전영태 ( Young Tae Jeon ),황정원 ( Jung Won Hwang ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Background: This clinical study was designed to evaluate the effect of midazolam as a premedication on the onset of propofol and rocuronium during propofol target-controlled infusion (TCI). Methods: Seventy four patients (ASA class I or II) were randomly allocated to receive either no premedication (control group) or premedication with 0.04 mg/kg intravenous midazolam (midazolam group). Anesthesia was induced and maintained with propofol TCI. Time from propofol injection to loss of consciousness (LOC) and estimated effect concentration at LOC were recorded. After LOC, rocuronium (0.6 mg/kg) was injected. We monitored the degree of neuromuscular blockade by acceleromyography. The following parameters were measured and compared between groups: Time from rocuronium injection to depression of twitch height below 25%, time to maximal depression of twitch height (defined as rocuronium onset time). Results: Systolic blood pressure before induction was lower in midazolam group (125±15 vs 135±20 mmHg), however, there was no difference in blood pressure at LOC between groups (111±16 vs 106±21 mmHg). In midazolam group, time to LOC in propofol TCI was shorter (63±22 vs. 203±118 sec) and estimated effect site concentration of propofol was significantly lower than control group (0.9±0.3 vs. 2.2±0.4 μl/ml). The onset time of rocuronium was not different between groups (120±39 vs. 137±42 sec). Conclusions: Midazolam pretreatment fastens the onset time of propofol and decreases the propofol requirement for LOC. However, it does not influence the onset of rocuronium. (Korean J Anesthesiol 2009;57:434∼7)
증례보고 : 자궁내시경적 근종제거술 동안 발생한 저나트륨혈증
김환희 ( Hwan Hee Kim ),황진영 ( Jin Young Hwang ),전영태 ( Young Tae Jeon ),황정원 ( Jung Won Hwang ),도상환 ( Sang Hwan Do ),나효석 ( Hyo Seok Na ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.5
Hysteroscopy is frequently used to assist the diagnosis and treatment of a series uterine diseases. However, complications associated with the procedure including fluid overload, hyponatremia, hypo-osmolality, hemorrhage, uterine perforation, and air embolism have been reported. The incidence of fluid overload with hyponatremia during hysteroscopic procedures has been reported to be up to 6% and it can probe fatal. Thus, early recognition of this condition and prompt intervention thereof is important to prevent adverse sequelae. Here, we report a case of hyponatremia with incidental fluid overload during hysteroscopy. We detected the signs of complication early on and were thus able to manage it promptly without any resulting adverse sequelae. (Korean J Anesthesiol 2009;57:629∼32)