http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Urate-lowering Efficacy and Safety of Febuxostat in Korean Patients with Gout
( Sung Hwan Park ),( Yeong Wook Song ),( Won Park ),( Eun Mi Koh ),( Bin Yoo ),( Soo Kon Lee ),( Dae Hyun Yoo ),( Yun Jong Lee ),( Hyun Ah Kim ),( Hyo Jin Choi ),( Ho Youn Kim ),( Hyong Gi Jung ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.4
Objective. To compare the urate-lowering efficacy and the safety of febuxostat, allopurinol and placebo in Korean patients with gout for 4 weeks. Methods. Subjects (n=182) with gout were randomized to febuxostat (40, 80, 120 mg), allopurinol 300 mg, or placebo group. The primary end point was the proportion of subjects whose serum urate concentration fell to less than 6.0 mg/dL after the 4-week treatment. Results. The primary end point was reached at 25.7%, 80.0% and 83.3% of patients receiving 40, 80 and 120 mg of febuxostat, respectively, 58.3% of those receiving 300 mg of allopurinol and none of the placebo (p<0.001: each febuxostat dose or allopurinol group versus placebo group, p=0.0484 and p=0.0196: febuxostat 80 and 120 mg compared with allopurinol, respectively). The number and proportion of subjects who developed adverse events (AEs) were 13 subjects (37%), 14 (39%) and 18 (50%) in the febuxostat of 40, 80 and 120 mg group, respectively, 21 (57%) in the allopurinol 300 mg group and 17 (46%) in the placebo group. No statistically significant differences in the incidence rates of adverse events were observed between the groups. There was no significant difference in gout flare-up incidence. Conclusion. Febuxostat, 80 mg or 120 mg, was more effective than allopurinol (300 mg) or placebo, when lowering the serum urate. The safety of febuxostat and allopurinol was comparable.
Improvement of Nonalcoholic Fatty Liver Disease Reduces the Risk of Type 2 Diabetes Mellitus
Hyo Jung Cho,Sunhyuk Hwang,Jong Ik Park,Min Jae Yang,Jae Chul Hwang,Byung Moo Yoo,Kee Myung Lee,Sung Jae Shin,Kwang Jae Lee,Jin Hong Kim,Jae Youn Cheong,,Sung Won Cho,Soon Sun Kim 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.4
Background/Aims: Little evidence is available about the effect of change in nonalcoholic fatty liver disease (NAFLD) status on risk of diabetes mellitus (DM) development. In this study, we tried to analyze the DM risk according to change in NAFLD status over time. Methods: Among a total of 10,141 individuals for whom routine healthcare assessment was performed, 2,726 subjects were selected according to the inclusion/exclusion criteria. NAFLD status change was determined by using serial abdominal ultrasonography and fatty liver index (FLI) during the follow-up period. Results: Subjects were categorized according to change in NAFLD status as follows: 670 subjects in the persistent NAFLD group, 155 subjects in the resolved NAFLD group, 498 subjects in the incident NAFLD group, and 1,403 subjects in the no NAFLD group. Multivariate Cox regression analysis revealed that incident NAFLD (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.08 to 3.50; p=0.026) and persistent NAFLD (HR, 3.59; 95% CI, 2.05 to 6.27; p<0.001) were independent risk factors for predicting DM development, whereas the risk with resolved NAFLD was not significantly different from that with no NAFLD. FLI could reproduce the results acquired by ultrasonography. Conclusions: This study demonstrated that future DM risk could be influenced by changes in NAFLD status over time. Resolution of NAFLD could reduce the risk of future DM development, while the development of new NAFLD could increase the risk of DM development.
Yoo, Hyo-Sang,Kim, Yong-Ho,Jung, Chang-Gi,Lee, Sang-Chan,Lee, Seong-Hee,Son, Hyeon-Taek American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.10
<P>Effects of Mn addition on microstructure and mechanical properties of as-cast and as-extruded Al0.15Si0.2Fe0.3Cu0.15ZnxMn alloys were investigated. After the as-cast billets were kept at 400 degrees C for 1 hr, hot extrusion was carried out with a reduction ratio of 38:1. Mn addition to Al0.15Si0.2Fe0.3Cu0.15Zn based alloys resulted in the formation of Al6(Fe, Mn) and Al15(Fe, Mn)(3)Si-2 intermetallic compounds and grain refinement. With increasing of addition of Mn, yield strength and ultimate tensile strength was increased and maximum value of yield strength and ultimate strength was 29 and 96 MPa at 2.1 Mn containing alloy, respectively. In the tensile properties at 420 degrees C, Mn containing intermetallic compounds plays an important role for the improvement of strength and elongation due to grain refinement and suppression of grain growth by the formation of thermally stable Mn containing intermetallic compounds.</P>
Yoo, Keon Hee,Lee, Soo Hyun,Sung, Ki Woong,Koo, Hong Hoe,Chung, Nak Gyun,Cho, Bin,Kim, Hack Ki,Kang, Hyoung Jin,Shin, Hee Young,Ahn, Hyo Seop,Baek, Hee Jo,Han, Dong Kyun,Kook, Hoon,Hwang, Tai Ju,Kim, Wiley Subscription Services, Inc., A Wiley Company 2011 American journal of hematology Vol.86 No.1
<P><B>Abstract</B></P><P>We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (<I>n</I> = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (<I>n</I> = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 10<SUP>7</SUP>/kg and 2.00 × 10<SUP>5</SUP>/kg, respectively. The median times to neutrophil (>0.5 × 10<SUP>9</SUP>/L) and platelet recovery (>20 × 10<SUP>9</SUP>/L) were 18 and 45 days, respectively. Grade 2–4 acute graft‐versus‐host‐disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty‐five patients developed CMV disease. The 5‐year overall and event‐free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation‐based conditioning (<I>P</I> = 0.007), salvage transplant (<I>P</I> = 0.001), failure to achieve early complete chimerism (<I>P</I> < 0.0005), and CMV disease (<I>P</I> = 0.001). The outcomes of the single‐ and double‐unit UCBT (<I>n</I> = 64) were similar, while double‐unit recipients were heavier (<I>P</I> < 0.0005) and older (<I>P</I> < 0.0005). We conclude that double‐unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%. Am. J. Hematol., 2011. © 2010 Wiley‐Liss, Inc.</P>
Reduced Mitochondrial Properties in Putative Progenitor/Stem Cells of Human Keratinocytes
( Sung Eun Chang ),( Young Mi Kim Pak ),( Hae Woong Lee ),( Jee Ho Choi ),( Eun Jeong Jeong ),( Seung Ho Choi ),( Hyo Won Chang ),( Yoo Sam Chung ),( Sang Yoon Kim ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.4
Background: The characterization of progenitor/keratinocyte stem cells (KSC) remains an unachieved goal. A previous study showed that rapid adhering cells to collagen IV had the characteristics of putative progenitor/KSCs. Objective: The purpose of this study was to investigate the genetic expression of rapid adhering cells compared to non adhering cells to determine the characteristic of KSCs. Methods: We isolated rapid adhering cells representative of KSCs from non adhering cells representative of transient amplifying cells. In addition, we differentiated cells from human tonsilar keratinocytes utilizing the adhering capability of the KSCs to collagen IV. Annealing control primer based differentially displayed polymerase chain reaction (PCR) was performed as well as Western blot analysis. Results: The levels of mitochondria- related gene expression were low in the rapid adhering cells compared to the non adhering cells. Mitochondrial complex I, COX IV, peroxiredoxins (I, II and IV) and mitochondrial membrane potential were all low in the rapid adhering cells compared to the non adhering cells. Conclusion: Using an adhesion method on human collagen IV-coated plates, our results suggest that reduced mitochondrial function may be an important characteristic of KSCs. (Ann Dermatol 21(4) 364~368, 2009)