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Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
Moon Hyeyeon,Suh Sunghwan,박미경 대한의학회 2023 Journal of Korean medical science Vol.38 No.2
During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year-old female patient who developed hyperglycemia after the second dose of COVID-19 mRNA-based vaccination without a prior history of diabetes. She visited our hospital with uncontrolled hyperglycemia despite administration of oral hyperglycemic agents. Her initial glycated hemoglobin level was high (11.0%), and fasting serum C-peptide level was normal. The fasting serum C-peptide level decreased to 0.269 ng/ mL 5 days after admission, and the anti-glutamic acid decarboxylase antibody was positive. The patient was discharged in stable condition with insulin treatment. To our knowledge, this is the first case of the development of type 1 diabetes without diabetic ketoacidosis after mRNA-based COVID-19 vaccination, and is the oldest case of type 1 diabetes development under such circumstances.
Hyeyeon Boo,So Yun Kim,Eui Sun Seoung,Min Hyung Kim,Moon Young Kim,류현미,You Jung Han,Jin Hoon Chung 대한의학유전학회 2018 대한의학유전학회지 Vol.15 No.2
Purpose: This study aimed to evaluate the clinical usefulness of non-invasive prenatal testing (NIPT) as an alternative testing of invasive diagnostic testing in pregnancies with ultrasound abnormalities. Materials and Methods: This was a retrospective study of pregnant women with abnormal ultrasound findings before 24 weeks of gestation between April 2016 and March 2017. Abnormal ultrasound ἀndings included isolated increased nuchal translucency, structural anomalies, and soft markers. The NIPT or diagnostic test was conducted and NIPT detected trisomy 21 (T21), T18, T13 and sex chromosomal abnormalities. We analyzed the false positive and residual risks of NIPT based on the ultrasound ἀndings.Results: During the study period, 824 pregnant women had abnormal ultrasound ἀndings. Among the study population, 139 patients (16.9%) underwent NIPT. When NIPT was solely performed in the patients with abnormal ultrasound ἀndings, over-all false positive risk was 2.2% and this study found residual risks of NIPT. However, the discordant results of NIPT differed ac-cording to the type of abnormal ultrasound ἀndings. Discordant results were signiἀcant in the group with structural anomalies with 4.4% false positive rate. However, no discordant results were found in the group with single soft markers. Conclusion: This study found different efἀcacy of NIPT according to the ultrasound ἀndings. The results emphasize the im-portance of individualized counseling for prenatal screening or diagnostic test based on the type of abnormal ultrasound.
( Laura Hyeyeon Boo ),( Jeong Kyu Hoh ),( Eun Hyun Lee ),( Young Sun Park ),( Moon Il Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The purpose of this study was to compare and analyze differences in antepartal fetal heart rate (FHR) parameters, non-linear indices, and perinatal outcomes between fetuses of normal and fetal distress at delivery. We surveyed all non-stress test (NST) data acquired using a computerized FHR analysis system at Hanyang University Hospital between 2003 and 2010, and selected 725 cases (fetal distress without any other complications=25 cases and normal 700 cases). NSTs were performed between 38 and 42 weeks of gestation, and all cases were delivered in 2 weeks after NST. Perinatal outcomes were compared, and FHR parameters analyzed using a linear method and a non-linear method using approximate entropy (ApEn), correlation dimension (CD), and short-term/ long-term scaling exponents (α1/ α2). One and 5 minutes Apgar scores (Ap1/Ap5) of fetal distress group were significantly lower than those of normal group (Ap1, 5.92±1.85 vs 6.89±0.73, p=0.0151; Ap5, 6.44±1.45 vs 8.87±0.58, p<0.0001). Other perinatal outcomes and NST parameters showed no significant difference between two groups. Non-linear indices (ApEn, CD, and α2) were significantly different in two groups (ApEn, 0.71 ± 0.18 vs 0.91 ± 0.13, p<0.0001; CD 3.49 ± 0.40 vs 3.83 ± 0.27, p=0.0003; α2, 0.91 ± 0.06 vs 0.86 ± 0.05, p=0.0016, respectively). Compared to normal fetuses, fetal distress cases at delivery show a difference in that the irregularity and complexity of the heart rate dynamics are decreased in antepartal NST, although no differences of FHR parameters between two groups. A more apparent difference is that the long-term fractal correlation of the fetal heart is increased and the fetal heart is smoother in the long-term scale.
Boo, Hyeyeon,Kim, So Yun,Seoung, Eui Sun,Kim, Min Hyung,Kim, Moon Young,Ryu, Hyun Mee,Han, You Jung,Chung, Jin Hoon Korean Society of Medical Genetics and Genomics 2018 대한의학유전학회지 Vol.15 No.2
Purpose: This study aimed to evaluate the clinical usefulness of non-invasive prenatal testing (NIPT) as an alternative testing of invasive diagnostic testing in pregnancies with ultrasound abnormalities. Materials and Methods: This was a retrospective study of pregnant women with abnormal ultrasound findings before 24 weeks of gestation between April 2016 and March 2017. Abnormal ultrasound findings included isolated increased nuchal translucency, structural anomalies, and soft markers. The NIPT or diagnostic test was conducted and NIPT detected trisomy 21 (T21), T18, T13 and sex chromosomal abnormalities. We analyzed the false positive and residual risks of NIPT based on the ultrasound findings. Results: During the study period, 824 pregnant women had abnormal ultrasound findings. Among the study population, 139 patients (16.9%) underwent NIPT. When NIPT was solely performed in the patients with abnormal ultrasound findings, overall false positive risk was 2.2% and this study found residual risks of NIPT. However, the discordant results of NIPT differed according to the type of abnormal ultrasound findings. Discordant results were significant in the group with structural anomalies with 4.4% false positive rate. However, no discordant results were found in the group with single soft markers. Conclusion: This study found different efficacy of NIPT according to the ultrasound findings. The results emphasize the importance of individualized counseling for prenatal screening or diagnostic test based on the type of abnormal ultrasound.
( Jeong Kyu Hoh ),( Laura Hyeyeon Boo ),( Eun Hyun Lee ),( Moon Il Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The aim of this study was to determine whether an interval cerclage reduced preterm delivery in those women who had undergone an emergency transvaginal cerclage due to dilated cervix and/or protruding fetal membrane with labor. A retrospective cohort study was conducted on women with a transvaginal cervical cerclage who also went over the interval cerclage. Sixteen cases underwent a transvaginal cerclage and composed the 7 cases of interval cerclage group, whereas 9 others without interval cerclage, only elective cerclage group due to bad obstetric history. Interval cerclage was performed to patients who previously had emergency cerclage due to symptoms of impending preterm delivery at a distance of time. Antibiotics and prophylactic tocolysis were given to all patients. Neonatal outcomes and perinatal complications were analyzed between two groups. Mean initial cervical length before the first surgery was 0.07 cm in interval cerclage group and 4.3 cm in elective cerclage group. Cervical length before second surgery in interval cerclage group was 1.94 cm. Of all 16 cases, no fetal loss was found during present pregnancy. Mean delivery weeks was 35+0 weeks in interval cerclage group while 35+1 weeks in elective cerclage group (p=0.4981). Mean birth weight in interval cerclage group was 1920.0 g and 2145.0 g in elective cerclage group (p=0.2901). Apgar score (1/5 min) was 6/8 in interval cerclage group and 6/8 in elective cerclage group (p=1.000). Other neonatal outcomes and perinatal complications were not different between two groups as well. It is thought that interval cerclage might be a good emergent surgical procedure that can be used in preventing preterm delivery in patients with incompetent internal os of cervix having preterm labor.
( Jeong Kyu Hoh ),( Laura Hyeyeon Boo ),( Eun Hyun Lee ),( Young Sun Park ),( Kyung Joon Cha ),( Moon Il Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The purpose of this study was to compare and analyze differences in maternal oxygen saturation (SpO2), blood pressure (BP), and heart rate (HR) when non-stress test (NST) was performed, according to the fetal reactivity. We selected 8 non-reactive and 119 reactive cases from total NST acquired using a computerized FHR analysis system at Hanyang University Hospital in 2012. Maternal SpO2, BP, and HR were recorded simultaneously when NST was performed. NSTs were performed between 31 and 42 weeks of gestation. Perinatal outcomes were compared, and FHR parameters analyzed. Statistical analysis was performed by Median test or Fisher`s exact test. General characteristics between two groups were not different. NST parameters showed no significant difference between two groups except the amplitude (29.73 vs 24.35; p=0.0274). Maternal BP and HR showed no significant difference between two groups, however, SpO2 showed a statistical difference (96.90 vs 97.23; p=0.0269). Neonatal outcomes between two groups were not different. It might be thought that maternal SpO2 was related to the fetal heart rate reactivity. Further studies would be needed for clarifying our result.