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Kim, Yukyung,Kim, Saerona,Noh, Seonmyeong,Kim, Semin,Park, Geunsu,Le, Thanh-Hai,Han, Hyunwoo,Kim, Yoong Ahm,Yoon, Hyeonseok Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.353 No.-
<P><B>Abstract</B></P> <P>A non-covalent approach to prepare nanotube-containing gels was developed based on the physical gelation of two polymers, polyvinyl alcohol (PVA) and polyacrylonitrile (PAN), with different microphase behaviors in water/dimethyl sulfoxide (DMSO) mixture. Single-walled carbon nanotubes (SWNTs) were incorporated into the binary-polymer/binary-solvent system to alter the physical gelation behavior and, in turn, to achieve unique physicochemical characteristics of the resulting gels. SWNTs were wrapped with PVA, which extended the binary polymer system to a ternary polymer system consisting of PVA bound to SWNTs, free PVA, and PAN. It was observed that the SWNT/PVA/PAN ensembles gelled with appropriate amounts of water in DMSO and the gelation behavior was reversible. The amounts of water and SWNT were determined to be key parameters affecting the formation of the gels. The SWNT/PVA/PAN gels were successfully converted to carbonaceous gels via heat treatment in an inert atmosphere, which can be extended to several applications such as electrode materials. The macroporous carbonaceous gels were further functionalized via manganese deposition followed by potassium hydroxide activation, which yielded excellent cell performance in a neutral electrolyte with the energy density of 9.6–24.8 Wh kg<SUP>−1</SUP> and power density of 8.0–0.1 kW kg<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of co-nonsolvents on the microstructure of the gel was demonstrated. </LI> <LI> The SWNT-mediated physical gelation of binary polymer blends were reported. </LI> <LI> Physically cross-linked gels were converted to versatile electrode materials. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Muscle Synergy Analysis for Stroke During Two Degrees of Freedom Reaching Task on Horizontal Plane
Hyeonseok Kim,Jongho Lee,Jaehyo Kim 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.2
This study aimed to investigate muscle synergies from major muscles that contribute to each degree of freedom (DOF) in a low DOF task with trunk restraint during a fundamental reaching task used frequently in daily life. Seven non-patients (controls) and eleven stroke patients (mild or severe groups) in Brunnstrom stage 2–4 recovery were assessed. Subjects performed two DOF reaching tasks requiring motor coordination of the elbow and shoulder on the horizontal plane. Electromyography signals were measured during the task, and muscle synergy data extracted from them were analyzed using cluster analysis. No significant differences were noted between patients with stroke and healthy subjects in terms of the coefficient of determination, R-squared, determined according to the number of modules. Cluster analysis revealed that each of the clusters in the control and mild groups was governed by one channel. However, one cluster in the severe group was governed by two channels. When the clusters of the mild group and the control group were compared, the highest similarities (all values exceeded 0.9) were noted between the corresponding clusters of the two groups. All other similarity values were < 0.8. A similar trend was noted when the severe group clusters were compared with control group clusters; however, only three corresponding pairs of clusters exhibited similarity values exceeding 0.9, while the rest were < 0.8. Muscle synergies during the two DOF reaching tasks with trunk restraint showed differences in extensors between healthy individuals and patients with stroke.
Kim, Young-Joo,Jeon, Youngsic,Kim, Taejung,Lim, Won-Chul,Ham, Jungyeob,Park, Young Nyun,Kim, Tae-Jin,Ko, Hyeonseok Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.4
<P><B>Abstract</B></P> <P>The epithelial–mesenchymal transition (EMT) is an important cellular process during which polarized epithelial cells become motile mesenchymal cells, which promote cancer metastasis. Ginger, the rhizome of Zingiber officinale, is extensively used in cooking worldwide and also as a traditional medicinal herb with antioxidant, anti-inflammatory and anticancer properties. Several pungent compounds have been identified in ginger, including zingerone, which has anticancer potential. However, the role of zingerone in EMT is unclear. We investigated the synergistic effect of zingerone and its derivative on EMT. Transforming growth factor-beta 1 (TGF-β1) induces the EMT to promote hepatocellular carcinoma metastasis, including migration and invasion. To understand the repressive role of the combination of zingerone and its derivative (ZD 2) in hepatocellular carcinoma metastasis, we investigated the potential use of each compound of ginger, such as zingerone, ZD 2 and 6-shogaol, or the mixture of zingerone and ZD 2 (ZD 2-1) as inhibitors of TGF-β1 induced EMT development in SNU182 hepatocellular carcinoma cells <I>in vitro</I>. We show that ZD 2-1, but not zingerone, ZD 2 and 6-shogaol significantly increased expression of the epithelial marker E-cadherin and repressed Snail upregulation and expression of the mesenchymal marker N-cadherin during initiation of the TGF-β1 induced EMT. In addition, ZD 2-1 inhibited the TGF-β1 induced increase in cell migration and invasion of SNU182 hepatocellular carcinoma cells. Furthermore, ZD 2-1 significantly inhibited TGF-β1 regulated matrix metalloproteinase-2/9 and activation of Smad2/3. We also found that ZD 2-1 inhibited nuclear translocation of NF-κB, activation of p42/44 MAPK/AP1 signaling pathway in the TGF-β1 induced EMT. Our findings provide new evidence that combined treatment with ZD 2, novel zingerone derivative, and zingerone synergistically suppresses hepatocellular carcinoma metastasis <I>in vitro</I> by inhibiting the TGF-β1 induced EMT.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Young‐,Joo,Kim, Han‐,Cheon,Ko, Hyeonseok,Amor, Evangeline C.,Lee, Jong Wha,Yang, Hyun Ok Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.2
<P><B>Abstract</B></P><P>We identified a chalcone, 2′,4′‐dihydroxy‐6′‐methoxy‐3′‐methylchalcone (stercurensin), as an active compound isolated from the leaves of <I>Syzygium samarangense</I>. In the present study, the anti‐inflammatory effects and underlying mechanisms of stercurensin were examined using lipopolysaccharide (LPS)‐stimulated RAW264.7 cells and mice. To determine the effects of stercurensin in vitro, inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) expression were analyzed by RT‐PCR and immunoblotting. Nuclear factor‐κB (NF‐κB) activation and its upstream signaling cascades were also investigated using a dual‐luciferase reporter assay, electrophoretic mobility shift assay, immunoblotting, immunofluorescence, and immunoprecipitation. To verify the effects of stercurensin in vivo, the mRNA expression levels of iNOS and COX‐2 were evaluated in isolated mouse peritoneal macrophages by quantitative real‐time PCR, and the production of tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and IL‐1β were assessed in serum samples from mice using a Luminex system. Pretreatment with stercurensin reduced LPS‐induced iNOS and COX‐2 expression, thereby inhibiting nitric oxide (NO) and prostaglandin E<SUB>2</SUB> production, respectively. In addition, an inhibitory effect of stercurensin on NF‐κB activation was shown by the recovery of LPS‐induced inhibitor of κB (I‐κB) degradation after blocking the transforming growth factor‐β‐activated kinase 1 (TAK1)/I‐κB kinase signaling pathway. In mouse models, stercurensin negatively regulated NF‐κB‐dependent pro‐inflammatory mediators and cytokines. These results demonstrate that stercurensin modulates NF‐κB‐dependent inflammatory pathways through the attenuation of TAK1–TAB1 complex formation. Our findings demonstrating the anti‐inflammatory effects of stercurensin in vitro and in vivo will aid in understanding the pharmacology and mode of action of stercurensin. J. Cell. Biochem. 112: 548–558, 2011. © 2010 Wiley‐Liss, Inc.</P>