고립성 폐결절의 조직학적 진단에 있어서 경기관지폐생검의 진단적 가치

김치훈,김정주,왕준호,연규민,김형수,리원연,용석중,신계철 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Transbronchial lung biopsy(TBLB) is a relatively simple and convenient diagnostic tool in solitary pulmonary nodule(SPN) on chest radiograph, which is cannot be diagnosed through routine tests. To investigate the diagnostic value and diagnostic rate of TBLB according to the variable factor, we analyzed 69 patients with radiologically SPN lesion on chest radiograph which was confirmed histologically. A histologic diagnosis of TBLB was made in 47 of 69 patients(68.1%), in which 26 of 37(70.3%) with malignancy and 21 of 32(65.6%) with benign lesion. There were no significant differences in diagnostic yield according to age, sex and location of the lesion. The diagnostic rate tended to increase with the more than 5 pieces to acquired by TBLB. When the size of SPN was less than 3 ㎝, it cannot be diagnosed. In conclusion, TBLB is a diagnostic procedure with good yield and safety, but percutaneous needle aspiration, transbronchial needle aspiration, and bronchial washing fluid cytology may be a complementary procedure to overcome the limitation of TBLB and get higher diagnostic yield for SPN.

MgO 버퍼층을 이용한 PZT 박막의 형성 및 특성 평가

김지미,전호승,강재경,최형봉,김철주 서울시립대학교정보기술연구소 2001 정보기술연구소 논문집 Vol.3 No.-

In this paper, we fabricated the MgO layer by sol-gel method and estimated possibility as a buffer layer for ferroelectric such as PZT. MgO(Magnesium Oxide) proposed as buffer layer of ferroelectric is already for much used as buffer layer in optic technology. There are many formation methods of MgO layer, but in this study, we selected the sol-gel method which is easy to control the content of material and possible for fabrication of uniform layer, then we formed thin layer through the composition of MgO and PZT solution, spin coating and annealing. To estimate the possibility as buffer layer about ferroelectric layer, we analyzed the physical and electrical characteristics about PZT on MgO layer.By SEM, AFM and XRD analysis, we could know facts that the surface condition of PZT on MgO was relatively smooth and the crystal orientation of PZT was enhanced by MgO layer. Due to the measurements of P-V, C-V and I-V characteristics of PZT/MgO capacitor structure, the polarization, fatigue and breakdown properties of PZT on MgO were much improved than those of PZT without MgO layer. Also, in MFIS structure, the PZT on MgO showed the stable memory property. These results could be compared to those of MgO buffer layer formed by sputtering, so, if studies about the composition of MgO solution and the formation of MgO layer are executed continuously, the fabrication process of MgO layer by sol-gel method can be applied as the process for buffer layer of ferroelectric.

牧楡湯이 人體 肺癌細胞의 變化에 미치는 影響에 關한 分子生物學的 硏究

李炯周,金相贊,徐富一,金先熙,卞晟僖 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This experimental study was performed to investigate the effects of Mokyou-Tang on cell cycle and gene expressions of human lung cancer cell. I examined the cell cycle progression and cell cycle-related gene expression in A549 using a flow cytometry and a quantitative PT-PCR analysis. The treatment groups, in accordance with concentration of Mokyou-Tang were classified as 3 group(MYT 100㎕/㎖, MYT 500㎕/㎖, MYT 1,000㎕/㎖), and according to treatment time, were classified as 2 group(24hours, 48hours). The results were summarized as follows; 1. In cell cycle stage, MYT 100㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups were increased as compared with control group, especially 1000㎕/㎖(48hours) group showed eminent increase. 2. In p53 gene, MYT 500㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups showed eminent suppressive effect to cancer cell. 4. CDKNI gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. 4. In GADD45 gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. The results suggest that MYT promotes G1 cell cycle arrest and suppresses the proliferation of cancer cell. Thus, it seems likely that MYT has suppressive effect to proliferation of lung cancer cell.

鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

都市街路의 遲滯度推定에 관한 硏究

임채문,권강훈,이주호,김태형 대구대학교 과학기술연구소 2001 科學技術硏究 Vol.8 No.1

This study suggested input variables whose effects have been considered by adjusting various input variables in the TRANSYT-7F and NETSIM, the Simulation programs employed in calculating the delay time at street sections. The results can be summarized as follow. 1. Among the input variables in the TRANSYT-7F needed to calculate the delay time at street sections, the excluded are those which effect the most on time delay, such as bus stops, pedestrian crossings and on/off ramps. Among the input variables the most affecting factors are Saturation flow rate and time delay whose suggested quotients are well summarized in the text of this study. 2. There are variables which affect the change of time delay in the NETSIM, such as bus stop, pedestrian crossing, bus appearance period, and departure time delay. This study did the Simulation program using those variables except pedestrian crossing because, as the result of the correlation analysis suggests, there is a strong correlation between bus stop and pedestrian crossing. In this study, the survey had been done in the morning and afternoon except the Peak time, so heavily congested sections were excluded. And both sides of three street sections were surveyed. Therefore, there should be further studies on heavily congested situations and many other street sections.

Clinical Experience of Rigid Bronchoscopy in Single Center

Kim, Hyun-Jin,Kim, Sei-Won,Lee, Hye-Yeon,Kang, Hyeon-Hui,Kang, Ji-Young,Kim, Ju-Sang,Kim, Myung-Sook,Kim, Seung-Soo,Kim, Jin-Woo,Yun, Hyeong-Gyu,Kim, Chi-Hong,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Cho, Kwang The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.6

Background: The aim of this study was to analyze clinical situations requiring rigid bronchoscopy and evaluate usefulness of rigid bronchoscopic intervention in benign or malignant airway disorders. Methods: We retrospectively reviewed 29 patients who underwent rigid bronchoscopy from November 2007 to February 2011 at St. Paul's Hospital, The Catholic University of Korea School of Medicine. Results: Of the 29 patients, the most frequent underlying etiology was benign stenosis of trachea (n=20). Of those 20 patients, 16 had post-intubation tracheal stenosis (PITS), 2 had tracheal stenosis due to inhalation burn (IBTS) and other 2 had obstructive fibrinous tracheal pseudomembrane (OFTP). Other etiologies were airway malignancy (n=6), endobronchial stenosis due to tuberculosis (n=2), and foreign body (n=1). For treatment, silicone stent insertion was done in 16 cases of PITS and IBTS and mechanical removal was performed in 2 cases of OFTP. In 6 cases of malignant airway obstruction mechanical debulking was performed and silicone stents were inserted additionally in 2 cases. Balloon dilatation and electrocautery were used in 2 cases of endobronchial stenosis due to tuberculosis. In all cases of stent, airway obstructive symptom improved immediately. Granulation tissue formation was the most common complication. Conclusion: Tracheal stenosis was most common indication and silicone stenting was most common procedure of rigid bronchoscopy in our center. Rigid bronchoscopic procedures, at least tracheal silicone stenting, should be included in pulmonary medicine fellowship programs because it is a very effective and indispensable method to relieve critical airway obstruction which needs training to learn.

Postoperative Pulmonary Function Change is Dependent on Preoperative RV/TLC in Patients Underwent Curative Lobectomy

( Hyeong Jun Cho ),( Chang Dong Yeo ),( Hwa Young Lee ),( Hye Seon Kang ),( Chan Kwon Park ),( Sung Kyung Kim ),( Ju Sang Kim ),( Jin Woo Kim ),( Seung Joon Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Prediction of postoperative lung function for lung cancer is crucial to predicting perioperative risk assessment and postoperative quality of life. The objective of this study was to identify other indicators than conventional formular in predicting postoperative lung function after lung resection for lung cancer. Methods We enrolled lung cancer patients who underwent curative lobectomy and performed pulmonary function test for lung cancer at seven hospital at The Catholic University of Korea from 2017 to 2019. Postoperative (ppo) 6 and 12 months forced expiratory volume 1 (FEV1) were compared with predicted ppo FEV1 using the convention formula as follows: ppo FEV1= preoperative FEV1 x (residual segment number/total segment number). Clinical characteristics were compared between ppo FEV1 increase and decrease groups compared with predicted FEV1 values. Results A total of 263 patients were analyzed in this study. Among 214 patients performed lung function after 6 months surgery, 69 (32.2%) and 145 (67.8%) patients were classified into ppo FEV1 increase and decrease group compared with predicted FEV1 values. In ppo FEV1 increase group, median ages were younger (65 vs 69 years old, p=0.01). This group showed higher predominance of both upper lobe cancer (67.2% vs 52.8%, p< 0.05), in addition, higher proportion of preoperative residual volume(RV)/total lung capacity(TLC) ratio >40% (79.5% vs 59.3%, p=0.01), significantly. Of 153 patients performed lung function after 12 months surgery, there were no significant clinical factors between two groups. In the multivariate analysis, preoperative RV/TLC ≥40% (HR, 2.87; 95% CI, 1.10-7.43; p=0.03) was significantly associated with ppo FEV1 increase compared with predicted values. Conclusions Preoperative RV/TLC >40% was an independent predictive factor for reserved lung function in patients who underwent curative lobectomy. Moreover, upper lobectomy and young age were also associated with postoperative FEV1 increase compared with predicted values.

Hemato-biochemical and Cortisol Profile of Holstein Growing-calves Supplemented with Vitamin C during Summer Season

Kim, Jong-Hyeong,Mamuad, Lovelia L.,Yang, Chul-Ju,Kim, Seon-Ho,Ha, Jong-K.,Lee, Wang-Shik,Cho, Kwang-Keun,Lee, Sang-Suk Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.3

Effect of vitamin C (VC) on biochemical, hematological and cortisol profile of growing Holstein calves during summer was investigated. Eighteen calves between 14 and 16 weeks of age were divided equally into two groups. One group received a diet supplemented with VC (20 g/d) for 60 days, while other non-supplemented diet fed group served as a control (CON). The temperature humidity index (THI) was recorded and computed during the experiment. From days 0 to 60, the THI exceeded 70. Blood samples were collected from the jugular vein of each calf at days 0, 15, 30, 45 and 60. Serum albumin and total protein decreased (p<0.05) in CON and VC calves with age. Serum glutamic-oxaloacetic transaminase concentrations were not affected by treatments. Serum creatinine, albumin and glutamic-pyruvic transaminase concentrations were higher in calves in the VC group than the CON group. While red blood cells, hemoglobin and hematocrit were lower (p<0.05) in VC calves, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell distribution width and mean platelet volume were higher (p<0.05) in these VC supplemented calves. Leukocyte parameters including white blood cells and full term for lymphocytes were not affected by the treatments. Also, serum cortisol was not affected by treatments. At day 15, 30 and 45, the total VC in plasma was higher (p<0.05) in calves fed with VC. In conclusion, serum cortisols were not affected by plasma VC concentration, while some blood parameters were positively influenced in calves fed with VC.

Periodontal biotype modification using a volume-stable collagen matrix and autogenous subepithelial connective tissue graft for the treatment of gingival recession: a case series

Kim, Hyun Ju,Chang, Hyeyoon,Kim, Sungtae,Seol, Yang-Jo,Kim, Hyeong-Il Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.6

Purpose: The purpose of this study was to propose a technique for periodontal biotype modification through thickening of the entire facial aspect using a volume-stable collagen matrix and autogenous subepithelial connective tissue graft (CTG) for the treatment of gingival recession. Methods: Four systemically healthy patients showing Miller class I or class II gingival recession in the mandibular incisor area were included in this study. Full-mouth scaling and root planing procedures were performed at least 4 weeks prior to periodontal plastic surgery. A split-thickness flap with a horizontal intrasulcular incision and 2 vertical incisions was used in cases 1-3, and the modified tunnel technique was used in case 4 for coronal advancement of the mucogingival complex. After the exposed root surfaces were debrided thoroughly, double-layered volume-stable collagen matrix was placed on the apical part of the recession and a subepithelial CTG harvested from the palatal area was placed on the coronal part. The amount of root coverage at 3 months postoperatively was evaluated in cases 1-3, and facio-lingual volumetric changes were analyzed in cases 1 and 2. Results: Healing was uneventful in all 4 cases and complete root coverage was shown in cases 1-3. In case 4, reduction of gingival recession was observed at 3 months after surgery. In cases 1 and 2, a comparison of stereolithographic files from the preoperative and postoperative time points demonstrated that the entire facio-lingual volume had increased. Conclusions: The surgical technique suggested herein, using a volume-stable collagen matrix and autogenous subepithelial CTG, may be an effective method for periodontal biotype modification through thickening of the entire facial aspect for the treatment of gingival recession.

비가족성 양성 재발성 간내 담즙울체증 1 예

김오영,김미경,김주호,성범용,오현택,손현이,이광웅,김형권,윤해성,공규돈,신용민 대한간학회 1998 Clinical and Molecular Hepatology(대한간학회지) Vol.4 No.2

Benign recurrent intrahepatic cholestasis (BRIC) is a rare desease, which usually manifests between the age of 10 and 20. Its main clinical feature is multiple recurrent episodes of cholestasis without extrahepatic bile duct obstruction. We report here a case of nonfamilial benign recurrent intrahepatic cholestasis. The patient has experienced recurrent jaundice with pruritus since childhood. Main bile duct obstrution was excluded by abdominal CT and endoscopic retrograde cholangiopancreatography. Other causes of cholestasis were not found. Hepatic histology revealed bile plug which were mainly concentrated in the centrilobular region, and increased number of mononuclear cells in the portal triad, but hepatic parenchyma showed no inflammation and necrosis. In the last anicteric period, she was healthy and the liver function test and biopsy specimen were normal. (Korean J Hepatol 1998;4:188 - 193)