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Seol-Hee Moon,Du-Yeol Kim,Jung-Min Lee,Hee-Won Park,Hye-Yeong Lee,Yong-Hoon Lee,Jaesung Lee,Jiwon Jung,Min-Ju Kim,Kyoung-Baek Choi,Yu-Kyoung Oh,Young-Bong Kim,Sujeong Kim,Seung Min Oh 환경독성보건학회 2014 환경독성보건학회지 Vol.29 No.-
Objectives : The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse-effect-level (NOAEL) of the cervical cancer vaccines was estimated. Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10<SUP>8</SUP>, 5×10<SUP>8</SUP>, and 2.5×10<SUP>9</SUP> copies/animal) of the cervical cancer vaccines. Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters. Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10<SUP>9</SUP> copies/animal.
Scopolamine 유도 인지 저하 마우스 모델에서 크릴 오일의 인지 개선 효과
설혜민(Hye-Min Seol),이정아(Jeong-Ah Lee),황미선(Mi-Sun Hwang),박상훈(Sang-Hoon Park),김형수(Hyeong-Soo Kim) 한국생명과학회 2024 생명과학회지 Vol.34 No.7
선행연구에서 크릴 오일의 항산화 작용을 통한 Amyloid β로 저하된 설치류의 인지능과 기억력을 개선시킨다는 것을 확인하였으나 신경전달물질 등의 조절에 대한 유효성 확인과 지질 과산화와 혈중지질과의 연계성이 필요하여 본 연구를 진행하였다. Scopolamine으로 신경전달 체계를 교란시킨 ICR mice에서 크릴 오일 섭취에 따른 수동회피, 수중미로, 신물질 탐색 등의 행동시험을 실시하여 인지 및 기억력 개선에 대한 유효성과 뇌 조직에서의 acetylcholine 수준과 acetylcholinesterase의 활성 변화와 함께 지질 과산화와 혈중지질 수준 그리고 신경세포 증식인자의 발현량에 대한 변화를 조사하였다. 그 결과 scopolamine 처리군에 비해 크릴 오일 섭취로 인한 수동회피시험에서의 정체시간 지연과 수중미로시험에서의 탈출지연시간 단축을 확인하여 인지 및 기억력을 개선을 확인하였다. 또한, acetylcholine 수준이 scopolamine 처리군 보다 증가되는 것을 확인하였고 여기에는 acetylcholine esterase의 활성 감소가 동반되었다. Scopolamine을 처리한 신경세포주에서도 크릴 오일 처리에 따라 acetylcholinesterase의 활성이 감소되는 것을 확인하였다. 또한, 크릴 오일이 지질 과산화 억제에 의한 malondialdehyde 생성 수준을 감소시키는 것이 혈중 중성지질, 콜레스테롤과 LDL-C 등의 저하와 HDL-C의 상승과 연관되는 것으로 확인되며 CREB의 활성 증가를 통해 BDNF의 상승으로 신경세포 증식인자 발현량 증가에 대한 효과가 있는 것으로 확인되었다. 따라서, 본 연구를 통해 크릴 오일은 뇌 조직 내 acetylcholine 등 신경전달물질 수준의 개선, 지질 과산화 억제 등을 통한 혈중지질 개선과 신경세포 증식 인지기능 및 기억력 개선 효과를 가지는 것으로 확인하였다. A previous study showed that krill oil improved recognition and memory through anti-oxidative effects in an amyloid β model, but the authors noted that further investigations are necessary of alterations to neurotransmitters’ states and of serum lipid profile improvements related to serum lipid peroxidation. Accordingly, in this study, ICR mice were pre-treated intraperitoneally with scopolamine prior to induced neurotransmission impairment, and the effects of krill oil provision on their capabilities of cognition were tested by performing a passive avoidance test (PAT), water maze test (WMT), and novel object recognition test. Then, parameters including the acetylcholine (ACh) concentration, acetylcholinesterase activity (AChE), lipid peroxidation, serum lipid levels, and nerve cell proliferation were investigated. The results showed that krill oil improved the mice’s abilities in recognition and memory as the times taken to complete the PAT and WMT were reduced compared to the mice in a comparison scopolamine-treated group. Krill oil produced an increased concentration of Ach, and this was accompanied by a decrease in AChE. As shown in a scopolamine-treated SH-SY5Y cell line, krill oil reduced the activity of AChE. Moreover, the suppression of lipid peroxidation-reflected in the finding that malondialdehyde was decreased with krill oil provision-is speculated to affect the recorded serum triglyceride and cholesterol decreases and LDL cholesterol increase. The intake of krill oil was also found to produce an improvement in brain-derived neurotrophic factor expression by stimulating the activation of cyclic AMP response element binding protein in the brain tissue. Overall, the current results imply that the provision of krill oil raises the cognition and memory by elevating neurotransmitters and by improving the serum lipid profile and nerve cell proliferation, which occur as lipid peroxidation is suppressed in the brain tissue.
연화열처리가 모의소성 된 금속-세라믹용 Pd-Au-Zn-In-Sn계 합금의 후열처리에 따른 경도 및 미세구조 변화에 미치는 영향
신혜정(Hye-Jeong Shin),김민정(Min-Jung Kim),김성민(Sung-Min Kim),권용훈(Yong-Hoon Kwon),김형일(Hyung-Il Kim),설효정(Hyo-Joung Seol) 대한치과재료학회 2016 대한치과재료학회지 Vol.43 No.3
Effect of softening heat-treatment on the hardness and microstructural changes by post-firing heat-treatment of a firing simulated Pd-Au-Zn-In-Sn metal-ceramic alloy was examined by observing the change in hardness, crystal structure and microstructure. By post-firing heat-treatment after firing simulation of the as-cast and softening heat-treated specimens, the hardness value increased gradually and then reached to the maximum value at holding time of 25min at 600℃. And the gap of hardness value among the specimens was not great. The increased hardness began to decrease from the holding time of 30min, thus post-firing heat-treatment longer than 25min was not advisable. The hardness increase during the post-firing heat-treatment was resulted from the precipitation of the Au-containing PdZn phase of the f.c.t. structure from the Pd-Au-rich matrix of the f.c.c. structure.
금속-세라믹용 Pd-Au-Ag-Sn계 합금의 모의소성 후 계류에 따른 석출경화
김민정(Min-Jung Kim),신혜정(Hye-Jung Shin),권용훈(Yong-Hoon Kwon),김형일(Hyung-Il Kim),설효정(Hyo-Joung Seol) 대한치과재료학회 2016 대한치과재료학회지 Vol.43 No.4
This experiment was carried out to examine whether the post-firing heat treatment is effective in increasing the hardness of metal-ceramic alloy of the Pd-Au-Ag-Sn system. Precipitation hardening by holding at 600°C after simulated complete porcelain firing in a metal-ceramic alloy of the Pd-Au-Ag-Sn system was examined by observing the change in hardness, crystal structure, and microstructure using a hardness test, X-ray diffraction (XRD), and field emission scanning electron microscopy (FE-SEM). The hardness of the alloy increased apparently by holding the specimen at 600°C for 30 min after simulated complete porcelain firing. The formation of fine grain interior precipitates during holding at 600°C caused the formation of lattice strain in the grain interior, resulting in apparent hardening. The faster cooling rate (stage 0) during simulated complete porcelain firing resulted in more effective precipitation hardening during holding at 600°C. From the above results, an appropriate post-firing heat treatment, such as holding at 600°C for 30 min after complete porcelain firing may increase the durability of metal-ceramic prostheses composed of Pd-Au-Ag-Sn alloy.
Juwon Jung,Jin Ah Baek,Hye Won Seol,Young Min Choi 한국발생생물학회 2016 발생과 생식 Vol.20 No.1
Human embryonic stem cells (hESCs) have been routinely cultured on mouse embryonic fibroblast feeder layers with a medium containing animal materials. For clinical application of hESCs, animal-derived products from the animal feeder cells, animal substrates such as gelatin or Matrigel and animal serum are strictly to be eliminated in the culture system. In this study, we performed that SNUhES32 and H1 were cultured on human amniotic fluid cells (hAFCs) with KOSR XenoFree and a humanized substrate. All of hESCs were relatively well propagated on hAFCs feeders with xeno-free conditions and they expressed pluripotent stem cell markers, alkaline phosphatase, SSEA-4, TRA1-60, TRA1-81, Oct-4, and Nanog like hESCs cultured on STO or human foreskin fibroblast feeders. In addition, we observed the expression of nonhuman N-glycolylneuraminic acid (Neu5GC) molecules by flow cytometry, which was xenotransplantation components of contamination in hESCs cultured on animal feeder conditions, was not detected in this xeno-free condition. In conclusion, SNUhES32 and H1 could be maintained on hAFCs for humanized culture conditions, therefore, we suggested that new xenofree conditions for clinical grade hESCs culture will be useful data in future clinical studies.
( Hye-rin Kwon ),( A-young Gil ),( Ji-min Kim ),( Ji-seon No ),( Ga-bin Park ),( Ji-yune Oh ),( Na-kyung Lee ),( Seol-hee Kim ) 한국치위생과학회 2021 치위생과학회지 Vol.21 No.4
Background: The importance of infection with COVID-19 is being emphasized in dentistry with high risks such as aerosols. The purpose of this study is to investigate the knowledge and practice of infection control, stress and coping, and turnover of dental hygienists. Methods: Questionnaire was conducted knowledge and practice of infection control, occupational stress and coping, turnover. Survey data was investigated about 149 dental hygienists from February to March 2021 Data were analyzed t-test, ANOVA, Pearson’s correlation using statistical programs of PASW Statistics ver. 21.0. Results: Regarding occupational stress, relationship conflict was higher in the group with less than 2 years of experience (p<0.05). Job anxiety, organizational system, inadequate compensation, and workplace culture were highly surveyed in the 3 to 5 year of experience. The group with more than 6 years of experience had the highest perception of lack of job autonomy (p<0.05). The group with higher knowledge of infection control had lower mean inappropriate rewards and stress (p<0.05). The group with high infection control performance had a lower average in items such as job instability, organizational system, inadequate compensation, workplace culture, and stress. And problem-focused coping ability was found to be high (p<0.05). Infection control knowledge and performance were positively correlated (r=0.251, p<0.01), infection control practice and stress were negatively correlated (r=-0.264, p<0.01), and stress and emotional coping were positively correlated (r=0.367, p<0.01). Stress was positively correlated with turnover rate (r=0.549, p<0.01). Conclusion: Infection control training was required to reduce occupational stress. Occupational stress was highly correlated with turnover, a holistic and systemic organizational operation and improvement of the quality of medical care were required to reduce stress.
The First Case of Novel Influenza A (H1N1) Fatality in Korea
Seol, Hee-Yun,Eom, Jung-Seop,Kim, Mi-Hyun,Cho, Woo-Hyun,Kim, Ji-Eun,Kim, Ki-Uk,Jeon, Doo-Soo,Park, Hye-Kyung,Kim, Yun-Seong,Lee, Min-Ki,Park, Soon-Kew The Korean Academy of Tuberculosis and Respiratory 2010 Tuberculosis and Respiratory Diseases Vol.68 No.6
Here we report the first fatality caused by H1N1 influenza virus infection with acute respiratory distress syndrome in Korea. A 55-year-old man presented at our emergency department with dyspnea, fever, diffuse myalgia and malaise. Bilateral lung air-space consolidation was detected on his initial chest radiograph combined with severe hypoxemia. He was supported by mechanical ventilation and treated with antibiotics. A nasopharyngeal aspirate was positive for influenza A rapid antigen and oseltamivir was started on day 3 of admission. The nasal swab sample was positive for influenza H1N1 virus by real-time reverse-transcriptase polymerase chain reaction. Despite aggressive treatment, he had refractory hypoxemia and uncontrolled septic shock. On day 5 of admission he went into cardiac arrest and expired.