http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yo-Seok Cho,Hyuk-Joon Lee,Shin-Hoo Park,Tae-Han Kim,Hwi Nyeong Choe,Yun-Suhk Suh,Seong-Ho Kong,Han-Kwang Yang 대한종양외과학회 2017 Korean Journal of Clinical Oncology Vol.13 No.2
Purpose: This study evaluated the adequacies of lymph node (LN) dissection according to the second version (determined by tumor location) or third/fourth version (determined by surgery extent) of the Japanese gastric cancer treatment guidelines. Methods: Prospectively collected data of 3,948 gastric cancer patients who underwent gastrectomy were analyzed. The prevalence of LN metastasis and 5-year survival were analyzed according to tumor invasion depth and tumor location. In early gastric cancer (EGC), the frequency of LNs were evaluated. In advanced gastric cancer (AGC), the frequency of LN metastasis and the 5-year survival rate of patients with positive LN were evaluated. Results: For lower-third EGC, the positive rates for the #1 and #4sb were 0.93% and 0%. For upper-third EGC, the positive rates for #4d, #5, #6, and #11p were 0.3%, 0%, 0.76%, and 1.22%. For lower-third AGC, the positive rates for #4sb and #14v were 2.48% and 7.64%, and the 5-year survival rates were 69.2% and 12.5%, respectively. For upper-third AGC, the positive rates for #5, #6, and #12a were 2.33%, 2.57%, and 2.03%, and the 5-year survival rates were 21.8%, 64.3%, and 0%, respectively. Conclusion: According to our analysis, in EGC, LN dissection in second edition seems more suitable, however LN dissection in #11p would be mandatory in upper third EGC. In AGC, LN dissection in third/fourth edition seems more suitable in terms of frequency of LN metastasis and survival rate.
Hyuk-Joon Lee,Sa-Hong Kim,박지현,Jong-Ho Choi,박신후,Hwi-Nyeong Choe,Seung-Young Oh,서윤석,공성호,박도중,Han-Kwang Yang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.3
Purpose: Gastric cancer with lymph node metastasis (LNM) more than 15 (N3b) was definedas stage IV until the 6th AJCC system. However, it has been reclassified as a localized disease(stage IIb or III) since the 7th system. The aim of this study is to demonstrate that thesurvival of N3b is comparable to cytology-only positive (CY1-only) stage IV and to proposea new TNM system interpreting N3b as an eligibility criterion for receiving more intensivechemotherapy regimens. Materials and Methods: 1,430 patients who underwent gastric cancer surgery at SeoulNational University Hospital from 2007 to 2012 were retrospectively analyzed. The 5-yearsurvival rate (5YSR) and 3-year recurrence-free survival (RFS) were evaluated according tothe 7th and 8th systems, as well as a new categorization based on N-classification; N0-2(LNM<7), N3a (LNM 7–15), or N3b (LNM>15). Results: The survival of N3b is comparable to that of CY1-only stage IV (log rank test,P=0.671) and is distinct from that of grossly stage IV (log rank test, P<0.001). The survivalof the remaining stage IIIc (T4bN3a) was comparable to those of N3b and CY1-only stage IV. Most N3b patients had significantly shorter 3-year RFS and mean RFS than those with IIb–IIIc, as if N3b itself was a higher TNM stage. Conclusions: In terms of survival, T4bN3a, N3b, and CY1-only stage IV were unified as stageIVa, while grossly stage IV was defined as stage IVb. N3b can be regarded as an eligibilitycriterion for undergoing more intensive chemotherapy regimens.
Min, Jimin,Choi, Boram,Han, Tae-Su,Lee, Hyuk-Joon,Kong, Seong-Ho,Suh, Yun-Suhk,Kim, Tae-Han,Choe, Hwi-Nyeong,Kim, Woo Ho,Hur, Keun,Yang, Han-Kwang Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.5
Long interspersed nuclear element-1 (LINE-1) is a retrotransposon that contains a CpG island in its 5'-untranslated region. The CpG island of LINE-1 is often heavily methylated in normal somatic cells, which is associated with poor prognosis in various cancers. DNA methylation can differ between formalin-fixed paraffin-embedded (FFPE) and frozen tissues. Therefore, this study aimed to compare the LINE-1 methylation status between the two tissue-storage conditions in gastric cancer (GC) clinical samples and to evaluate whether LINE-1 can be used as an independent prognostic marker for each tissue-storage type. We analyzed four CpG sites of LINE-1 and examined the methylation levels at these sites in 25 FFPE and 41 frozen GC tissues by quantitative bisulfite pyrosequencing. The LINE-1 methylation status was significantly different between the FFPE and frozen GC tissues (p < 0.001). We further analyzed the clinicopathological features in the two groups separately. In the frozen GC tissues, LINE-1 was significantly hypomethylated in GC tissues compared to their corresponding normal gastric mucosa tissues (p < 0.001), and its methylation status was associated with gender, differentiation state, and lymphatic and venous invasion of GC. In the FFPE GC tissues, the methylation levels of LINE-1 differed according to tumor location and venous invasion of GC. In conclusion, LINE-1 can be used as a useful methylation marker for venous invasion in both FFPE and frozen tumor tissues of GC.
Kim, Sa-Hong,Lee, Hyuk-Joon,Park, Ji-Hyeon,Choi, Jong-Ho,Park, Shin-Hoo,Choe, Hwi-Nyeong,Oh, Seung-Young,Suh, Yun-Suhk,Kong, Seong-Ho,Park, Do-Joong,Yang, Han-Kwang The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.3
Purpose: Gastric cancer with lymph node metastasis (LNM) more than 15 (N3b) was defined as stage IV until the 6th AJCC system. However, it has been reclassified as a localized disease (stage IIb or III) since the 7th system. The aim of this study is to demonstrate that the survival of N3b is comparable to cytology-only positive (CY1-only) stage IV and to propose a new TNM system interpreting N3b as an eligibility criterion for receiving more intensive chemotherapy regimens. Materials and Methods: 1,430 patients who underwent gastric cancer surgery at Seoul National University Hospital from 2007 to 2012 were retrospectively analyzed. The 5-year survival rate (5YSR) and 3-year recurrence-free survival (RFS) were evaluated according to the 7th and 8th systems, as well as a new categorization based on N-classification; N0-2 (LNM<7), N3a (LNM 7-15), or N3b (LNM>15). Results: The survival of N3b is comparable to that of CY1-only stage IV (log rank test, P=0.671) and is distinct from that of grossly stage IV (log rank test, P<0.001). The survival of the remaining stage IIIc (T4bN3a) was comparable to those of N3b and CY1-only stage IV. Most N3b patients had significantly shorter 3-year RFS and mean RFS than those with IIb-IIIc, as if N3b itself was a higher TNM stage. Conclusions: In terms of survival, T4bN3a, N3b, and CY1-only stage IV were unified as stage IVa, while grossly stage IV was defined as stage IVb. N3b can be regarded as an eligibility criterion for undergoing more intensive chemotherapy regimens.
Lee, Ayoung,Chung, Hyunsoo,Lee, Hyuk-Joon,Cho, Soo-Jeong,Kim, Jue Lie,Ahn, Hye Seong,Suh, Yun-Suhk,Kong, Seong-Ho,Choe, Hwi Nyeong,Yang, Han-Kwang,Kim, Sang Gyun The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.2
Purpose: The impact of the interval between previous endoscopy and diagnosis on the treatment modality or mortality of undifferentiated (UD)-type gastric cancer is unclear. This study aimed to investigate the effect of endoscopic screening interval on the stage, cancer-related mortality, and treatment methods of UD-type gastric cancer. Materials and Methods: We reviewed the medical records of newly diagnosed patients with UD gastric cancer in 2013, in whom the interval between previous endoscopy and diagnosis could be determined. The patients were classified into different groups according to the period from the previous endoscopy to diagnosis (<12 months, 12-23 months, 24-35 months, ≥36 months, and no history of endoscopy), and the outcomes were compared between the groups. In addition, patients who underwent endoscopic and surgical treatment were reclassified based on the final treatment results. Results: The number of enrolled patients was 440, with males representing 64.1% of the study population; 11.8% of the participants reported that they had undergone endoscopy for the first time in their cancer diagnosis. The percentage of stage I cancer at diagnosis significantly decreased as the interval from the previous endoscopy to diagnosis increased (65.4%, 63.2%, 64.2%, 45.9%, and 35.2% for intervals of <12 months, 12-23 months, 24-35 months, ≥36 months, and no previous endoscopy, respectively, P<0.01). Cancer-related mortality was significantly lower for a 3-year interval of endoscopy (P<0.001). Conclusions: A 3-year interval of endoscopic screening reduces gastric-cancer-related mortality, particularly in cases of UD histology.
Prediction Model for Screening Patients at Risk of Malnutrition after Gastric Cancer Surgery
Ji-Hyeon Park,Eunjung Kim,Eun-Mi Seol,Seong-Ho Kong,Do-Joong Park,Han-Kwang Yang,Jong-Ho Choi,Shin-Hoo Park,Hwi-Nyeong Choe,Meera Kweon,Jiwon Park,Yunhee Choi,Hyuk-Joon Lee 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11