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Preparation and Determination of Optical Purity of γ-Lysine Modified Peptide Nucleic Acid Analogues
Hu Huang,이원재,조군호,Sung Rok Choi,Su Nam Kim,Yong Tae Kim,Hwang Siek Pak,Sung Kee Kim,Joon Hee Hong,한효경,강종성 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3
Peptide nucleic acids (PNAs) are DNA analogues in which the nucleic acid backbone is replaced by a pseudopeptide backbone and nucleobases are attached to the backbone by methylene carbonyl linkers. γ-Carbon modification of the PNA structure allows monomers, and subsequently oligomers, with improved properties to be obtained. In this study, we report the convenient synthesis of γ-lysine-modified PNA monomers for pyrimidine bases (thymine and cytosine) with high optical purity (> 99.5%) and direct enantiomer separation of γ-lysine-modified PNA analogs, using chiral HPLC to determine the optical purity.