http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Simple Preparation of Fluorescent Silicon Nanoparticles from Used Si Wafers
Hwang, Jangsun,Jeong, Yoon,Lee, Kwan Hong,Seo, Youngmin,Kim, Jieun,Hong, Jong Wook,Kamaloo, Elaheh,Camesano, Terri A.,Choi, Jonghoon American Chemical Society 2015 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.54 No.22
<P>A simple way of preparing fluorescent silicon nanoparticles (SiNPs) with a mean diameter of ∼5 nm was demonstrated from used silicon wafers. Anodic etching of used wafers performed in a customized electrochemical cell produced H-terminated, nano- and micropores on the wafer surface, and SiNPs were attained by mechanically crumbling the nano-/microporous Si surface structures on the etched wafers in an ultrasonic bath. The obtained SiNPs were then re-etched in different ratios of HF/HNO<SUB>3</SUB> acid mixture to produce different PL intensities, sizes, and yields. When the particle sizes were decreased by adjusting the experimental conditions (e.g., strength of the acid mixture, reaction time), the PL spectra from etched SiNPs were also shifted from red to blue, indicating the quantum confinement effect from the nanoparticles. Typically, blue-emitting SiNPs were observed with an average diameter of 2.7 nm and a yield of 0.3 mg/cm<SUP>2</SUP> of used wafers. Re-etched SiNPs were dialyzed by a 1K-dialysis membrane for purification and for potential use in bioapplications. The efficient method of preparing fluorescent nanoparticles from used monocrystalline Si wafers was demonstrated with a high production yield. The produced particles showed outstanding physical and chemical properties, indicating the applicability of these materials in semiconductor research and bioapplications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/iecred/2015/iecred.2015.54.issue-22/acs.iecr.5b00446/production/images/medium/ie-2015-00446b_0005.gif'></P>
Hwang, Jangsun,Son, Jaewoo,Seo, Youngmin,Jo, Yeonho,Lee, Kyungwoo,Lee, Dohyun,Khan, Muhammad Saad,Chavan, Sachin,Park, Chanhwi,Sharma, Anand,Gilad, Assaf A.,Choi, Jonghoon Elsevier 2018 Journal of industrial and engineering chemistry Vol.58 No.-
<P><B>Abstract</B></P> <P>Bacterial infections and resistance against antibiotics are on the rise despite new drug development. New developments in the field of nanomedicine are proving to be an alternative for traditional antibiotics. Silica nanoparticles (SiNPs) have a promising role in emerging nanomedicine because of their low cytotoxicity and efficient drug delivery potential. In current study, we developed and analyzed silica nanoparticles of ∼50nm in size that are capable of encapsulating small organic molecules and drugs, such as fluorescein isothiocyanate (FITC), doxorubicin (DOX), 4′, 6-diamidino-2-phenylindole (DAPI) and/or isoniazid (INH). Our drug delivery contains the anti-tuberculosis drug, INH, which is encapsulated in beta (β)-glucan-conjugated SiNPs. We focused on synthesizing and encapsulating SiNPs that have amine functional groups as well as the ability to conjugate with β-glucan molecules, making the nanocomplex both a drug carrier and a stimulus for host immune systems.</P> <P><B>Graphical abstract</B></P> <P>Beta-glucan modified silica nanoparticles carrying and secreting anti-tuberculosis drug molecules: SA treated Glu was presenting carboxyl groups on their surface while SiNPs encapsulating INH were terminated with amine groups. Glu and SiNPs were then conjugated with by EDC/NHS linkers. INH@SiNPs/Glu complexes released drug molecules while macrophages recognizing Glu secreted cytokines (Red arrows: Glu, Yellow arrows: INH encapsulated SiNPs: Right, Drug release profiling: Left).</P> <P>[DISPLAY OMISSION]</P>
An assessment of the toxicity of polypropylene microplastics in human derived cells
Hwang, Jangsun,Choi, Daheui,Han, Seora,Choi, Jonghoon,Hong, Jinkee Elsevier 2019 Science of the Total Environment Vol.684 No.-
<P><B>Abstract</B></P> <P>Environmental pollution caused by plastic waste is a growing global problem. Discarded plastic products and debris (microplastic particles) in the oceans detrimentally affect marine ecosystems and may impact human. Humans are exposed to plastic debris via the consumption of seafood and drinking water, contact with food packaging, or inhalation of particles. The accumulation of microplastic particles in humans has potential health risks such as cytotoxicity, hypersensitivity, unwanted immune response, and acute response like hemolysis. We investigated the cellular responses of secondary polypropylene microplastics (PP particles) of approximately ~20 μm and 25–200 μm in different condition and size to normal cells, immune cells, blood cells, and murine immune cells by cytokine analysis, ROS assay, polarization assay and proliferation assay. We found that PP particles showed low cytotoxicity effect in size and concentration manner, however, a high concentration, small sized, DMSO method of PP particles stimulated the immune system and enhanced potential hypersensitivity to PP particles via an increase in the levels of cytokines and histamines in PBMCs, Raw 264.7 and HMC-1 cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PP particles are able to induce pro-inflammatory cytokines such as IL-6, TNF alpha and histamine that cause local immune response. </LI> <LI> PP particles induce pro-inflammatory cytokines in size-dependent and concentration manner. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Engineered nanomaterials for their applications in theragnostics
Hwang, Jangsun,Lee, Dohyun,Seo, Youngmin,Son, Jaewoo,Jo, Yeonho,Lee, Kyungwoo,Park, Chanhwi,Choi, Jonghoon THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.66 No.-
<P><B>Abstract</B></P> <P>Owing to their abundant unique properties and ready compatibility with healthcare and therapeutic technology, nanoparticles are becoming one of the most desirable materials in the biomedical industry. Particularly, novel nanoparticles possess distinctive photoluminescence, biocompatibility, antibacterial effect, surface plasmon resonance, and immunogenicity. In this review, we describe the general synthesis, physical properties, cellular activity, and biological applications of popular nanoparticles/nanomaterials (i.e., silicon, gold, iron oxide, and carbon nanotubes), while focusing on the immunology encompassing these nanoparticles and their potential applications in the fields of nanotherapy. We further highlight major challenges and promises in this area and review the uses of nanoparticles in current technologies, such as nanoparticle-mediated cellular immunology and cytotoxicity in therapeutic applications.</P> <P><B>Graphical abstract</B></P> <P>Summary of several nanomaterials were reported for their preparation and characterization. Recent applications of nanomaterials for immunological studies and the highlight of major challenges and promises were discussed in employing them to the immunological applications.</P> <P>[DISPLAY OMISSION]</P>
Synthesis and Characterization of Functional Nanofilm-Coated Live Immune Cells
Hwang, Jangsun,Choi, Daheui,Choi, Moonhyun,Seo, Youngmin,Son, Jaewoo,Hong, Jinkee,Choi, Jonghoon American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.21
<P>Layer-by-layer (LbL) assembly techniques have been extensively studied in cell biology because of their simplicity of preparation and versatility. The applications of the LbL platform technology using polysaccharides, silicon, and graphene have been investigated. However, the applications of the above-mentioned technology using living cells remain to be fully understood. This study demonstrates a living cell-based LbL platform using various types of living cells. In addition, it confirms that the surplus charge on the outer surface of the coated cells can be used to bind the target protein. We develop a living cell-based LbL platform technology by stacking layers of hyaluronic acid (HA) and poly-<SMALL>L</SMALL>-lysine (PLL). The HA/PLL stacking results in three bilayers with a thickness of 4 ± 1 nm on the cell surface. Furthermore, the multilayer nanofilms on the cells are completely degraded after 3 days of the application of the LbL method. We also evaluate and visualize three bilayers of the nanofilm on adherent (AML-12 cells)-, nonadherent (trypsin-treated AML-12 cells)-, and circulation type [peripheral blood mononuclear cells (PBMCs)] cells by analyzing the zeta potential, cell viability, and imaging via scanning electron microscopy and confocal microscopy. Finally, we study the cytotoxicity of the nanofilm and characteristic functions of the immune cells after the nanofilm coating. The multilayer nanofilms are not acutely cytotoxic and did not inhibit the immune response of the PBMCs against stimulant. We conclude that a two bilayer nanofilm would be ideal for further study in any cell type. The living cell-based LbL platform is expected to be useful for a variety of applications in cell biology.</P> [FIG OMISSION]</BR>
Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
Hwang, Jangsun,Lee, Eunwon,Kim, Jieun,Seo, Youngmin,Lee, Kwan Hong,Hong, Jong Wook,Gilad, Assaf A.,Park, Hansoo,Choi, Jonghoon Elsevier 2016 Colloids and Surfaces B Vol. No.
<P><B>Abstract</B></P> <P>Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5nm and 5nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor α, with a minimal concentration of MPA. In conclusion, IOS/M may have potential applications in both efficient drug delivery and MRI.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We prepared silica coated iron oxide nanoparticles delivering immunosuppressive drugs. </LI> <LI> We examine drug releasing and immunomodulatory effects of nanoparticles. </LI> <LI> Drug delivering nanoparticles inhibited the secretion of the cytokines. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Nanoparticles delivering immunosuppressive drug molecules to the human peripheral blood mononuclear cells.</P> <P>[DISPLAY OMISSION]</P>