양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

주거 공간 개조에 관한 사례 분석 연구

신화경,안진희 상명대학교 자연과학연구소 2002 自然科學硏究 Vol.9 No.-

주거 공간의 개조는 삶의 질을 보다 향상시키고자 하는 필요에서 거주자 고유의 개성을 인정하는 생활을 담아 내기 위한 수단으로 시행되고 있다. 개조의 필요성에 대한 홍보가 점차 증가하고 있으며 개조에 관한 시민 의식과 관심이 고조되는 현 시점에서 본 연구는 주거 공간 개조 사례를 통해 주거 공간 개조 특성을 파악하여 향후 거주 공간 계획에 필요한 자료를 제시하고자 한다. 주거 공간은 개인 공간, 공동 공간, 위생 공간, 가사 작업 공간, 기타 공간으로 구분하고 각 공간별로 새로 만들어진 공간, 기존 공간의 분리, 공간의 확장, 위치 변경 등의 내용으로 개조 특성을 파악하였다. 분석 결과, 주거 공간 중 개인 공간의 개조가 가장 많이 나타났으며, 다음으로는 가사 작업 공간에서의 개조가 많이 나타났다. 개조 내용으로는 공간의 확장이 가장 많이 나타났으며, 다음으로는 위치 변경이 많이 나타났다.

대관령의 일조시간을 이용한 월별 일사량의 추정

박진기, 오시영, 백신철, 김봉섭, 신형섭, 박종화 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1

The monthly mean daily global solar radiation and sunshine duration, have been employed in this study to develop correlation model for Daegwallyeong during 2011. The corresponding monthly value of extraterrestrial solar radiation and possible duration of sunshine are calculated for Daegwallyeong meteorological data. Forecasting performance parameters such as coefficient of determination (R2), mean bias error (MBE) and root mean square error (RMSE) are presented as analyzed for the model. The model with multi-linear regression has the highest R2 value of 0.95 and average MBE and RMSE values of −0.11 MJ/m2day and 1.63 MJ/m2day, respectively. The model exhibited negative MBE which shows that the model resulted in underestimation of the global solar radiation relative to the meteorological measured value. The equation could be employed in the estimation of solar radiation at Daegwallyeong, other locations with similar meteorological characteristics.

CSB^(+)-Tree 기반의 DTD 통합 그래프를 이용한 XML 문서 저장 시스템 설계 기법

신성현,송화선,김진호,정영준 강원대학교 정보통신연구소 2004 정보통신논문지 Vol.8 No.-

As information processing recently increases over Internet. there have been many researches about designing an efficient storage system to process a huge amount of information, which is based upon DTD in XML However, most of them have some difficulties in meaningful and structural presentation of XML documents and some restrictions in integration of many heterogeneous documents. In other word, we need a storage system which well-defines the structure of heterogeneous XML documents and integrates them. In this paper, we proposed a technique of an XML documentation storage system using DTD integration graphs based on CSB+-tree. This technique retrieves structural information from elements of XML documents, creates a CSB+-tree based DTD integrated graphs of the man storage system, and generates an integrated storage system by using element mappings. The proposed technique utilizes the man storage system more efficiently in space and provides more faster response time.

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

NaCl이 보리(Hordeum vulgare L.) 잎의 엽록소 형광에 미치는 영향

정화숙,임영진,박강은,박신영 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12

This study was conducted to investigate the changes of chlorophyll contents and chlorophyll fluorescence in barley(Hordeum vulgare L.) 7 day old seedling treated with 0.2M, 0.4M, 0.6M, 0.8M, and 1.0M NaCl concentration containing Hepes buffer(pH 7.5). Barley was affected by NaCl treatment. The chlorophyll a, b and carotenoid of barley decreased with an increase in NaCl concentration. However, chlorophyll a, b and carotenoid of barley were not greatly influenced by o.8M and 1.0M NaCl. Fv, Fv/Fm and qP were gradually decreased by higher concentration of NaCl. qP, qNP, qR and qE were gradually decreased by 6hr. During barley chloroplast was development NaCl affected chlorophyll synthesis than photosynthetic activity. Whereas barley seedling leaves were more influenced photosynthetic activity than chlorophyll contents by NaCl.

급성충소돌기염의 임상 : 병리학적 고찰

양기화,조준필,하영천,한진우,정학재,손수창,이성희,황재훈,신철호 최신의학사 1989 最新醫學 Vol.32 No.4

茂朱九天洞의 나방相에 關하여

田眞和,申裕恒 慶熙大學校 1980 論文集 Vol.10 No.-

1. Entomological field surveys on the moth fauna at Gucheondong, Muju, Cholla Puk Do were undertaken in July 4, 21 and August 13 in 1978 respectively. In addition to the above collected moth specimens, the museum specimens which were collected in 1976 from the same area were also examined in this study. 2. As a result, a total of 139 newly recorded species of Gucheondong area which comprises 18 families were recovered. Therefore, moth fauna form the area recorded so far, are amounted to the total of 166 species belonging to 18 families. 3. In this survey and study, the following twelve species are recorded newly from Korea. Ceruridae Lophopteryx kuwayae Matsumura Cochlidionidae Ceratonema butler Kawada Geometridae Aracima muscosa Butler Arichanna albomaculata Leech Duliophyle majuscularia Leech Garaeus mirandus Bu¨tler Nipponorgelasma immunis Prout Selenia retralunaria Hu¨fnagel Synegia hadassa Butler Synegia ichinosawana Matsumura Tristrophis veneris Butler Pyralidae Myelois subcognata Ragonot

토끼 수막염 모델을 이용한 다제내성 폐렴구균에 대한 Meropenem의 치료 효과

김신우,진정화,강수정,정숙인,김연숙,기현균,김춘관,이혁,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

목적 : 다제내성 폐렴구균에 의한 수막염은 기존과 단일 항생제로는 근치가 어려워 ceftriaxone과 vancomycin 혹은 rifampin의 병용요법이 권유되고 있다. 다제내성 폐렴구균에 사용할 수 있는 다른 약제 중 meropenem은 시험관내 폐렴구균에 대한 항균력이 좋고 경련 등의 중추신경계 부작용이 거의 없어 다제내성 폐렴구균에 의한 수막염의 치료에 이용할 수 있을 것으로 기대되나 이에 대한 자료가 매우 부족한 상태이다. 이에 연자 등은 meropenem과 meropenem+vancomycin의 병용요법이 다제내성 폐렴구균 수막염의 치료에 효과가 있는지를 토끼 수막염 동물 모델을 이용하여 검증하고자 하였다. 방법 : 인체에서 수막염을 일으킨 다제내성 폐렴구균 균주(penicillin MIC 2, ceftriaxone MIC 4, meropenem MIC 0.5㎍/㎖)를 토끼 척수강 내에 직접 주입하여 수막염을 유발한 후 ceftriaxone, vancomycin, rifampin, meropenem의 단일 항균요법, ceftriaxone+vancomycin, ceftriaxone+rifampin, meropenem+vancomycin의 병용요법 간에 치료 효과의 차이를 비교 하였다. 각 치료군은 6 마리의 토끼를 대상으로 하였다. 각각의 항생제는 5 시간 간격으로 2번 정주하였으며, ceftriaxone은 1회 투여하였다. 균주 주입 후 각 치료군이 토끼에서 치료 후 0, 5, 10, 24 시간에 척수액을 채취하여 균주의 수를 측정하여 24시간째의 살균 여부를 최종 치료 효과로 판정하였다. 결과 : meropenem 단독 요법은 10시간째에 모든 균주를 살균하였으나 24시간 째에 다시 균의 성장이 관찰되었으며, meropenem+vancomycin의 병용요법은 단독 약제보다 우수한 살균효과를 보였으나 상승작용은 없었다. 결론 : meropenem+vancomycin의 병용요법은 기존의 ceftriaxone+vancomycin보다 24시간째에 더 큰 균의 감소 경향을 보여(P=0.054) 임상에서 사용이 가능할 것으로 기대되며 향후 실제 수막염 환자에서의 임상효과를 증명하는 연구가 필요할 것으로 생각된다. Background : Because antimicrobial monotherapy for pneumococcal meningitis caused by penicillin-resistant strains is not satisfactory, ceftriaxone+vancomycin [C+V] or ceftriaxone+rifampin [C+R] regimens are recommended. Meropenern [M] is one of the monotherapy options for penicillin-resistant pneumococcal meningitis due to good in-vitro activity against pneumococci and rare adverse reactions in CNS. But there have been few reports in the efficacy of meropenern against pneumococcal meningitis. We evaluated therapeutic efficacy of the meropenern and meropenem+vancomycin in a rabbit model of meningitis caused by penicillin-resistant S. pneumoniae (PRSP). Methods : Meningitis was induced by intracistemal inoculation of a pneumococcal strain isolated from a patient with meningitis (MIC; penicillin 2, ceftriaxone 4, meropenem 0.5 g/㎖). Bacterial concentrations in the CSF were measured at 0, 5, 10, and 24 h after therapy was started. Therapeutic efficacy was evaluated by the final bacterial concentration in the CSF at 24 h. Results : C+V cleared the CSF at 10 h, but regrowth of bacteria was noted at 24 h. Meropenem monotherapy resulted in sterilization at 10 h but regrowth at 24 h. M+V was superior to M or V monotherapy but did not show synergism. Therapeutic efficacy of M+V was at least equal or superior to that of C+V (P = 0.054). Conclusion : Meropenem+vancomycin regimen could be one of the useful options in the treatment of PRSP meningitis. Clinical trials to evaluate the M or M +V are warranted in the future.

무릎운동훈련들이 안쪽빗넓은근과 가쪽넓은근의 수축 개시시간에 미치는 효과

김명진,김지원,이재온,박경희,신화경 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.2

The purpose of this study was to investigate the effect of knee exercises on the onset times of vastus medialis oblique muscle (VMO) and vastus lateralis muscle (VL) and in healthy subjects. Fifteen subjects (7 men, 8 women) in a mean age of 25.4 years participated in the study. Electromyographic (EMG) signals were recorded from the VMO and VL under four exercises. Knee exercises consisted of open kinematic terminal knee extension, straight leg raising, isometric hip adduction exercise, and closed kinematic terminal knee extension. No significant differences were found in the onset times of EMG activities of VMO and VL in the four exercises. There were also no significant differences among the exercises. These results coincided with previous studies that found no difference between onset of VMO and VL. However, it is difficult to say that there is no difference between onset of VMO and VL in healthy subjects. To confirm this results, further researches that follow same onset determination metod and exercises are needed. Not only is the study of onset time of muscle needed, but also the studies of the amount of activation and the rate of increase of muscle activation are needed.