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ADJUSTABLE ACCURACY BEHAVIORAL MODELS FOR SYSTEM-LEVEL ANALOG SIMULATION
Hamad,Hatem,Huss,Sorin A. 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
Methods for generating macromodels for analog functional blocks, as reported in literature, are of limited use in general circuit simulation due to either accuracy or efficiency problems. In this paper we propose a new approach to model the behavior of nonlinear analog functional blocks which produces application specific simulation models of adjustable accuracy. Experimental results are presented for an operational amplifier and art active RC-filter operating in large signal, nonlinear domain. The outlined methodology results in an increase of the simulation speed by at least one order of magnitude and opens an opportunity of system-level simulation of complex analog modules.
EXECUTABLE SPECIFICATIONS IN MULTI-MEDIA SYSTEM DESIGN ENVIRONMENT
Deegener,Matthias,Huss,Sorin A. 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
This paper presents a $quot;meet in the middle$quot; design approach for complex technical systems. Part of this approach is the consideration of the design environment in the specification process. M U S E is a research project which supports a systems engineer by its tools for the specification, simulation and validation of the system's behavior. After an introduction, this paper outlines the M U S E view on system level design. A major topic is expoiting of different the specification languages. Validation is hased on distributed parallel simulation and is demonstrated by exploiting the hypertext and virtual reality components of M U S E.
A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock
Judit Kovac,Jana Husse,Henrik Oster 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.2
The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.
( Harsha Pokkalla ),( Kishalve Pethia ),( Benjamin Glass ),( Jennifer Kaplan Kerner ),( Ling Han ),( Catherine Jia ),( Ryan Huss ),( Mar-ianne Camargo ),( Kathryn Kersey ),( Chuhan Chung ),( G. Mani S 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Fibrosis is the primary determinant of disease progression in patients with nonalcoholic steatohepatitis (NASH), but the prognostic impact of other histological features is unclear. We used a machine learning(ML) approach to identify novel morphologic features and associations with disease progression in NASH patients with F3/4 fibrosis. Methods: Biopsies from 644 patients screened in phase3 trial of selonsertib (STELLAR-4) were scored by a central pathologist( CP) according to the NASH CRN and Ishak staging systems. The PathAI research platform(PathAI, Boston, MA) was trained a convolutional neural network(CNN) with >68,000 annotations (e.g. steatosis, ballooning, lobular/portal inflammation) collected from 75 board-certified pathologists on images of H&E and trichrome(TC) stained slides. For staging fibrosis, CNN models were trained using slide-level pathologist scores to recognize unique patterns associated with each stage within fibrotic regions of TC images. 202 features were extracted from biopsy images from patients (F3-F4) enrolled in the STELLAR trials. Cox regression was used to identify associations between these features with progression to cirrhosis in F3 patients, and liver-related events (e.g. decompensation, transplantation, death) in F4 patients. Results: 1526 NASH patients with F3-F4 fibrosis (median age 59 yrs, 73% diabetic, 52% F4) were included. During a median follow-up of 16.5 mos, 14.5% (105/726) of F3 patients progressed to cirrhosis, and over 15.9 mos, 2.8% (22/800) of F4 patients had liver-related events. Progression to cirrhosis was associated with greater area of Ishak 6 fibrosis and portal inflammation (Figure). Similar associations were observed in F4 patients, with hepatocellular ballooning and clinical events. In F3, a greater proportion of area of Ishak 1 fibrosis and steatosis were associated with a reduced risk of progression. In F4, area of steatosis was similarly protective, while proportion of Ishak Stage 1 Fibrosis over Ishak scored area trended towards protective. Conclusions: Liver histological evaluation using ML approach identified novel features associated with progression in NASH patients with advanced fibrosis. These data support the utility of ML approaches to evaluation of liver histology as endpoints in NASH clinical trials.