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Yun, Hyo-in,Park, Seung-chun,Jiang, Cheng-zhe,Huh, Won,Rhee, Jae-chin,Park, Jong-myung,Choi, Sang-ho,Cho, Joon-hyoung 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.2 No.-
세균 감염증으로 인한 돼지 설사증의 효과적인 치료 및 예방을 위해 돼지 설사 분변으로부터 분리한 E coli 와 S typhimurium을 시험균주로 하여 norfloxacin과 국내 가축 치료에 주로 이용되고 있는 여러 항생제를 실험실적 방법으로 병용투여시 두 항생제 간의 상호작용을 checkerboard method를 이용하여 실험하였다. E coli를 시험균주로 실험한 결과, norfloxacin과 colistin의 두 항생제간의 상호작용은 상승작용을 나타내었다. 그러나 norfloxacin과 tetracycline의 병용 처치 실험에서는 길항작용을 보여주었다. S typhimurium을 시험균주로 실험한 결과, norfloxacin과 colistin의 병용 처치 실험에서는 E coli에서와 마찬가지로 상승 작용을 나타내었다. Norfloxacin과 colistin에서의 배합 비율에 따른 E coli에 대한 FIC 값은 norfloxacin이 0.08 그리고 colistin이 0.78일 때 0.38로 가장 항균 작용이 높았으며, S typhimurium에 대한 FIC 값은 E coli에서와 같은 비율에서 가장 활성이 높은 0.25를 보여주어 두 항생제의 항균력은 배합 비율에 따라서 차이가 있음을 알 수 있었다.
Transmission Dose Estimation Algorithm for in vivo Dosimetry
Yun, Hyong-Geun,Huh, Soon-Nyung,Lee, Hyoung-Koo,Woo, Hong-Gyun,Shin, Kyo-Chul,Ha, Sung-Whan The Korean Association for Radiation Protection 2003 방사선방어학회지 Vol.28 No.1
Purpose : Measurement of transmission dose is useful for in vivo dosimetry of QA purpose. The objective of this study is to develope an algorithm for estimation of tumor dose using measured transmission dose for open radiation field. Materials and Methods : Transmission dose was measured with various field size (FS), phantom thickness (Tp), and phantom chamber distance (PCD) with a acrylic phantom for 6 MV and 10 MV X-ray Source to chamber distance (SCD) was set to 150 cm. Measurement was conducted with a 0.6 cc Farmer type ion chamber. Using measured data and regression analysis, an algorithm was developed for estimation of expected reading of transmission dose. Accuracy of the algorithm was tested with flat solid phantom with various settings. Results : The algorithm consisted of quadratic function of log(A/P) (where A/P is area-perimeter ratio) and tertiary function of PCD. The algorithm could estimate dose with very high accuracy for open square field, with errors within ${\pm}0.5%$. For elongated radiation field, the errors were limited to ${\pm}1.0%$. Conclusion : The developed algorithm can accurately estimate the transmission dose in open radiation fields with various treatment settings.
투과선량을 이용한 생체내 (in vivo) 선량측정을 위한 알고리즘
윤형근,지의규,허순녕,이형구,우홍균,신교철,김시용,하성환 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.3
연구 목적 : 각종 암 환자의 방사선치료시 환자에 조사되는 방사선량을 매 치료시마다 간편하게 확인하기 위한 생체내(in vivo) 선량측정의 한 방법으로 투과선량을 이용하는 새로운 시스템에 필요한 알고리즘을 개발하고자 하였다. 이를 위하여 본 교실에서 이미 개발한 바 있는 알고리즘을 개선하고자 하였다. 연구 재료 및 방법 : 알고리즘은 투과선량의 기본 측정치를 A/P (area-perimeter ratio)의 4차 함수로 회귀한 후에 각 계수들을 PCD (phantom-chamber distance)의 3차 함수로 회귀하여 구성하였다. 또한 기본 측정조건들의 감소 가능성을 확인하기 위하여 각각의 PCD 및 Tp(phantom thickness)당 조사야를 8개만 사용한 경우와 15개를 사용한 경우에서 측정치와 계산치를 비교하였다. 임의의 방사선조사조건에서의 알고리즘의 정확도를 확인하기 위하여 기본 측정 조건에 포함되지 않은 장방형의 방사선조사야, 기본 측정에 포함되지 않은 임의의 팬톰 두께, 임의의 PCD 조건에서 측정을 시행하고 알고리즘을 이용한 계산치와 비교하였다. 연구 결과 : 기본 측정치와 알고리즘을 이용한 계산치 간의 오차를 분석한 결과 기존의 알고리즘에 비하여 정확도가 크게 향상되었으며 정방형 개방 조사야의 경우 오차의 범위를 ±0.5% 이내로 제안할 수 있었다. 또한 기본 측정조건을 약 2분의 1로 감소시킬 수 있었다. 임의의 개방조사야의 방사선조사조건에서 측정을 시행하고 알고리즘을 이용한 계산치와 비교한 경우도 대부분의 경우 ±1.0% 이하의 오차를 나타내었다. 결론 : 악성종양환자의 방사선치료시 투과선량을 이용하여 환자에 조사되는 방사선량을 실시간으로 측정하기 위한 생체내 선량측정시스템에 필요한 개선된 알고리즘은 기본 측정자료를 약 2분의 1로 축소한 경우에도 정방형 개방 조사야의 경우 ±0.5% 이하의 오차 범위, 장방형의 개방 조사야에서는 ±1.0% 이하의 오차 범위로 정확히 투과선량을 계산할 수 있음을 확인하였다. Purpose : Measurement of transmission dose is useful for in vivo dosimetry of QA purpose. The objective of this study is to develope an algorithm for estimation of tumor dose using measured transmission dose for open radiation field. Materials and Methods : Transmission dose was measured with various field size (FS), phantom thickness (Tp), and phantom chamber distance (PCD) with a acrylic phantom for 6MV and 10 MV X-ray. Source to chamber distance (SCD) was set to 150 cm, Measurement was conducted with a 0.6 cc Farmer type ion chamber. Using measured data and regression analysis, an algorithm was developed for estimation of expected reading of transmission dose. Accuracy of the algorithm was tested with flat solid phantom with various settings. Results : The algorithm consisted of quadratic function of log(A/P) (where A/P is area-perimeter ratio) and tertiary function of PCD. The algorithm could estimate dose with very high accuracy for open square field, with errors within ±0.5%. For elongated radiation field, the errors were limited to ±1.0%. Conclusion : The developed algorithm can accurately estimate the transmission dose in open radiation fields with various treatment settings.
Diphenyl-dimethyl-dicarboxylate 및 그 유도체가 흰쥐의 Complete Freund's Adjuvant 유발 염증에 미치는 효과
윤형종,허인회 중앙대학교 약학연구소 1994 약학 논총 Vol.8 No.-
PMC(Dimethyl-4,4'-dimethoxy-5,6-5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxlylate) and its derivatives, PMC1(4,4'-Dimethoxy-5,6-5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylic acid) and PMC2(Dimethyl-4,4'-dihydroxy-5,6-5',6'-dimethylene dioxybiphenyl-2,3'-dicaboxylate), were administered orally to mice and rats in order to investigate the anti-inflammatory effects. The results are as follows; 1. the anti-inflammatory effects of PMC, PMC1 and PMC2 were significant on hind paw carrageenin induced edema in rats. 2. PMC, PMC1 and PMC2 inhibited dose-dependently the capillary permeability of pontamin sky blue in mice administered HAc intraperitoneally 3. PMC, PMC1 and PMC2 had significant anti-inflammatory effects on hind paw edema induced by complete Freund's adjuvant in rats.
이형진 ( Hyoung-jin Lee ),윤영배 ( Yeong-bae Yun ),허정훈 ( Jeong-hoon Huh ),김영기 ( Young-kee Kim ) 한국응용생명화학회 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.2
Contamination and growth of Trichoderma, a green mold, on the oak log and wooden chip or sawdust media can severely inhibit the growth of oak mushroom. Chemicals including pesticides and antibiotics are generally not allowed for the control of green mold disease during mushroom cultivation. In this study, bacterial pathogens causing blotch disease on the oyster mushrooms were isolated and their peptide toxins were purified for the control of green mold disease. Strains of Pseudomonas tolaasii secret various peptide toxins, tolaasin and its structural analogues, having antifungal activities. These peptides have shown no effects on the growth of oak mushrooms. When the peptide toxins were applied to the green mold, Trichoderma harzianum H1, they inhibited the growth of green molds. Among the 20 strains of peptide-forming P. tolaasii, strong, moderate, and weak antifungal activities were measured from 8, 5, and 7 strains, respectively. During oak mushroom cultivation, bacterial culture supernatants containing the peptide toxins were sprayed on the aerial mycelia of green molds grown on the surface of sawdust media. The culture supernatants were able to suppress the fungal growth of green molds while no effect was observed on the mushroom growth and production. They changed the color of molds from white aerial mycelium into yellowish dried scab, representing the powerful anti-fungal and sterilization activities of peptide toxins.
Assessing the safety of an Ephedrae Herba aqueous extract in rats: A repeat dose toxicity study
Han, Hyoung-Yun,Huh, Jung-Im,Han, So-Ri,Kang, Myung-Gyun,Yoon, Seokjoo,Han, Ji-Seok,Lee, Byoung-Seok,Kim, Jeong Ah,Min, Byung-Sun Elsevier 2018 Regulatory toxicology and pharmacology Vol.94 No.-
<P><B>Abstract</B></P> <P>Ephedrae Herba (EH) has been used in Asian traditional herbal medicine to cure bronchial asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. In this study, we evaluated the subchronic toxicity of an Ephedrae Herba aqueous extract (EHAE) in male and female F344 rats. The EHAE was administered orally daily at doses of 0, 125, 250, 500, and 1000 mg/kg bw/day for 13 weeks. Toxicological assessment was performed to determine mortality, clinical signs, and changes in body weight, food consumption, ophthalmological, urinary, hematological, and serum biochemical parameters, macroscopic and microscopic evaluations, and organ weights. We found that oral administration of EHAE to F344 rats for 13 weeks resulted in histopathological changes in the kidneys and salivary glands. In the kidneys, increased incidence and severity of tubular basophilia were observed in females administered 1000 mg/kg bw/day of the extract. In the salivary glands, acinar cell hypertrophy was observed in males administered 500 mg/kg bw/day and in both sexes administered 1000 mg/kg bw/day of the extract. All test article-treated groups of males and females administered ≥250 mg/kg bw/day showed increased absolute and relative salivary gland weights. Therefore, the NOAEL (No Observed Adverse Effect Level) was determined as 125 mg/kg bw/day for both sexes of rats under the present experimental conditions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> There is little data in the literature on the toxic effects of Ephedrae Herba. </LI> <LI> Three males and two females in the highest dose group (1000 mg/kg bw/day) were found dead at weeks 1 and 9. </LI> <LI> In macroscopic observation, test article-related changes were observed in the kidneys and salivary glands. </LI> <LI> The no-observed-adverse-effect level was determined as 125 mg/kg bw bw/day for both sexes. </LI> </UL> </P>