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Synthesis of nanocrystalline NASICON-type thin film ceramics
Paul A. Lessing,Gary Huestis 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.1
Experiments were conducted to fabricate nano-crystalline ceramic thin films (membranes) using polymeric resin precursors. Two different NASICON compositions were chosen for fabrication: (1) NaZr2SixP3-xO12, and (2) Na1+xSn2-xInxP3O12. Zirconium-containing resins could not be synthesized without precipitations; however, clear resins were successfully generated using a tin-based composition (NaSn2P3O12). The tin-based resins were spin-coated onto silicon substrates and then heated (calcined) to high temperatures using ozone as an oxidant. Optimum resin viscosity, spin coating, and calcination conditions were developed. The resulting thin films were characterized using X-ray diffraction (XRD) and Transmission Electron Microscopy (TEM) techniques. Fully-oxidized, single phase, crack-free films were generated that were approximately 80-100 nanometres thick containing crystalline grains about 5-10 nanometres in diameter after calcining at temperatures of about 600 oC to 700 oC. These grain sizes did not correlate with those measured in “chunks” of resins that were calcined using the same conditions. Therefore, thin films of the Sn-NaSICON precursor coatings appear to provide physical constraints that are conducive to the formation of nano-crystals at temperatures of about 600 oC to 700 oC. Enhanced transport of the ions in the nano-crystalline grain boundaries at relatively low temperatures is predicted. The films should prove suitable for ion exchange of the sodium ions with protons where the resulting enhanced conductivity could lead to practical devices, including: hydrogen separation membranes, fuel cells, hydrogen “pumps”, electrolyzers, thermoelectric generators, electrochemical reactors, and sensors.
Patel, Snahel,Cohen, Frederick,Dean, Brian J,De La Torre, Kelly,Deshmukh, Gauri,Estrada, Anthony A,Ghosh, Arundhati Sengupta,Gibbons, Paul,Gustafson, Amy,Huestis, Malcolm P,Le Pichon, Claire E,Lin, Ha American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.1
<P>Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer a binding mode and specific design parameters to optimize for CNS druglike molecules, we came to focus on the di(pyridin-2-yl)amines because of their combination of desirable potency and good brain penetration following oral dosing. Our lead inhibitor GNE-3511 (26) displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that specific pharmacological inhibition of DLK may have therapeutic potential in multiple indications.</P>