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- 검색키워드
- 저자 : Huanxin Li (검색결과 4 건)
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Deyu Li,Qin Tong,Yuane Lian,Zhizhong Chen,Yaru Zhu,Weimei Huang,Yang Wen,Qiongyao Wang,Shumei Liang,Man Li,Jianjing Zheng,Zhenhua Liu,Huanxin Liu,Linlang Guo 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose Drug resistance is one of the main causes of chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into chemotherapy drug resistance are required. Materials and Methods In this study, we performed lncRNA microarray, in vitro functional assays, in vivo models and cDNA microarray to evaluate the impact of lncRNA in SCLC chemoresistance. Results The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-β1 mediated epithelial-to-mesenchymal transition in SCLC cells. Conclusion Taken together, our study revealed the role of KCNQ1OT1 in the progression and chemoresistance of SCLC, and suggested KCNQ1OT1 as a potential diagnostic and prognostic biomarker in SCLC clinical management.
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Zhao, Chunjie,Bai, Lu,Li, Huanxin,Li, Fei,Xin, Chunhong 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
A method involving depuration of 12 organochlorine pesticides (OCPs) and 7 heavy metals from Epimedium brevicornum Maxim was developed using supercritical fluid extraction (SPE). The pesticides in the study consisted of ${\alpha},\;{\beta}-,\;{\gamma}-,\;and\;{\delta}-Benzene$ hexachloride, Pentachloronitrobenzene (PCNB), Pentachloroaniline (PCA), Heptachlor (HEPT), Methyl -pentachlorophenyl sulfide (MPCPS), pp'-DDE[1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene], op'-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane], pp'-DDD [1,1-dichloro-2-2-bis(p-chlorophenyl)]ethane, pp'-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane]. A series of experiments was conducted to optimize the final extraction conditions as following: pure $CO_2$, extraction pressure of 15 Mpa, extration temperature of $60^{\circ}C$, extraction time of 10 min, flow rate at 55 kg/h. A GC method with electron capture detection was employed to determination of the OCPs, and an atomic absorption spectrometry (AAS) was designed for the determination of 7 heavy metals including of Pb, Cd, Cu, Fe, Zn, As, Hg in Epimedium brevicornum Maxim. A HPLC method was developed for the quantitative determination of active constituents. The SFE was used to remove the organochlorine pesticide and heavy metals from Epimedium brevicornum Maxim, receiving high decontamination rate of pesticide residue and low loss of active constituents.
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Chunjie Zhao,Lu Bai,Huanxin Li,Fei Li,Chunhong Xin 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
A method involving depuration of 12 organochlorine pesticides (OCPs) and 7 heavy metals from Epimedium brevicornum Maxim was developed using supercritical fluid extraction (SPE). The pesticides in the study consisted of α, β-, γ-, and δ-Benzene hexachloride, Pentachloronitrobenzene (PCNB ), Pentachloroaniline (PCA), Heptachlor (HEPT), Methyl -pentachlorophenyl sulfide (MPCPS), pp'-DDE[1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene], op'-DDT [1,1,1- trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane], pp'-DDD [1,1-dichloro-2-2-bis(p-chlorophenyl)] ethane, pp'-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane]. A series of experiments was conducted to optimize the final extraction conditions as following: pure CO2, extraction pressure of 15 Mpa, extration temperature of 60oC, extraction time of 10 min, flow rate at 55 kg/h. A GC method with electron capture detection was employed to determination of the OCPs, and an atomic absorption spectrometry (AAS) was designed for the determination of 7 heavy metals including of Pb, Cd, Cu, Fe, Zn, As, Hg in Epimedium brevicornum Maxim. A HPLC method was developed for the quantitative determination of active constituents. The SFE was used to remove the organochlorine pesticide and heavy metals from Epimedium brevicornum Maxim, receiving high decontamination rate of pesticide residue and low loss of active constituents.
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Zhenyu He,San-Gang Wu,Juan Zhou,Fengyan Li,Jiayan Sun,Qin Lin,Huanxin Lin,Xunxing Guan 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3
Purpose: Several accelerated partial breast irradiation (APBI)techniques are being investigated in patients with early-stagebreast cancer. The present study evaluated the feasibility, earlytoxicity, initial efficacy, and cosmetic outcomes of acceleratedpartial breast intensity-modulated radiotherapy (IMRT) for Chinesefemale patients with early-stage breast cancer after breastconservingsurgery. Methods: A total of 38 patients met the inclusioncriteria and an accelerated partial breast intensity-modulatedradiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction,twice a day, in intervals of more than 6 hours. Results: Of the38 patients, six patients did not meet the planning criteria. Theremaining 32 patients received APBI-IMRT with a mean targetvolume conformity index of 0.67 and a dose homogeneity indexof 1.06. The median follow-up time was 53 months and no localrecurrence or distant metastasis was detected. The most commonacute toxicities observed within 3 months after radiotherapywere erythema, breast edema, pigmentation, and pain in the irradiatedlocation, among which 43.8%, 12.5%, 31.3%, and28.1% were grade 1 toxicities, respectively. The most commonlate toxicities occurring after 3 months until the end of the followupperiod were breast edema, pigmentation, pain in the irradiatedlocation, and subcutaneous fibrosis, among which 6.2%,28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes,and only one patient had a poor cosmetic outcome. Conclusion: It is feasible for Chinese females to receive APBIIMRTafter breast conserving surgery. The radiotherapeutic toxicityis acceptable, and both the initial efficacy and cosmeticoutcomes are good.
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