http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hu Zhiqing (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Hu Zhiqing,Li Jiaji,Yu Ge,Lin Baojun 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.8
Clustering balls spinning method is a new method for fabricating curved surfaces by clustering rigid balls. It is always one of options to explore forming mechanism by using numerical simulation method that is closer to the real experimental process. In this article, we have adopted a new numerical model with multi-layer rigid balls (MlRB), which is named as MlRB model and more responsive to actual experiments. The model subroutine is developed based on the ABAQUS software. Simulation procedure using MlRB model is introduced, and cross-section, thickness distribution and springback using MlRB model are analyzed and compared to the experimental results and simulated results using previous numerical model with single-layer rigid balls (SlRB), which is named as SlRB model. The results are shown that, curved surface and thickness distribution simulated by MlRB model are closed to experimental results, and springback of curved surface is much less. Furthermore, auxiliary forming region that benefits to make the sheet deformed furtherly is proposed and analyzed. It is indicated that MlRB model is successful to simulate the deformation of the sheet according to the experiment, and it lays the foundation for the optimization of the technology parameters in the future.
-
The conditional risk probability-based seawall height design method
Yang, Xing,Hu, Xiaodong,Li, Zhiqing The Society of Naval Architects of Korea 2015 International Journal of Naval Architecture and Oc Vol.7 No.6
The determination of the required seawall height is usually based on the combination of wind speed (or wave height) and still water level according to a specified return period, e.g., 50-year return period wind speed and 50-year return period still water level. In reality, the two variables are be partially correlated. This may be lead to over-design (costs) of seawall structures. The above-mentioned return period for the design of a seawall depends on economy, society and natural environment in the region. This means a specified risk level of overtopping or damage of a seawall structure is usually allowed. The aim of this paper is to present a conditional risk probability-based seawall height design method which incorporates the correlation of the two variables. For purposes of demonstration, the wind speeds and water levels collected from Jiangsu of China are analyzed. The results show this method can improve seawall height design accuracy.
-
The conditional risk probability-based seawall height design method
Xing Yang,Xiaodong Hu,Zhiqing Li 대한조선학회 2015 International Journal of Naval Architecture and Oc Vol.7 No.6
The determination of the required seawall height is usually based on the combination of wind speed (or wave height) and still water level according to a specified return period, e.g., 50-year return period wind speed and 50- year return period still water level. In reality, the two variables are be partially correlated. This may be lead to overdesign (costs) of seawall structures. The above-mentioned return period for the design of a seawall depends on economy, society and natural environment in the region. This means a specified risk level of overtopping or damage of a seawall structure is usually allowed. The aim of this paper is to present a conditional risk probability-based seawall height design method which incorporates the correlation of the two variables. For purposes of demonstration, the wind speeds and water levels collected from Jiangsu of China are analyzed. The results show this method can improve seawall height design accuracy.
-
GATA2-Mediated Transcriptional Activation of Notch3 Promotes Pancreatic Cancer Liver Metastasis
Heng Lin,Peng Hu,Hongyu Zhang,Yong Deng,Zhiqing Yang,Leida Zhang 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.5
The liver is the predominant metastatic site for pancreatic cancer. However, the factors that determine the liver metastasis and the specific molecular mechanisms are still unclear. In this study, we used human pancreatic cancer cell line Hs766T to establish Hs766T-L3, a subline of Hs766T with stable liver metastatic ability. We performed RNA sequencing of Hs766T-L3 and its parental cell line Hs766T, and revealed huge differences in gene expression patterns and pathway activation between these two cell lines. We correlated the difference in pathway activation with the expression of the four core transcriptional factors including STAT1, NR2F2, GATA2, and SMAD4. Using the TCGA database, we examined the relative expression of these transcription factors (TFs) in pan-cancer and their relationship with the prognosis of the pancreatic cancer. Among these TFs, we considered GATA2 is closely involved in tumor metastasis and may serve as a potential metastatic driver. Further in vitro and in vivo experiments confirmed that GATA2-mediated transcriptional activation of Notch3 promotes the liver metastasis of Hs766T-L3, and knockdown of either GATA2 or Notch3 reduces the metastatic ability of Hs766T-L3. Therefore, we claim that GATA2 may serve as a metastatic driver of pancreatic cancer and a potential therapeutic target to treat liver metastasis of pancreatic cancer.
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
