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Yue Hu,Jun Zhou Korea Genome Organization 2023 Genomics & informatics Vol.21 No.4
Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.
Phase equilibrium data of methane hydrates in mixed brine solutions
Hu, Yue,Lee, Bo Ram,Sum, Amadeu K. Elsevier 2017 Journal of natural gas science and engineering Vol.46 No.-
<P><B>Abstract</B></P> <P>Knowing the hydrate phase equilibria in brines is critically important to assess the risk of hydrate formation, especially for conditions involving high salinity and very high pressure, which are becoming more prevalent in oil/gas exploration and production. Hydrate phase equilibria data for mixed salt brines over a wide range of pressure is very limited in the open literature. Inorganic salts are thermodynamic hydrate inhibitors and are commonly present in produced water from oil/gas production. As such, this study reports methane hydrate phase equilibria in brines composed of mixed salts (NaCl, KCl, CaCl<SUB>2</SUB> and MgCl<SUB>2</SUB>) for total salt concentration up to 29.2 wt% and for pressures ranging from 20 to 200 MPa (2900 to 29,000 psia). Data under these conditions are the first reported and they add significant value in furthering knowledge of the phase space for hydrate formation. In addition, these data are used for the development and assessment of models to capture hydrate phase equilibria over a wide range of salt concentrations and pressures. At last, critical factors (such as pressure, salt species, and concentration) that influence the hydrate suppression temperature relative to the uninhibited (salt-free) systems are also investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Methane hydrate phase equilibria in mixed salt brines were measured up to 200 MPa. </LI> <LI> Measured data were compared with predicted results from commonly used tools. </LI> <LI> Data provided information on the hydrate suppression temperature dependence on pressure. </LI> </UL> </P>
Gas Hydrates Phase Equilibria and Formation from High Concentration NaCl Brines up to 200 MPa
Hu, Yue,Makogon, Taras Y.,Karanjkar, Prasad,Lee, Kun-Hong,Lee, Bo Ram,Sum, Amadeu K. American Chemical Society 2017 Journal of chemical and engineering data Vol.62 No.6
<P>Gas hydrate phase equilibrium and kinetics at high NaCl concentrations (near and at saturation in solution) and very high pressures (up to similar to 200 MPa) are investigated to study the interplay of hydrate formation and salt precipitation. Limited experimental data above 80 MPa exist for hydrate phase equilibrium in high salinity systems. This study reveals the unusual formation of gas hydrates under these extreme conditions of high salinity and very high pressure. In particular, the results demonstrate that hydrates can form from saturated salt solutions, and the formation of hydrates and salt precipitation are competing effects. It is determined that hydrates will remain in equilibrium with a saturated salt solution, with the amount of salt precipitation determined by the amount of hydrates formed. These data are essential fundamental data for gas hydrates applications in the oil and gas production flow assurance and seawater desalination.</P>
New regularity criterion for the Navier-Stokes equations
Hu Yue,Yuanshan Zhaoy 장전수학회 2009 Proceedings of the Jangjeon mathematical society Vol.12 No.3
We study the incompressible Navier-stokes equations in the entire three-dimensional space, We prove that if [tntlr] where [tntlr] then the solution is regular.
Hu, Yue,Lee, Bo Ram,Sum, Amadeu K. Elsevier 2017 Fluid phase equilibria Vol.450 No.-
<P><B>Abstract</B></P> <P>The methane hydrate dissociation conditions are measured at high pressures (up to 200 MPa) to fundamentally understand the hydrate properties. The results show an increased enthalpy of dissociation, from about 53 to 58 kJ/mol, as the hydrate equilibrium pressures transition from low (<80 MPa) to higher pressures (up to 200 MPa), indicating greater stability for the hydrates. Molecular simulations are used to understand and explain the increased stability with increasing pressure, by calculating the enthalpy and molecular structure of the phases.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Efficient removal of Cr(VI) by spent coffee grounds: Molecular adsorption and reduction mechanism
Yue Hu,Meiting Zhi,Shilin Chen,Wenguan Lu,Yinlong Lai,Xiaobing Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
Spent coffee ground (SCG), a byproduct from the soluble coffee industry, is usually discarded as waste. Thereutilization of SCG for the removal of toxic heavy metal ions is a novel research direction. Until recently, the molecularadsorption and reduction mechanism of Cr(VI) on SCG was barely investigated. In this study, SCG was used forthe efficient removal of Cr(VI) at a concentration range of 2-100mg/L, with a maximum Cr(VI) uptake up to 36.2mg/g. Structural characterization and ATR-FTIR analysis indicated that SCG possessed abundant surface O and N- containingfunctional groups. The corresponding adsorption and reduction effects on the Cr(VI) removal were investigatedby the carboxyl and hydroxyl groups elimination experiments and ATR-FTIR characterization, respectively. Theresults revealed that HCrO4 ions were preliminarily adsorbed on SCG surfaced-COOH/-OH/-NH by the formation ofhydrogen bond (SCG surfaced-COOH/-OH/-NH···HCrO4), and quickly reduced to Cr(III) by the electron denoted byphenolic compounds, and then in-situ immobilized on the surface of SCG. The effect of Cr(VI) concentration, coexistingions, and humic acid was systematically studied to optimize the removal of Cr(VI) wastewater. Column experimentsprovided a new substitution to restore the Cr(VI)-containing groundwater for the permeable reactive barrierapplication. Thus, the proposed study uncovered the intrinsic Cr(VI) removal mechanism at the molecular level andexplored the application of SCG for the efficient removal of Cr(VI).
Hu, Yue,Makogon, Taras Y.,Karanjkar, Prasad,Lee, Kun-Hong,Lee, Bo Ram,Sum, Amadeu K. Elsevier 2018 The Journal of chemical thermodynamics Vol.117 No.-
<P><B>Abstract</B></P> <P>Gas hydrates phase equilibria for structure I and II hydrates with chloride salts (NaCl, CaCl<SUB>2</SUB>, KCl and MgCl<SUB>2</SUB>) were measured at high salt concentrations and up to 200MPa. The measured equilibrium data represent three-phase (Solution – Hydrate – Vapor) or four-phase (Solution – Hydrate – Salt precipitated – Vapor) equilibrium depending on the salt concentration. The hydrate phase boundary with salts was shifted to lower temperatures and higher pressures when the experimental system was below the salt saturation concentration, while the boundaries were unchanged at salt concentrations above saturation, corresponding to quadruple points. The experimental data were compared with hydrate equilibrium predictions calculated by commonly used predictive tools to assess the reliability of these tools for the brines and conditions considered. The comparison demonstrates that predictive tools exhibit large deviation to the measured data, especially at high pressures and high salinity conditions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Gas hydrates phase equilibria with chloride salts were measured up to 200MPa. </LI> <LI> Predictions deviate from measured data at high salt concentration and high pressure. </LI> <LI> Measured data are valuable to test and improve hydrate predictive tools. </LI> </UL> </P>